Kero Guynes
@kguynes.bsky.social
Postdoc at Blizard Institute (Branco Lab) | Alumnus of @IMBA_Vienna (Burga Lab), @Martin-Duran Lab (QMUL), and Partridge Lab (IHA, UCL)
Reposted by Kero Guynes
#TEsky TE-SCALE: a comprehensive database for exploring transposable element expression across human cancers at single-cell resolution doi.org/10.1093/nar/...
TE-SCALE: a comprehensive database for exploring transposable element expression across human cancers at single-cell resolution
Abstract. Transposable elements (TEs) are repetitive DNA sequences typically silenced in normal tissues. Their dysregulation in cancer can significantly im
doi.org
November 27, 2025 at 1:45 PM
#TEsky TE-SCALE: a comprehensive database for exploring transposable element expression across human cancers at single-cell resolution doi.org/10.1093/nar/...
Reposted by Kero Guynes
Bah, who needs cohesin if you're at the right place (near). Grover once taught us the difference between near and far (my favourite Sesame Street piece), and now amazing work from @elphegenoralab.bsky.social led by @karissalhansen.bsky.social shows us how: www.science.org/doi/10.1126/...
Synergy between regulatory elements can render cohesin dispensable for distal enhancer function
Enhancers are critical genetic elements controlling transcription from promoters, yet how they convey regulatory information across large genomic distances remains unclear. Here, we engineer pluripote...
www.science.org
November 27, 2025 at 7:10 PM
Bah, who needs cohesin if you're at the right place (near). Grover once taught us the difference between near and far (my favourite Sesame Street piece), and now amazing work from @elphegenoralab.bsky.social led by @karissalhansen.bsky.social shows us how: www.science.org/doi/10.1126/...
Reposted by Kero Guynes
📣 I hereby make my Bluesky debut to announce that our work linking DNA binding affinities and kinetics 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 and 𝘪𝘯 𝘷𝘪𝘷𝘰 for the human transcription factor KLF1 just got published in Cell! @cp-cell.bsky.social
www.cell.com/cell/fulltex...
Key findings in a thread (1/6):
www.cell.com/cell/fulltex...
Key findings in a thread (1/6):
November 27, 2025 at 1:17 PM
📣 I hereby make my Bluesky debut to announce that our work linking DNA binding affinities and kinetics 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 and 𝘪𝘯 𝘷𝘪𝘷𝘰 for the human transcription factor KLF1 just got published in Cell! @cp-cell.bsky.social
www.cell.com/cell/fulltex...
Key findings in a thread (1/6):
www.cell.com/cell/fulltex...
Key findings in a thread (1/6):
Reposted by Kero Guynes
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 12:16 PM
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
More on condensates:
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Fluorescent protein and peptide tags alter condensate formation and dynamics in vivo and in vitro | EMBO reports
imageimageProtein and peptide tags can profoundly alter condensation in a tag- and protein-specific
manner, both in cells and in vitro, highlighting the need for careful validation in
condensate studi...
www.embopress.org
November 24, 2025 at 9:52 PM
More on condensates:
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Kero Guynes
TE x ZFP = Evolution!
Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
November 18, 2025 at 3:16 PM
TE x ZFP = Evolution!
Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
Emphasis on the nomenclature I hope 🤞
Grandchamp, @drdomain.bsky.social et al. publish a new Review on commonly used methods for de novo gene detection, address the limitations of nomenclature and detection methods, and establish a de novo gene annotation format to standardize reporting
🔗 doi.org/10.1093/gbe/evaf197
#genome #evolution
🔗 doi.org/10.1093/gbe/evaf197
#genome #evolution
November 20, 2025 at 6:39 PM
Emphasis on the nomenclature I hope 🤞
Useful resource
Dissecting sequence determinants of DNA methylation and in silico perturbation https://www.biorxiv.org/content/10.1101/2025.11.20.689274v1
November 20, 2025 at 6:38 PM
Useful resource
Reposted by Kero Guynes
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
November 19, 2025 at 11:22 PM
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
Surreal to finally see Žižek live! Fortunate to have had a short, fulfilling exchange with him.
I think about negation of predicate vs affirmation of non-predicate quite a lot; the subtle semantic differences can be quite striking although logic formalism often treats them the same.
#slavojzizek
I think about negation of predicate vs affirmation of non-predicate quite a lot; the subtle semantic differences can be quite striking although logic formalism often treats them the same.
#slavojzizek
November 10, 2025 at 10:01 PM
Surreal to finally see Žižek live! Fortunate to have had a short, fulfilling exchange with him.
I think about negation of predicate vs affirmation of non-predicate quite a lot; the subtle semantic differences can be quite striking although logic formalism often treats them the same.
#slavojzizek
I think about negation of predicate vs affirmation of non-predicate quite a lot; the subtle semantic differences can be quite striking although logic formalism often treats them the same.
#slavojzizek
Reposted by Kero Guynes
Want to automate workflows in #FIJI?
Don't know where to start?
We (@lankylaste.bsky.social, Alicja Skórkowska and Sara Salgueiro Torres) have added a step-by-step tutorial to the wiki to get you started.
Thanks @ctrue.bsky.social for adding!
imagej.github.io/tutorials/ba...
Don't know where to start?
We (@lankylaste.bsky.social, Alicja Skórkowska and Sara Salgueiro Torres) have added a step-by-step tutorial to the wiki to get you started.
Thanks @ctrue.bsky.social for adding!
imagej.github.io/tutorials/ba...
Batch Processing with the ImageJ Macro Language
The ImageJ wiki is a community-edited knowledge base on topics relating to ImageJ, a public domain program for processing and analyzing scientific images, and its ecosystem of derivatives and variants...
imagej.github.io
October 23, 2025 at 4:32 PM
Want to automate workflows in #FIJI?
Don't know where to start?
We (@lankylaste.bsky.social, Alicja Skórkowska and Sara Salgueiro Torres) have added a step-by-step tutorial to the wiki to get you started.
Thanks @ctrue.bsky.social for adding!
imagej.github.io/tutorials/ba...
Don't know where to start?
We (@lankylaste.bsky.social, Alicja Skórkowska and Sara Salgueiro Torres) have added a step-by-step tutorial to the wiki to get you started.
Thanks @ctrue.bsky.social for adding!
imagej.github.io/tutorials/ba...
Transposon addiction unseating ancestral mechanism is my favourite bit
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
rdcu.be
October 23, 2025 at 3:01 PM
Transposon addiction unseating ancestral mechanism is my favourite bit
Reposted by Kero Guynes
another fascinating collaboration with the Turco lab @fmiscience.bsky.social www.biorxiv.org/content/10.1...
A model of apical-out human first trimester trophoblast organoids to study regeneration after syncytial damage
The villous syncytiotrophoblast in humans is the interface between maternal blood and the placenta and its functions are essential for a successful pregnancy. The syncytium can be damaged in vivo foca...
www.biorxiv.org
October 23, 2025 at 6:45 AM
another fascinating collaboration with the Turco lab @fmiscience.bsky.social www.biorxiv.org/content/10.1...
Reposted by Kero Guynes
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins
Transcription factors (TFs) bind specific DNA sequences to control gene expression. Modulating TF activity is of considerable therapeutic interest but very few TFs have been successfully drugged. TF D...
www.biorxiv.org
October 23, 2025 at 12:50 PM
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
The histone code at a crossroads: history, context, and new approaches: Trends in Genetics www.cell.com/trends/genet...
The histone code at a crossroads: history, context, and new approaches
Recent studies have reported that catalytically dead histone-modifying enzymes can
rescue the function of their null alleles. Histone ‘replacement’ experiments have
similarly found a lack of phenotype...
www.cell.com
October 14, 2025 at 2:48 PM
The histone code at a crossroads: history, context, and new approaches: Trends in Genetics www.cell.com/trends/genet...
Reposted by Kero Guynes
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.
➡️ www.cell.com/cell-genomic...
➡️ www.cell.com/cell-genomic...
October 10, 2025 at 12:57 PM
Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social.
➡️ www.cell.com/cell-genomic...
➡️ www.cell.com/cell-genomic...
Reposted by Kero Guynes
Naked mole-rat workers may have specific roles, such as cleaning the toilet chamber or transporting waste, rather than being generalist helpers. The findings suggest their colonies are even more complex than we thought. 🧪 #animals #zoology #nature
www.livescience.com/animals/land...
www.livescience.com/animals/land...
Some naked mole rats are designated toilet cleaners, study suggests
Naked mole rats may have specific roles, such as cleaning the toilet chamber or transporting waste, rather than being generalist helpers. The findings suggest naked-mole-rat colonies are even more com...
www.livescience.com
October 9, 2025 at 6:00 AM
Naked mole-rat workers may have specific roles, such as cleaning the toilet chamber or transporting waste, rather than being generalist helpers. The findings suggest their colonies are even more complex than we thought. 🧪 #animals #zoology #nature
www.livescience.com/animals/land...
www.livescience.com/animals/land...
Reposted by Kero Guynes
Interested in understanding how new cell types evolve? Consider joining our group for a PhD!
2026 PhD recruitment is now open.
As well as our main PhD recruitment, which is open to all, we are pleased to be offering scholarships for candidates of Black or mixed Black heritage. Learn more and apply on our website:
www.crick.ac.uk/careers-stud...
As well as our main PhD recruitment, which is open to all, we are pleased to be offering scholarships for candidates of Black or mixed Black heritage. Learn more and apply on our website:
www.crick.ac.uk/careers-stud...
PhD student recruitment
PhD recruitment information.
www.crick.ac.uk
October 7, 2025 at 4:43 PM
Interested in understanding how new cell types evolve? Consider joining our group for a PhD!
Excellent resource - thank you!
Just published an interactive article about a magical algorithm known as the Burrows-Wheeler Transform, which powers sequence alignment tools like bowtie and bwa: sandbox.bio/concepts/bwt
It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
October 9, 2025 at 5:27 PM
Excellent resource - thank you!
Reposted by Kero Guynes
I really love this experimental study on emergence of plasmid stability by @daganlab.bsky.social
They cleverly mimicked fluctuations in antibiotic levels to catch the evolution of stable plasmids that still carry antibiotic resistance.
Very insightful for plasmid evolution!
They cleverly mimicked fluctuations in antibiotic levels to catch the evolution of stable plasmids that still carry antibiotic resistance.
Very insightful for plasmid evolution!
Emergence of plasmid stability under non-selective conditions maintains antibiotic resistance - Nature Communications
It is expected that plasmids are costly and therefore that selection is required to maintain them within bacterial populations. Here, Wein et al. show that plasmid stability can emerge even in the absence of positive selection and that loss may be determined by transcription-replication conflict.
www.nature.com
October 3, 2025 at 9:44 AM
I really love this experimental study on emergence of plasmid stability by @daganlab.bsky.social
They cleverly mimicked fluctuations in antibiotic levels to catch the evolution of stable plasmids that still carry antibiotic resistance.
Very insightful for plasmid evolution!
They cleverly mimicked fluctuations in antibiotic levels to catch the evolution of stable plasmids that still carry antibiotic resistance.
Very insightful for plasmid evolution!
Reposted by Kero Guynes
#TEsky Evolutionary dynamics of repetitive elements and genome size in Tetrigidae (Orthoptera: Caelifera) doi.org/10.1038/s415...
Evolutionary dynamics of repetitive elements and genome size in Tetrigidae (Orthoptera: Caelifera) - Scientific Reports
Scientific Reports - Evolutionary dynamics of repetitive elements and genome size in Tetrigidae (Orthoptera: Caelifera)
doi.org
October 4, 2025 at 5:12 PM
#TEsky Evolutionary dynamics of repetitive elements and genome size in Tetrigidae (Orthoptera: Caelifera) doi.org/10.1038/s415...
Reposted by Kero Guynes
The RNA-binding protein NOVA-1 regulates circRNA expression, alternative splicing, and aging in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.02.679314v1
October 3, 2025 at 7:34 AM
The RNA-binding protein NOVA-1 regulates circRNA expression, alternative splicing, and aging in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.02.679314v1
Sad loss, but will continue to inspire many more generations
JUST IN: Jane Goodall, primatologist who transformed our understanding of the lives of apes, has died, according to an announcement from the Jane Goodall Institute.
Jane Goodall, legendary primatologist, has died at age 91
Jane Goodall, primatologist who transformed our understanding of the lives of apes, has died, according to an announcement from the Jane Goodall Institute.
n.pr
October 1, 2025 at 7:18 PM
Sad loss, but will continue to inspire many more generations