Nature Synthesis
@natsynth.nature.com
A synthesis-oriented chemistry & materials science journal from
@natureportfolio.nature.com. Posts by the editors @peterseavill.bsky.social @alexrgroves.bsky.social @jetsinglee.bsky.social
https://www.nature.com/natsynth/
@natureportfolio.nature.com. Posts by the editors @peterseavill.bsky.social @alexrgroves.bsky.social @jetsinglee.bsky.social
https://www.nature.com/natsynth/
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An Editorial highlighting some of the excellent covers featured in Nature Synthesis in 2025 as well as the research they represent. Thanks to our authors for submitting such great covers!
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An Editorial highlighting some of the excellent covers featured in Nature Synthesis in 2025 as well as the research they represent. Thanks to our authors for submitting such great covers!
www.nature.com/articles/s44...
Research Highlight now online:
Co-crystallizing stability into perovskite modules by @jetsinglee.bsky.social
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Highlighting the @natenergy.nature.com Article by Narges Yaghoobi Nia, Mahmoud Zendehdel, Aldo Di Carlo & co-workers
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Co-crystallizing stability into perovskite modules by @jetsinglee.bsky.social
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Highlighting the @natenergy.nature.com Article by Narges Yaghoobi Nia, Mahmoud Zendehdel, Aldo Di Carlo & co-workers
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Co-crystallizing stability into perovskite modules - Nature Synthesis
Nature Synthesis - Co-crystallizing stability into perovskite modules
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February 2, 2026 at 2:37 PM
Research Highlight now online:
Co-crystallizing stability into perovskite modules by @jetsinglee.bsky.social
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Highlighting the @natenergy.nature.com Article by Narges Yaghoobi Nia, Mahmoud Zendehdel, Aldo Di Carlo & co-workers
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Co-crystallizing stability into perovskite modules by @jetsinglee.bsky.social
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Highlighting the @natenergy.nature.com Article by Narges Yaghoobi Nia, Mahmoud Zendehdel, Aldo Di Carlo & co-workers
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Now online:
Article by Xin-Yuan Liu & co-workers
Copper-catalysed enantioconvergent radical C(sp3)–C(sp3) cross-coupling of tertiary electrophiles with cyclopropanols for quaternary carbon formation
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Article by Xin-Yuan Liu & co-workers
Copper-catalysed enantioconvergent radical C(sp3)–C(sp3) cross-coupling of tertiary electrophiles with cyclopropanols for quaternary carbon formation
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Copper-catalysed enantioconvergent radical C(sp3)–C(sp3) cross-coupling of tertiary electrophiles with cyclopropanols for quaternary carbon formation - Nature Synthesis
A copper-catalysed, enantioconvergent coupling reaction between racemic tertiary electrophiles and cyclopropanols is reported. Employing a rationally designed N,N,N-ligand, this method facilitates the...
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February 2, 2026 at 2:34 PM
Now online:
Article by Xin-Yuan Liu & co-workers
Copper-catalysed enantioconvergent radical C(sp3)–C(sp3) cross-coupling of tertiary electrophiles with cyclopropanols for quaternary carbon formation
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Article by Xin-Yuan Liu & co-workers
Copper-catalysed enantioconvergent radical C(sp3)–C(sp3) cross-coupling of tertiary electrophiles with cyclopropanols for quaternary carbon formation
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Now online:
Article by Robert S. Paton, Jonathan W. Burton & co-workers
Synthesis and properties of allylic, benzylic, propargylic and allenylic oxonium ions
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Article by Robert S. Paton, Jonathan W. Burton & co-workers
Synthesis and properties of allylic, benzylic, propargylic and allenylic oxonium ions
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Synthesis and properties of allylic, benzylic, propargylic and allenylic oxonium ions - Nature Synthesis
Exploration of the chemistry of allylic, benzylic, propargylic and allenylic oxonium ions is lacking despite the latest developments in onium ion chemistry. Now, a unified approach for the synthesis a...
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February 2, 2026 at 2:31 PM
Now online:
Article by Robert S. Paton, Jonathan W. Burton & co-workers
Synthesis and properties of allylic, benzylic, propargylic and allenylic oxonium ions
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Article by Robert S. Paton, Jonathan W. Burton & co-workers
Synthesis and properties of allylic, benzylic, propargylic and allenylic oxonium ions
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Now online:
Article by Jing-Jing Guo, Anhua Hu & co-workers
Photoinduced benzene ring contraction of arylhydrazines for the synthesis of fused pyridines
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Article by Jing-Jing Guo, Anhua Hu & co-workers
Photoinduced benzene ring contraction of arylhydrazines for the synthesis of fused pyridines
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Photoinduced benzene ring contraction of arylhydrazines for the synthesis of fused pyridines - Nature Synthesis
The use of benzene ring contraction in chemical synthesis is challenging due to the need to disrupt aromaticity and generate highly strained intermediates. Now, a photothermal ring contraction reactio...
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February 2, 2026 at 2:28 PM
Now online:
Article by Jing-Jing Guo, Anhua Hu & co-workers
Photoinduced benzene ring contraction of arylhydrazines for the synthesis of fused pyridines
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Article by Jing-Jing Guo, Anhua Hu & co-workers
Photoinduced benzene ring contraction of arylhydrazines for the synthesis of fused pyridines
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Now online:
Article by Jing Gong, Qian Wang & Jieping Zhu
Concerted 1,3-migration through regiodivergent consecutive 1,2-rearrangements using palladium catalysis
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Article by Jing Gong, Qian Wang & Jieping Zhu
Concerted 1,3-migration through regiodivergent consecutive 1,2-rearrangements using palladium catalysis
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Concerted 1,3-migration through regiodivergent consecutive 1,2-rearrangements using palladium catalysis - Nature Synthesis
Concerted 1,3-alkyl shifts are often challenging due to antiaromatic transition states and geometric strain. Now, a formal 1,3-migration can be achieved through two consecutive 1,2-shifts—a Pd(II)-cat...
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February 2, 2026 at 2:24 PM
Now online:
Article by Jing Gong, Qian Wang & Jieping Zhu
Concerted 1,3-migration through regiodivergent consecutive 1,2-rearrangements using palladium catalysis
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Article by Jing Gong, Qian Wang & Jieping Zhu
Concerted 1,3-migration through regiodivergent consecutive 1,2-rearrangements using palladium catalysis
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Now online:
Article by Bo Zhang, Hui Ming Ge & co-workers
Structural and mechanistic insights into iminium-catalysed macrocyclization by nuclear transport factor 2-like enzymes
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Article by Bo Zhang, Hui Ming Ge & co-workers
Structural and mechanistic insights into iminium-catalysed macrocyclization by nuclear transport factor 2-like enzymes
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Structural and mechanistic insights into iminium-catalysed macrocyclization by nuclear transport factor 2-like enzymes - Nature Synthesis
Macrocyclization typically proceeds via thioesterase mediation in type I polyketide synthases. Now, using genome mining and crystallographic analysis, an alternative mechanism for stereoselective macr...
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January 29, 2026 at 12:36 PM
Now online:
Article by Bo Zhang, Hui Ming Ge & co-workers
Structural and mechanistic insights into iminium-catalysed macrocyclization by nuclear transport factor 2-like enzymes
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Article by Bo Zhang, Hui Ming Ge & co-workers
Structural and mechanistic insights into iminium-catalysed macrocyclization by nuclear transport factor 2-like enzymes
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Now online:
Article by Yan Huang, Qing Zhu, Jun Jiang & co-workers
A practical inverse design approach for high-entropy catalysts using generative AI
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Article by Yan Huang, Qing Zhu, Jun Jiang & co-workers
A practical inverse design approach for high-entropy catalysts using generative AI
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A practical inverse design approach for high-entropy catalysts using generative AI - Nature Synthesis
An artificial intelligence-driven robotic chemist that integrates generative machine-learning models incorporating spectroscopic descriptors with automated experimentation is developed, enabling the i...
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January 29, 2026 at 12:33 PM
Now online:
Article by Yan Huang, Qing Zhu, Jun Jiang & co-workers
A practical inverse design approach for high-entropy catalysts using generative AI
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Article by Yan Huang, Qing Zhu, Jun Jiang & co-workers
A practical inverse design approach for high-entropy catalysts using generative AI
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Research Highlight now online:
CO2 electroreduction under elevated conditions by Bei Zhang
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Highlighting the @natcatal.nature.com Article by Marc T. M. Koper & co-workers
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CO2 electroreduction under elevated conditions by Bei Zhang
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Highlighting the @natcatal.nature.com Article by Marc T. M. Koper & co-workers
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CO2 electroreduction under elevated conditions - Nature Synthesis
Nature Synthesis - CO2 electroreduction under elevated conditions
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January 27, 2026 at 12:17 PM
Research Highlight now online:
CO2 electroreduction under elevated conditions by Bei Zhang
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Highlighting the @natcatal.nature.com Article by Marc T. M. Koper & co-workers
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CO2 electroreduction under elevated conditions by Bei Zhang
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Highlighting the @natcatal.nature.com Article by Marc T. M. Koper & co-workers
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Now online:
Article by Hongyu Wang, Jiancheng Li & Liu Leo Liu @llliugroup.bsky.social
A crystalline isodiazomethyl anion
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Article by Hongyu Wang, Jiancheng Li & Liu Leo Liu @llliugroup.bsky.social
A crystalline isodiazomethyl anion
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A crystalline isodiazomethyl anion - Nature Synthesis
A boryl-isodiazomethyl anion featuring a bent eneyne-type B=N–N≡C scaffold is isolated and structurally characterized. The highly nucleophilic boron-bound nitrogen centre makes this species an effecti...
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January 27, 2026 at 12:13 PM
Now online:
Article by Hongyu Wang, Jiancheng Li & Liu Leo Liu @llliugroup.bsky.social
A crystalline isodiazomethyl anion
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Article by Hongyu Wang, Jiancheng Li & Liu Leo Liu @llliugroup.bsky.social
A crystalline isodiazomethyl anion
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Now online:
Article by Yi-Tao Dai & co-workers
Scalable light-driven deuteration of N-heteroarenes over atomically dispersed palladium
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Article by Yi-Tao Dai & co-workers
Scalable light-driven deuteration of N-heteroarenes over atomically dispersed palladium
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Scalable light-driven deuteration of N-heteroarenes over atomically dispersed palladium - Nature Synthesis
A photocatalytic synthetic route to deuterated N-heteroarenes over an atomically dispersed palladium photocatalyst in D2O is developed. By recycling used D2O and photocatalyst, up to 1.157 kg of deute...
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January 26, 2026 at 10:47 AM
Now online:
Article by Yi-Tao Dai & co-workers
Scalable light-driven deuteration of N-heteroarenes over atomically dispersed palladium
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Article by Yi-Tao Dai & co-workers
Scalable light-driven deuteration of N-heteroarenes over atomically dispersed palladium
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Now online:
Review article by Dongyuan Zhao, Zuankai Wang & co-workers
Nanoemulsion modular assembly for the synthesis of functional mesoporous nanomaterials
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Review article by Dongyuan Zhao, Zuankai Wang & co-workers
Nanoemulsion modular assembly for the synthesis of functional mesoporous nanomaterials
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Nanoemulsion modular assembly for the synthesis of functional mesoporous nanomaterials - Nature Synthesis
Nanoemulsion modular assembly is emerging as a versatile strategy for synthesizing diverse functional mesoporous nanomaterials. This Review highlights the capabilities of nanoemulsion modular assembly...
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January 20, 2026 at 12:06 PM
Now online:
Review article by Dongyuan Zhao, Zuankai Wang & co-workers
Nanoemulsion modular assembly for the synthesis of functional mesoporous nanomaterials
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Review article by Dongyuan Zhao, Zuankai Wang & co-workers
Nanoemulsion modular assembly for the synthesis of functional mesoporous nanomaterials
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Now online:
Article by Eric Chun Yong Chan, Ming Joo Koh & co-workers
Photocatalytic coupling of unprotected sugars and N-heteroarenes
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Article by Eric Chun Yong Chan, Ming Joo Koh & co-workers
Photocatalytic coupling of unprotected sugars and N-heteroarenes
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Photocatalytic coupling of unprotected sugars and N-heteroarenes - Nature Synthesis
The synthesis of unprotected C-heteroaryl glycosides is challenging because of the lack of methods to utilize native saccharides as substrates. Now these compounds, capped as redox-active glycosyl sul...
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January 19, 2026 at 11:25 AM
Now online:
Article by Eric Chun Yong Chan, Ming Joo Koh & co-workers
Photocatalytic coupling of unprotected sugars and N-heteroarenes
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Article by Eric Chun Yong Chan, Ming Joo Koh & co-workers
Photocatalytic coupling of unprotected sugars and N-heteroarenes
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Now online:
Article by Genping Huang, Yifeng Chen & co-workers
Enantio- and linear-selective allylic radical addition to imines using reductive cobalt catalysis
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Article by Genping Huang, Yifeng Chen & co-workers
Enantio- and linear-selective allylic radical addition to imines using reductive cobalt catalysis
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Enantio- and linear-selective allylic radical addition to imines using reductive cobalt catalysis - Nature Synthesis
The linear-selective allylic addition to carbonyls remains challenging owing to the inversion of the six-membered transition state. Now an enantio- and linear-selective allylic addition to ketimines u...
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January 19, 2026 at 11:22 AM
Now online:
Article by Genping Huang, Yifeng Chen & co-workers
Enantio- and linear-selective allylic radical addition to imines using reductive cobalt catalysis
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Article by Genping Huang, Yifeng Chen & co-workers
Enantio- and linear-selective allylic radical addition to imines using reductive cobalt catalysis
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Now online:
Article by Zhenwei Wei, Wu Li, Hong Yi, Aiwen Lei & co-workers
Parallel paired electrolysis of industrial exhaust SO2 and diols for value-added sulfite esters synthesis
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Article by Zhenwei Wei, Wu Li, Hong Yi, Aiwen Lei & co-workers
Parallel paired electrolysis of industrial exhaust SO2 and diols for value-added sulfite esters synthesis
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Parallel paired electrolysis of industrial exhaust SO2 and diols for value-added sulfite esters synthesis - Nature Synthesis
Paired electrolysis converts industrial SO2 directly into valuable cyclic sulfite esters, turning a common pollutant into useful chemicals. Mechanistic studies reveal key intermediates, offering a sus...
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January 16, 2026 at 1:31 PM
Now online:
Article by Zhenwei Wei, Wu Li, Hong Yi, Aiwen Lei & co-workers
Parallel paired electrolysis of industrial exhaust SO2 and diols for value-added sulfite esters synthesis
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Article by Zhenwei Wei, Wu Li, Hong Yi, Aiwen Lei & co-workers
Parallel paired electrolysis of industrial exhaust SO2 and diols for value-added sulfite esters synthesis
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Now online:
Article by Jinqiao Dong, Anthony P. Davis, Yong Cui & co-workers
Amino-acid-encoded assembly of programmable chiral Solomon links
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Article by Jinqiao Dong, Anthony P. Davis, Yong Cui & co-workers
Amino-acid-encoded assembly of programmable chiral Solomon links
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Amino-acid-encoded assembly of programmable chiral Solomon links - Nature Synthesis
An amino-acid-encoded assembly strategy is developed for the synthesis of programmable chiral Solomon links, featuring tunable cavity dimensions and shapes. This template-free synthetic approach favou...
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January 16, 2026 at 1:30 PM
Now online:
Article by Jinqiao Dong, Anthony P. Davis, Yong Cui & co-workers
Amino-acid-encoded assembly of programmable chiral Solomon links
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Article by Jinqiao Dong, Anthony P. Davis, Yong Cui & co-workers
Amino-acid-encoded assembly of programmable chiral Solomon links
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Now online:
An Editorial highlighting some of the excellent covers featured in Nature Synthesis in 2025 as well as the research they represent. Thanks to our authors for submitting such great covers!
www.nature.com/articles/s44...
An Editorial highlighting some of the excellent covers featured in Nature Synthesis in 2025 as well as the research they represent. Thanks to our authors for submitting such great covers!
www.nature.com/articles/s44...
January 14, 2026 at 10:11 AM
Now online:
An Editorial highlighting some of the excellent covers featured in Nature Synthesis in 2025 as well as the research they represent. Thanks to our authors for submitting such great covers!
www.nature.com/articles/s44...
An Editorial highlighting some of the excellent covers featured in Nature Synthesis in 2025 as well as the research they represent. Thanks to our authors for submitting such great covers!
www.nature.com/articles/s44...
January 13, 2026 at 4:58 PM
Now online:
Article by Tao Xiong & co-workers
Catalytic asymmetric hydroalkylation of 1,1-dialkyl-substituted alkenes with unactivated alkyl electrophiles
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Article by Tao Xiong & co-workers
Catalytic asymmetric hydroalkylation of 1,1-dialkyl-substituted alkenes with unactivated alkyl electrophiles
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Client Challenge
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January 13, 2026 at 12:57 PM
Now online:
Article by Tao Xiong & co-workers
Catalytic asymmetric hydroalkylation of 1,1-dialkyl-substituted alkenes with unactivated alkyl electrophiles
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Article by Tao Xiong & co-workers
Catalytic asymmetric hydroalkylation of 1,1-dialkyl-substituted alkenes with unactivated alkyl electrophiles
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Now online:
Article by Zhenxing Wang, Feng Wang, Qingdao Zeng, Zhenpeng Hu, Jun He & co-workers
Synthesis of wafer-scale uniaxially oriented tellurium films via molecular engineering
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Article by Zhenxing Wang, Feng Wang, Qingdao Zeng, Zhenpeng Hu, Jun He & co-workers
Synthesis of wafer-scale uniaxially oriented tellurium films via molecular engineering
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Synthesis of wafer-scale uniaxially oriented tellurium films via molecular engineering - Nature Synthesis
Using a molecular engineering approach, wafer-scale uniaxially oriented Te nanowire thin films are synthesized with excellent controllability and uniformity. The anchor-rope structural molecules form ...
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January 6, 2026 at 11:55 AM
Now online:
Article by Zhenxing Wang, Feng Wang, Qingdao Zeng, Zhenpeng Hu, Jun He & co-workers
Synthesis of wafer-scale uniaxially oriented tellurium films via molecular engineering
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Article by Zhenxing Wang, Feng Wang, Qingdao Zeng, Zhenpeng Hu, Jun He & co-workers
Synthesis of wafer-scale uniaxially oriented tellurium films via molecular engineering
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Now online:
Article by Kang Cai, Dong-Sheng Guo, Jonathan L. Sessler, Chunju Li & co-workers
Customized cycloparaphenylene skeletons prepared via the intramolecular coupling of extended biphen[n]arenes
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Article by Kang Cai, Dong-Sheng Guo, Jonathan L. Sessler, Chunju Li & co-workers
Customized cycloparaphenylene skeletons prepared via the intramolecular coupling of extended biphen[n]arenes
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Customized cycloparaphenylene skeletons prepared via the intramolecular coupling of extended biphen[n]arenes - Nature Synthesis
Intramolecular coupling of extended biphen[n]arenes is developed to yield cycloparaphenylenes (CPPs). The modular nature of biphen[n]arenes makes it possible to customize CPP structures, which permits...
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January 6, 2026 at 11:51 AM
Now online:
Article by Kang Cai, Dong-Sheng Guo, Jonathan L. Sessler, Chunju Li & co-workers
Customized cycloparaphenylene skeletons prepared via the intramolecular coupling of extended biphen[n]arenes
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Article by Kang Cai, Dong-Sheng Guo, Jonathan L. Sessler, Chunju Li & co-workers
Customized cycloparaphenylene skeletons prepared via the intramolecular coupling of extended biphen[n]arenes
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Now online and open access:
Article by Hai I. Wang, Minghao Yu, Xinliang Feng & co-workers
Triphasic synthesis of MXenes with uniform and controlled halogen terminations
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Article by Hai I. Wang, Minghao Yu, Xinliang Feng & co-workers
Triphasic synthesis of MXenes with uniform and controlled halogen terminations
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Triphasic synthesis of MXenes with uniform and controlled halogen terminations - Nature Synthesis
A gas–liquid–solid triphasic etching strategy is demonstrated to obtain MXenes with uniform and tunable halogen terminations. The resulting MXenes have highly ordered structures, enhanced charge trans...
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January 6, 2026 at 11:49 AM
Now online and open access:
Article by Hai I. Wang, Minghao Yu, Xinliang Feng & co-workers
Triphasic synthesis of MXenes with uniform and controlled halogen terminations
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Article by Hai I. Wang, Minghao Yu, Xinliang Feng & co-workers
Triphasic synthesis of MXenes with uniform and controlled halogen terminations
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Research Highlight now online:
A terminal germanium oxido dianion by Bei Zhang
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Highlighting the @jacs.acspublications.org article by Valentin D. Hannibal & Lutz Greb
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A terminal germanium oxido dianion by Bei Zhang
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Highlighting the @jacs.acspublications.org article by Valentin D. Hannibal & Lutz Greb
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A terminal germanium oxido dianion - Nature Synthesis
Nature Synthesis - A terminal germanium oxido dianion
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January 5, 2026 at 12:51 PM
Research Highlight now online:
A terminal germanium oxido dianion by Bei Zhang
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Highlighting the @jacs.acspublications.org article by Valentin D. Hannibal & Lutz Greb
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A terminal germanium oxido dianion by Bei Zhang
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Highlighting the @jacs.acspublications.org article by Valentin D. Hannibal & Lutz Greb
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Research Highlight now online:
Ammonia synthesis over AuRu alloys by @alexrgroves.bsky.social
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Highlighting the @natenergy.nature.com Article by Lin Yuan, Junwei Lucas Bao, Jennifer A. Dionne & co-workers
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Ammonia synthesis over AuRu alloys by @alexrgroves.bsky.social
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Highlighting the @natenergy.nature.com Article by Lin Yuan, Junwei Lucas Bao, Jennifer A. Dionne & co-workers
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Ammonia synthesis over AuRu alloys - Nature Synthesis
Nature Synthesis - Ammonia synthesis over AuRu alloys
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January 5, 2026 at 12:49 PM
Research Highlight now online:
Ammonia synthesis over AuRu alloys by @alexrgroves.bsky.social
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Highlighting the @natenergy.nature.com Article by Lin Yuan, Junwei Lucas Bao, Jennifer A. Dionne & co-workers
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Ammonia synthesis over AuRu alloys by @alexrgroves.bsky.social
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Highlighting the @natenergy.nature.com Article by Lin Yuan, Junwei Lucas Bao, Jennifer A. Dionne & co-workers
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Now online:
News & Views on the Articles:
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And
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meta-Selective radical halogenation of pyridines by Nirmala Mohanta & Jacquelyne A. Read
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News & Views on the Articles:
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And
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meta-Selective radical halogenation of pyridines by Nirmala Mohanta & Jacquelyne A. Read
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meta-Selective radical halogenation of pyridines - Nature Synthesis
Radical processes can be leveraged to impart meta selectivity in pyridine functionalization, offering a valuable approach for the late-stage functionalization of bioactive molecules.
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January 5, 2026 at 12:44 PM
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News & Views on the Articles:
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And
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meta-Selective radical halogenation of pyridines by Nirmala Mohanta & Jacquelyne A. Read
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News & Views on the Articles:
www.nature.com/articles/s44... ($)
And
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meta-Selective radical halogenation of pyridines by Nirmala Mohanta & Jacquelyne A. Read
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Now online:
News & Views on the Article by Aoni Xu, Sung-Fu Hung & co-workers
www.nature.com/articles/s44... ($)
Sulfur enhances electrochemical CO2 reduction over porphyrin catalysts by Karl Adrian Gandionco, Zhiyuan Zhang & Jongwoo Lim
www.nature.com/articles/s44... ($)
#Chemsky
News & Views on the Article by Aoni Xu, Sung-Fu Hung & co-workers
www.nature.com/articles/s44... ($)
Sulfur enhances electrochemical CO2 reduction over porphyrin catalysts by Karl Adrian Gandionco, Zhiyuan Zhang & Jongwoo Lim
www.nature.com/articles/s44... ($)
#Chemsky
Sulfur enhances electrochemical CO2 reduction over porphyrin catalysts - Nature Synthesis
The strategic placement of sulfur within a nickel porphyrin complex coupled with copper facilitates efficient electrochemical CO2 reduction to ethylene and ethanol.
www.nature.com
January 5, 2026 at 12:35 PM
Now online:
News & Views on the Article by Aoni Xu, Sung-Fu Hung & co-workers
www.nature.com/articles/s44... ($)
Sulfur enhances electrochemical CO2 reduction over porphyrin catalysts by Karl Adrian Gandionco, Zhiyuan Zhang & Jongwoo Lim
www.nature.com/articles/s44... ($)
#Chemsky
News & Views on the Article by Aoni Xu, Sung-Fu Hung & co-workers
www.nature.com/articles/s44... ($)
Sulfur enhances electrochemical CO2 reduction over porphyrin catalysts by Karl Adrian Gandionco, Zhiyuan Zhang & Jongwoo Lim
www.nature.com/articles/s44... ($)
#Chemsky