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Bryon Silva

@neurogut.bsky.social

1.5K followers 5.1K following 13 posts

Decoding how the gut thinks 🦠🪱🧠💪 Neuroscientist with interests in #EnergyMetabolism #EntericNeurons #Fats @crick.ac.uk @institutducerveau.bsky.social

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Bryon Silva @neurogut.bsky.social · Sep 10

Glia feed neurons upon starvation: our 2022 Nature Metabolism paper revealed a glia-to-neuron ketone body shuttle 💪
#Memories #EnergyMetabolism #Glia @naturemetabolism.bsky.social ky.social

www.nature.com/articles/s42...

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Reposted by Bryon Silva

Çağrı Çevrim @cagricevrim.bsky.social · 4d

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉
@karalmckinley.bsky.social
We built the first transgenic model of menstruation in mice.
We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪
www.biorxiv.org/content/10.1...
🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

www.biorxiv.org

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Bryon Silva @neurogut.bsky.social · 6d

under construction... 😶‍🌫️

Bryon Silva @neurogut.bsky.social · 9d

oh thank you! :)

Reposted by Bryon Silva

FlyBase @flybase.bsky.social · 11d

There's an update on the state of FlyBase on the FlyBase.org front page. You can contribute to FlyBase at this link wiki.flybase.org/wiki/FlyBase...
We express enormous gratitude to the people, labs, groups, and foundations who have already helped us.
#FlyBase #Drosophila

FlyBase Update – October 2025
The termination of the NIH/NHGRI FlyBase grant has placed the long-term sustainability of FlyBase at risk. However, thanks to the generous support of several key individuals and institutions, we are pleased to announce that FlyBase will remain operational through the coming year. We extend our deepest gratitude to Yukiko Yamashita, Cassandra Extavour, Hugo Bellen, Thom Kaufman, the Genetics Society of America / Drosophila Board, the Bloomington Drosophila Stock Center, an anonymous donor and the Wellcome Trust. We are especially thankful for a generous gift from Seemay Chou, Jed McCaleb, and The Navigation Fund. We also greatly appreciate the continued support from the broader Drosophila community – your donations and service fees have been vital in helping us stay afloat. Special thanks also go to Jessica Manning for her tireless administrative work at Harvard, to Ruth Lehmann, Hugo Bellen, and Paul Sternberg for advice and efforts, and to the Board of the European Drosophila Society for all their efforts. Sadly, we must also share that several long-standing FlyBase team members have recently moved on. We are immensely grateful to Susan Russo-Gelbart, Lynn Crosby, Gil dos Santos, Kris Broll, Victoria Jenkins, and TyAnna Lovato for their many years of dedicated service and contributions to FlyBase. Looking ahead, ensuring FlyBase’s sustainability beyond the next year – and successfully integrating with the Alliance – will require new funding sources. We kindly ask for your continued support:
• European labs: Please consider contributing to the Cambridge, U.K. FlyBase group
• U.S. and other non-European labs: Please consider contributing to the U.S. FlyBase groups
• Both U.K. and U.S. FlyBase are working diligently to establish an invoicing system. We appreciate your continued patience.
For more information on how to support us, please visit: Contribute to FlyBase wiki page https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase

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Bryon Silva @neurogut.bsky.social · 10d

This is really fantastic, whenever an old dogma is broken is worth highlighting it as one of the key papers of the year :)!
Congratulations, I have been following this article since it was posted on biorxiv, very huge contribution to the metabolism field 💪

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Reposted by Bryon Silva

Dafni Hadjieconomou @drosostalis.bsky.social · 19d

If you find yourself at @edrc2025.bsky.social please check my wonderful postdoc's talk @neurogut.bsky.social at the gut workshop this afternoon. Gut, sex, reproduction, our new story! In combo with @irenemiguel-aliaga.bsky.social! @fly-jedi.bsky.social #EDRC2025

A restricted subset of gut-innervating neurons that express the neuropeptide myosuppressin (Ms)
innervate the crop, a stomach-like structure of the fly intestine. This figure shows co-expression
between the Ms protein reporter (green) and Ms peptide (red) in the nervous system, and in
neuronal projections towards the gut (blue).

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Bryon Silva @neurogut.bsky.social · 16d

🫶

Bryon Silva @neurogut.bsky.social · 19d

Thank you Jose, I'm glad you enjoyed it :)

Bryon Silva @neurogut.bsky.social · 29d

A fantastic way of imaging lipids!

Itay Budin @ibudin.bsky.social · 29d

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology

An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

www.nature.com

Bryon Silva @neurogut.bsky.social · Sep 12

Dual-cycle CO2 fixation enhances growth and lipid synthesis in Arabidopsis thaliana | Science www.science.org/doi/10.1126/...
Woooooow

Dual-cycle CO2 fixation enhances growth and lipid synthesis in Arabidopsis thaliana

Carbon fixation through the Calvin-Benson-Bassham (CBB) cycle accounts for the majority of carbon dioxide (CO2) uptake from the atmosphere. The CBB cycle generates C3 carbohydrates but is inefficient ...

www.science.org

Bryon Silva @neurogut.bsky.social · Sep 10

In 2022, I had the honor of publishing this paper as the cover of Nature Metabolism. We uncovered a glia-to-neuron ketone body shuttle (reminiscent of the ANLS model) that shaped my work on neuronal energy metabolism. It is rewarding to see these findings now inspiring questions across many fields

Bryon Silva @neurogut.bsky.social · Sep 10

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Bryon Silva @neurogut.bsky.social · Sep 7

Good job :)

Bryon Silva @neurogut.bsky.social · Sep 6

you see @drosostalis.bsky.social the peanut butter texture was just my innate talent 😜

Bryon Silva @neurogut.bsky.social · Aug 27

This is awesome! Lipid probes for quantitative imaging of lipid transport. A real need in the lipid field!

@nadlerlab.bsky.social

Quantitative imaging of lipid transport in mammalian cells - Nature

Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

www.nature.com

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Reposted by Bryon Silva

Irene Miguel-Aliaga @irenemiguel-aliaga.bsky.social · Mar 19

Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...

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Bryon Silva @neurogut.bsky.social · Jul 9

I am ready :)

Reposted by Bryon Silva

Helena Cocheme @cochemelab.bsky.social · Jun 27

🎉Excited to share our latest paper, published in Nature Communications!🎉

"Enhancing autophagy by redox regulation extends lifespan in Drosophila"

#redox #metabolism #ageing #Drosophila

@natcomms.nature.com @mrc-lms.bsky.social

doi.org/10.1038/s414...

Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications

Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

doi.org

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