Deepak Shilkar
@deepakshilkar.in
Academic Editor and researcher in chemical biology and drug discovery. Simultaneously exploring existentialism, nihilism, zen, and advaita.
Profile links + Blog: https://deepakshilkar.in/
Profile links + Blog: https://deepakshilkar.in/
Reposted by Deepak Shilkar
Students applying for grad school, or reaching out to professors. I have an important piece of advice for you: STOP DOING THIS 👇 (a thread) #STEM #PhD #gradschool #academictips
November 21, 2025 at 9:53 PM
Students applying for grad school, or reaching out to professors. I have an important piece of advice for you: STOP DOING THIS 👇 (a thread) #STEM #PhD #gradschool #academictips
Reposted by Deepak Shilkar
The scientific world would be a better place if reviews routinely reflected this degree of critical thinking and graphical excellence.
Thanks for putting this together @plaschkalab.bsky.social @rupertfaraway.bsky.social and @thezenklusen.bsky.social
Thanks for putting this together @plaschkalab.bsky.social @rupertfaraway.bsky.social and @thezenklusen.bsky.social
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
November 24, 2025 at 9:54 AM
The scientific world would be a better place if reviews routinely reflected this degree of critical thinking and graphical excellence.
Thanks for putting this together @plaschkalab.bsky.social @rupertfaraway.bsky.social and @thezenklusen.bsky.social
Thanks for putting this together @plaschkalab.bsky.social @rupertfaraway.bsky.social and @thezenklusen.bsky.social
Reposted by Deepak Shilkar
The Cost of Forgetting
by Chelsi — Vaccines have made a world that is safer and healthier. But, vaccines have made us comfortable enough to forget.
by Chelsi — Vaccines have made a world that is safer and healthier. But, vaccines have made us comfortable enough to forget.
The Cost of Forgetting
by Chelsi — Vaccines have made a world that is safer and healthier. But, vaccines have made us comfortable enough to forget.
smallthingsconsidered.blog
November 24, 2025 at 9:00 AM
The Cost of Forgetting
by Chelsi — Vaccines have made a world that is safer and healthier. But, vaccines have made us comfortable enough to forget.
by Chelsi — Vaccines have made a world that is safer and healthier. But, vaccines have made us comfortable enough to forget.
Reposted by Deepak Shilkar
Sharing this important article... for no reason whatsoever.
"We must also continue to deepen and refine our understanding of fundamental biological processes because these details frequently hold the keys to major advances in applied research."
elifesciences.org/articles/102...
"We must also continue to deepen and refine our understanding of fundamental biological processes because these details frequently hold the keys to major advances in applied research."
elifesciences.org/articles/102...
November 23, 2025 at 12:21 AM
Sharing this important article... for no reason whatsoever.
"We must also continue to deepen and refine our understanding of fundamental biological processes because these details frequently hold the keys to major advances in applied research."
elifesciences.org/articles/102...
"We must also continue to deepen and refine our understanding of fundamental biological processes because these details frequently hold the keys to major advances in applied research."
elifesciences.org/articles/102...
Reposted by Deepak Shilkar
It's PhD application season. If you are applying for a PhD in neuroscience or biomedical field or are mentoring someone who is applying, please check out our @storiesofwin.bsky.social episode with advice! www.storiesofwin.org/profiles/202...
Neuroscience PhD applications — Stories of WiN
Dr. Nancy Padilla-Coreano chats with Dr. Ben Giasson, the director of the neuroscience PhD program at the University of Florida, to demystify the PhD application process.
www.storiesofwin.org
November 21, 2025 at 2:50 PM
It's PhD application season. If you are applying for a PhD in neuroscience or biomedical field or are mentoring someone who is applying, please check out our @storiesofwin.bsky.social episode with advice! www.storiesofwin.org/profiles/202...
Reposted by Deepak Shilkar
You dont have to be in the profession of science to contribute to science. You can do publishable research as a hobbyist too.
November 21, 2025 at 3:07 PM
You dont have to be in the profession of science to contribute to science. You can do publishable research as a hobbyist too.
Reposted by Deepak Shilkar
Exploring the living world, with whatever means you have, without any sifting for grander purpose or ulterior motives, is such a unique high. There is so much beauty and so many stories to tell around the proverbial campfire, and so many people are missing out.
Gotta fix this.
Gotta fix this.
November 21, 2025 at 2:47 PM
Exploring the living world, with whatever means you have, without any sifting for grander purpose or ulterior motives, is such a unique high. There is so much beauty and so many stories to tell around the proverbial campfire, and so many people are missing out.
Gotta fix this.
Gotta fix this.
Reposted by Deepak Shilkar
"We need more institutional experiments for science" makes sense to me @seemaychou.bsky.social. We might not like some of 'em and some'll fail, but given academic science often looks like a feudal system needing an industrial revolution trying things can't hurt.. seemay.substack.com/p/big-experi...
Big experiments are only big if they can fail
Some reflections on Arena Bioworks' unexpected wind down as a fellow institutional experimentalist
seemay.substack.com
November 6, 2025 at 7:08 PM
"We need more institutional experiments for science" makes sense to me @seemaychou.bsky.social. We might not like some of 'em and some'll fail, but given academic science often looks like a feudal system needing an industrial revolution trying things can't hurt.. seemay.substack.com/p/big-experi...
Tried @qedscience.bsky.social by running our published paper through it. It identified 2 issues unknown to us. Amazing work, Dr. @odedrechavi.bsky.social and team. 👌👌👌
November 9, 2025 at 7:32 AM
Tried @qedscience.bsky.social by running our published paper through it. It identified 2 issues unknown to us. Amazing work, Dr. @odedrechavi.bsky.social and team. 👌👌👌
Reposted by Deepak Shilkar
James Watson has died www.nytimes.com/2025/11/07/s...
James Watson, Co-Discoverer of the Structure of DNA, Is Dead at 97
www.nytimes.com
November 7, 2025 at 8:00 PM
James Watson has died www.nytimes.com/2025/11/07/s...
Reposted by Deepak Shilkar
And another thing: I am far more concerned with data provenance and information/identity verification than peer review right now… 1/2 journals.plos.org/plosbiology/...
November 7, 2025 at 2:30 PM
And another thing: I am far more concerned with data provenance and information/identity verification than peer review right now… 1/2 journals.plos.org/plosbiology/...
Reposted by Deepak Shilkar
UniProt is changing its reference proteomes resource.
Reference proteomes will remain in UniProtKB, while others will move to UniParc.
Read more about these changes:
www.ebi.ac.uk/about/news/u...
🧬 🖥️
Uniprot is a collaboration between EMBL-EBI, @sib.swiss & the Protein Information Resource.
Reference proteomes will remain in UniProtKB, while others will move to UniParc.
Read more about these changes:
www.ebi.ac.uk/about/news/u...
🧬 🖥️
Uniprot is a collaboration between EMBL-EBI, @sib.swiss & the Protein Information Resource.
Changes to UniProt proteomes
UniProt, the data resource for protein sequence and function information, is making major changes to its proteomes resource and to the UniProt Knowledgebase. UniProt has developed a new workflow that ...
www.ebi.ac.uk
November 4, 2025 at 9:58 AM
UniProt is changing its reference proteomes resource.
Reference proteomes will remain in UniProtKB, while others will move to UniParc.
Read more about these changes:
www.ebi.ac.uk/about/news/u...
🧬 🖥️
Uniprot is a collaboration between EMBL-EBI, @sib.swiss & the Protein Information Resource.
Reference proteomes will remain in UniProtKB, while others will move to UniParc.
Read more about these changes:
www.ebi.ac.uk/about/news/u...
🧬 🖥️
Uniprot is a collaboration between EMBL-EBI, @sib.swiss & the Protein Information Resource.
Reposted by Deepak Shilkar
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
November 3, 2025 at 1:55 PM
Nature suggests you use their "Manuscript Adviser" bot to get advice before submitting
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
I uploaded the classic Watson & Crick paper about DNA structure, and the Adviser had this to say about one of the greatest paper endings of the century:
Reposted by Deepak Shilkar
but...you shouldn't use a calculator when you are learning elementary math...the whole point is to develop the language of math...
letting elementary math students use a calculator to 'learn math' would be like letting elementary reading students use a voice reader to 'learn to read'
letting elementary math students use a calculator to 'learn math' would be like letting elementary reading students use a voice reader to 'learn to read'
November 3, 2025 at 5:15 PM
but...you shouldn't use a calculator when you are learning elementary math...the whole point is to develop the language of math...
letting elementary math students use a calculator to 'learn math' would be like letting elementary reading students use a voice reader to 'learn to read'
letting elementary math students use a calculator to 'learn math' would be like letting elementary reading students use a voice reader to 'learn to read'
Reposted by Deepak Shilkar
Excited to share our new work on transgenerational adaptation www.science.org/doi/epdf/10.... out today spearheaded by outstanding former undergraduate @kathleenkim.bsky.social. C. elegans adapt to repeated generational stresses and no longer display altered fertility, fat content, + longevity 1/9
Transgenerational adaptation to hypoxia
You have to enable JavaScript in your browser's settings in order to use the eReader.
www.science.org
October 24, 2025 at 7:32 PM
Excited to share our new work on transgenerational adaptation www.science.org/doi/epdf/10.... out today spearheaded by outstanding former undergraduate @kathleenkim.bsky.social. C. elegans adapt to repeated generational stresses and no longer display altered fertility, fat content, + longevity 1/9
Reposted by Deepak Shilkar
This is so good to see - a young baby has had a life changing treatable disease diagnosed early due to broad based (healthy baby) genome sequencing. He has a rare eye cancer gene, and has immediately been put into the effective treatment pathway.
4 weeks after being born, Freddie was diagnosed with a rare form of eye cancer. He is one of numerous babies born with rare conditions who are receiving earlier diagnoses and treatment as a result of the Generation Study.
Read the full story: ow.ly/YJ7850XcTNk
Read the full story: ow.ly/YJ7850XcTNk
October 18, 2025 at 8:05 AM
This is so good to see - a young baby has had a life changing treatable disease diagnosed early due to broad based (healthy baby) genome sequencing. He has a rare eye cancer gene, and has immediately been put into the effective treatment pathway.
Reposted by Deepak Shilkar
A few alumni have collected in Rochester this weekend to say thank you and happy retirement to my PhD advisor Tom Eickbush, along with three other amazing evolutionary biologists: Allen Orr, John Jaenike, and Jack Werren.
My heart is filled with gratitude for having trained with them.
My heart is filled with gratitude for having trained with them.
October 4, 2025 at 3:14 AM
A few alumni have collected in Rochester this weekend to say thank you and happy retirement to my PhD advisor Tom Eickbush, along with three other amazing evolutionary biologists: Allen Orr, John Jaenike, and Jack Werren.
My heart is filled with gratitude for having trained with them.
My heart is filled with gratitude for having trained with them.
Reposted by Deepak Shilkar
How many chromosomes can an animal have?
In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact.
www.cell.com/current-biol...
In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact.
www.cell.com/current-biol...
Constraints on chromosome evolution revealed by the 229 chromosome pairs of the Atlas blue butterfly
The genome of the Atlas blue butterfly contains ten times more chromosomes than most
butterflies, and more than any other known diploid animal. Wright et al. show that
this extraordinary karyotype is ...
tinyurl.com
September 11, 2025 at 3:22 PM
How many chromosomes can an animal have?
In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact.
www.cell.com/current-biol...
In our paper out now in @currentbiology.bsky.social we show that the Atlas blue butterfly has 229 chromosome pairs- the highest in diploid Metazoa! These arose by rapid autosome fragmentation while sex chromosomes stayed intact.
www.cell.com/current-biol...
Reposted by Deepak Shilkar
Our department @lsu.bsky.social LSU Biological Sciences is hiring an Assistant Professor in Neurobiology.
Our department is amazing - come join us...
lsu.wd1.myworkdayjobs.com/LSU/job/0202...
Our department is amazing - come join us...
lsu.wd1.myworkdayjobs.com/LSU/job/0202...
Assistant Professor-Neurobiology
All Job Postings will close at 12:01a.m. CST (1:01a.m. EST) on the specified Closing Date (if designated). If you close the browser or exit your application prior to submitting, the application progre...
lsu.wd1.myworkdayjobs.com
September 12, 2025 at 10:44 PM
Our department @lsu.bsky.social LSU Biological Sciences is hiring an Assistant Professor in Neurobiology.
Our department is amazing - come join us...
lsu.wd1.myworkdayjobs.com/LSU/job/0202...
Our department is amazing - come join us...
lsu.wd1.myworkdayjobs.com/LSU/job/0202...
Reposted by Deepak Shilkar
Putting all the dads on alert that we got an Edmund Fitzgerald book coming out this fall wwnorton.com/books/978132...
The Gales of November
<strong>On the fiftieth anniversary of the Edmund Fitzgerald’s sinking, the bestselling author of <em>The Great Halifax Explosion</em> tells the definitive story of the “Mighty Fitz.”...
wwnorton.com
August 4, 2025 at 1:54 AM
Reposted by Deepak Shilkar
We wrote a review on the free nucleotide pool as a central playground in human, bacterial, and plant immunity – now out in Nature Reviews in Immunology
www.nature.com/articles/s41...
Was fun to write this piece with Dina Hochhauser!
Here is a thread to explain the premises
1/
www.nature.com/articles/s41...
Was fun to write this piece with Dina Hochhauser!
Here is a thread to explain the premises
1/
Manipulation of the nucleotide pool in human, bacterial and plant immunity - Nature Reviews Immunology
Modification of the nucleotide pool is emerging as key to innate immunity in animals, plants and bacteria. This Review explains how immune pathways conserved from bacteria to humans manipulate the nuc...
www.nature.com
July 30, 2025 at 6:05 AM
We wrote a review on the free nucleotide pool as a central playground in human, bacterial, and plant immunity – now out in Nature Reviews in Immunology
www.nature.com/articles/s41...
Was fun to write this piece with Dina Hochhauser!
Here is a thread to explain the premises
1/
www.nature.com/articles/s41...
Was fun to write this piece with Dina Hochhauser!
Here is a thread to explain the premises
1/
Reposted by Deepak Shilkar
How does the brain 🧠 change around the clock 🕰️? Can this inform treatments?
Learn more in a new review from the lab 'Harnessing the #circadian nature of the choroid plexus and cerebrospinal fluid' ➡️ npj Biological Timing & Sleep | #Nature @natureportfolio.nature.com
www.nature.com/articles/s44...
Learn more in a new review from the lab 'Harnessing the #circadian nature of the choroid plexus and cerebrospinal fluid' ➡️ npj Biological Timing & Sleep | #Nature @natureportfolio.nature.com
www.nature.com/articles/s44...
May 26, 2025 at 9:25 PM
How does the brain 🧠 change around the clock 🕰️? Can this inform treatments?
Learn more in a new review from the lab 'Harnessing the #circadian nature of the choroid plexus and cerebrospinal fluid' ➡️ npj Biological Timing & Sleep | #Nature @natureportfolio.nature.com
www.nature.com/articles/s44...
Learn more in a new review from the lab 'Harnessing the #circadian nature of the choroid plexus and cerebrospinal fluid' ➡️ npj Biological Timing & Sleep | #Nature @natureportfolio.nature.com
www.nature.com/articles/s44...
Reposted by Deepak Shilkar
Malaria parasite population genomics during an elimination program in Eastern Myanmar https://www.biorxiv.org/content/10.1101/2025.05.21.655408v1
May 26, 2025 at 9:33 PM
Malaria parasite population genomics during an elimination program in Eastern Myanmar https://www.biorxiv.org/content/10.1101/2025.05.21.655408v1
Reposted by Deepak Shilkar
I will be recruiting new postdocs with start dates end 2025 - early 2026. If you'd like to work at the Pasteur Institute in the heart of Paris surrounded by amazing scientists, reach out to discuss possible projects on SynBio / Bacterial Immunity!
May 18, 2025 at 3:20 PM
I will be recruiting new postdocs with start dates end 2025 - early 2026. If you'd like to work at the Pasteur Institute in the heart of Paris surrounded by amazing scientists, reach out to discuss possible projects on SynBio / Bacterial Immunity!
Reposted by Deepak Shilkar
