Michelle Grunin, PhD
@mgrunin.bsky.social
Geneticist/scientist/geek🔬
Postdoc@HUJI;Carmi Lab & collaboration with Haines Lab@CWRU-complex aging genetics🧬
BrightFocus Fellow
PhD@mol👁️HUJI Views my own
MGrunin5 from X/Twitter
www.michellegrunin.com
Postdoc@HUJI;Carmi Lab & collaboration with Haines Lab@CWRU-complex aging genetics🧬
BrightFocus Fellow
PhD@mol👁️HUJI Views my own
MGrunin5 from X/Twitter
www.michellegrunin.com
Back at ASHG and got to hear Drs Sarah Tishoff, Francis Collins, the new GLP1 MR study, the GIANT study on hwr, Dr C. Mason's lab on space flight 'omics, and it's just day one! Excited for the rest of the week. My poster on fine mapping/eQTLs in AD is today, if you want to check it out!
October 15, 2025 at 10:57 AM
Back at ASHG and got to hear Drs Sarah Tishoff, Francis Collins, the new GLP1 MR study, the GIANT study on hwr, Dr C. Mason's lab on space flight 'omics, and it's just day one! Excited for the rest of the week. My poster on fine mapping/eQTLs in AD is today, if you want to check it out!
Research has been really busy, but today research came out in Genome Biology that I've been waiting for!
Proud to be a main analyst (yes there are a lot of us) in this largest multi ethnic study of Alzheimers disease via the ADGC.
Congrats to all on publication day!
doi.org/10.1186/s130...
Proud to be a main analyst (yes there are a lot of us) in this largest multi ethnic study of Alzheimers disease via the ADGC.
Congrats to all on publication day!
doi.org/10.1186/s130...
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer’s disease - Genome Biolog...
Background Limited ancestral diversity has impaired our ability to detect risk variants more prevalent in ancestry groups of predominantly non-European ancestral background in genome-wide association ...
doi.org
July 18, 2025 at 5:16 AM
Research has been really busy, but today research came out in Genome Biology that I've been waiting for!
Proud to be a main analyst (yes there are a lot of us) in this largest multi ethnic study of Alzheimers disease via the ADGC.
Congrats to all on publication day!
doi.org/10.1186/s130...
Proud to be a main analyst (yes there are a lot of us) in this largest multi ethnic study of Alzheimers disease via the ADGC.
Congrats to all on publication day!
doi.org/10.1186/s130...
Really grateful to be here at #ARVO2025.
Also honored to be giving a talk on Tuesday on a TWAS + monocytes + the pathogenesis of AMD!
Come find out why gene expression matters, 1:45pm, Ballroom E, Tues.
Thank you to @brightfocus.bsky.social
for the opportunity!
Also honored to be giving a talk on Tuesday on a TWAS + monocytes + the pathogenesis of AMD!
Come find out why gene expression matters, 1:45pm, Ballroom E, Tues.
Thank you to @brightfocus.bsky.social
for the opportunity!
May 4, 2025 at 5:04 PM
Really grateful to be here at #ARVO2025.
Also honored to be giving a talk on Tuesday on a TWAS + monocytes + the pathogenesis of AMD!
Come find out why gene expression matters, 1:45pm, Ballroom E, Tues.
Thank you to @brightfocus.bsky.social
for the opportunity!
Also honored to be giving a talk on Tuesday on a TWAS + monocytes + the pathogenesis of AMD!
Come find out why gene expression matters, 1:45pm, Ballroom E, Tues.
Thank you to @brightfocus.bsky.social
for the opportunity!
Reposted by Michelle Grunin, PhD
Hubble has spent 35 years in orbit! 🥳 Celebrate with an array of compelling images recently taken by Hubble: Mars, dramatic views of stellar birth and death, and a magnificent spiral galaxy: bit.ly/4jjsAs7 🔭 🧪
April 23, 2025 at 2:08 PM
Hubble has spent 35 years in orbit! 🥳 Celebrate with an array of compelling images recently taken by Hubble: Mars, dramatic views of stellar birth and death, and a magnificent spiral galaxy: bit.ly/4jjsAs7 🔭 🧪
Reposted by Michelle Grunin, PhD
The first comprehensive atlas of allele-specific DNA methylation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Atlas of imprinted and allele-specific DNA methylation in the human body - Nature Communications
DNA methylation drives parental expression differences at imprinted genes. Here, the authors uncover hundreds of ubiquitous and tissue-specific differentially methylated regions, offering insights int...
www.nature.com
March 11, 2025 at 2:20 PM
The first comprehensive atlas of allele-specific DNA methylation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Michelle Grunin, PhD
Key reads from last week on human genetics, multiomics, and precision medicine 🧵
1⃣New e/sQTL resource from TOPMed
In 14,324 whole blood & tissue samples the study detects cis- and trans-e/sQTLs and colocalizes them with 10,000 GWAS signals for 164 traits.
🔗 www.medrxiv.org/content/10.1...
1⃣New e/sQTL resource from TOPMed
In 14,324 whole blood & tissue samples the study detects cis- and trans-e/sQTLs and colocalizes them with 10,000 GWAS signals for 164 traits.
🔗 www.medrxiv.org/content/10.1...
February 24, 2025 at 4:09 PM
Key reads from last week on human genetics, multiomics, and precision medicine 🧵
1⃣New e/sQTL resource from TOPMed
In 14,324 whole blood & tissue samples the study detects cis- and trans-e/sQTLs and colocalizes them with 10,000 GWAS signals for 164 traits.
🔗 www.medrxiv.org/content/10.1...
1⃣New e/sQTL resource from TOPMed
In 14,324 whole blood & tissue samples the study detects cis- and trans-e/sQTLs and colocalizes them with 10,000 GWAS signals for 164 traits.
🔗 www.medrxiv.org/content/10.1...
Reposted by Michelle Grunin, PhD
📢New Yorkers! We're meeting for the second session of the 'Postdoc Night Science NYC' club on January 30th 5-7pm. This time we'll be at NYU (Washington Square campus), with the topic of 'A hypothesis is a liability'. Space is limited so please register: docs.google.com/forms/d/1Shc...
January 16, 2025 at 4:27 AM
📢New Yorkers! We're meeting for the second session of the 'Postdoc Night Science NYC' club on January 30th 5-7pm. This time we'll be at NYU (Washington Square campus), with the topic of 'A hypothesis is a liability'. Space is limited so please register: docs.google.com/forms/d/1Shc...
Reposted by Michelle Grunin, PhD
"Roman writers found the relative empowerment of Celtic women remarkable." Wonderful start to a new #ancientDNA paper out today about the communities of Iron Age Britain in an increasingly connected and mobile world. www.nature.com/articles/s41...
Continental influx and pervasive matrilocality in Iron Age Britain - Nature
An analysis of ancient mitochondrial and nuclear DNA shows evidence of matrilocal communities in Iron Age Britain.
www.nature.com
January 15, 2025 at 5:27 PM
"Roman writers found the relative empowerment of Celtic women remarkable." Wonderful start to a new #ancientDNA paper out today about the communities of Iron Age Britain in an increasingly connected and mobile world. www.nature.com/articles/s41...
A really interesting response to the paper in Nature.
Eugenics, statistical hubris, and unknowable unknowns in human genetics www.wiringthebrain.com/2025/01/euge...
Eugenics, statistical hubris, and unknowable unknowns in human genetics
A new paper just out in Nature , by Peter Visscher and colleagues (including bio-ethicist Julian Salvulescu) explores the idea of polygenic...
www.wiringthebrain.com
January 16, 2025 at 7:16 AM
A really interesting response to the paper in Nature.
This get a repost because Prof Carmi's response made me laugh.
NIH researchers study ancestry in All of Us.
"Middle Eastern ancestry ... [in White persons was] significantly higher in New York and New Jersey (~15%) compared to states like Alabama and Arkansas (~3%)."
Very mysterious, really.
www.biorxiv.org/content/10.1...
"Middle Eastern ancestry ... [in White persons was] significantly higher in New York and New Jersey (~15%) compared to states like Alabama and Arkansas (~3%)."
Very mysterious, really.
www.biorxiv.org/content/10.1...
January 16, 2025 at 7:15 AM
This get a repost because Prof Carmi's response made me laugh.
Reposted by Michelle Grunin, PhD
Our mentor Casey Brown, apart from being an extraordinary scientist, was a brilliant teacher who loved everything genetics. In his honor, some of the world's leading experts came together to create the 'Casey Brown Lecture Series' on human genetics 1/ shorturl.at/eCm7S
Casey Brown Lecture Series - YouTube
shorturl.at
January 4, 2025 at 2:54 PM
Our mentor Casey Brown, apart from being an extraordinary scientist, was a brilliant teacher who loved everything genetics. In his honor, some of the world's leading experts came together to create the 'Casey Brown Lecture Series' on human genetics 1/ shorturl.at/eCm7S
Reposted by Michelle Grunin, PhD
Reflecting on another Earth year – from Mars!
From saying goodbye to my pal Ingenuity to reaching the rim of Jezero Crater after a long, treacherous climb... Here are some of my biggest moments of 2024. 🧵
From saying goodbye to my pal Ingenuity to reaching the rim of Jezero Crater after a long, treacherous climb... Here are some of my biggest moments of 2024. 🧵
December 31, 2024 at 9:22 PM
Reflecting on another Earth year – from Mars!
From saying goodbye to my pal Ingenuity to reaching the rim of Jezero Crater after a long, treacherous climb... Here are some of my biggest moments of 2024. 🧵
From saying goodbye to my pal Ingenuity to reaching the rim of Jezero Crater after a long, treacherous climb... Here are some of my biggest moments of 2024. 🧵
The #1 question I got at ASHG was where is the IAMDGC 2.0: it's under review, but preprint is finally out!
A brand new diverse ancestry analysis, two new loci, and a full TOPMed imputed dataset. I am equal first author and thrilled to see it live! 🧵
www.medrxiv.org/content/10.1...
A brand new diverse ancestry analysis, two new loci, and a full TOPMed imputed dataset. I am equal first author and thrilled to see it live! 🧵
www.medrxiv.org/content/10.1...
Diverse ancestry GWAS for advanced age-related macular degeneration in TOPMed-imputed and Ophthalmologically-confirmed 16,108 cases and 18,038 controls
Age-related macular degeneration (AMD) is a leading cause of blindness with $344 billion dollars global costs. In 2016, the International Age-related Macular Degeneration Genomics Consortium devised g...
www.medrxiv.org
December 22, 2024 at 6:28 AM
The #1 question I got at ASHG was where is the IAMDGC 2.0: it's under review, but preprint is finally out!
A brand new diverse ancestry analysis, two new loci, and a full TOPMed imputed dataset. I am equal first author and thrilled to see it live! 🧵
www.medrxiv.org/content/10.1...
A brand new diverse ancestry analysis, two new loci, and a full TOPMed imputed dataset. I am equal first author and thrilled to see it live! 🧵
www.medrxiv.org/content/10.1...
Going to post the relatively new paper by Bryan Gorman and colleagues, with the IAMDGC (that I am a part of) analyzing the Million Veterans Project and AMD, in @naturegenet.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries - Nature Genetics
Multi-ancestry genome-wide analyses identify new risk loci for age-related macular degeneration. Ancestry-specific analyses identify distinct effects at major risk loci, including smaller effect sizes...
www.nature.com
December 22, 2024 at 6:23 AM
Going to post the relatively new paper by Bryan Gorman and colleagues, with the IAMDGC (that I am a part of) analyzing the Million Veterans Project and AMD, in @naturegenet.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...