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mjkoh87.bsky.social
MJ Koh Group
@mjkoh87.bsky.social
72 followers 98 following 6 posts
Research Group in the Department of Chemistry at the National University of Singapore (NUS). Transforming chemical & carbohydrate synthesis through base metal catalysis, radical cross-coupling & molecular editing.
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Reposted by MJ Koh Group
sciencex.bsky.social
Science X / Phys.org @sciencex.bsky.social · 2h
A new photocatalytic atom-swapping method enables efficient conversion of oxetanes into diverse four-membered saturated rings, streamlining access to key pharmaceutical building blocks. doi.org/g96442
Atom-swapping blueprint could streamline synthesis of pharmaceutical building blocks
Researchers from NUS have pioneered a photocatalytic atom-swapping transformation that converts oxetanes into a variety of four-membered saturated cyclic molecules, which are key scaffolds in medicinal chemistry.
phys.org
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Reposted by MJ Koh Group
gomobel.bsky.social
Fer @gomobel.bsky.social · 8h
Swapping oxygen in oxetanes? 🪄 Done! With skeletal editing 🙌🏼🦴✨ My latest @chemistryworld.com story covers a cool strategy to introduce nitrogen, carbon, or sulfur instead at a single stroke 🖌️🎨 Amazing, almost magic @nature.com paper by @mjkoh87.bsky.social 👉🏼 www.chemistryworld.com/news/stimula...
‘Stimulating discovery’ leads to strategy to swap oxygen in saturated rings
Skeletal editing pushed beyond aromatic structures, sparking new opportunities in drug discovery
www.chemistryworld.com
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mjkoh87.bsky.social
MJ Koh Group @mjkoh87.bsky.social · 1d
Atom-swapping in a saturated heterocycle? We report a photocatalytic transmutation strategy in @nature.com that exchanges O within an oxetane for N, S, C & even dual atoms, affording various non-aromatic cyclic pharmacophores. #skeletalediting #atomswap #photocatalysis www.nature.com/articles/s41...
Reposted by MJ Koh Group
natsynth.nature.com
Nature Synthesis @natsynth.nature.com · Sep 4
Now online:

Review article by Achyut R. Gogoi, Ángel Rentería-Gómez, Tong-De Tan, Jun Wei Ng, Ming Joo Koh & Osvaldo Gutierrez

Iron-catalysed radical difunctionalization of alkenes

www.nature.com/articles/s44... ($)
#Chemsky
Iron-catalysed radical difunctionalization of alkenes - Nature Synthesis
Three-component, iron-based catalytic transformations offer a promising and sustainable approach to building complex molecules in a single step. This Review highlights advances and ongoing challenges ...
www.nature.com
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Reposted by MJ Koh Group
carolynbertozzi.bskyverified.social
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Aug 27
Applications are now open for the Stanford Science Fellows postdoctoral program, opportunity to join an exciting community of scholars!

stanfordsciencefellows.stanford.edu
Science Fellows
stanfordsciencefellows.stanford.edu
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mjkoh87.bsky.social
MJ Koh Group @mjkoh87.bsky.social · Aug 4
Cool to have Todd Hyster from Princeton University with us today at NUS Chemistry in Singapore. Photo credits: Jie Wu, Yu Zhao. #photoenzymatic #catalysis
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mjkoh87.bsky.social
MJ Koh Group @mjkoh87.bsky.social · Jun 23
It's a privilege to have Marisa Kozlowski from
@pennchemistry.bsky.social with us today at NUS Chemistry in Singapore. Photo credit: Yixin Lu. #organicchemistry #OrgLett
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mjkoh87.bsky.social
MJ Koh Group @mjkoh87.bsky.social · May 23
Excited to see our recent difluorocarbene skeletal expansion chemistry being used to make a molecule of the week! Read more about making difluorooxetanes from here: lnkd.in/gad_5fNq
Now available from Enamine: new.enaminestore.com/catalog/EN30...
mjkoh87.bsky.social
MJ Koh Group @mjkoh87.bsky.social · Apr 7
A new skeletal expansion approach to make γ-lactam pharmacophores by Cu-catalyzed difluorocarbene insertion into azetidines. It turns out that some γ-lactam scaffolds are harder to access than azetidines. Just accepted in @angewandtechemie.bsky.social. onlinelibrary.wiley.com/doi/10.1002/...
Site‐Selective Carbonylation of Azetidines via Copper‐Catalyzed Difluorocarbene Insertion
γ-Lactams are privileged five-membered pharmaco-phores in numerous bioactive compounds, but access to these motifs typically rely on cycloaddition/substitution chemistry involving activated substrate...
onlinelibrary.wiley.com
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mjkoh87.bsky.social
MJ Koh Group @mjkoh87.bsky.social · Feb 22
Our latest work in @naturechemistry.bsky.social using copper catalysis to promote difluorocarbene insertion into epoxides, allowing us to access an interesting but elusive class of α,α-difluoro-oxetane pharmacophores. www.nature.com/articles/s41...
Catalytic difluorocarbene insertion enables access to fluorinated oxetane isosteres - Nature Chemistry
Catalytic methods to introduce fluorine into the backbone of small-ring heterocycles are challenging due to the problems of strain-induced ring cleavage and defluorination. Now, a copper catalyst medi...
www.nature.com