Paolo Aretini
@paretini966.bsky.social
Bioinformatician at Fondazione Pisana per la Scienza (https://www.fpscience.it/aretini-paolo/) Next Generation Sequencing/ Genetic Oncology/ Molecular Genetics/
Il 15/9/25 alla Fondazione Pisana per la Scienza si terrà #BH12, la giornata toscana di bioinformatica e systems biology, con UniPI, CNR e partner regionali.
Maggiori dettagli a: www.bioinformatiha.it/index.php?pg...
Maggiori dettagli a: www.bioinformatiha.it/index.php?pg...
Home - bioinformatiha
www.bioinformatiha.it
September 4, 2025 at 9:37 AM
Il 15/9/25 alla Fondazione Pisana per la Scienza si terrà #BH12, la giornata toscana di bioinformatica e systems biology, con UniPI, CNR e partner regionali.
Maggiori dettagli a: www.bioinformatiha.it/index.php?pg...
Maggiori dettagli a: www.bioinformatiha.it/index.php?pg...
A BRCA2 founder mutation (c.7007G>C) was found in 26.5% of cancer patients from the Jewish community of Rome. Shared haplotype suggests ancient roots. Underscores need for targeted BRCA screening in overlooked ethnic groups. #BRCA #Genetics #CancerRisk
www.mdpi.com/2072-6694/17...
www.mdpi.com/2072-6694/17...
www.mdpi.com
September 4, 2025 at 7:49 AM
A BRCA2 founder mutation (c.7007G>C) was found in 26.5% of cancer patients from the Jewish community of Rome. Shared haplotype suggests ancient roots. Underscores need for targeted BRCA screening in overlooked ethnic groups. #BRCA #Genetics #CancerRisk
www.mdpi.com/2072-6694/17...
www.mdpi.com/2072-6694/17...
Reposted by Paolo Aretini
A founder BRCA1 exonic duplication involving breakpoint in T2T reference genome-specific region results in constitutional fusion transcript. #T2T #ReferenceGenome #GeneticVariants #VariantAssessment #HQreferenceGenomes #NPJgenomicMedicine 🧬 🧪 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 9, 2025 at 9:15 AM
A founder BRCA1 exonic duplication involving breakpoint in T2T reference genome-specific region results in constitutional fusion transcript. #T2T #ReferenceGenome #GeneticVariants #VariantAssessment #HQreferenceGenomes #NPJgenomicMedicine 🧬 🧪 🖥️
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Advances in Preventing Transmission of Mitochondrial DNA Diseases | New England Journal of Medicine www.nejm.org/doi/full/10....
Advances in Preventing Transmission of Mitochondrial DNA Diseases | NEJM
The author describes pronuclear transfer, a type of mitochondrial donation, which
was made available to women with mitochondrial DNA disease in a reproductive care
pathway implemented in Newcastle,...
www.nejm.org
July 26, 2025 at 8:39 AM
Advances in Preventing Transmission of Mitochondrial DNA Diseases | New England Journal of Medicine www.nejm.org/doi/full/10....
PDAC is often diagnosed late with no widespread screening, but high-risk individuals may be screened. This review covers risk identification, biomarker detection, AI applications, and cost-effectiveness.
www.sciencedirect.com/science/arti...
#pancreaticcancer#AI
www.sciencedirect.com/science/arti...
#pancreaticcancer#AI
Biomarkers, Omics and Artificial Intelligence for Early Detection of Pancreatic Cancer.
Pancreatic ductal adenocarcinoma (PDAC) is frequently diagnosed in its late stages when treatment options are limited. Unlike other common cancers, th…
www.sciencedirect.com
February 27, 2025 at 2:07 PM
PDAC is often diagnosed late with no widespread screening, but high-risk individuals may be screened. This review covers risk identification, biomarker detection, AI applications, and cost-effectiveness.
www.sciencedirect.com/science/arti...
#pancreaticcancer#AI
www.sciencedirect.com/science/arti...
#pancreaticcancer#AI
Interesting work to which our institute actively contributed
#cancertherapies #bioinformatics
www.nature.com/articles/s41...
#cancertherapies #bioinformatics
www.nature.com/articles/s41...
Learning and actioning general principles of cancer cell drug sensitivity - Nature Communications
Potential anti-tumor therapies remain to be discovered in cancer cell line high-throughput screening datasets. Here, the authors develop a machine learning approach to infer cancer cell drug sensitivi...
www.nature.com
February 18, 2025 at 1:07 PM
Interesting work to which our institute actively contributed
#cancertherapies #bioinformatics
www.nature.com/articles/s41...
#cancertherapies #bioinformatics
www.nature.com/articles/s41...
Reposted by Paolo Aretini
An innovative strategy to identify potential anti-cancer drugs using patients' transcriptomics data has been developed by the Bioinformatics group at BIO@SNS Lab, Scuola Normale Superiore.
Read the study on Nature Communications
#CancerResearch #Bioinformatics #Science
www.nature.com/articles/s41...
Read the study on Nature Communications
#CancerResearch #Bioinformatics #Science
www.nature.com/articles/s41...
Learning and actioning general principles of cancer cell drug sensitivity - Nature Communications
Potential anti-tumor therapies remain to be discovered in cancer cell line high-throughput screening datasets. Here, the authors develop a machine learning approach to infer cancer cell drug sensitivi...
www.nature.com
February 18, 2025 at 11:18 AM
An innovative strategy to identify potential anti-cancer drugs using patients' transcriptomics data has been developed by the Bioinformatics group at BIO@SNS Lab, Scuola Normale Superiore.
Read the study on Nature Communications
#CancerResearch #Bioinformatics #Science
www.nature.com/articles/s41...
Read the study on Nature Communications
#CancerResearch #Bioinformatics #Science
www.nature.com/articles/s41...
Reposted by Paolo Aretini
Abbiamo a disposizione il più potente "farmaco" per ridurre drasticamente il rischio di malattie cardiovascolari, cancro e malattie neurodegenerative abbattendo anche il rischio di morte e tutto questo è GRATIS. Dovete muovervi tenendo a mente che OGNI MINUTO CONTA! È per il vostro futuro. 🧪❣️
February 5, 2025 at 9:31 AM
Abbiamo a disposizione il più potente "farmaco" per ridurre drasticamente il rischio di malattie cardiovascolari, cancro e malattie neurodegenerative abbattendo anche il rischio di morte e tutto questo è GRATIS. Dovete muovervi tenendo a mente che OGNI MINUTO CONTA! È per il vostro futuro. 🧪❣️
Reposted by Paolo Aretini
📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you.
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
November 25, 2024 at 11:19 AM
📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you.
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
PhD: shorturl.at/Oc04N
Postdoc: shorturl.at/1ShHB
RPs and shares would be greatly appreciated!
🧪🧬🖥️ #ScienceJobs #PostdocJobs
I am proud to be part of Dr Chiara Mazzanti's team, winner of an AIRC Investigator Grant on glioblastoma research.(www.fpscience.it/mazzanti-chi...)
#glioblastoma#cancer
#glioblastoma#cancer
Fondazione Pisa Scienza - fpscience
www.fpscience.it
December 2, 2024 at 9:33 AM
I am proud to be part of Dr Chiara Mazzanti's team, winner of an AIRC Investigator Grant on glioblastoma research.(www.fpscience.it/mazzanti-chi...)
#glioblastoma#cancer
#glioblastoma#cancer
Reposted by Paolo Aretini
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
November 27, 2024 at 5:58 PM
1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...
Reposted by Paolo Aretini
From @seedgeorge.bsky.social Johann De Bono and colleagues (us !). In BRCA2m CRPC, reversion mutations emerge in 79% by end of olaparib treatment. Reversions associate with PFS and OS. Rare subclones without BRCA2-loss also emerge authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
November 21, 2024 at 4:31 PM
From @seedgeorge.bsky.social Johann De Bono and colleagues (us !). In BRCA2m CRPC, reversion mutations emerge in 79% by end of olaparib treatment. Reversions associate with PFS and OS. Rare subclones without BRCA2-loss also emerge authors.elsevier.com/sd/article/S...
Reposted by Paolo Aretini
Exploring public cancer gene expression signatures across bulk, single-cell and spatial transcriptomics data with signifinder Bioconductor package academic.oup.com/nargab/artic...
Exploring public cancer gene expression signatures across bulk, single-cell and spatial transcriptomics data with signifinder Bioconductor package
Abstract. Understanding cancer mechanisms, defining subtypes, predicting prognosis and assessing therapy efficacy are crucial aspects of cancer research. G
academic.oup.com
November 21, 2024 at 3:55 AM
Exploring public cancer gene expression signatures across bulk, single-cell and spatial transcriptomics data with signifinder Bioconductor package academic.oup.com/nargab/artic...
Reposted by Paolo Aretini
📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
a couple of cartoon characters standing next to each other with one wearing a purple earring
Alt: a couple of cartoon characters standing next to each other with one wearing a purple earring
media.tenor.com
November 20, 2024 at 4:03 PM
📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...
Reposted by Paolo Aretini
Many thanks to The Scientist for covering our recent paper on fibrotic scarring and brain tumor recurrence 🙏
Here's the #openaccess link for our original paper in Cancer Cell led by Watson*, Zomer* et al:
www.cell.com/cancer-cell/...
#scicomm 🧪🔬
www.the-scientist.com/blocking-sca...
Here's the #openaccess link for our original paper in Cancer Cell led by Watson*, Zomer* et al:
www.cell.com/cancer-cell/...
#scicomm 🧪🔬
www.the-scientist.com/blocking-sca...
Blocking Scar Formation Prevents Glioblastoma Recurrence
A combination of three therapies prevented scar tissue and stopped glioblastoma in its tracks in mice.
www.the-scientist.com
November 20, 2024 at 1:14 PM
Many thanks to The Scientist for covering our recent paper on fibrotic scarring and brain tumor recurrence 🙏
Here's the #openaccess link for our original paper in Cancer Cell led by Watson*, Zomer* et al:
www.cell.com/cancer-cell/...
#scicomm 🧪🔬
www.the-scientist.com/blocking-sca...
Here's the #openaccess link for our original paper in Cancer Cell led by Watson*, Zomer* et al:
www.cell.com/cancer-cell/...
#scicomm 🧪🔬
www.the-scientist.com/blocking-sca...
Reposted by Paolo Aretini
Ops.
[BTW che casino sta diventando distinguere il vero dal falso se anche le testate cascano spesso per l'ansia da prestazione]
[BTW che casino sta diventando distinguere il vero dal falso se anche le testate cascano spesso per l'ansia da prestazione]
Molti video usati dalla stampa sui fatti del 6-8nov ad Amsterdam mostravano violenze DI tifosi israeliani, non contro di loro. Quando l'hanno scoperto, testate come il NYT hanno preferito rimuoverli piuttosto che scusarsi e dar conto della realtà di quanto accaduto, come confermato da mail interne
NY Times killed investigation of Israeli hooligans, internal email reveals
Reporter reveals frustration that editors blocked story on Amsterdam events falsely portrayed as anti-Semitic.
electronicintifada.net
November 20, 2024 at 8:34 AM
Ops.
[BTW che casino sta diventando distinguere il vero dal falso se anche le testate cascano spesso per l'ansia da prestazione]
[BTW che casino sta diventando distinguere il vero dal falso se anche le testate cascano spesso per l'ansia da prestazione]
Reposted by Paolo Aretini
—Please give me an A.I. that automatically detects, interprets all types of medical. images (scans, retina, endoscopy, skin) that I can interact with, can integrate data from other sources, saves a lot of time, and improves accuracy
—Sure, here it is
www.nature.com/articles/s41...
—Sure, here it is
www.nature.com/articles/s41...
November 20, 2024 at 2:28 PM
—Please give me an A.I. that automatically detects, interprets all types of medical. images (scans, retina, endoscopy, skin) that I can interact with, can integrate data from other sources, saves a lot of time, and improves accuracy
—Sure, here it is
www.nature.com/articles/s41...
—Sure, here it is
www.nature.com/articles/s41...
UCSCXenaShiny, an interactive tool for exploring thousands of cancer datasets available on UCSC Xena. UCSCXenaShiny v2 is an open-source R package and a web application, freely accessible at github.com/openbiox/UCS....
GitHub - openbiox/UCSCXenaShiny: 📊 An R package for interactively exploring UCSC Xena https://xenabrowser.net/datapages/; Book: https://lishensuo.github.io/UCSCXenaShiny_Book; App online: https://shin...
📊 An R package for interactively exploring UCSC Xena https://xenabrowser.net/datapages/; Book: https://lishensuo.github.io/UCSCXenaShiny_Book; App online: https://shiny.hiplot.cn/ucsc-xena-shiny/, ...
github.com
November 20, 2024 at 3:32 PM
UCSCXenaShiny, an interactive tool for exploring thousands of cancer datasets available on UCSC Xena. UCSCXenaShiny v2 is an open-source R package and a web application, freely accessible at github.com/openbiox/UCS....
A stunning review of the pathways involved in innate immunity and implications for cancer treatment.
#innateimmunity
#cancer
www.nature.com/articles/s41...
#innateimmunity
#cancer
www.nature.com/articles/s41...
Harnessing innate immune pathways for therapeutic advancement in cancer - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Harnessing innate immune pathways for therapeutic advancement in cancer
www.nature.com
November 20, 2024 at 1:50 PM
A stunning review of the pathways involved in innate immunity and implications for cancer treatment.
#innateimmunity
#cancer
www.nature.com/articles/s41...
#innateimmunity
#cancer
www.nature.com/articles/s41...
We investigated the potential of NAD(P)H fluorescence lifetime imaging microscopy to predict Glioblastoma's response to Temozolomide (TMZ) treatment.
#TMZ
#FLIM
#Glioblastoma
www.fortunejournals.com/articles/nap...
#TMZ
#FLIM
#Glioblastoma
www.fortunejournals.com/articles/nap...
NAPH-Fluorescence Lifetime Imaging Informed Machine Learning Modelling Reliably Predicts Temozolomide Responsiveness in Glioblastoma
NAPH-Fluorescence Lifetime Imaging Informed Machine Learning Modelling Reliably Predicts Temozolomide Responsiveness in Glioblastoma. PubMed, SCI, Scopus, ESCI, PMC indexed
www.fortunejournals.com
November 20, 2024 at 11:37 AM
We investigated the potential of NAD(P)H fluorescence lifetime imaging microscopy to predict Glioblastoma's response to Temozolomide (TMZ) treatment.
#TMZ
#FLIM
#Glioblastoma
www.fortunejournals.com/articles/nap...
#TMZ
#FLIM
#Glioblastoma
www.fortunejournals.com/articles/nap...
Glioblastoma (GBM) is an aggressive brain cancer with limited treatment options. This research aims to enhance our understanding of GBM progression by investigating extracellular vesicles (EVs) released by tumor cells.
#glioblastoma
#cancer
www.mdpi.com/2072-6694/16...
#glioblastoma
#cancer
www.mdpi.com/2072-6694/16...
Exploring Extracellular Vesicle Surface Protein Markers Produced by Glioblastoma Tumors: A Characterization Study Using In Vitro 3D Patient-Derived Cultures
Background/Objectives: Glioblastoma (GBM) is an aggressive brain cancer with limited treatment options. Extracellular vesicles (EVs) derived from GBM cells contain important biomarkers, such as microR...
www.mdpi.com
November 18, 2024 at 11:05 PM
Glioblastoma (GBM) is an aggressive brain cancer with limited treatment options. This research aims to enhance our understanding of GBM progression by investigating extracellular vesicles (EVs) released by tumor cells.
#glioblastoma
#cancer
www.mdpi.com/2072-6694/16...
#glioblastoma
#cancer
www.mdpi.com/2072-6694/16...