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Léa Bernaleau

@lbernaleau.bsky.social

60 followers 110 following 4 posts

PhD student studying innate immunity, autoimmunity, TLRs, & SLCs. Research at @rebsamenlab.bsky.social | @dib-unil.bsky.social https://rebsamenlab.org/

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Léa Bernaleau @lbernaleau.bsky.social · Dec 10

I’m proud to share the latest work of my PhD thesis, just published in @jexpmed.bsky.social! You’ll find how CCDC134 controls TLR biogenesis through the ER-chaperone Gp96, a very exciting discovery!

rupress.org/jem/article-...

More info here: bsky.app/profile/rebs...

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Reposted by Léa Bernaleau

Nature Reviews Rheumatology @natrevrheum.nature.com · Feb 28

TASL has a key role in SLE

Nature Reviews Rheumatology, Published online: 28 February 2025; doi:10.1038/s41584-025-01232-xTwo studies provide insights into the function of TASL in the pathogenesis of systemic lupus erythematosus and highlight the therapeutic potential of targeting…

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Reposted by Léa Bernaleau

Rebsamen Lab @UNIL @rebsamenlab.bsky.social · Feb 10

Check out the Insights piece from A Blumenthal & L Dominguez Cadena on our discovery of CCDC134’s role in Gp96 stability and TLR biogenesis.
Many thanks to the authors for discussing our work broadly, integrating recent studies by Rohatgi and Locher/Kaelin labs, and highlighting key open questions.

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Léa Bernaleau @lbernaleau.bsky.social · Feb 5

Thrilled to see our recent paper on CCDC134 highlighted in @jem.org !
Grateful for the opportunity to contribute to this field and engage in meaningful discussions!

Journal of Experimental Medicine @jem.org · Feb 5

Insights from Cadena & Blumenthal: Bernaleau et al. @rebsamenlab.bsky.social (https://buff.ly/3ZrE70d) show that CCDC134 located in the ER is required for TLR biogenesis by controlling the N-glycosylation, folding, and stabilization of the ER chaperone Gp96. https://buff.ly/4gwjt5N

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Reposted by Léa Bernaleau

Rebsamen Lab @UNIL @rebsamenlab.bsky.social · Jan 28

We are excited to announce the 2nd Symposium on the Immunobiology of Pattern Recognition Receptors, Oct 1-2 2025, Lausanne, Switzerland.

Registrations open March 1 - Attendance limited to 150 participants.

More info: wp.unil.ch/immunobiolog...

#ImmunoSky

Symposium immunobiology

wp.unil.ch

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Reposted by Léa Bernaleau

Broz Lab @brozlab.bsky.social · Jan 28

Check out our latest pre print! Alexandra and colleagues show that the enigmatic inflammasome receptor, NLRP6 is activated by sterile and pathogen induced endolysosomal damage. Hot off the press!

www.biorxiv.org/content/10.1...

Sterile- or pathogen-induced endolysosomal damage activate the NLRP6 inflammasome in human intestinal epithelial cells

NLRP6 controls host defense against bacteria and viruses in the gastrointestinal tract by a poorly understood mechanism. Here, we report that NLRP6 forms an inflammasome upon endolysosomal damage caus...

www.biorxiv.org

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Léa Bernaleau @lbernaleau.bsky.social · Jan 25

I’m thrilled to share our latest work from the @rebsamenlab.bsky.social, now published in @naturecomms.bsky.social!

For the first time, we reveal the importance of the SLC15A4-TASL-IRF5 pathway in vivo.

It was a great pleasure to contribute to this project!

Rebsamen Lab @UNIL @rebsamenlab.bsky.social · Jan 24

Excited to share our latest paper out today in @naturecomms.bsky.social !

Great work led by postdoc Ales Drobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago.

#ImmunoSky #InterferoSky

The TLR7/9 adaptors TASL and TASL2 mediate IRF5-dependent antiviral responses and autoimmunity in mouse - Nature Communications

TASL is an adaptor molecule bridging Toll-like receptor signalling and transcription activation by IRF5. Here the authors show that TASL deficiency impacts TLR7/9 responses, and that a TASL paralogue,...

www.nature.com

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Reposted by Léa Bernaleau

Alexis A. Jourdain @jourdainlab.bsky.social · Dec 16

📢We're recruiting📢

Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo!

Please share

#uridine #cancermetabolism #immunometabolism

@unil.bsky.social

🔗(PDF): www.jourdainlab.org/wp-content/u...

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Léa Bernaleau @lbernaleau.bsky.social · Dec 10

Special thanks to the @rebsamenlab.bsky.social, @brozlab.bsky.social, the Majer group at @mpiib.bsky.social and the support of all our colleagues at @dib-unil.bsky.social!
#TLR
#screen
#CRISPR
#ImmunoSky

Léa Bernaleau @lbernaleau.bsky.social · Dec 10

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