Pascalis Vergidis, MD
@pascalisid.bsky.social
Infectious Disease physician | Associate Professor at Mayo Clinic | Microbiology Course Director | ABIM Governance Member
Reposted by Pascalis Vergidis, MD
How best to treat invasive aspergillosis? @pascalisid.bsky.social reviewing key clinical studies informing this choice - important to monitor vori levels , NB: AmB @idweek.bsky.social #IDWeek2025 #TxID #IDSky
October 20, 2025 at 12:33 PM
How best to treat invasive aspergillosis? @pascalisid.bsky.social reviewing key clinical studies informing this choice - important to monitor vori levels , NB: AmB @idweek.bsky.social #IDWeek2025 #TxID #IDSky
Please join us this Monday 8-9 am at IDWeek. Difficult-to-treat mold infections. Dimitrios Farmakiotis will be discussing treatment of mucormycosis. I will be discussing aspergillosis.
October 18, 2025 at 5:13 PM
Please join us this Monday 8-9 am at IDWeek. Difficult-to-treat mold infections. Dimitrios Farmakiotis will be discussing treatment of mucormycosis. I will be discussing aspergillosis.
Reposted by Pascalis Vergidis, MD
There’s now an app for all things fungi 🦠🍄
Dr. Matthew Pullen, Assistant Professor at the University of Minnesota, helped launch Dr Fungus—a free app that brings the trusted resource to your phone.
Explore fungal infections, antifungal treatments, and case-based learning—all in one place.
Dr. Matthew Pullen, Assistant Professor at the University of Minnesota, helped launch Dr Fungus—a free app that brings the trusted resource to your phone.
Explore fungal infections, antifungal treatments, and case-based learning—all in one place.
Home - Doctor Fungus
Welcome to Doctor Fungus! An Educational Website of theMycoses Study Group Education and Research Consortium (MSGERC) [View Legal Information] Where to Start Mycology Case of the Month An Introducti...
DrFungus.org
October 7, 2025 at 1:09 PM
There’s now an app for all things fungi 🦠🍄
Dr. Matthew Pullen, Assistant Professor at the University of Minnesota, helped launch Dr Fungus—a free app that brings the trusted resource to your phone.
Explore fungal infections, antifungal treatments, and case-based learning—all in one place.
Dr. Matthew Pullen, Assistant Professor at the University of Minnesota, helped launch Dr Fungus—a free app that brings the trusted resource to your phone.
Explore fungal infections, antifungal treatments, and case-based learning—all in one place.
Reposted by Pascalis Vergidis, MD
🆕 MMWR: In NYC, NDM-CRE just surpassed KPC-CRE for the first time.
And nearly 75% of these cases had no long-term care facility link
This is a changing landscape of antibiotic resistance - happening across US
#IDSky
📄: www.cdc.gov/mmwr/volumes...
And nearly 75% of these cases had no long-term care facility link
This is a changing landscape of antibiotic resistance - happening across US
#IDSky
📄: www.cdc.gov/mmwr/volumes...
July 10, 2025 at 5:10 PM
🆕 MMWR: In NYC, NDM-CRE just surpassed KPC-CRE for the first time.
And nearly 75% of these cases had no long-term care facility link
This is a changing landscape of antibiotic resistance - happening across US
#IDSky
📄: www.cdc.gov/mmwr/volumes...
And nearly 75% of these cases had no long-term care facility link
This is a changing landscape of antibiotic resistance - happening across US
#IDSky
📄: www.cdc.gov/mmwr/volumes...
Reposted by Pascalis Vergidis, MD
Detection of Mucorales antigen in BAL samples using a newly developed lateral-flow device
A Mucorales antigen test is sorely needed
This one had Sn of 76.92%, Sp of 75.51%, respectively, PPV 45.45%, and a NPV 92.5% (Not good enough but could augment qPCR)
journals.asm.org/doi/10.1128/...
A Mucorales antigen test is sorely needed
This one had Sn of 76.92%, Sp of 75.51%, respectively, PPV 45.45%, and a NPV 92.5% (Not good enough but could augment qPCR)
journals.asm.org/doi/10.1128/...
June 20, 2025 at 7:27 PM
Detection of Mucorales antigen in BAL samples using a newly developed lateral-flow device
A Mucorales antigen test is sorely needed
This one had Sn of 76.92%, Sp of 75.51%, respectively, PPV 45.45%, and a NPV 92.5% (Not good enough but could augment qPCR)
journals.asm.org/doi/10.1128/...
A Mucorales antigen test is sorely needed
This one had Sn of 76.92%, Sp of 75.51%, respectively, PPV 45.45%, and a NPV 92.5% (Not good enough but could augment qPCR)
journals.asm.org/doi/10.1128/...
Join us for a panel discussion on “Leveraging Partnerships to Fight Fungal Diseases” June 19
2.55-3.25 pm @ASMicrobiology
Dallas Smith @CDCgov
Sean Zhang, Fungal Diagnostics Laboratory Consortium
Rob Purdie, MYCology Advocacy, Research & Education
Zachary Rubin @lapublichealth
Me @MSG_ERC
2.55-3.25 pm @ASMicrobiology
Dallas Smith @CDCgov
Sean Zhang, Fungal Diagnostics Laboratory Consortium
Rob Purdie, MYCology Advocacy, Research & Education
Zachary Rubin @lapublichealth
Me @MSG_ERC
June 13, 2025 at 5:20 PM
Join us for a panel discussion on “Leveraging Partnerships to Fight Fungal Diseases” June 19
2.55-3.25 pm @ASMicrobiology
Dallas Smith @CDCgov
Sean Zhang, Fungal Diagnostics Laboratory Consortium
Rob Purdie, MYCology Advocacy, Research & Education
Zachary Rubin @lapublichealth
Me @MSG_ERC
2.55-3.25 pm @ASMicrobiology
Dallas Smith @CDCgov
Sean Zhang, Fungal Diagnostics Laboratory Consortium
Rob Purdie, MYCology Advocacy, Research & Education
Zachary Rubin @lapublichealth
Me @MSG_ERC
Visited the historic city of Philadelphia to attend the American Board of Internal Medicine (ABIM) New Governance Orientation. Looking forward to serving on the Infectious Disease Approval Committee.
Of the profession, for the public
Of the profession, for the public
June 12, 2025 at 2:04 PM
Visited the historic city of Philadelphia to attend the American Board of Internal Medicine (ABIM) New Governance Orientation. Looking forward to serving on the Infectious Disease Approval Committee.
Of the profession, for the public
Of the profession, for the public
Synthesis of the available literature on the use of CMV-specific T-cell therapy in adult and pediatric HSCT and SOT recipients.
Several patients on concurrent antivirals, which confounded the effectiveness of VSTs
@CIDJournal @transplantidnet.bsky.social
academic.oup.com/cid/advance-...
Several patients on concurrent antivirals, which confounded the effectiveness of VSTs
@CIDJournal @transplantidnet.bsky.social
academic.oup.com/cid/advance-...
Virus-Specific T-Cell Therapy for Prophylaxis and Treatment of Cytomegalovirus Infections After Transplantation: a Scoping Review
Cytomegalovirus-specific T cells have been used in studies of primarily adult hematopoietic stem cell transplant recipients. Heterogenous trial design and
academic.oup.com
June 8, 2025 at 11:24 AM
Synthesis of the available literature on the use of CMV-specific T-cell therapy in adult and pediatric HSCT and SOT recipients.
Several patients on concurrent antivirals, which confounded the effectiveness of VSTs
@CIDJournal @transplantidnet.bsky.social
academic.oup.com/cid/advance-...
Several patients on concurrent antivirals, which confounded the effectiveness of VSTs
@CIDJournal @transplantidnet.bsky.social
academic.oup.com/cid/advance-...
Dr. Jeniel Nett discussing biofilm at the 2025 Scientific Meeting on Candida auris @msgerc.bsky.social
June 6, 2025 at 7:52 PM
Dr. Jeniel Nett discussing biofilm at the 2025 Scientific Meeting on Candida auris @msgerc.bsky.social
High Kaposi sarcoma-associated herpesvirus seroprevalence in donors and recipients with HIV, particularly among MSM. Reassuringly, disease was rare.
@transplantidnet.bsky.social
academic.oup.com/cid/advance-...
@transplantidnet.bsky.social
academic.oup.com/cid/advance-...
Kaposi Sarcoma–Associated Herpesvirus Risk and Disease in Kidney Donors and Transplant Recipients With Human Immunodeficiency Virus in the United States
The prevalence of Kaposi sarcoma–associated herpesvirus (KSHV) was high among kidney donor and transplant recipients with HIV. Posttransplant KSHV-associat
academic.oup.com
June 6, 2025 at 1:10 PM
High Kaposi sarcoma-associated herpesvirus seroprevalence in donors and recipients with HIV, particularly among MSM. Reassuringly, disease was rare.
@transplantidnet.bsky.social
academic.oup.com/cid/advance-...
@transplantidnet.bsky.social
academic.oup.com/cid/advance-...
In a phase 3 clinical trial, pemivibart provided prophylactic efficacy against COVID-19 in immunocompromised patients and individuals at risk for exposure. Four of 623 participants experienced anaphylactic reactions @transplantidnet.bsky.social
academic.oup.com/cid/advance-...
academic.oup.com/cid/advance-...
Safety and Efficacy of Pemivibart, a Long-Acting Monoclonal Antibody, for Prevention of Symptomatic COVID-19: Interim Results From a Phase 3 Randomized Clinical Trial (CANOPY)
AbstractBackground. We report an interim analysis of safety and efficacy of pemivibart in individuals with (cohort A) or without (cohort B) significant imm
academic.oup.com
June 2, 2025 at 9:08 PM
In a phase 3 clinical trial, pemivibart provided prophylactic efficacy against COVID-19 in immunocompromised patients and individuals at risk for exposure. Four of 623 participants experienced anaphylactic reactions @transplantidnet.bsky.social
academic.oup.com/cid/advance-...
academic.oup.com/cid/advance-...
Reposted by Pascalis Vergidis, MD
Increasing Fluconazole Resistance in Candida parapsilosis: A 10-Year Analysis of Blood Culture Isolates at a US Reference Laboratory (2015–2024)
Fluco-R C parapsilosis ⬆️ from 8.2% to 20.3% in BCx isolates tested @ Mayo
Jack McHugh ... @pascalisid.bsky.social
academic.oup.com/jid/advance-...
Fluco-R C parapsilosis ⬆️ from 8.2% to 20.3% in BCx isolates tested @ Mayo
Jack McHugh ... @pascalisid.bsky.social
academic.oup.com/jid/advance-...
May 15, 2025 at 3:54 PM
Increasing Fluconazole Resistance in Candida parapsilosis: A 10-Year Analysis of Blood Culture Isolates at a US Reference Laboratory (2015–2024)
Fluco-R C parapsilosis ⬆️ from 8.2% to 20.3% in BCx isolates tested @ Mayo
Jack McHugh ... @pascalisid.bsky.social
academic.oup.com/jid/advance-...
Fluco-R C parapsilosis ⬆️ from 8.2% to 20.3% in BCx isolates tested @ Mayo
Jack McHugh ... @pascalisid.bsky.social
academic.oup.com/jid/advance-...
Reposted by Pascalis Vergidis, MD
Silence=Death Redux: Infectious Diseases, Public Health, and the Imperative to Resist
✅ Just Accepted
✍️ @ericmeyerowitz.bsky.social @germhuntermd.bsky.social
#IDSky
✅ Just Accepted
✍️ @ericmeyerowitz.bsky.social @germhuntermd.bsky.social
#IDSky
Silence=Death Redux: Infectious Diseases, Public Health, and the Imperative to Resist
In this perspective, we recount the early executive actions that impact every aspect of the field infectious diseases.
doi.org
March 31, 2025 at 7:28 PM
ID Grand Rounds.
I discussed the following:
- ONE Health
- Aspergillus urine antigen
- Giant magnetoresistance-enabled PCR
- Rezafungin for prevention in bone marrow transplant
- Ibrexafungerp (FURI)
- Olorofim (Study 32)
- Our experience with fosmanogepix
I discussed the following:
- ONE Health
- Aspergillus urine antigen
- Giant magnetoresistance-enabled PCR
- Rezafungin for prevention in bone marrow transplant
- Ibrexafungerp (FURI)
- Olorofim (Study 32)
- Our experience with fosmanogepix
March 23, 2025 at 2:40 PM
ID Grand Rounds.
I discussed the following:
- ONE Health
- Aspergillus urine antigen
- Giant magnetoresistance-enabled PCR
- Rezafungin for prevention in bone marrow transplant
- Ibrexafungerp (FURI)
- Olorofim (Study 32)
- Our experience with fosmanogepix
I discussed the following:
- ONE Health
- Aspergillus urine antigen
- Giant magnetoresistance-enabled PCR
- Rezafungin for prevention in bone marrow transplant
- Ibrexafungerp (FURI)
- Olorofim (Study 32)
- Our experience with fosmanogepix
In rare cases, vaping-associated lung injury (EVALI) may lead to irreversible damage requiring lung transplantation
March 13, 2025 at 11:48 AM
In rare cases, vaping-associated lung injury (EVALI) may lead to irreversible damage requiring lung transplantation
Can filgrastim precipitate organ rejection ?
March 12, 2025 at 2:55 PM
Can filgrastim precipitate organ rejection ?
We used Giant Magnetoresistance to diagnose invasive fungal infection. The assay has the potential to detect trace amounts of fungal DNA in serum
academic.oup.com/ofid/article...
academic.oup.com/ofid/article...
A Novel Giant Magnetoresistance–Enabled Multiplex Polymerase Chain Reaction Assay for the Diagnosis of Invasive Fungal Infection
AbstractBackground. Despite advances in clinical microbiology, the diagnosis of invasive fungal infections remains challenging. Giant magnetoresistance (GM
academic.oup.com
February 27, 2025 at 5:01 PM
We used Giant Magnetoresistance to diagnose invasive fungal infection. The assay has the potential to detect trace amounts of fungal DNA in serum
academic.oup.com/ofid/article...
academic.oup.com/ofid/article...
Aspergillus pseudodeflectus belongs to the Aspergillus section Usti. Can be multidrug resistant (similar to calidoustus) - Learning something every day!
February 26, 2025 at 3:31 PM
Aspergillus pseudodeflectus belongs to the Aspergillus section Usti. Can be multidrug resistant (similar to calidoustus) - Learning something every day!
Highly recommended! Fungal Update: Mycology 2025 in London.
This a pic from last year… @germhuntermd.bsky.social
This a pic from last year… @germhuntermd.bsky.social
February 22, 2025 at 3:40 PM
Highly recommended! Fungal Update: Mycology 2025 in London.
This a pic from last year… @germhuntermd.bsky.social
This a pic from last year… @germhuntermd.bsky.social
Recommendation to screen, even though no cases of TB transmission reported after allogeneic stem cell transplant
Recommendations to Reduce the Risk of Transmission of Mtb
This is the Guidance for Industry - Recommendations to Reduce the Risk of Transmission of Mycobacterium tuberculosis (Mtb) by Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps)
www.fda.gov
February 21, 2025 at 12:38 PM
Recommendation to screen, even though no cases of TB transmission reported after allogeneic stem cell transplant
Remember that fosmanogepix can cause neurotoxicity (approx 10%)
February 20, 2025 at 12:13 PM
Remember that fosmanogepix can cause neurotoxicity (approx 10%)
Generative AI platforms for clinical conversations create mediocre medical notes
February 19, 2025 at 1:18 PM
Generative AI platforms for clinical conversations create mediocre medical notes
Reposted by Pascalis Vergidis, MD
Mayo Clinic remains committed to Diversity and Inclusion
Equity, Inclusion and Diversity at Mayo Clinic
To provide the best care experience, Equity, Inclusion and Diversity at Mayo Clinic provides a variety of services to meet the diverse needs of patients.
www.mayoclinic.org
February 16, 2025 at 1:15 PM
Mayo Clinic remains committed to Diversity and Inclusion
You are all familiar with immune checkpoint inhibitor-associated pneumonitis. Adagrasib inhibits KRAS G12C and is used to treat non-small cell lung cancer. It can also be associated with pneumonitis. Need to rule out infection first. Discontinue adagrasib and treat with corticosteroids.
February 17, 2025 at 3:20 PM
You are all familiar with immune checkpoint inhibitor-associated pneumonitis. Adagrasib inhibits KRAS G12C and is used to treat non-small cell lung cancer. It can also be associated with pneumonitis. Need to rule out infection first. Discontinue adagrasib and treat with corticosteroids.
Mayo Clinic remains committed to Diversity and Inclusion
Equity, Inclusion and Diversity at Mayo Clinic
To provide the best care experience, Equity, Inclusion and Diversity at Mayo Clinic provides a variety of services to meet the diverse needs of patients.
www.mayoclinic.org
February 16, 2025 at 1:15 PM
Mayo Clinic remains committed to Diversity and Inclusion