Anthony Ramnauth
@philoneurosci.bsky.social
Postdoc - https://bsky.app/profile/lukesjulson.bsky.social @ Albert Einstein College of Medicine | Ph.D. JHU SOM - https://bsky.app/profile/martinowk.bsky.social @ LIBD.
Reposted by Anthony Ramnauth
fMRI signals “up,” but neural metabolism might be going “down.”
In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.
rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:
In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.
rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:
December 16, 2025 at 3:43 PM
fMRI signals “up,” but neural metabolism might be going “down.”
In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.
rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:
In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.
rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:
Glad to have contributed to this cool project!
spaTransfer: transfer learning for single- #cell and spatial #transcriptomics data using non-negative matrix factorization
www.biorxiv.org/content/10.6...
spaTransfer: transfer learning for single- #cell and spatial #transcriptomics data using non-negative matrix factorization
www.biorxiv.org/content/10.6...
spaTransfer: transfer learning for single-cell and spatial transcriptomics data using non-negative matrix factorization
Recent advances in spatially-resolved transcriptomics have enabled profiling of gene expression in a spatial context, which has led to the generation of large-scale single-cell and spatial atlases wit...
www.biorxiv.org
December 16, 2025 at 6:37 PM
Glad to have contributed to this cool project!
spaTransfer: transfer learning for single- #cell and spatial #transcriptomics data using non-negative matrix factorization
www.biorxiv.org/content/10.6...
spaTransfer: transfer learning for single- #cell and spatial #transcriptomics data using non-negative matrix factorization
www.biorxiv.org/content/10.6...
Reposted by Anthony Ramnauth
@russpoldrack.org's guidelines for AI-assisted coding can help researchers ensure the integrity of their work while accelerating progress on important scientific questions.
#neuroskyence
www.thetransmitter.org/artificial-i...
#neuroskyence
www.thetransmitter.org/artificial-i...
AI-assisted coding: 10 simple rules to maintain scientific rigor
These guidelines can help researchers ensure the integrity of their work while accelerating progress on important scientific questions.
www.thetransmitter.org
December 16, 2025 at 3:00 PM
@russpoldrack.org's guidelines for AI-assisted coding can help researchers ensure the integrity of their work while accelerating progress on important scientific questions.
#neuroskyence
www.thetransmitter.org/artificial-i...
#neuroskyence
www.thetransmitter.org/artificial-i...
Reposted by Anthony Ramnauth
Finally on Bluesky and I’m really excited to share this latest preprint with @jorge-miranda.bsky.social in which we functionally examined the role of a medial prefrontal cortex (mPFC)- Locus Coeruleus (LC) circuit in regulating sustained attention.
1/7
www.biorxiv.org/content/10.6...
1/7
www.biorxiv.org/content/10.6...
Top-down control of sustained attention by the medial prefrontal cortex (mPFC)- locus coeruleus (LC) circuit during the rodent continuous performance task (rCPT)
The medial prefrontal cortex (mPFC) plays a pivotal role in attention by exerting top-down control to allocate cognitive resources toward behaviorally relevant stimuli based on learned context and exp...
www.biorxiv.org
December 15, 2025 at 9:53 PM
Finally on Bluesky and I’m really excited to share this latest preprint with @jorge-miranda.bsky.social in which we functionally examined the role of a medial prefrontal cortex (mPFC)- Locus Coeruleus (LC) circuit in regulating sustained attention.
1/7
www.biorxiv.org/content/10.6...
1/7
www.biorxiv.org/content/10.6...
Interesting results. Non-linear mixed selectivity #neurons supposedly twist manifolds to solve linearly inseparable problems
From #sensory to #perceptual #manifolds: The twist of #neural #geometry | Science Advances www.science.org/doi/10.1126/...
From #sensory to #perceptual #manifolds: The twist of #neural #geometry | Science Advances www.science.org/doi/10.1126/...
From sensory to perceptual manifolds: The twist of neural geometry
The brain uses geometric twists to expand neural dimensionality, thus untangling perception from sensation.
www.science.org
December 15, 2025 at 5:18 PM
Interesting results. Non-linear mixed selectivity #neurons supposedly twist manifolds to solve linearly inseparable problems
From #sensory to #perceptual #manifolds: The twist of #neural #geometry | Science Advances www.science.org/doi/10.1126/...
From #sensory to #perceptual #manifolds: The twist of #neural #geometry | Science Advances www.science.org/doi/10.1126/...
Reposted by Anthony Ramnauth
🥳Excited to share our latest human multipatch paper, now out in @natneuro.nature.com
🧠 We studied the cellular and synaptic physiology of human L2–3 pyramidal neurons and identified subtype-specific local connectivity rules across individuals.
www.nature.com/articles/s41...
Join us: penglab.de
🧠 We studied the cellular and synaptic physiology of human L2–3 pyramidal neurons and identified subtype-specific local connectivity rules across individuals.
www.nature.com/articles/s41...
Join us: penglab.de
December 13, 2025 at 7:59 AM
🥳Excited to share our latest human multipatch paper, now out in @natneuro.nature.com
🧠 We studied the cellular and synaptic physiology of human L2–3 pyramidal neurons and identified subtype-specific local connectivity rules across individuals.
www.nature.com/articles/s41...
Join us: penglab.de
🧠 We studied the cellular and synaptic physiology of human L2–3 pyramidal neurons and identified subtype-specific local connectivity rules across individuals.
www.nature.com/articles/s41...
Join us: penglab.de
Mechanosensitive #genomic enhancers potentiate the cellular response to matrix stiffness | Science www.science.org/doi/10.1126/...
Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness
Epigenetic control of gene expression and cellular phenotype is influenced by changes in the local microenvironment, yet how mechanical cues precisely influence epigenetic state to regulate transcript...
www.science.org
December 12, 2025 at 4:54 PM
Mechanosensitive #genomic enhancers potentiate the cellular response to matrix stiffness | Science www.science.org/doi/10.1126/...
#Cortical glutamatergic and GABAergic inputs support #learning -driven #hippocampal stability | Science www.science.org/doi/10.1126/...
Cortical glutamatergic and GABAergic inputs support learning-driven hippocampal stability
Flexibility and stability of neuronal ensembles are crucial features of brain function. Little is known about how these properties of local circuits are influenced by long-range inputs. We show, in mi...
www.science.org
December 12, 2025 at 4:43 PM
#Cortical glutamatergic and GABAergic inputs support #learning -driven #hippocampal stability | Science www.science.org/doi/10.1126/...
Nice review of some of the novel methods out.
In vivo multimodal neurochemical interfaces for real-time #decoding of #brain circuit
doi.org/10.1038/s415...
In vivo multimodal neurochemical interfaces for real-time #decoding of #brain circuit
doi.org/10.1038/s415...
In vivo multimodal neurochemical interfaces for real-time decoding of brain circuit - Nature Reviews Neuroscience
Neural decoding remains constrained by methods that miss the brain’s chemical signalling dimension. In this Review, Kim and Park discuss hybrid and transformative neurochemical interfaces that provide...
doi.org
December 12, 2025 at 4:34 PM
Nice review of some of the novel methods out.
In vivo multimodal neurochemical interfaces for real-time #decoding of #brain circuit
doi.org/10.1038/s415...
In vivo multimodal neurochemical interfaces for real-time #decoding of #brain circuit
doi.org/10.1038/s415...
Reposted by Anthony Ramnauth
At Johns Hopkins, a once-robust diversity office has quietly withered, shrinking from 14 staffers to three, pausing programs for underrepresented scholars and restricting race-based initiatives on campus. The disappearing diversity programs at Hopkins:
www.thebanner.com/education/hi...
www.thebanner.com/education/hi...
The disappearing diversity programs at Johns Hopkins University
Under Donald Trump, Johns Hopkins University has changed policies and scaled back its diversity office.
www.thebanner.com
December 12, 2025 at 2:19 PM
At Johns Hopkins, a once-robust diversity office has quietly withered, shrinking from 14 staffers to three, pausing programs for underrepresented scholars and restricting race-based initiatives on campus. The disappearing diversity programs at Hopkins:
www.thebanner.com/education/hi...
www.thebanner.com/education/hi...
Reposted by Anthony Ramnauth
Dimensionality reduction may be the wrong approach to understanding neural representations. Our new paper shows that across human visual cortex, dimensionality is unbounded and scales with dataset size—we show this across nearly four orders of magnitude. journals.plos.org/ploscompbiol...
December 11, 2025 at 3:32 PM
Dimensionality reduction may be the wrong approach to understanding neural representations. Our new paper shows that across human visual cortex, dimensionality is unbounded and scales with dataset size—we show this across nearly four orders of magnitude. journals.plos.org/ploscompbiol...
Reposted by Anthony Ramnauth
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult.
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Causal modelling of gene effects from regulators to programs to traits - Nature
Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.
www.nature.com
December 11, 2025 at 5:54 PM
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult.
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
Single-cell spatiotemporal #transcriptomic and #chromatin accessibility profiling in #developing postnatal #human and #macaque prefrontal #cortex
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Single-cell spatiotemporal transcriptomic and chromatin accessibility profiling in developing postnatal human and macaque prefrontal cortex - Nature Neuroscience
Human-specific molecular and cellular regulatory programs prolong prefrontal cortical maturation by orchestrating postnatal development of neurons and glia, with implications for cognitive function an...
doi.org
December 11, 2025 at 8:17 PM
Single-cell spatiotemporal #transcriptomic and #chromatin accessibility profiling in #developing postnatal #human and #macaque prefrontal #cortex
doi.org/10.1038/s415...
doi.org/10.1038/s415...
"Here we present evidence of fire-making on a 400,000-year-old buried landsurface at Barnham (UK)"
That rewrites many things we assumed about our #history!
www.nature.com/articles/s41...
That rewrites many things we assumed about our #history!
www.nature.com/articles/s41...
Earliest evidence of making fire - Nature
Baked sediment, heat-shattered artefacts and introduced pyrite in a 400,000-year-old Palaeolithic occupation site in Suffolk, UK provide evidence of intentional fire-making, marking a pivotal moment i...
www.nature.com
December 11, 2025 at 2:00 PM
"Here we present evidence of fire-making on a 400,000-year-old buried landsurface at Barnham (UK)"
That rewrites many things we assumed about our #history!
www.nature.com/articles/s41...
That rewrites many things we assumed about our #history!
www.nature.com/articles/s41...
Reposted by Anthony Ramnauth
Excited to share our latest preprint from @lieberinstitute.bsky.social spatial + single-cell RNA-seq map the ERC & explore how AD risk shapes gene expression doi.org/10.1101/2025...
Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”
Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”
December 11, 2025 at 12:13 PM
Excited to share our latest preprint from @lieberinstitute.bsky.social spatial + single-cell RNA-seq map the ERC & explore how AD risk shapes gene expression doi.org/10.1101/2025...
Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”
Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”
Reposted by Anthony Ramnauth
A high #fat #diet increases risk taking and suppresses escape neurons
in🐁🐁🐁
#neuroscience
www.cell.com/current-biol...
in🐁🐁🐁
#neuroscience
www.cell.com/current-biol...
High-fat food reinforces risk taking by suppressing defensive neurons
This study by de Araujo Salgado and Krashes reveals how high-fat diets suppress defensive
neural circuits, driving riskier foraging in the presence of predation. The findings
highlight how high-fat fo...
www.cell.com
December 9, 2025 at 6:20 PM
A high #fat #diet increases risk taking and suppresses escape neurons
in🐁🐁🐁
#neuroscience
www.cell.com/current-biol...
in🐁🐁🐁
#neuroscience
www.cell.com/current-biol...
Reposted by Anthony Ramnauth
🧠 We're hiring! 🧠 Are you passionate about neuroscience and education? Join our faculty at UNC Chapel Hill to inspire and teach the next generation of neuroscientists. Apply now: 🔗https://unc.peopleadmin.com/postings/308455
#Neuroscience #TeachingJobs #AcademicJobs #HigherEd
#Neuroscience #TeachingJobs #AcademicJobs #HigherEd
December 9, 2025 at 7:20 PM
🧠 We're hiring! 🧠 Are you passionate about neuroscience and education? Join our faculty at UNC Chapel Hill to inspire and teach the next generation of neuroscientists. Apply now: 🔗https://unc.peopleadmin.com/postings/308455
#Neuroscience #TeachingJobs #AcademicJobs #HigherEd
#Neuroscience #TeachingJobs #AcademicJobs #HigherEd
Multi-region m6A #epitranscriptome profiling of the #human #brain reveals spatial and temporal variation and enrichment of disease-associated loci
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Multi-region m6A epitranscriptome profiling of the human brain reveals spatial and temporal variation and enrichment of disease-associated loci - Nature Neuroscience
Epitranscriptomic (m6A) profiling across five human brain regions and developmental stages uncovers region-specific and age-specific dynamics, preferential enrichment in disease-associated genes, and ...
doi.org
December 9, 2025 at 7:16 PM
Multi-region m6A #epitranscriptome profiling of the #human #brain reveals spatial and temporal variation and enrichment of disease-associated loci
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Reposted by Anthony Ramnauth
I am thrilled to share our latest work led by @zurisullivan.bsky.social in collaboration with @moffittlab.bsky.social ! We find that the brain encodes distinct, pathogen-specific sickness states across behavior, physiology, neural activity, and gene expression 1/6
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
December 9, 2025 at 12:05 PM
I am thrilled to share our latest work led by @zurisullivan.bsky.social in collaboration with @moffittlab.bsky.social ! We find that the brain encodes distinct, pathogen-specific sickness states across behavior, physiology, neural activity, and gene expression 1/6
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
#Psilocybin triggers an activity-dependent rewiring of large-scale #cortical #networks: Cell www.cell.com/cell/fulltex...
Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks
Psilocybin reshapes brain networks through activity-dependent plasticity, including
a weakening of recurrent cortical loops that could underlie its therapeutic effects.
www.cell.com
December 8, 2025 at 8:54 PM
#Psilocybin triggers an activity-dependent rewiring of large-scale #cortical #networks: Cell www.cell.com/cell/fulltex...
Reposted by Anthony Ramnauth
This is why I find high-level discussions of “the entire brain works this way according a single organizing principle” so irritating. Like no, evolution means 3.5 billion years of the most spaghetti legacy code with no refactoring allowed! It’s not intelligent design . . .
December 8, 2025 at 5:24 AM
This is why I find high-level discussions of “the entire brain works this way according a single organizing principle” so irritating. Like no, evolution means 3.5 billion years of the most spaghetti legacy code with no refactoring allowed! It’s not intelligent design . . .
Discovery of an ancient neolithic people in the Arabian desert that built scaled models of their large animal traps!
www.pbs.org/video/ancien...
www.pbs.org/video/ancien...
NOVA | Ancient Desert Death Trap | Season 52 | Episode 17
Explore mysterious 9,000-year-old Stone Age megastructures found in the Arabian Desert.
www.pbs.org
December 7, 2025 at 2:18 PM
Discovery of an ancient neolithic people in the Arabian desert that built scaled models of their large animal traps!
www.pbs.org/video/ancien...
www.pbs.org/video/ancien...
This is interesting, the authors retracted this paper (for experimental errors). Made updated experiments and analyses, then released it as a preprint here:
doi.org/10.6084/m9.f...
Why didn't they go through the publication process with the same journal?
www.cell.com/cell/fulltex...
doi.org/10.6084/m9.f...
Why didn't they go through the publication process with the same journal?
www.cell.com/cell/fulltex...
Retraction notice to: Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells
(Cell 187, 7637–7654.e1–e29; December 26, 2024)
www.cell.com
December 3, 2025 at 10:00 PM
This is interesting, the authors retracted this paper (for experimental errors). Made updated experiments and analyses, then released it as a preprint here:
doi.org/10.6084/m9.f...
Why didn't they go through the publication process with the same journal?
www.cell.com/cell/fulltex...
doi.org/10.6084/m9.f...
Why didn't they go through the publication process with the same journal?
www.cell.com/cell/fulltex...
VTA #dopaminergic #neuronal activity during #NREM #sleep is modulated by #learning and facilitates motor #memory consolidation | Science Advances www.science.org/doi/10.1126/...
VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation
Activity of VTA dopaminergic neurons during NREM sleep facilitates motor memory consolidation and is coordinated with spindles.
www.science.org
December 3, 2025 at 9:50 PM
VTA #dopaminergic #neuronal activity during #NREM #sleep is modulated by #learning and facilitates motor #memory consolidation | Science Advances www.science.org/doi/10.1126/...
This is a good example of low-hanging fruit, but needed to be done!
Single-cell #sequencing of #rodent ventral pallidum reveals diverse #neuronal subtypes with noncanonical interregional continuity | Science Advances www.science.org/doi/10.1126/...
Single-cell #sequencing of #rodent ventral pallidum reveals diverse #neuronal subtypes with noncanonical interregional continuity | Science Advances www.science.org/doi/10.1126/...
Single-cell sequencing of rodent ventral pallidum reveals diverse neuronal subtypes with noncanonical interregional continuity
Ventral pallidum contains 16 cell types with diverse gene expression and spatial patterns extending beyond its borders.
www.science.org
December 3, 2025 at 9:43 PM
This is a good example of low-hanging fruit, but needed to be done!
Single-cell #sequencing of #rodent ventral pallidum reveals diverse #neuronal subtypes with noncanonical interregional continuity | Science Advances www.science.org/doi/10.1126/...
Single-cell #sequencing of #rodent ventral pallidum reveals diverse #neuronal subtypes with noncanonical interregional continuity | Science Advances www.science.org/doi/10.1126/...