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Cambridge Clinical Mitochondrial Research Group

@mitocamb.bsky.social

330 followers 260 following 51 posts

MitoCAMB brings together a team of clinical researchers focused on mitochondrial and neurodegenerative disease translational research. mitocamb.medschl.cam.ac.uk (Photo: Florian Klimm)

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Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 18d

📢 We are recruiting a post-doctoral clinical research associate to join the @lifearc.bsky.social Centre for Rare #Mitochondrial Diseases, supported by @mdukcharity.bsky.social It's an exciting time in mito research! For further details and to apply visit: www.cam.ac.uk/jobs/clinica...

Clinical Research Associate (Fixed Term)

This is a unique opportunity to carry out a period of clinical postdoctoral research focused on developing and validating new treatments and biomarkers for mitochondrial disorders, as part of a new

www.cam.ac.uk

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Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 4d

Congrats Michele! Great work! @jellevda.bsky.social @mrc-mbu.bsky.social @mbu-postdocs.bsky.social

Michele Frison @frisophagy.bsky.social · 4d

Bluesky, I am pleased to present to you the main product of postdoc work, published in @science.org ☝️

As it turns out, the very quality control mechanism that can remove mutant mtDNA copies is the one that maintains high mutant burden, or heteroplasmy levels

High heteroplasmy decreases mitochondrial ubiquitination

Reposted by Cambridge Clinical Mitochondrial Research Group

The Lily Foundation @lilyfoundation.bsky.social · 5d

👁️Today is World Sight Day – and we’re proud to reshare some incredible news for the mito community. Idebenone is now available for patients with LHON – a breakthrough that could help preserve vision and improve lives.

📖 Read Mary’s story to learn more: https://ow.ly/MZhL50X3wtH

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Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 5d

Seconded!!

Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 6d

Congratulations to @lucialugut.bsky.social who passed her PhD with flying colours last week; and with no thesis corrections ☺️🎓👏

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Reposted by Cambridge Clinical Mitochondrial Research Group

The Lily Foundation @lilyfoundation.bsky.social · 8d

🔬 Supporting medical research into mitochondrial disease is at the heart of our mission.

Explore our past and current research projects - https://www.thelilyfoundation.org.uk/affected-by-mito/our-research/lily-funded-research-projects/

Together, we’re driving hope through science. 💚

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Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 18d

@lilyfoundation.bsky.social @ritahorvath.bsky.social @jellevda.bsky.social @mitowomen.bsky.social @camneuro.bsky.social @uclqsion.bsky.social @mitonewcastle.bsky.social @mrc-mbu.bsky.social @camneurodept.bsky.social @cambridge-scm.bsky.social @londonmito.bsky.social @needhamneuro.bsky.social

Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 18d

Clinical Research Associate (Fixed Term)

This is a unique opportunity to carry out a period of clinical postdoctoral research focused on developing and validating new treatments and biomarkers for mitochondrial disorders, as part of a new

www.cam.ac.uk

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Reposted by Cambridge Clinical Mitochondrial Research Group

LifeArc @lifearc.bsky.social · 21d

Rare disease is collectively common, affecting ~1 in 17 people in the UK.

The LifeArc Translational Centres for Rare Disease each tackle a different area of unmet need, but together they're building a stronger rare disease research ecosystem.

Learn more: https://t.ly/zAEj-

#LifeArcTCRD

LifeArc Translational Centres for Rare Diseases

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

t.ly

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Reposted by Cambridge Clinical Mitochondrial Research Group

The Lily Foundation @lilyfoundation.bsky.social · 25d

Raising awareness of #mito isn't easy – it’s a complex disease that can be hard to explain 🤔

To help put mito on the map during World Mitochondrial Disease Week, our Research Manager @abioblog.bsky.social is here to explain the disease in a really simple way

Watch, learn and share! 💚

#mitoaware

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Reposted by Cambridge Clinical Mitochondrial Research Group

LifeArc @lifearc.bsky.social · 28d

🎉Today marks one year of the LifeArc Translational Centres for Rare Disease.

These four Centres are breaking down the barriers in rare disease research and accelerating the development of new tests and treatments.

#RareDisease #LifeArcTCRD #OneYearOfImpact

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Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · 28d

A Publication of interest 🎓 🧬 💚

Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration. Link to paper: bit.ly/41Xwxg5

Reposted by Cambridge Clinical Mitochondrial Research Group

www.MitoWorld.org @mitoworld.bsky.social · 29d

MitoWorld Supports Mitochondrial Disease Week

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Reposted by Cambridge Clinical Mitochondrial Research Group

Anupam Patgiri @apatgiri.bsky.social · Sep 14

Replication competition drives the selective mtDNA inheritance in Drosophila ovary www.cell.com/cell-reports...

Replication competition drives the selective mtDNA inheritance in Drosophila ovary

Zhang et al. report a novel imaging method that can distinguish mtDNA variants with single-nucleotide polymorphisms at single-molecule resolution in situ. Using this method, they visualized dynamics o...

www.cell.com

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Reposted by Cambridge Clinical Mitochondrial Research Group

The Lily Foundation @lilyfoundation.bsky.social · 29d

It’s here – World Mitochondrial Disease Week! 💚

We’re proud to collaborate with other mito charities across the UK to put mito on the map – let's spread the word together!

👉 See how you can get involved:
🔗 thelilyfoundation.org.uk/charity/get-involved/world-mitochondrial-disease-week

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Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · Sep 11

A discussion about the approval of idebenone for #LHON from the patients’ perspective: www.moorfields.nhs.uk/about-us/new... @moorfieldsbrc.bsky.social @moorfields.bsky.social

Treatment for cause of sudden sight loss now available through the NHS in England - Moorfields Eye Hospital

www.moorfields.nhs.uk

Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · Aug 28

RNIB Connect Radio’s Toby Davey was joined by Patrick Yu-Wai-Man, Professor of Ophthalmology at the University of Cambridge who was involved in the research into using idebenone to treat Leber hereditary optic neuropathy (LHON). Listen here: audioboom.com/posts/876813...
@lilyfoundation.bsky.social

NICE Approves New Treatment for Leber Hereditary Optic Neuropathy (LHON)

NICE, the National Institute for Health and Care Excellence has recently approved new treatment in England for people living with the eye condition Leber hereditary optic neuropathy (LHON) helped by R...

audioboom.com

Reposted by Cambridge Clinical Mitochondrial Research Group

NIHR Cambridge Biomedical Research Centre @cambridgebrc.bsky.social · Aug 7

👉 'A huge win for the mito community' First ever treatment for a mitochondrial condition that causes sudden vision loss has been approved for use on the NHS in England!
👉 bit.ly/4oHO8m3

@cuh.nhs.uk @mitocamb.bsky.social @cam.ac.uk @moorfieldsbrc.bsky.social @lilyfoundation.bsky.social

First ever mitochondrial disease treatment approved by NHS England - NIHR Cambridge Biomedical Research Centre

The first ever treatment for a mitochondrial condition has been approved for use on the NHS in England in a major breakthrough in the fight against the disease.

bit.ly

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Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · Aug 7

This is amazing news!! @camneurodept.bsky.social @mrc-mbu.bsky.social @jellevda.bsky.social @ritahorvath.bsky.social @mito-news.bsky.social

The Lily Foundation @lilyfoundation.bsky.social · Aug 7

📢 BREAKING NEWS!

The first ever treatment for a mitochondrial disease has been approved for use by NHS England! Idebenone is now available for LHON patients

A huge milestone for the mito community! 💥

www.thelilyfoundation.org.uk/news/first-e...

@mitocamb.bsky.social

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Reposted by Cambridge Clinical Mitochondrial Research Group

Cambridge Rare Disease Network @camrare.bsky.social · Aug 5

Did you catch the latest about #RAREsummit25? - the programme is shaping up!
RAREsummit alumni, patients pitching research ideas, interactive workshops, networking dinner and more...
Read more here & grab your tickets before they're all snapped up!
www.camraredisease.org/raresummit25...

Catch a glimpse of the much anticipated RAREsummit25 programme.

Celebrating 10 years of progress and impact in rare diseases, the UK’s leading multi stakeholder RAREsummit returns to Cambridge

www.camraredisease.org

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Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · Aug 1

📢 We are hiring a Senior Research Associate in Bioinformatics & Statistical genetics @cam.ac.uk @mrc-mbu.bsky.social @camneurodept.bsky.social @jellevda.bsky.social It's a great time to join this dynamic and world leading team working on #mitochondria Closes 28/8/25

www.cam.ac.uk/jobs/senior-...

Senior Research Associate (Fixed Term)

Nuclear-mitochondrial genetic interactions in health and neurodegenerative diseases Fixed-term: The funds for this post are available until 30 September 2028 in the first instance. The University of

www.cam.ac.uk

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Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · Aug 1

Kerry & Jelle discuss developing gene therapies for mitochondrial disease — in collaboration with labs around the world! - Watch the Video
bit.ly/3UCF0kC

🌍Sign up to IMPACT to let your voice be heard
bit.ly/4ohHhiN

Make an IMPACT - The Lily Foundation

Join IMPACT, The Lily Foundation’s virtual committee for those affected by mitochondrial disease. Share your insights to shape research, care and treatments.

bit.ly

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Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · Aug 1

Love this! @ritahorvath.bsky.social

The Lily Foundation @lilyfoundation.bsky.social · Jul 31

Zebrafish are helping scientists tackle rare #mitochondrialdiseases like MDDS

In 2018/19, Lily funded research using zebrafish to test treatments

Find out what happened in our latest Research Zone post with Research Manager Maria and Dr Ben Munro

www.thelilyfoundation.org.uk/affected-by-...

Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · Jul 31

How to go about designing a leaflet with patients newly diagnosed with mitochondrial disease - a Video from Heather & Elizabeth bit.ly/475t7em
#Mito #PPIE

Reposted by Cambridge Clinical Mitochondrial Research Group

The Lily Foundation @lilyfoundation.bsky.social · Jul 17

We’ve been hearing a lot about #mitochondrialdonation today – but what exactly is it?

It’s a groundbreaking fertility technique that helps women with faulty mitochondrial DNA have healthy babies

Want to understand more? Watch our explainer video 👇
www.thelilyfoundation.org.uk/affected-by-...

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Reposted by Cambridge Clinical Mitochondrial Research Group

michaelpacold.bsky.social @michaelpacold.bsky.social · Jul 9

Out now:

rdcu.be/evxCv

We've used CoQ10 headgroup intermediates to treat mouse models of a mitochondrial disease and improve the neurological symptoms of a patient with this disease.

Grateful for funding from @damonrunyon.org , Pershing Square Foundation, @americancancersoc.bsky.social, NIH!

Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy - Nature

Decreased brain coenzyme Q10 levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q10 synthesis in mice and humans with HPDL vari...

www.nature.com

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