Jorge Castorena
@jcastorena.bsky.social
Very proud of my student @maryschulz.bsky.social, who just received a NOA for her NIH-F31 project to study obesity-induced lymphatic dysfunction and explore novel therapeutics. Also, her recent paper (www.ahajournals.org/doi/10.1161/...), has been highlighted by an Editorial at ATVB. Congrats, Mary!
August 13, 2025 at 3:03 AM
Very proud of my student @maryschulz.bsky.social, who just received a NOA for her NIH-F31 project to study obesity-induced lymphatic dysfunction and explore novel therapeutics. Also, her recent paper (www.ahajournals.org/doi/10.1161/...), has been highlighted by an Editorial at ATVB. Congrats, Mary!
Reposted by Jorge Castorena
This beautiful work from the lab in Uppsala @taijamakinenlab.bs made it to the cover ! Happy to be part of it ! Congrats again to the first author Marle Kraft ! Stunning images
❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more!
www.nature.com/natcardiovas...
www.nature.com/natcardiovas...
July 15, 2025 at 5:54 PM
This beautiful work from the lab in Uppsala @taijamakinenlab.bs made it to the cover ! Happy to be part of it ! Congrats again to the first author Marle Kraft ! Stunning images
Reposted by Jorge Castorena
scRNAseq of🐭collecting lymphatic vessels😎
Cell type-specific #LymphaticEndothelialCell vs peri-lymphatic myeloid cell contributions of TRPV4 in distinct stages of lymphatic contractile activity
@maryschulz.bsky.social
@jcastorena.bsky.social
#ATVB 2025
www.ahajournals.org/doi/full/10....
Cell type-specific #LymphaticEndothelialCell vs peri-lymphatic myeloid cell contributions of TRPV4 in distinct stages of lymphatic contractile activity
@maryschulz.bsky.social
@jcastorena.bsky.social
#ATVB 2025
www.ahajournals.org/doi/full/10....
June 19, 2025 at 7:07 PM
scRNAseq of🐭collecting lymphatic vessels😎
Cell type-specific #LymphaticEndothelialCell vs peri-lymphatic myeloid cell contributions of TRPV4 in distinct stages of lymphatic contractile activity
@maryschulz.bsky.social
@jcastorena.bsky.social
#ATVB 2025
www.ahajournals.org/doi/full/10....
Cell type-specific #LymphaticEndothelialCell vs peri-lymphatic myeloid cell contributions of TRPV4 in distinct stages of lymphatic contractile activity
@maryschulz.bsky.social
@jcastorena.bsky.social
#ATVB 2025
www.ahajournals.org/doi/full/10....
Our lab had a great time learning and catching up with friends and colleagues at the Lymphatic Forum 2025. Congrats to @maryschulz.bsky.social and @keithkeane.bsky.social for receiving Travel Awards! Thank you @navbo.bsky.social, LE&RN, and @mcsociety.bsky.social for your support.
June 14, 2025 at 11:54 PM
Our lab had a great time learning and catching up with friends and colleagues at the Lymphatic Forum 2025. Congrats to @maryschulz.bsky.social and @keithkeane.bsky.social for receiving Travel Awards! Thank you @navbo.bsky.social, LE&RN, and @mcsociety.bsky.social for your support.
Reposted by Jorge Castorena
Excited to share our work on TRPV4 channels in lymphatic contractile function! www.ahajournals.org/doi/10.1161/...
@jcastorena.bsky.social
@ahajournals.bsky.social
@ahascience.bsky.social
@jcastorena.bsky.social
@ahajournals.bsky.social
@ahascience.bsky.social
Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: Dysregulation of TRPV4 (transient receptor potential vanilloid type 4)–mediated signaling
has been associated with inflammation and tissue fibrosis, both of which are key features
in the p...
www.ahajournals.org
June 2, 2025 at 7:48 PM
Excited to share our work on TRPV4 channels in lymphatic contractile function! www.ahajournals.org/doi/10.1161/...
@jcastorena.bsky.social
@ahajournals.bsky.social
@ahascience.bsky.social
@jcastorena.bsky.social
@ahajournals.bsky.social
@ahascience.bsky.social
Our study with Mike Davis showing that a component of the lymphatic contractile impairment in db/db mice is mediated by the activation of KATP channels in lymphatic muscle cells, in part due to chronic metabolic stress associated with elevated glucose, is now out.
www.frontiersin.org/journals/phy...
www.frontiersin.org/journals/phy...
Frontiers | Chronic metabolic stress impairs lymphatic contractility via activation of KATP channels in a mouse model of Type-2 diabetes
www.frontiersin.org
May 1, 2025 at 1:51 AM
Our study with Mike Davis showing that a component of the lymphatic contractile impairment in db/db mice is mediated by the activation of KATP channels in lymphatic muscle cells, in part due to chronic metabolic stress associated with elevated glucose, is now out.
www.frontiersin.org/journals/phy...
www.frontiersin.org/journals/phy...
Reposted by Jorge Castorena
Our latest publication investigating the role of #palmitoylation in #lymphatic endothelial integrity.
Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏
www.sciencedirect.com/science/arti...
Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏
www.sciencedirect.com/science/arti...
Insulin regulates lymphatic endothelial integrity via palmitoylation
Lipid metabolism plays a critical role in lymphatic endothelial cell (LEC) development and vessel maintenance. Altered lipid metabolism is associated …
www.sciencedirect.com
March 12, 2025 at 7:13 PM
Our latest publication investigating the role of #palmitoylation in #lymphatic endothelial integrity.
Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏
www.sciencedirect.com/science/arti...
Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏
www.sciencedirect.com/science/arti...
Reposted by Jorge Castorena
We are studying the biology of wound healing, using the smallest possible acute vascular injury we can imagine—a 5 um micropoint pulsed laser deformation of the endothelial cell plasma membrane. 🧪 #MedSky #EMSky #EMedSky #immunosky
February 4, 2025 at 1:06 AM
We are studying the biology of wound healing, using the smallest possible acute vascular injury we can imagine—a 5 um micropoint pulsed laser deformation of the endothelial cell plasma membrane. 🧪 #MedSky #EMSky #EMedSky #immunosky
Reposted by Jorge Castorena
🦕🦕 I’m happy this fun little book is finally out exploring how the physiology of the sauropod dino helped contribute to its dominance on earth for so long. However, I think I’ll stick to my day job 😁 🦕🦕
January 7, 2025 at 4:39 PM
🦕🦕 I’m happy this fun little book is finally out exploring how the physiology of the sauropod dino helped contribute to its dominance on earth for so long. However, I think I’ll stick to my day job 😁 🦕🦕