Jan Wenzel
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janwenzel.bsky.social
Jan Wenzel
@janwenzel.bsky.social
Reposted by Jan Wenzel
Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - @huiskenlab.bsky.social go.nature.com/4odcS49
Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - Nature Biotechnology
A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.
go.nature.com
November 13, 2025 at 3:34 PM
Reposted by Jan Wenzel
The same microscope can image larger samples, including a whole mouse brain (1 cm^3), and supports hybrid low- and high-resolution modes. Low-resolution imaging gives a full overview, while high-resolution mode enables multi-ROI isotropic submicron imaging on the same specimen.
November 14, 2025 at 4:41 PM
For technical details see the following post:
Happy to see our paper “Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue” in @natbiotech.nature.com – with Tobias Moser’s lab from @unimedizin-goe.bsky.social and @janwenzel.bsky.social
www.nature.com/articles/s41...

#microscopy #lightsheet
November 16, 2025 at 2:47 PM
I am happy to share a recent collaboration with @huiskenlab.bsky.social and @aakhte.bsky.social , who developed a great technique for performing fast and, above all, isotropic light-sheet microscopy. www.nature.com/articles/s41...
Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - Nature Biotechnology
A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.
www.nature.com
November 16, 2025 at 2:45 PM