This study shows that mammary branching morphogenesis is regulated by extracellular matrix (ECM) stress relaxation. Slow stress-relaxing matrices promote branching through focal adhesion signaling, c...

Using multiplexed super-resolution imaging with fluorophore-labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending ...

17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple...

A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specifi...

The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED-ApoVs) in the treatment of CD8+ T cell-mediated hypersensitivity reactions is noteworthy. SHED-A...

Hoffmann et al. describe within cells how the Dictyostelium discoideum nuclear pore complex structure constricts and dilates as a consequence of osmotic stress. Based on their experimental findings, they propose a hydrodynamics model and quantify fluid flow across nuclear pore complexes under conditions when nuclei change their volume rapidly.