Michal Galdzicki
@mgaldzic.bsky.social
I work on data at Arzeda the protein design company.
Reposted by Michal Galdzicki
this is wild - i was aware of Mary-Claire King's absurdly important discoveries on BRCA / inherited breast cancer but I had no idea that her first PhD paper (King & Wilson 1975, Science, not bad lol) is the "99% of protein coding shared btwn chimps and humans" result
www.science.org/doi/abs/10.1...
www.science.org/doi/abs/10.1...
September 20, 2025 at 9:17 AM
this is wild - i was aware of Mary-Claire King's absurdly important discoveries on BRCA / inherited breast cancer but I had no idea that her first PhD paper (King & Wilson 1975, Science, not bad lol) is the "99% of protein coding shared btwn chimps and humans" result
www.science.org/doi/abs/10.1...
www.science.org/doi/abs/10.1...
Reposted by Michal Galdzicki
RosettaFold 3 is here! 🧬🚀
AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!
Congratulations @simonmathis.bsky.social and team!!! ❤️
bioRxiv preprint: www.biorxiv.org/content/10.1...
AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!
Congratulations @simonmathis.bsky.social and team!!! ❤️
bioRxiv preprint: www.biorxiv.org/content/10.1...
August 15, 2025 at 1:26 PM
RosettaFold 3 is here! 🧬🚀
AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!
Congratulations @simonmathis.bsky.social and team!!! ❤️
bioRxiv preprint: www.biorxiv.org/content/10.1...
AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!
Congratulations @simonmathis.bsky.social and team!!! ❤️
bioRxiv preprint: www.biorxiv.org/content/10.1...
Boltz-1 update Boltz-1x introduces inference-time steering for much higher physical quality, CUDA kernels for faster, more memory-efficient inference and training.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Boltz-1: Democratizing Biomolecular Interaction Modeling
Understanding biomolecular interactions is fundamental to advancing fields like drug discovery and protein design. In this paper, we introduce Boltz-1, an open-source deep learning model incorporating...
www.biorxiv.org
April 27, 2025 at 6:41 PM
Boltz-1 update Boltz-1x introduces inference-time steering for much higher physical quality, CUDA kernels for faster, more memory-efficient inference and training.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Michal Galdzicki
BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design https://www.biorxiv.org/content/10.1101/2025.04.06.647261v1
April 7, 2025 at 5:18 AM
BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design https://www.biorxiv.org/content/10.1101/2025.04.06.647261v1
Reposted by Michal Galdzicki
...where a powerful toy slingshot can be used to mount the LoRa node in a tree for better line-of-sight communications with other devices.
www.instructables.com/Meshtastic-S...
www.instructables.com/Meshtastic-S...
April 6, 2025 at 2:37 PM
...where a powerful toy slingshot can be used to mount the LoRa node in a tree for better line-of-sight communications with other devices.
www.instructables.com/Meshtastic-S...
www.instructables.com/Meshtastic-S...
Reposted by Michal Galdzicki
🚀 Thrilled to share our latest work from Zhang Lab, now published in Science (www.science.org/doi/10.1126/...)
We introduce TIGR-Tas, a PAM-free, compact, modular RNA-guided DNA-targeting system in prokaryotes & their viruses.
More details coming soon 👀
#TIGR #RNA #GeneEditing #CRISPR
We introduce TIGR-Tas, a PAM-free, compact, modular RNA-guided DNA-targeting system in prokaryotes & their viruses.
More details coming soon 👀
#TIGR #RNA #GeneEditing #CRISPR
February 28, 2025 at 10:41 PM
🚀 Thrilled to share our latest work from Zhang Lab, now published in Science (www.science.org/doi/10.1126/...)
We introduce TIGR-Tas, a PAM-free, compact, modular RNA-guided DNA-targeting system in prokaryotes & their viruses.
More details coming soon 👀
#TIGR #RNA #GeneEditing #CRISPR
We introduce TIGR-Tas, a PAM-free, compact, modular RNA-guided DNA-targeting system in prokaryotes & their viruses.
More details coming soon 👀
#TIGR #RNA #GeneEditing #CRISPR
Reposted by Michal Galdzicki
Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology https://www.biorxiv.org/content/10.1101/2025.02.19.639056v1
February 24, 2025 at 9:33 PM
Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology https://www.biorxiv.org/content/10.1101/2025.02.19.639056v1
Wait-a-minute 3 in 1 COVID, Flu A, and B tests are already available from Amazon. Is the RSV one coming?
I missed the memo.
a.co/d/4s5izkO
I missed the memo.
a.co/d/4s5izkO
February 1, 2025 at 6:23 AM
Wait-a-minute 3 in 1 COVID, Flu A, and B tests are already available from Amazon. Is the RSV one coming?
I missed the memo.
a.co/d/4s5izkO
I missed the memo.
a.co/d/4s5izkO
Reposted by Michal Galdzicki
This is pretty cool: Scientists have isolated the gene that may be responsible for the reason grapefruit interferes with some meds. It's not the solution, but it's a start. I love grapefruit but it messes with one of my meds, so this makes me happy.
www.scientificamerican.com/article/why-...
www.scientificamerican.com/article/why-...
Why Grapefruit Interferes with Medication, and What to Do about It
Could gene editing produce a tasty citrus fruit that doesn’t interfere with prescription drugs?
www.scientificamerican.com
January 25, 2025 at 6:18 PM
This is pretty cool: Scientists have isolated the gene that may be responsible for the reason grapefruit interferes with some meds. It's not the solution, but it's a start. I love grapefruit but it messes with one of my meds, so this makes me happy.
www.scientificamerican.com/article/why-...
www.scientificamerican.com/article/why-...
Arzeda has been awarded DARPA funding to advance AI-driven protein design—even with limited data! We're pushing the boundaries to create next-gen proteins for national security, sustainability, and beyond. #AI #ProteinDesign
www.prnewswire.com/news-release...
www.prnewswire.com/news-release...
Arzeda Awarded DARPA Funding to Advance AI-Driven Protein Design for National Security
/PRNewswire/ -- Arzeda, the industry-leading Protein Design Company™, today announced it has been selected for an award from the Defense Advanced Research...
www.prnewswire.com
January 25, 2025 at 3:41 AM
Arzeda has been awarded DARPA funding to advance AI-driven protein design—even with limited data! We're pushing the boundaries to create next-gen proteins for national security, sustainability, and beyond. #AI #ProteinDesign
www.prnewswire.com/news-release...
www.prnewswire.com/news-release...
Speculative writeup and the webinar Feb 20
web.cvent.com/event/e77566...
web.cvent.com/event/e77566...
January 23, 2025 at 3:37 PM
Speculative writeup and the webinar Feb 20
web.cvent.com/event/e77566...
web.cvent.com/event/e77566...
Reposted by Michal Galdzicki
From the dependably insightful @aukehoekstra.bsky.social .
This can't be repeated often enough: batteries are getting cheaper incredibly fast.
This not only means that our cars can drive on electricity.
But also that solar and wind become "firm" sources of power, and we can use our electricity grid much better.
www.iea.org/reports/batt...
January 16, 2025 at 5:37 PM
From the dependably insightful @aukehoekstra.bsky.social .
Reposted by Michal Galdzicki
Our inability to reliably study algorithmic info ecosystems, and why it matters for #scicomm. Pre-publication version of our forthcoming PNAS piece led by Nicky Krause and Isabelle Freiling : osf.io/preprints/so... (a 🧵)
December 21, 2024 at 10:09 PM
Our inability to reliably study algorithmic info ecosystems, and why it matters for #scicomm. Pre-publication version of our forthcoming PNAS piece led by Nicky Krause and Isabelle Freiling : osf.io/preprints/so... (a 🧵)
Reposted by Michal Galdzicki
You guys remember TweetDeck?
Bluesky has it, and it's free.
Check out 🔗 deck.blue by @gildaswise.com for a multi-column interface.
2/10
Bluesky has it, and it's free.
Check out 🔗 deck.blue by @gildaswise.com for a multi-column interface.
2/10
November 28, 2024 at 6:19 AM
You guys remember TweetDeck?
Bluesky has it, and it's free.
Check out 🔗 deck.blue by @gildaswise.com for a multi-column interface.
2/10
Bluesky has it, and it's free.
Check out 🔗 deck.blue by @gildaswise.com for a multi-column interface.
2/10
Reposted by Michal Galdzicki
NEW paper 🚨! We engineered TNT sensors in soil bacteria for long-term detection of explosive in natural soil, enabling geospatial detection of contaminated soil. This work (led by Erin Essington) included new sensors, circuits, modeling, & a 28-day testing workflow. 1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An autonomous microbial sensor enables long-term detection of TNT explosive in natural soil - Nature Communications
Engineered microbes can detect harmful chemicals, but may not work well in complex environments. Here, the authors built microbial sensors for detection of TNT explosive and tested their response over...
www.nature.com
December 2, 2024 at 1:00 PM
NEW paper 🚨! We engineered TNT sensors in soil bacteria for long-term detection of explosive in natural soil, enabling geospatial detection of contaminated soil. This work (led by Erin Essington) included new sensors, circuits, modeling, & a 28-day testing workflow. 1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
This is a really cool paper. They developed a reasonably robust circuit to generate patterns.
SynBio Turing patterns in E.coli. I've seen this amazing project progress over the last few years at Imperial and excited that it's now published. Well done to all involved! www.cell.com/cell-systems...
A three-node Turing gene circuit forms periodic spatial patterns in bacteria
Engineering Turing patterns has been one of the most challenging problems in synthetic
biology because even tiny changes in the reaction parameters destroy patterning. Here,
the authors construct a mo...
www.cell.com
December 3, 2024 at 4:34 AM
This is a really cool paper. They developed a reasonably robust circuit to generate patterns.
Reposted by Michal Galdzicki
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
Reposted by Michal Galdzicki
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
November 17, 2024 at 4:20 PM
Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!
Reposted by Michal Galdzicki
The infographic & some extra info here if anyone is interested www.compoundchem.com/2014/08/21/c...
Compound Interest: Why Doesn’t Honey Spoil? – The Chemistry of Honey
Honey is something of an oddity, in that, unlike most foods, it doesn’t spoil over time. In fact, the oldest known sample of honey, found in an Ancient Egyptian tomb and dated to approximatel…
www.compoundchem.com
November 10, 2024 at 4:30 PM
The infographic & some extra info here if anyone is interested www.compoundchem.com/2014/08/21/c...
Reposted by Michal Galdzicki
Rumors are that they will release model and weights next week.
November 9, 2024 at 2:44 AM
Rumors are that they will release model and weights next week.
Reposted by Michal Galdzicki
Arzeda has now produced and sold 10 tons of ProSweet RebM™ stevia, a natural, zero-calorie sweetener, marking a major step forward in sustainable production for the food industry. #biosky
www.businesswire.com/news/home/20...
www.businesswire.com/news/home/20...
Arzeda, Co-founded by Nobel Laureate David Baker, Drives Industry Innovation with Intelligent Protein Design Technology™ and Delivers Performance Products to Fortune 500 Companies
Arzeda, the leading industrial protein design company co-founded in 2009 by Nobel laureate and University of Washington School of Medicine biochemistr
www.businesswire.com
November 8, 2024 at 5:10 PM
Arzeda has now produced and sold 10 tons of ProSweet RebM™ stevia, a natural, zero-calorie sweetener, marking a major step forward in sustainable production for the food industry. #biosky
www.businesswire.com/news/home/20...
www.businesswire.com/news/home/20...
Washington's Dream, plants!
youtube.com/shorts/Mz-Er...
youtube.com/shorts/Mz-Er...
Greenhouse Nursery Trade Gallons Part 2
YouTube video by Smith's Gardentown
youtube.com
November 8, 2024 at 5:18 AM
Washington's Dream, plants!
youtube.com/shorts/Mz-Er...
youtube.com/shorts/Mz-Er...
Reposted by Michal Galdzicki
Bluesky has grown to 13M users in a year and a half — thank you all for choosing us! We’ve raised a $15M Series A to support our growth and continue to build an open social network that is designed around you, the user.
Bluesky now has 13M+ users, the @atproto.com developer ecosystem continues to grow, and we’ve shipped features like DMs and video!
We’re excited to announce that we’ve raised a $15M Series A to continue growing the community, investing in Trust and Safety, and supporting the dev ecosystem.
We’re excited to announce that we’ve raised a $15M Series A to continue growing the community, investing in Trust and Safety, and supporting the dev ecosystem.
Bluesky Announces Series A to Grow Network of 13M+ Users - Bluesky
Bluesky now exceeds 13 million users, the AT Protocol developer ecosystem continues to grow, and we’ve shipped highly requested features like direct messages and video.
bsky.social
October 24, 2024 at 5:58 PM
Bluesky has grown to 13M users in a year and a half — thank you all for choosing us! We’ve raised a $15M Series A to support our growth and continue to build an open social network that is designed around you, the user.
Reposted by Michal Galdzicki
New preprint by @jgi.doe.gov's Leo Baumgart, Ronan O'Malley and many others
Mapping binding sites of 360 TFs across 10 🌿Brassicaceae genomes. 1.1 million TF-target gene assignments in Arabidopsis thaliana alone!
Mapping binding sites of 360 TFs across 10 🌿Brassicaceae genomes. 1.1 million TF-target gene assignments in Arabidopsis thaliana alone!
October 14, 2024 at 10:19 PM
New preprint by @jgi.doe.gov's Leo Baumgart, Ronan O'Malley and many others
Mapping binding sites of 360 TFs across 10 🌿Brassicaceae genomes. 1.1 million TF-target gene assignments in Arabidopsis thaliana alone!
Mapping binding sites of 360 TFs across 10 🌿Brassicaceae genomes. 1.1 million TF-target gene assignments in Arabidopsis thaliana alone!