Devon Ryan
dpryan79.bsky.social
Devon Ryan
@dpryan79.bsky.social
1.4K followers 150 following 28 posts
An American in Germany, an ion channel guy in bioinformatics, a proponent of scientific skepticism in an irrational world. @[email protected], @dpryan79 on twitter and github
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Reposted by Devon Ryan
End qualified immunity.
"According to his running club, the man, who is a U.S. citizen, was returning from a team run when agents pulled him out of his vehicle, tackled him to the ground and kneeled on top of him, allegedly breaking six ribs and causing internal bleeding"
US citizen, 67, ‘has six ribs broken’ by Border Patrol agents, his running club says
The incident unfolded Saturday in Chicago’s Old Irving Park neighborhood, where residents say federal agents disrupted a children’s Halloween parade
www.independent.co.uk
Reposted by Devon Ryan
PubMed is running on autopilot during shutdown, but key independent committee has been abolished www.bmj.com/content/391/... 🧪
Reposted by Devon Ryan
Graduate seminar did a deep dive on Thomas Paine’s Common Sense yesterday. At the line, “in America the law is king,” they (14 students from 6 countries) burst out laughing. I've been doing this for 35 years and this is the first time that was a laugh line.
You know you work for a software company when the description of meeting room names in your new office comes with regex that they will all follow.
Reposted by Devon Ryan
Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11
Reposted by Devon Ryan
New blog post – A quick look at Roche's SBX
lh3.github.io/2025/09/11/a...
Reposted by Devon Ryan
Now published in GigaScience with minor improvements: academic.oup.com/gigascience/...

* Download: zenodo.org/records/1490...
* More info: github.com/lh3/panmask
Preprint on "Finding easy regions for short-read variant calling from pangenome data": arxiv.org/abs/2507.03718
Reposted by Devon Ryan
Plants phylogeny is a mess anyway

Credit : @xkcd.com
Reposted by Devon Ryan
My 6th grader is doing a survey for ethics class on the concepts of happiness and luck (or Glück for the German speakers). If you have a few minutes to submit your thoughts she’d appreciate it. docs.google.com/forms/d/1y2b...
Reposted by Devon Ryan
These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years.

It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
Reposted by Devon Ryan
I’m overwhelmed by the expressions of sympathy and support.

And still this pales in comparison to what they are doing to immigrants and to undermine the Bill of Rights.

If you could do one thing for me, call your representatives and demand accountability for their white supremacist terrorism.
Just got mine.

Totally expected, but it still sucks.

Probably the most for all the work that so many of us put in on behalf of US taxpayers that is now wasted and will never come to fruition.
This seems like a good thing. Are we aloud to have good things? I feel like this is going to turn into a Charlie Brown and Lucy with the football sort of situation.
NEW: ICE says it is restoring the legal status of thousands of international students in the SEVIS database (used jointly by the govt and universities) after continuing court losses. (h/t @johnhawkinson.bsky.social) storage.courtlistener.com/recap/gov.us...
Were you able to screenshot that? All I see is „blocked“.
Anyone want to go in on an industry collab to fund this?
what kind of doge disaster is this one?

the nnsa kind - where they oops!ed then tried to hire people back

the ebola kind - where they oops!ed then failed to hire people back

the lead poisoning kind - where they oopsed! then didn't even try to hire people back

www.theregister.com/2025/04/16/h...
Homeland Security funding for CVE program expires
: Because vulnerability management has nothing to do with national security, right?
www.theregister.com
Reposted by Devon Ryan
I've seen enough. Donald Trump is not abiding by a lawful Supreme Court ruling. As a member of Congress, I fully support impeaching him. NOW.
Reposted by Devon Ryan
Reposted by Devon Ryan
Cruel Fate, 1525: Our cow died during the night. We will surely perish.

Cruel Fate, 2025: Our Keurig stopped working during the night. We will surely perish.
Reposted by Devon Ryan
That’s a wild backdoor…
1. LLM-generated code tries to run code from online software packages. Which is normal but
2. The packages don’t exist. Which would normally cause an error but
3. Nefarious people have made malware under the package names that LLMs make up most often. So
4. Now the LLM code points to malware.
LLMs hallucinating nonexistent software packages with plausible names leads to a new malware vulnerability: "slopsquatting."
Burn
The problem with most machine-based random number generators is that they’re not TRULY random, so if you need genuine randomness it is sometimes necessary to link your code to an external random process like a physical noise source or the current rate of US tariffs on a given country.
I have yet to see a boring thread from you…
Someone needs to do a dramatic reenactment of this
Govt: Don't know what members of the admin who were listening in to call

Judge: You can't think of anyone else?

Govt: No?

Judge: Anyone you *believe* were listening in?

Govt: Maybe covered by atty/client privilege?

Judge: ... Why?
Is this the legal equivalent of questioning a 4 year old that is denying having eaten chocolate while they have chocolate smeared all over their face?
HAPPENING NOW: Judge Boasberg holds a "show cause" hearing on whether the government defied his orders when it deported Venezuelans accused of being members of Tren de Aragua to a nightmarish Salvadoran prison
Great, let’s loosen controls on snake oil, just what we need more of.
Big setback to regulate tests ProPublica wrote about:

How Prenatal Screenings Have Escaped Regulation www.propublica.org/article/how-...