DrayLab
@draylab.bsky.social
We're the Dray lab! We should focus more but where is the fun in that. Studying recombination, chromosome structure and all things DNA- in toasty Texas
Beautiful new story from Neil Johnson's lab, hard work driven by Wang, many collaborators incl' Jean Yves Masson, and small contribution from us. Super happy to see this in press! PALB2 and 53BP1 govern post-resection homologous recombination DNA repair: Molecular Cell www.cell.com/molecular-ce...
PALB2 and 53BP1 govern post-resection homologous recombination DNA repair
Wang et al. demonstrate that the PALB2 CC domain has single-stranded (ss)DNA-binding
activity that is essential for PALB2 and RAD51 to form DNA-damage foci. By creating
Palb2 CC-mutated mice, they fou...
www.cell.com
August 1, 2025 at 3:53 AM
Beautiful new story from Neil Johnson's lab, hard work driven by Wang, many collaborators incl' Jean Yves Masson, and small contribution from us. Super happy to see this in press! PALB2 and 53BP1 govern post-resection homologous recombination DNA repair: Molecular Cell www.cell.com/molecular-ce...
Fresh of the press, a beautiful collaborative work with and from the Sung lab, led by the amazing Francisco Neal, now back to his "normal" life (med school) post PhD. doi.org/10.1016/j.ce... Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservation
Redirecting
doi.org
May 7, 2025 at 3:25 PM
Fresh of the press, a beautiful collaborative work with and from the Sung lab, led by the amazing Francisco Neal, now back to his "normal" life (med school) post PhD. doi.org/10.1016/j.ce... Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservation
Want to learn more about RB? Here is a free author link to a new review. Hot of the press, out of the @duijflab.bsky.social Well done Pascal :) authors.elsevier.com/c/1k-zt5Eb1B...
authors.elsevier.com
April 28, 2025 at 10:39 PM
Want to learn more about RB? Here is a free author link to a new review. Hot of the press, out of the @duijflab.bsky.social Well done Pascal :) authors.elsevier.com/c/1k-zt5Eb1B...
Reposted by DrayLab
We just wanted to take a moment to thank all our new supporters! Tomorrow, there will be more of us!
March 17, 2025 at 9:53 PM
We just wanted to take a moment to thank all our new supporters! Tomorrow, there will be more of us!
Reposted by DrayLab
www.newyorker.com/podcast/the-... @agawande.bsky.social speaks with @newyorker.com editor David Remnick on the mass casualties being inflicted by the Musk-Trump program
the numbers are too much for Remnick to keep his composure
the numbers are too much for Remnick to keep his composure
March 16, 2025 at 7:51 AM
www.newyorker.com/podcast/the-... @agawande.bsky.social speaks with @newyorker.com editor David Remnick on the mass casualties being inflicted by the Musk-Trump program
the numbers are too much for Remnick to keep his composure
the numbers are too much for Remnick to keep his composure
Reposted by DrayLab
Guerilla advertising seen in the London Metro
March 1, 2025 at 10:29 PM
Guerilla advertising seen in the London Metro
Not fun that the websites are down on the Saturday that I was supposed to enter scores, and one more concern to add to the list. But when I look at that graph, what jumps at me is that I am not alone.
- When do PIs sleep?
- At 3am.
- That's it?
- That's it.
- When do PIs sleep?
- At 3am.
- That's it?
- That's it.
March 2, 2025 at 1:23 PM
Not fun that the websites are down on the Saturday that I was supposed to enter scores, and one more concern to add to the list. But when I look at that graph, what jumps at me is that I am not alone.
- When do PIs sleep?
- At 3am.
- That's it?
- That's it.
- When do PIs sleep?
- At 3am.
- That's it?
- That's it.
Reposted by DrayLab
Get in Dorks, we are going protesting.
STAND UP FOR SCIENCE. MARCH 7th 12-4pm. DC AND YOUR STATE CAPITALS.
More information to come.
STAND UP FOR SCIENCE. MARCH 7th 12-4pm. DC AND YOUR STATE CAPITALS.
More information to come.
February 9, 2025 at 2:23 PM
Get in Dorks, we are going protesting.
STAND UP FOR SCIENCE. MARCH 7th 12-4pm. DC AND YOUR STATE CAPITALS.
More information to come.
STAND UP FOR SCIENCE. MARCH 7th 12-4pm. DC AND YOUR STATE CAPITALS.
More information to come.
I hope that European agencies take note of what's happening in the US right now and go on a shopping spree. It has been a few years that my European colleagues and I have been considering moving back home. If there was a way, we would. In drove. China could do the same: large mistreated talent pool.
February 8, 2025 at 1:28 PM
I hope that European agencies take note of what's happening in the US right now and go on a shopping spree. It has been a few years that my European colleagues and I have been considering moving back home. If there was a way, we would. In drove. China could do the same: large mistreated talent pool.
Reposted by DrayLab
The lab 2024 article is out! BRCA1/BARD1 ubiquitinates PCNA to promote continuous, ssDNA-free, DNA synthesis in a RAD18-independent pathway.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis - Nature Communications
Here the authors identify PCNA, a master regulator of DNA replication, as a ubiquitin substrate for the BRCA1/BARD1 heterodimer. This modification is crucial to avoid the appearance of unreplicated DN...
www.nature.com
November 15, 2024 at 3:24 PM
The lab 2024 article is out! BRCA1/BARD1 ubiquitinates PCNA to promote continuous, ssDNA-free, DNA synthesis in a RAD18-independent pathway.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by DrayLab
I am looking PhD students interested in structural and mechanistic enzymology. We have DOE-funded CryoEM projects teed up great thesis work on higher order protein assembly and to capture protein motion during turnover. If you know of undergrad students looking please send them (NSF-GRFP ideas)..
a woman says " would you like to join us " with her eyes closed
ALT: a woman says " would you like to join us " with her eyes closed
media.tenor.com
November 15, 2024 at 4:27 PM
I am looking PhD students interested in structural and mechanistic enzymology. We have DOE-funded CryoEM projects teed up great thesis work on higher order protein assembly and to capture protein motion during turnover. If you know of undergrad students looking please send them (NSF-GRFP ideas)..
Reposted by DrayLab
ok, I tried to make a starter pack on genome stability/DNA replication/DNA repair etc. Sorry if I couldn't find someone, please nominate yourself and your colleagues in comments or DMs, looking forward to connecting with everyone!
go.bsky.app/9jdDNxG
go.bsky.app/9jdDNxG
November 12, 2024 at 1:11 AM
ok, I tried to make a starter pack on genome stability/DNA replication/DNA repair etc. Sorry if I couldn't find someone, please nominate yourself and your colleagues in comments or DMs, looking forward to connecting with everyone!
go.bsky.app/9jdDNxG
go.bsky.app/9jdDNxG