poisonreview
@poisonreview.bsky.social
450 followers 1.5K following 130 posts
Medical toxicologist in the Toxikon Group Chicago. Columnist for "Emergency Medicine News." Peloton fanatic. Mitochondriac. Posts reflect my own opinions and should to be taken as medical advice. Reposts do not imply endorsement. #MedTox
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poisonreview.bsky.social
GLP-1 drugs such as Wegovy and Mounjaro can cause dramatic changes in GI motility and function, as well as dehydration and malnutrition. Will this change the way we treat poisoned patients on these meds?

journals.lww.com/em-news/full...
journals.lww.com
poisonreview.bsky.social
GLP-1 receptor agonists can impair gastric emptying, decrease gallbladder contractility, and cause dehydration and malnutrition. Will this affect management of poisoned patients? I discussed in this month's Toxicology Rounds column.

journals.lww.com/em-news/full...
journals.lww.com
poisonreview.bsky.social
The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral i…
Reposted by poisonreview
pulmcrit.bsky.social
we're seeing *lots* of cocaine & methamphetamine use, especially via inhalational routes

presentations vary, including:

🥵 acute agitation/psychosis
🥵 seizures
🥵 vascular events, esp in young people (stroke, MI)

Local news www.wcax.com/2025/10/02/v...

IBCC chapter emcrit.org/ibcc/symp/ #EMIMCC
Vermont health officials alarmed by shift from opioid abuse to stimulants
Vermont health officials say the state is entering a new wave of the drug crisis.
www.wcax.com
poisonreview.bsky.social
The new weight loss drugs like Ozempic and Mounjaro cause all sorts of changes in the GI tract. How may these changes affect management of poisoned patients?

journals.lww.com/em-news/full...
journals.lww.com
Reposted by poisonreview
pulmcrit.bsky.social
"consensus" guideline on the management of DKA & HHS

with ZERO input from:
- anyone in emergency medicine
- anyone in critical care
- anyone in hospital medicine

the guidelines (published in 2024) contain many antiquated practices and big errors... 🧵#1/3 #EMIMCC

pubmed.ncbi.nlm.nih.gov/39052901/
https://diabetesjournals.org/care/article/47/8/1257/156808/Hyperglycemic-Crises-in-Adults-With-Diabetes-A
Reposted by poisonreview
mja.com.au
🔔 New in InSight+

An Australian MD, and a mycologist, have been the first to publish a study on Wood-lover’s Paralysis, a rare toxidrome associated with ingesting species of ‘magic mushrooms.’

Read more: buff.ly/gU5OJ0Y
poisonreview.bsky.social
Harvard Dean was paid $150,000 as expert witness in Tylenol lawsuits
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pulmcrit.bsky.social
super important point 👇

sometimes creatinine falls due to dilution from large-volume fluid resuscitation.

if the urine output is zero then the GFR must be zero (regardless of how much the creatinine has decreased).
sargsyanz.bsky.social
The serum creatinine level is a concentration, amount per volume.

If you quickly expand plasma volume by 20%, the Cr will decrease by ~20%, saying nothing of GFR.

Same goes for ALT, WBC, CRP, and other values that we trend and sometimes overinterpret small fluctuations of.
poisonreview.bsky.social
I would add that fomepizole, in addition to inhibiting CYP2E1, blocks the cascade of increasing oxidative damage that eventually leads to hepatocyte death. This suggests fomepizole may add benefit even when the acetaminophen level is low or undetectable and there's no more drug left to metabolize.