Life Science Alliance
@lsajournal.org
#OpenAccess community-driven journal for peer-reviewed research in all areas of the life sciences. By EMBO Press (@embopress.org), Rockefeller University Press (@rupress.org), and Cold Spring Harbor Laboratory Press (@cshlpress.bsky.social).
Cytotrophoblasts in the placenta produce amyloid β. Amyloid β deposits in preeclamptic placentas, and amyloid β fibrils can detrimentally suppress the syncytialization of cytotrophoblasts. @nishi-kazu.bsky.social @reviewcommons.org
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
January 22, 2026 at 4:04 PM
Cytotrophoblasts in the placenta produce amyloid β. Amyloid β deposits in preeclamptic placentas, and amyloid β fibrils can detrimentally suppress the syncytialization of cytotrophoblasts. @nishi-kazu.bsky.social @reviewcommons.org
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
Researchers in Japan have discovered that amyloid-β deposits disrupt the formation of the placenta & may therefore contribute to the development of #preeclampsia during #pregnancy.
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
January 21, 2026 at 8:48 AM
Researchers in Japan have discovered that amyloid-β deposits disrupt the formation of the placenta & may therefore contribute to the development of #preeclampsia during #pregnancy.
www.life-science-alliance.org/content/9/4/...
www.life-science-alliance.org/content/9/4/...
Because CNS axons regenerate poorly, new mechanisms are urgently needed. This study provides evidence that axonal Reticulon-1 synthesis holds back Spastin-mediated microtubule severing with relevant implications for cortical axon outgrowth after injury. www.life-science-alliance.org/content/9/4/...
January 20, 2026 at 4:04 PM
Because CNS axons regenerate poorly, new mechanisms are urgently needed. This study provides evidence that axonal Reticulon-1 synthesis holds back Spastin-mediated microtubule severing with relevant implications for cortical axon outgrowth after injury. www.life-science-alliance.org/content/9/4/...
Apicortin shapes the Plasmodium cytoskeleton at the apical end without impacting transmission www.life-science-alliance.org/content/9/4/...
January 19, 2026 at 9:34 PM
Apicortin shapes the Plasmodium cytoskeleton at the apical end without impacting transmission www.life-science-alliance.org/content/9/4/...
By combining super-resolution imaging & machine learning, the authors show that this deconstruction goes from a microbe-mediated strategy to a dynamic redistribution of cellulosomes during growth.
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
January 19, 2026 at 4:04 PM
By combining super-resolution imaging & machine learning, the authors show that this deconstruction goes from a microbe-mediated strategy to a dynamic redistribution of cellulosomes during growth.
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
Reposted by Life Science Alliance
Fantastic work on autophagy in flies from Juhasz and Szabo labs!! Super happy see this work out from world experts in this area.
This study shows that glial Stat92E transcription factor activity is derepressed by selective autophagic elimination of the Stat92E repressor Su(var)2-10/PIAS in Drosophila glia after neural injury.
@BRCGenetics.bsky.social
www.life-science-alliance.org/content/9/3/...
@BRCGenetics.bsky.social
www.life-science-alliance.org/content/9/3/...
January 15, 2026 at 2:49 PM
Fantastic work on autophagy in flies from Juhasz and Szabo labs!! Super happy see this work out from world experts in this area.
This study identifies a unique cellular mechanism involving basolateral endothelial cilia, platelet-derived growth factor-BB and heparan sulfate proteoglycans that helps explain vascular stability in vertebrates.
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
January 15, 2026 at 9:34 PM
This study identifies a unique cellular mechanism involving basolateral endothelial cilia, platelet-derived growth factor-BB and heparan sulfate proteoglycans that helps explain vascular stability in vertebrates.
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
Check out this Research Article recently published in LSA:
Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS in Drosophila glia
@BRCGenetics.bsky.social @reviewcommons.org
www.life-science-alliance.org/content/9/3/...
Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS in Drosophila glia
@BRCGenetics.bsky.social @reviewcommons.org
www.life-science-alliance.org/content/9/3/...
January 15, 2026 at 4:04 PM
Check out this Research Article recently published in LSA:
Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS in Drosophila glia
@BRCGenetics.bsky.social @reviewcommons.org
www.life-science-alliance.org/content/9/3/...
Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS in Drosophila glia
@BRCGenetics.bsky.social @reviewcommons.org
www.life-science-alliance.org/content/9/3/...
Have you already had a chance to look at this methods paper recently published in LSA:
Intravital imaging the formation and resolution of MHC class II–positive T cell activation niches?
@urochester.bsky.social
www.life-science-alliance.org/content/9/3/...
Intravital imaging the formation and resolution of MHC class II–positive T cell activation niches?
@urochester.bsky.social
www.life-science-alliance.org/content/9/3/...
January 12, 2026 at 4:04 PM
Have you already had a chance to look at this methods paper recently published in LSA:
Intravital imaging the formation and resolution of MHC class II–positive T cell activation niches?
@urochester.bsky.social
www.life-science-alliance.org/content/9/3/...
Intravital imaging the formation and resolution of MHC class II–positive T cell activation niches?
@urochester.bsky.social
www.life-science-alliance.org/content/9/3/...
Discovery of a novel endothelial basolateral cilia based mechanism for embryonic vascular stability that is based on platelet-derived growth factor-BB and heparan sulfate proteoglycans interaction to promote pericyte migration and recruitment.
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
January 9, 2026 at 4:05 PM
Discovery of a novel endothelial basolateral cilia based mechanism for embryonic vascular stability that is based on platelet-derived growth factor-BB and heparan sulfate proteoglycans interaction to promote pericyte migration and recruitment.
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
This study shows that glial Stat92E transcription factor activity is derepressed by selective autophagic elimination of the Stat92E repressor Su(var)2-10/PIAS in Drosophila glia after neural injury.
@BRCGenetics.bsky.social
www.life-science-alliance.org/content/9/3/...
@BRCGenetics.bsky.social
www.life-science-alliance.org/content/9/3/...
January 8, 2026 at 9:34 PM
This study shows that glial Stat92E transcription factor activity is derepressed by selective autophagic elimination of the Stat92E repressor Su(var)2-10/PIAS in Drosophila glia after neural injury.
@BRCGenetics.bsky.social
www.life-science-alliance.org/content/9/3/...
@BRCGenetics.bsky.social
www.life-science-alliance.org/content/9/3/...
Reposted by Life Science Alliance
New study ( @gram-lab.bsky.social and @fengfishlab.bsky.social ) finds that tissue regeneration is controlled by a well-orchestrated network of signals. This network is influenced by injury severity, timing, and the immune system.
🔎 edin.ac/4styRa0
📰 edin.ac/4jnQsfq
@lsajournal.org
🔎 edin.ac/4styRa0
📰 edin.ac/4jnQsfq
@lsajournal.org
January 6, 2026 at 12:43 PM
New study ( @gram-lab.bsky.social and @fengfishlab.bsky.social ) finds that tissue regeneration is controlled by a well-orchestrated network of signals. This network is influenced by injury severity, timing, and the immune system.
🔎 edin.ac/4styRa0
📰 edin.ac/4jnQsfq
@lsajournal.org
🔎 edin.ac/4styRa0
📰 edin.ac/4jnQsfq
@lsajournal.org
This Perspective discusses how the Integrated Stress Response restores homeostasis during acute stress but may become maladaptive when chronically engaged, disrupting cell trajectories. www.life-science-alliance.org/content/9/3/...
January 6, 2026 at 9:34 PM
This Perspective discusses how the Integrated Stress Response restores homeostasis during acute stress but may become maladaptive when chronically engaged, disrupting cell trajectories. www.life-science-alliance.org/content/9/3/...
In vivo screen reveals specific roles of Hippo pathway components in development and regeneration
@gram-lab.bsky.social @edinuni-irr.bsky.social @fengfishlab.bsky.social @michaelanosfairley.bsky.social
www.life-science-alliance.org/content/9/3/...
@gram-lab.bsky.social @edinuni-irr.bsky.social @fengfishlab.bsky.social @michaelanosfairley.bsky.social
www.life-science-alliance.org/content/9/3/...
January 6, 2026 at 4:04 PM
In vivo screen reveals specific roles of Hippo pathway components in development and regeneration
@gram-lab.bsky.social @edinuni-irr.bsky.social @fengfishlab.bsky.social @michaelanosfairley.bsky.social
www.life-science-alliance.org/content/9/3/...
@gram-lab.bsky.social @edinuni-irr.bsky.social @fengfishlab.bsky.social @michaelanosfairley.bsky.social
www.life-science-alliance.org/content/9/3/...
This study describes the generation of two new fluorescent reporter strains that label MHC class II-positive cells, CD8-positive T cells & the utilization of the class II reporter to image the kinetics of an inflammatory response. @urochester.bsky.social www.life-science-alliance.org/content/9/3/...
January 5, 2026 at 9:34 PM
This study describes the generation of two new fluorescent reporter strains that label MHC class II-positive cells, CD8-positive T cells & the utilization of the class II reporter to image the kinetics of an inflammatory response. @urochester.bsky.social www.life-science-alliance.org/content/9/3/...
Kicking off 2026 with amazing findings in our latest issue:
-Modulating T cell glycolysis boosts cytotoxicity
-A subtle temperature shift rewires epigenetics in Drosophila
-Structural flexibility determines fluorescence spectra of luciferases
www.life-science-alliance.org/content/9/1
-Modulating T cell glycolysis boosts cytotoxicity
-A subtle temperature shift rewires epigenetics in Drosophila
-Structural flexibility determines fluorescence spectra of luciferases
www.life-science-alliance.org/content/9/1
January 5, 2026 at 4:04 PM
Kicking off 2026 with amazing findings in our latest issue:
-Modulating T cell glycolysis boosts cytotoxicity
-A subtle temperature shift rewires epigenetics in Drosophila
-Structural flexibility determines fluorescence spectra of luciferases
www.life-science-alliance.org/content/9/1
-Modulating T cell glycolysis boosts cytotoxicity
-A subtle temperature shift rewires epigenetics in Drosophila
-Structural flexibility determines fluorescence spectra of luciferases
www.life-science-alliance.org/content/9/1
This new Perspective explores how the Integrated Stress Response maintains homeostasis during acute stress but may become maladaptive when chronically engaged, driving pathological cell trajectories with key implications for chronic diseases.
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
December 30, 2025 at 9:34 PM
This new Perspective explores how the Integrated Stress Response maintains homeostasis during acute stress but may become maladaptive when chronically engaged, driving pathological cell trajectories with key implications for chronic diseases.
www.life-science-alliance.org/content/9/3/...
www.life-science-alliance.org/content/9/3/...
Distinct roles of Yap/Taz highlight their essential function in coordinating tissue growth and immune responses during repair.
@gram-lab.bsky.social @edinuni-irr.bsky.social @fengfishlab.bsky.social @michaelanosfairley.bsky.social
www.life-science-alliance.org/content/9/3/...
@gram-lab.bsky.social @edinuni-irr.bsky.social @fengfishlab.bsky.social @michaelanosfairley.bsky.social
www.life-science-alliance.org/content/9/3/...
December 30, 2025 at 4:04 PM
Distinct roles of Yap/Taz highlight their essential function in coordinating tissue growth and immune responses during repair.
@gram-lab.bsky.social @edinuni-irr.bsky.social @fengfishlab.bsky.social @michaelanosfairley.bsky.social
www.life-science-alliance.org/content/9/3/...
@gram-lab.bsky.social @edinuni-irr.bsky.social @fengfishlab.bsky.social @michaelanosfairley.bsky.social
www.life-science-alliance.org/content/9/3/...
Loss of the RB tumor suppressor drives centromere transcription, resulting in DNA damage and whole chromosome segregation errors. www.life-science-alliance.org/content/9/3/...
December 26, 2025 at 4:04 PM
Loss of the RB tumor suppressor drives centromere transcription, resulting in DNA damage and whole chromosome segregation errors. www.life-science-alliance.org/content/9/3/...
Reposted by Life Science Alliance
Scientific publishing has a bias against negative results and that hurts science, says Tim Fessenden, editor of @lsajournal.org, a publication of @rupress.org. Here’s how journal editors can help.
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies ...
www.rockefeller.edu
December 23, 2025 at 2:30 PM
Scientific publishing has a bias against negative results and that hurts science, says Tim Fessenden, editor of @lsajournal.org, a publication of @rupress.org. Here’s how journal editors can help.
The study shows how blood and lymphatic endothelial cells change their metabolism when they are growing and resting. It reveals different pathways that support their specific functions.
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
December 25, 2025 at 4:04 PM
The study shows how blood and lymphatic endothelial cells change their metabolism when they are growing and resting. It reveals different pathways that support their specific functions.
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
@reviewcommons.org
www.life-science-alliance.org/content/9/3/...
Reposted by Life Science Alliance
Giving the gift of negative data 🥰
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies ...
www.rockefeller.edu
December 23, 2025 at 1:26 PM
Giving the gift of negative data 🥰
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Enhancing lung tissue preservation during cold storage and ex vivo lung perfusion is possible by adding Cystatin C to the preservation solution. This approach boosts tissue protection and minimizes injury.
#LungHealth #MedicalInnovation
www.life-science-alliance.org/content/9/2/...
#LungHealth #MedicalInnovation
www.life-science-alliance.org/content/9/2/...
December 24, 2025 at 4:04 PM
Enhancing lung tissue preservation during cold storage and ex vivo lung perfusion is possible by adding Cystatin C to the preservation solution. This approach boosts tissue protection and minimizes injury.
#LungHealth #MedicalInnovation
www.life-science-alliance.org/content/9/2/...
#LungHealth #MedicalInnovation
www.life-science-alliance.org/content/9/2/...
Reposted by Life Science Alliance
Why do negative data, or null results, matter? @lsajournal.org's Tim Fessenden (@timisstuck.bsky.social) shares his insider perspective on why and how the scientific community should actively encourage the publication of negative results. From @rockefeller.edu 👉 www.rockefeller.edu/news/38829-t...
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies…
www.rockefeller.edu
December 23, 2025 at 4:00 PM
Why do negative data, or null results, matter? @lsajournal.org's Tim Fessenden (@timisstuck.bsky.social) shares his insider perspective on why and how the scientific community should actively encourage the publication of negative results. From @rockefeller.edu 👉 www.rockefeller.edu/news/38829-t...
CryoEM and biochemical analyses reveal that CENP-A/H4 octasomes form stable, flexible chromatin intermediates that may facilitate CCAN engagement and centromere organization.
@uio.no
www.life-science-alliance.org/content/9/3/...
@uio.no
www.life-science-alliance.org/content/9/3/...
December 23, 2025 at 9:34 PM
CryoEM and biochemical analyses reveal that CENP-A/H4 octasomes form stable, flexible chromatin intermediates that may facilitate CCAN engagement and centromere organization.
@uio.no
www.life-science-alliance.org/content/9/3/...
@uio.no
www.life-science-alliance.org/content/9/3/...