Simons Postdoctoral Fellowships in Plant Biology on Simons Foundation

Background Structural variants are genomic variants that impact at least 50 nucleotides. Structural variants can play major roles in diversity and human health. Many structural variants are difficult to interpret and understand with existing visualization tools, especially when comprised of inverted sequences or multiple breakend pairs. Results We present SVTopo, a tool to visualize germline structural variants with supporting evidence from high-accuracy long reads in easily understood figures. We include examples of 101 visually complex structural variants from seven unrelated human genomes, manually assigned to ten categories. These demonstrate a broad spectrum of rearrangement and showcase the frequency of complex structural variants in human genomes. Conclusions SVTopo shows breakpoint evidence in ways that aid reasoning about the impact of multi-breakpoint rearrangements. The images created aid human reasoning about the result of structural variation on gene and regulatory regions.

Accurate parametric inference on complex demographic models is a continuing challenge in population genetics. Ancestral recombination graphs (ARGs) provide richer information than simple population ge...

Title: Postdoctoral Associate Summary statement: The postdoctoral research associate is responsible for developing novel computational methodology for high-throughput sequence genomics tasks, as well ...

Ancestral Recombination Graphs (ARGs) provide an expressive and compact way to represent genetic variation data generated by simulations embedded within its genealogical history, and it can dramatical...

Population history learning by averaging sampled histories is a new Bayesian method for estimating historical effective population size from recombining sequence data that offers improved speed and ac...

Genotype imputation, the inference of missing genotypes using a reference set of population haplotypes, is a cost-effective tool for improving the quality and quantity of genetic datasets. Imputation...

This study discovered that locally confined DNA differences boost crossover rates in both Arabidopsis and maize, revealing a conserved mechanism that can accelerate plant breeding and trait introgress...

Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For

A long-standing goal in ecological, evolutionary, and conservation genetics is to identify genomic correlates of fitness and inbreeding depression. Over the past several years, a growing body of theor...

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