Felipe de Souza Leite
@fsleite.bsky.social
Physiologist interested in Muscle Biology and rare diseases. Senior Scientist at the Boston Children’s Hospital and Harvard Medical School.
Reposted by Felipe de Souza Leite
New #CellStemCell paper from Helen Blau and colleagues: Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. #Myoblue tinyurl.com/yvf4cdch
Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength
Wang et al. uncover that aged muscle stem cells have blunted PGE2-EP4 signaling that
is critical for their regenerative function. Treatment with exogenous PGE2 reverses
age-related defects in muscle s...
tinyurl.com
June 12, 2025 at 4:10 PM
New #CellStemCell paper from Helen Blau and colleagues: Multiomic profiling reveals that prostaglandin E2 reverses aged muscle stem cell dysfunction, leading to increased regeneration and strength. #Myoblue tinyurl.com/yvf4cdch
Reposted by Felipe de Souza Leite
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
May 13, 2025 at 7:55 PM
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
Reposted by Felipe de Souza Leite
The PowerLab ( uofgpowerlab.weebly.com ) is having some big turnover this summer and this opens the door to take on new PhD students to work on projects related to muscular adaptations to use/disuse across various structural levels.
Happy to chat!!
Happy to chat!!
My Site
About Me I am currently an Associate Professor in the Department of Human Health and Nutritional Sciences (HHNS) in the College of Biological Sciences (CBS) at the University of Guelph and Director...
uofgpowerlab.weebly.com
April 4, 2025 at 5:03 PM
The PowerLab ( uofgpowerlab.weebly.com ) is having some big turnover this summer and this opens the door to take on new PhD students to work on projects related to muscular adaptations to use/disuse across various structural levels.
Happy to chat!!
Happy to chat!!
I would be glad to have feedback on this. The new preprint from Kunkel lab explores Jag1 overexpression in mice dystrophic muscles. #myoblue
Muscle-specific increased expression of JAG1 improves skeletal muscle phenotype in dystrophin-deficient mice.
Therapeutic strategies for Duchenne Muscular Dystrophy (DMD) will likely require complementary approaches. One possibility is to explore genetic modifiers that improve muscle regeneration and function...
www.biorxiv.org
March 15, 2025 at 2:31 PM
I would be glad to have feedback on this. The new preprint from Kunkel lab explores Jag1 overexpression in mice dystrophic muscles. #myoblue
Reposted by Felipe de Souza Leite
This has been a long time in the making but I am absolutely delighted to share our latest paper published in
@pnas.org where we use time-resolved X-ray diffraction to elucidate the regulatory roles of the thick and thin filaments during muscle relaxation #myoblue
www.pnas.org/doi/10.1073/...
@pnas.org where we use time-resolved X-ray diffraction to elucidate the regulatory roles of the thick and thin filaments during muscle relaxation #myoblue
www.pnas.org/doi/10.1073/...
Dual-filament regulation of relaxation in mammalian fast skeletal muscle | PNAS
Muscle contraction is driven by myosin motors from the thick filaments pulling on
the actin-containing thin filaments of the sarcomere, and it is r...
www.pnas.org
March 13, 2025 at 1:06 PM
This has been a long time in the making but I am absolutely delighted to share our latest paper published in
@pnas.org where we use time-resolved X-ray diffraction to elucidate the regulatory roles of the thick and thin filaments during muscle relaxation #myoblue
www.pnas.org/doi/10.1073/...
@pnas.org where we use time-resolved X-ray diffraction to elucidate the regulatory roles of the thick and thin filaments during muscle relaxation #myoblue
www.pnas.org/doi/10.1073/...
Reposted by Felipe de Souza Leite
John Gurdon on early "encouragement" from his science teacher @nobelprize.bsky.social
March 13, 2025 at 9:28 PM
John Gurdon on early "encouragement" from his science teacher @nobelprize.bsky.social
Reposted by Felipe de Souza Leite
Amazonian deforestation is making wet seasons wetter and dry seasons dryer, according to research in Nature. The analysis highlights the local and regional effects of removing trees from the tropical region. https://go.nature.com/41jCClO 🧪
March 13, 2025 at 1:12 AM
Amazonian deforestation is making wet seasons wetter and dry seasons dryer, according to research in Nature. The analysis highlights the local and regional effects of removing trees from the tropical region. https://go.nature.com/41jCClO 🧪
Reposted by Felipe de Souza Leite
Happy to be a part of another great collaboration with @JimDowling for this new @MolTherapy #MTNA paper: microRNA-133a as an indicator of disease progression and treatment response in X-linked myotubular myopathy. #Myoblue. 1/n tinyurl.com/yc5bdbfe
microRNA-133a as an indicator of disease progression and treatment response in X-linked myotubular myopathy
Dowling and colleagues identify miR-133a as a non-invasive biomarker for monitoring
disease progression and treatment response in X-linked myotubular myopathy (XLMTM).
Their study reveals its correlat...
tinyurl.com
March 10, 2025 at 12:20 AM
Happy to be a part of another great collaboration with @JimDowling for this new @MolTherapy #MTNA paper: microRNA-133a as an indicator of disease progression and treatment response in X-linked myotubular myopathy. #Myoblue. 1/n tinyurl.com/yc5bdbfe
Viva! Que alegria, Brasil!
March 3, 2025 at 3:00 AM
Viva! Que alegria, Brasil!
Reposted by Felipe de Souza Leite
I hope Brazil will make history tonight.
I wrote about why the most important Oscar nominee is the movie about how living under authoritarian rule can feel surprisingly normal.
The Year’s Most Urgent Best Picture Contender Is the One Almost No One Has Seen
I’m Still Here has a warning—and a reason for hope.
slate.com
March 2, 2025 at 6:40 PM
I hope Brazil will make history tonight.
Reposted by Felipe de Souza Leite
Children who learn maths working in markets and children who learn maths only from school were both unable to transfer their skills to new contexts, highlighting a need to reconsider how maths is taught in school, according to a paper in Nature. https://go.nature.com/4aXHcuu 🧪
February 17, 2025 at 2:34 PM
Children who learn maths working in markets and children who learn maths only from school were both unable to transfer their skills to new contexts, highlighting a need to reconsider how maths is taught in school, according to a paper in Nature. https://go.nature.com/4aXHcuu 🧪
Reposted by Felipe de Souza Leite
Nature research paper: Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy
https://go.nature.com/41bSbNq
https://go.nature.com/41bSbNq
Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy - Nature
Transcriptional adaptation upregulates UTRN in Duchenne muscular dystrophy (DMD) patients, as supported by several lines of evidence, including the use of splice-switching antisense oligonucleotides to induce the skipping of out-of-frame exons of the DMD gene.
go.nature.com
February 12, 2025 at 7:12 PM
Nature research paper: Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy
https://go.nature.com/41bSbNq
https://go.nature.com/41bSbNq
Reposted by Felipe de Souza Leite
"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...
February 6, 2025 at 4:02 PM
"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...
Glissando sarcomeres in a single myofibril. 😉
December 19, 2024 at 9:37 PM
Glissando sarcomeres in a single myofibril. 😉
Reposted by Felipe de Souza Leite
Titin is massive in size – at 3,800kD it’s the largest protein in your body and really important for heart function.
In a new paper, led by Yuri Kim and the Seidman lab, we describe an enhancer critical for normal Titin expression.
Here is the overview (1/n)
Paper: www.jci.org/articles/vie...
In a new paper, led by Yuri Kim and the Seidman lab, we describe an enhancer critical for normal Titin expression.
Here is the overview (1/n)
Paper: www.jci.org/articles/vie...
December 18, 2024 at 9:04 PM
Titin is massive in size – at 3,800kD it’s the largest protein in your body and really important for heart function.
In a new paper, led by Yuri Kim and the Seidman lab, we describe an enhancer critical for normal Titin expression.
Here is the overview (1/n)
Paper: www.jci.org/articles/vie...
In a new paper, led by Yuri Kim and the Seidman lab, we describe an enhancer critical for normal Titin expression.
Here is the overview (1/n)
Paper: www.jci.org/articles/vie...
Jeff is an outstanding muscle physiologist with whom I’m fortunate to work. This is an excellent study using #AI to track the swimming of dystrophic #zebrafish.
High resolution kinematic approach for quantifying impaired mobility of dystrophic zebrafish larvae https://www.biorxiv.org/content/10.1101/2024.12.05.627004v1
December 9, 2024 at 7:55 PM
Jeff is an outstanding muscle physiologist with whom I’m fortunate to work. This is an excellent study using #AI to track the swimming of dystrophic #zebrafish.