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JAMA Psychiatry
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JAMA Psychiatry is a member of the JAMA Network, a consortium of peer-reviewed, general medical and specialty publications.

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Individuals with schizophrenia exhibit region-specific reductions in dendritic spine densities across cortical regions involved in visual-spatial working memory. ja.ma/48dYiTW
November 21, 2025 at 12:00 PM
💬 Viewpoint: Generative #AI could transform mental health assessment by combining qualitative narratives with quantitative rigor; responsible development requires robust frameworks for validity, reliability, and fairness.

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November 20, 2025 at 3:00 PM
After the October 7, 2023, terrorist attacks in Israel, benzodiazepine prescriptions increased by 219% in the first week, primarily from primary care physicians. ja.ma/3JMyNRv
November 20, 2025 at 12:00 PM
Meta-analysis: Mental health apps for #depression or #anxiety are widely adopted (92%) but adherence is moderate (62%). Reminders and personalization boost engagement; attrition remains a key challenge. ja.ma/47LOqSk
November 19, 2025 at 4:30 PM
In this cohort study, young people with mental health problems meeting criteria for early clinical stages were at heightened risk of developing subsequent stages, independent of early life risk factors. ja.ma/49pONDs
November 18, 2025 at 12:00 PM
Individuals with #ADHD treated with stimulants have a nonnegligible risk of developing psychosis or bipolar disorder, with a higher risk associated with amphetamines compared to methylphenidate. ja.ma/49hysAD
November 17, 2025 at 12:00 PM
Despite a slight overall decline in psychiatric bed capacity between 2011 and 2023, the share of beds at freestanding psychiatric facilities owned by large for-profit chains increased. ja.ma/4nRKcgw
November 16, 2025 at 12:00 PM
Soft drink consumption is linked to an increased risk of major depressive disorder and greater depressive symptom severity, mediated by changes in gut microbiota, particularly Eggerthella abundance. ja.ma/4oDZmr3
November 15, 2025 at 12:00 PM
A Swedish register-based cohort study involving almost 3.5 million individuals followed from birth found that offspring exposed to parental mental disorders had an increased risk of mortality up to the age of 51 years. ja.ma/3WKsYH1
November 14, 2025 at 12:00 PM
Adults exposed to sexual assault were at higher risk of developing functional somatic disorders, including single-organ and multiorgan subtypes—over five years, finds this cohort study.

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November 12, 2025 at 4:15 PM
RCT: Daily oxytocin administration combined with positive physical intimacy was linked to improved wound healing and reduced cortisol; oxytocin alone or positive interactions without physical intimacy did not enhance healing.

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November 12, 2025 at 3:00 PM
A growing body of literature suggests that transgender and nonbinary individuals experience poorer mental health outcomes compared to cisgender people.

This review summarizes current evidence and identifies knowledge gaps in the existing literature. ja.ma/47OsnJx
November 11, 2025 at 12:00 PM
An automated treatment decision rule (TDR) can effectively assign older adults with late-life depression to psychotherapy or usual care, improving treatment outcomes and potentially increasing precision and cost-effectiveness. ja.ma/47KbZcQ
November 10, 2025 at 12:00 PM
RCT: In patients with #schizophrenia, #prediabetes, and #obesity, once-weekly #semaglutide injections, up to 1.0 mg/week, were safe and effective. ja.ma/4hRQmw6
November 9, 2025 at 12:00 PM
Viewpoint: OTC naltrexone may address gaps in treatment for unhealthy alcohol use by supporting early intervention and harm reduction, especially for individuals not seeking traditional care or facing barriers to access.

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November 8, 2025 at 12:00 PM
Chronic, delayed, and shifting patterns of PTSD, CPTSD, and PGD were linked to higher levels of somatization and pain, highlighting the need for integrated trauma-informed care addressing physical and psychological health. ja.ma/3Xc8p6u
November 7, 2025 at 11:00 AM
Individuals with chronic opioid use, with or without opioid addiction, exhibited stronger learning from negative reinforcement and reduced choice consistency, supporting preclinical models of avoidance-driven behaviors.

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November 6, 2025 at 1:15 PM
Use of psilocybin mushrooms has sharply increased in the US, with variability in potency and frequent co-use with cannabis.

This Special Communication reviews emerging evidence on the public health implications of unregulated psilocybin mushroom use.

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November 6, 2025 at 12:00 PM
Is soft drink consumption related to depression diagnosis and severity? Could gut microbiome alterations mediate and explain disassociation?"

🎙️ In this podcast, Sharmili Edwin Thanarajah, MD discusses this and more, with John Torous, MD.

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Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations
Interview with Sharmili Edwin Thanarajah, MD, author of Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations. Hosted by John Torous, MD.
ja.ma
November 5, 2025 at 5:45 PM
Soft drink consumption is linked to an increased risk of major depressive disorder and greater depressive symptom severity, mediated by changes in gut microbiota, particularly Eggerthella abundance.

ja.ma/4hFDeKe
November 5, 2025 at 5:30 PM
This systematic review and meta-analysis found that ketogenic diet interventions were associated with small to moderate improvements in depressive symptoms, especially in RCTs with ketone monitoring.

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November 5, 2025 at 4:30 PM
💬 Viewpoint: Clinical application of psychedelics in psychiatry should advance through empirical evaluation of biological, psychological, and contextual factors, emphasizing scientific rigor over uncritical idealism.

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October 31, 2025 at 1:00 PM
Integrating complexity theory into mental health research may reveal unique resilience dynamics and inform more effective, individualized interventions.

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October 30, 2025 at 1:00 PM
Case-control analyses of matched veterans discharged from VA and VA-paid community mental health residential treatment found lower postdischarge all-cause mortality in VA programs by up to 27% at one year. ja.ma/47wlqNa
October 29, 2025 at 3:30 PM
Viewpoint: Integrating psychologists into inpatient teams can reduce coercive practices, improve diagnosis and risk management, boost staff morale, and contribute to more effective treatment and discharge planning. ja.ma/3JdTQvW
October 24, 2025 at 1:00 PM