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eunheechoilab.bsky.social
Eunhee Choi
@eunheechoilab.bsky.social
89 followers 150 following 7 posts
Cell biologist with an interest in insulin/IGF signaling and cell division. Assistant professor @Columbia University
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eunheechoilab.bsky.social
Eunhee Choi @eunheechoilab.bsky.social · 2d
Proud collaboration with the Baker Lab (UW) and Bai Lab (UTSW).
#ProteinDesign #InsulinReceptor #MolecularCell #BiasedAgonism #TranslationalScience
eunheechoilab.bsky.social
Eunhee Choi @eunheechoilab.bsky.social · 2d
Mechanistically, these ligands reveal how different IR conformations drive distinct signaling outcomes — offering both mechanistic insight and potential therapies for diabetes, cancer, and severe insulin resistance syndromes.
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eunheechoilab.bsky.social
Eunhee Choi @eunheechoilab.bsky.social · 2d
⚙️ Balanced agonists mimic insulin’s full activity on metabolism and growth.
⚖️ Partial/biased agonists activate only the metabolic branch, without triggering receptor endocytosis or proliferation.
🚫 Antagonists block insulin-dependent activation.
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eunheechoilab.bsky.social
Eunhee Choi @eunheechoilab.bsky.social · 2d
🎉 Excited to share our new paper just published in Molecular Cell!

Using computational protein design, we developed de novo ligands that induce distinct active conformations of the insulin receptor (IR).
🔗 Read the paper: authors.elsevier.com/sd/article/S...
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eunheechoilab.bsky.social
Eunhee Choi @eunheechoilab.bsky.social · 2d
Using computational protein design, we developed de novo ligands that induce distinct active conformations of the insulin receptor (IR) — including balanced agonists, partial/biased agonists, and antagonists.
eunheechoilab.bsky.social
Eunhee Choi @eunheechoilab.bsky.social · Feb 11
Thank you for your great comments for this Review!
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eunheechoilab.bsky.social
Eunhee Choi @eunheechoilab.bsky.social · Feb 10
Excited to share our recent review on the insulin-IGF receptor signaling!
natrevmcb.nature.com
Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · Feb 10
New Online! Regulation and function of insulin and insulin-like growth factor receptor signalling
Regulation and function of insulin and insulin-like growth factor receptor signalling
Nature Reviews Molecular Cell Biology, Published online: 10 February 2025; doi:10.1038/s41580-025-00826-3Insulin and insulin-like growth factor (IGF) signalling regulates metabolism, cell growth and proliferation and diverse cell-specific processes. This…
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