Dr Lizzie Coker
@lizziecoker.bsky.social
Cambridge-based data scientist modelling drug combinations to improve patient outcomes. Views my own, she/her 🇪🇺
Reposted by Dr Lizzie Coker
We continue with the talk from @icrlordlab.bsky.social focusing on the complexity of synthetic lethality in cancer and how we can move forward in exploiting it @eurocancerdepmap.bsky.social
November 20, 2025 at 11:25 AM
We continue with the talk from @icrlordlab.bsky.social focusing on the complexity of synthetic lethality in cancer and how we can move forward in exploiting it @eurocancerdepmap.bsky.social
Reposted by Dr Lizzie Coker
We are back, starting the afternoon session with a joint talk by Debora Sesia/ @ciriellolab.bsky.social and @aurorasavino.bsky.social / @ioriolab.bsky.social showing their work on the functional assessment of Variants of Unknown Significance through cancer dependency map data analysis
November 20, 2025 at 1:56 PM
We are back, starting the afternoon session with a joint talk by Debora Sesia/ @ciriellolab.bsky.social and @aurorasavino.bsky.social / @ioriolab.bsky.social showing their work on the functional assessment of Variants of Unknown Significance through cancer dependency map data analysis
Reposted by Dr Lizzie Coker
Next we have @emanuelvgo.bsky.social , presenting the work on Minimal Libraries and use of AI-Synthetic Augmentation of CRISPR-Cas9 Screens for Drug Target Discovery
November 20, 2025 at 2:17 PM
Next we have @emanuelvgo.bsky.social , presenting the work on Minimal Libraries and use of AI-Synthetic Augmentation of CRISPR-Cas9 Screens for Drug Target Discovery
Reposted by Dr Lizzie Coker
@colmr.bsky.social takes the stage to share the work of his group that aims to understand and predict synthetic lethality between paralogs in cancer
November 20, 2025 at 2:52 PM
@colmr.bsky.social takes the stage to share the work of his group that aims to understand and predict synthetic lethality between paralogs in cancer
Reposted by Dr Lizzie Coker
And we finish this session with @epetsalaki.bsky.social showing the potential of using CRISPR data to study context specific signalling and drug responses
November 20, 2025 at 4:18 PM
And we finish this session with @epetsalaki.bsky.social showing the potential of using CRISPR data to study context specific signalling and drug responses
Reposted by Dr Lizzie Coker
Last but not least, we are thrilled to have representatives from academia, industry, foundations and publishers to share with us their take during the roundtable discussion on Bridging Sectors for Translational Impact!
November 20, 2025 at 4:50 PM
Last but not least, we are thrilled to have representatives from academia, industry, foundations and publishers to share with us their take during the roundtable discussion on Bridging Sectors for Translational Impact!
Reposted by Dr Lizzie Coker
We start with Carmen Herranz-Ors from @sangerinstitute.bsky.social giving us an overview of the impressive work done to generate Tumour Organoid Biobank and develop a 3D Dependency Map @eurocancerdepmap.bsky.social
November 20, 2025 at 9:26 AM
We start with Carmen Herranz-Ors from @sangerinstitute.bsky.social giving us an overview of the impressive work done to generate Tumour Organoid Biobank and develop a 3D Dependency Map @eurocancerdepmap.bsky.social
Reposted by Dr Lizzie Coker
Now @alejandrapcelab.bsky.social is taking us through the multidimensional map of early adaptation to treatment and how targeting cell plasticity can prevent childhood cancer relapse @eurocancerdepmap.bsky.social
November 20, 2025 at 9:39 AM
Now @alejandrapcelab.bsky.social is taking us through the multidimensional map of early adaptation to treatment and how targeting cell plasticity can prevent childhood cancer relapse @eurocancerdepmap.bsky.social
Reposted by Dr Lizzie Coker
The last session starts with Lodewyk Wessels from @nkinl.bsky.social sharing the work on perturbation response models!
November 20, 2025 at 3:56 PM
The last session starts with Lodewyk Wessels from @nkinl.bsky.social sharing the work on perturbation response models!
@emanuelvgo.bsky.social insisting the metaphors used in @eurocancerdepmap.bsky.social presentations have strong Portuguese representation 😄
November 20, 2025 at 2:21 PM
@emanuelvgo.bsky.social insisting the metaphors used in @eurocancerdepmap.bsky.social presentations have strong Portuguese representation 😄
Reposted by Dr Lizzie Coker
The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social
November 20, 2025 at 8:59 AM
The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social
Reposted by Dr Lizzie Coker
To wrap up the second session, Roland Rad from the Institute of Molecular Oncology and Functional Genomics is sharing their work on mapping genetic interactions in cancer evolution and therapy @eurocancerdepmap.bsky.social
November 20, 2025 at 11:47 AM
To wrap up the second session, Roland Rad from the Institute of Molecular Oncology and Functional Genomics is sharing their work on mapping genetic interactions in cancer evolution and therapy @eurocancerdepmap.bsky.social
First session of the @eurocancerdepmap.bsky.social symposium and so much fantastic work presented already! #CancerResearch #TranslationalScience #plasticity
November 20, 2025 at 9:58 AM
First session of the @eurocancerdepmap.bsky.social symposium and so much fantastic work presented already! #CancerResearch #TranslationalScience #plasticity
Reposted by Dr Lizzie Coker
pre-writing a devastating obituary for your enemy is god-tier hating of a kind you don’t often see anymore. renaissance haterism. beautiful stuff.
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 9, 2025 at 12:55 AM
pre-writing a devastating obituary for your enemy is god-tier hating of a kind you don’t often see anymore. renaissance haterism. beautiful stuff.
Reposted by Dr Lizzie Coker
🚨 THIS IS NOT A DRILL 🚨
We’ve just seen this, by creator “Menapian” - a 4,998-piece set of the Great Exhibition (1851) Crystal Palace - complete with a bonus Megalosaurus and Ichthyosaur…
beta.ideas.lego.com/product-idea...
We’ve just seen this, by creator “Menapian” - a 4,998-piece set of the Great Exhibition (1851) Crystal Palace - complete with a bonus Megalosaurus and Ichthyosaur…
beta.ideas.lego.com/product-idea...
September 16, 2025 at 6:57 PM
🚨 THIS IS NOT A DRILL 🚨
We’ve just seen this, by creator “Menapian” - a 4,998-piece set of the Great Exhibition (1851) Crystal Palace - complete with a bonus Megalosaurus and Ichthyosaur…
beta.ideas.lego.com/product-idea...
We’ve just seen this, by creator “Menapian” - a 4,998-piece set of the Great Exhibition (1851) Crystal Palace - complete with a bonus Megalosaurus and Ichthyosaur…
beta.ideas.lego.com/product-idea...
Reposted by Dr Lizzie Coker
CUH Cancer Support Service are teaming up with local organisations to run a #MentalHealthAwarenessWeek Wellbeing Event on the 16 May at the Cambridge Cancer Help Centre, CB22 5JT. 💚
Come along and find out how local services and teams can assist with mental health. @cuh.nhs.uk
Come along and find out how local services and teams can assist with mental health. @cuh.nhs.uk
May 1, 2025 at 10:50 AM
CUH Cancer Support Service are teaming up with local organisations to run a #MentalHealthAwarenessWeek Wellbeing Event on the 16 May at the Cambridge Cancer Help Centre, CB22 5JT. 💚
Come along and find out how local services and teams can assist with mental health. @cuh.nhs.uk
Come along and find out how local services and teams can assist with mental health. @cuh.nhs.uk
@dereklowe.bsky.social puts it perfectly yet again! #facepalm #AI #machinelearning #dontbelievethehype
Thoughts on Demis Hassabis of Google DeepMind saying that AI could cure disease in general in ten years.
Bonus index to my longer posts on AI/computational drug discovery over nearly 20 years!
Bonus index to my longer posts on AI/computational drug discovery over nearly 20 years!
The End of Disease
www.science.org
April 21, 2025 at 9:06 PM
@dereklowe.bsky.social puts it perfectly yet again! #facepalm #AI #machinelearning #dontbelievethehype
Reposted by Dr Lizzie Coker
No one realized it until recently, but a new drug was forming inside some of the patient-controlled-anaesthesia pumps used in hospitals. Beware the Mannich condensation:
Metamorphine, An Unwelcome Product
www.science.org
March 21, 2025 at 6:01 PM
No one realized it until recently, but a new drug was forming inside some of the patient-controlled-anaesthesia pumps used in hospitals. Beware the Mannich condensation:
Reposted by Dr Lizzie Coker
Today I lost an NIH grant training clinicians to do research about intimate partner violence with perinatal women.
More women are murdered in the perinatal period than die of obstetric complications.
I didn't just lose a grant. We lost an entire cohort of people building careers to prevent that.
More women are murdered in the perinatal period than die of obstetric complications.
I didn't just lose a grant. We lost an entire cohort of people building careers to prevent that.
March 22, 2025 at 12:19 AM
Today I lost an NIH grant training clinicians to do research about intimate partner violence with perinatal women.
More women are murdered in the perinatal period than die of obstetric complications.
I didn't just lose a grant. We lost an entire cohort of people building careers to prevent that.
More women are murdered in the perinatal period than die of obstetric complications.
I didn't just lose a grant. We lost an entire cohort of people building careers to prevent that.
Reposted by Dr Lizzie Coker
If this story checks out according to the below, it is insane and shameful. As I asked on the blog the other day: "What are we turning into?"
Le Monde reporting that a French scientist traveling to Houston to attend a conference was denied entry to US after a search of his phone & computer revealed messages critical of Trump's science cuts, "which [says CPB] conveyed hatred of Trump & could be qualified as terrorism". Computer confiscated
March 19, 2025 at 10:31 PM
If this story checks out according to the below, it is insane and shameful. As I asked on the blog the other day: "What are we turning into?"
Reposted by Dr Lizzie Coker
If teams forming around the 'Rewiring Cancer Cells' or 'TME Dynamics' Grand Challenges would like to include our high-throughput organoid co-culture signalling technologies please get in touch!
Just announced! Seven new Cancer Grand Challenges – with awards of up to £20m – available for research teams around the world to tackle the biggest questions in cancer research.
Read more: cruk.ink/4ha3LgZ 1/2
Read more: cruk.ink/4ha3LgZ 1/2
March 6, 2025 at 8:44 AM
If teams forming around the 'Rewiring Cancer Cells' or 'TME Dynamics' Grand Challenges would like to include our high-throughput organoid co-culture signalling technologies please get in touch!
Reposted by Dr Lizzie Coker
Termination notices going out this afternoon to more than 300 employees of the National Cancer Institute. Access likely ends today. Four weeks paid leave and that’s it.
Strong power move for Team Cancer.
Strong power move for Team Cancer.
February 14, 2025 at 7:01 PM
Termination notices going out this afternoon to more than 300 employees of the National Cancer Institute. Access likely ends today. Four weeks paid leave and that’s it.
Strong power move for Team Cancer.
Strong power move for Team Cancer.
Fantastic to see fellow @newnhamcollege.bsky.social alumna @carolcooper.bsky.social this evening at Hart’s bookshop - can highly recommend ‘The History of Medicine in Twelve Objects’ #Medicine #MedicalHistory #HartsBookshop
February 5, 2025 at 7:57 PM
Fantastic to see fellow @newnhamcollege.bsky.social alumna @carolcooper.bsky.social this evening at Hart’s bookshop - can highly recommend ‘The History of Medicine in Twelve Objects’ #Medicine #MedicalHistory #HartsBookshop
Fascinating paper on how different races/ethnicities respond differently to anticancer therapies - such an important thing to understand for personalised medicine #CancerResearch
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations
Abstract. Systematic multiomic analysis has revealed ancestry-dependent molecular alterations, but their impact on the efficacy of anticancer treatment is yet largely unknown. In this study, we analyz...
aacrjournals.org
January 30, 2025 at 10:00 AM
Fascinating paper on how different races/ethnicities respond differently to anticancer therapies - such an important thing to understand for personalised medicine #CancerResearch
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Reposted by Dr Lizzie Coker
Not the banner you want seeing over this article from … checks notes … 8 days ago
January 30, 2025 at 3:15 AM
Not the banner you want seeing over this article from … checks notes … 8 days ago