Dennis Kappei
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denniskappei.bsky.social
Dennis Kappei
@denniskappei.bsky.social
86 followers 91 following 9 posts
Assistant Professor @NUS & PI @csisingapore.bsky.social | EMBO Global Investigator | Our research group works on telomeres, chromatin & proteomics
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csisingapore.bsky.social
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December 18, 2024 at 9:57 AM
denniskappei.bsky.social
So wonderful to see our recent work on the cover of
@embojournal.bsky.social, beautifully illustrated by
@drawimpacts.bsky.social
- not only visualising our scientific discovery but also celebrating our beautiful environment in #Singapore. 🤩
embojournal.org The EMBO Journal @embojournal.org · Dec 16
Our final 2024 issue!
Highlight: New players in lysosomal sorting via mannose-6-phosphate
mRNA deadenylation & decay relations
Plant ALBA proteins facilitate m6A reading
METTL3/MYCN cooperation
and lots more!
Cover: Grishma Rane, @denniskappei.bsky.social et al
www.embopress.org/toc/14602075...
This cover highlights the article ZBTB48 is a priming factor regulating B-cell-specific CIITA expression by Grishma Rane, Dennis Kappei and colleagues. The study identifies how ZBTB48, represented as pangolins, binds to two distinct binding sites at the B-cell-specific promoter of CIITA, the master regulator of the MHC-II immune gene expression program, to activate the CIITA "switchboard" and initiate CIITA expression. This in turn causes expression of MHC-II molecules, antigen-presenting complexes at the cell surface, here represented by illumination of the iconic supertrees found in Singapore's Gardens by the Bay. Cover concept by Grishma Rane and Dennis Kappei, scientific illustration by DrawImpacts
December 19, 2024 at 3:13 AM