Bisrat Debeb
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debeblab.bsky.social
Bisrat Debeb
@debeblab.bsky.social
870 followers 270 following 20 posts
Associate Professor at MD Anderson Cancer Center- investigating the biology of brain metastasis in aggressive breast cancers, Inflammatory breast cancer (IBC), TNBC. Posts are my own.
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debeblab.bsky.social
Bisrat Debeb @debeblab.bsky.social · Jun 27
Excited to share our latest pre-print “Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer” led by the outstanding Xiaoding Hu, an instructor in my lab. #Breastcancer #Brainmetastasis #IBC #Ecadherin #ReactiveAstrocytes #CXCR2

👉 biorxiv.org/content/10.110…
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Reposted by Bisrat Debeb
elizsmckenna.bsky.social
Elizabeth McKenna @elizsmckenna.bsky.social · Aug 4
Now online in Cancer Discovery @aacrjournals.bsky.social: Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling - by Hsi-wen Yeh, Nicole Del Gaudio, Kivanç Birsoy, and colleagues doi.org/10.1158/2159... @rockefelleruniv.bsky.social
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Reposted by Bisrat Debeb
jaguirreghisolab.bsky.social
Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Jul 30
Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...
Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...
www.nature.com
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Reposted by Bisrat Debeb
lizessleywhyte.bsky.social
Liz Essley Whyte @lizessleywhyte.bsky.social · Jul 30
UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...
Trump Administration Scraps Effort to Pause Health-Research Funding
The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.
www.wsj.com
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Reposted by Bisrat Debeb
jeremymberg.bsky.social
Jeremy Berg @jeremymberg.bsky.social · Jul 29
New Science story about multi-year funding and it potential catastrophic consequences

www.science.org/content/arti...

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Odds of winning NIH grants plummet as new funding policy and spending delays bite
Funding multiyear grants up front will sharply cut number of investigators receiving awards
www.science.org
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Reposted by Bisrat Debeb
bloomberg.com
Bloomberg News @bloomberg.com · Jul 24
President Donald Trump’s cuts to research funding are putting the US at risk of losing the technological race against other countries including China, said former US Commerce Secretary Penny Pritzker
Penny Pritzker Warns Trump Cuts Threaten US in Global Tech Race
President Donald Trump’s cuts to research funding are putting the US at risk of losing the technological race against other countries including China, said Penny Pritzker, former US commerce secretary and chair of Harvard University’s powerful governing body.
bloom.bg
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Reposted by Bisrat Debeb
nparmalee.bsky.social
Nancy Parmalee @nparmalee.bsky.social · Jul 24
In light of today’s news about the National Cancer Institute announcing a 4% payline, it’s really important to communicate to people that the previous 10% payline was still effectively a lottery and the result of decades of underfunding the NIH. Paylines used to be 25%.
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roelverhaak.bsky.social
Roel Verhaak @roelverhaak.bsky.social · Jul 23
PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.
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Reposted by Bisrat Debeb
ahnaskop.bsky.social
Dr. Ahna Skop @ahnaskop.bsky.social · Jul 20
“Simply put, there is never a good time to pull out of an investment that continually pays such strong dividends and directly benefits the citizens of our state.”

Cuts to research funding risk the collapse of U.S. science and technology | Guest Column | wyomingnews.com
Fay: Cuts to research funding risk the collapse of U.S. science and technology
I started as an assistant professor of molecular biology at the University of Wyoming in 2001.
www.wyomingnews.com
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debeblab.bsky.social
Bisrat Debeb @debeblab.bsky.social · Jul 16
Funding scientific research is the only way we will cure cancer penncapital-star.com/commentary/f...
Funding scientific research is the only way we will cure cancer • Pennsylvania Capital-Star
The proposed federal budget for next year includes a 55% cut to the National Science Foundation (NSF) and a 44% cut to National Institutes of Health (NIH).
penncapital-star.com
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debeblab.bsky.social
Bisrat Debeb @debeblab.bsky.social · Jul 14
Pan-cancer human brain metastases atlas at single-cell resolution: Cancer Cell www.cell.com/cancer-cell/...
Pan-cancer human brain metastases atlas at single-cell resolution
Xing et al. construct a comprehensive pan-cancer human brain metastasis (BrM) atlas at single-cell resolution, uncovering five major BrM ecotypes associated with distinct phenotypic characteristics. T...
www.cell.com
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davidimiller.bsky.social
Dr. David Miller 🏳️‍🌈 @davidimiller.bsky.social · Jul 10
🧪 BREAKING (good news): Senate subcommittee says NO! to Trump's proposed slashes to NASA & NSF funding.

Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24.

See 7:15 below. Full Senate appropriations committee meets tomorrow about it.

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Subcommittee Markup of the Commerce, Justice, Science, and Related Agencies Appropriations Act | United States Senate Committee on Appropriations
United States Senate Committee on Appropriations
www.appropriations.senate.gov
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mdanderson.bsky.social
MD Anderson Cancer Center @mdanderson.bsky.social · Jul 10
Patients with advanced melanoma who received nivolumab + relatlimab before and after surgery had lasting results four years later.

Biomarkers may help predict who benefits most. http://spr.ly/633224xKCO #EndCancer
Most patients with advanced melanoma who received pre-surgical immunotherapy remain alive and disease free four years later
Four years after pre-surgery treatment with a novel combination of immune checkpoint inhibitors, nivolumab and relatlimab, 87% of patients with stage III melanoma remained alive, according to new results from a study led by researchers at The University of Texas MD Anderson Cancer Center.
spr.ly
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debeblab.bsky.social
Bisrat Debeb @debeblab.bsky.social · Jul 8
Congrats!
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Reposted by Bisrat Debeb
dr-kevin-pruitt.bsky.social
Kevin Pruitt @dr-kevin-pruitt.bsky.social · Jul 3
After years of searching, we now describe elusive roles of Dishevelled, a potent regulator of development, co-opted in #cancer. Dalia, a talented postdoc, along w/ our amazing team describe new dimensions of DVL1 function. Please check it out soon @natcomms.nature.com ❤️

@dalimartinez.bsky.social 🧪
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Reposted by Bisrat Debeb
ibc-advocate.bsky.social
Alisa @ibc-advocate.bsky.social · Jun 29
Important research on IBC that can also benefit understanding other types of aggressive #breastcancer
debeblab.bsky.social Bisrat Debeb @debeblab.bsky.social · Jun 27
Excited to share our latest pre-print “Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer” led by the outstanding Xiaoding Hu, an instructor in my lab. #Breastcancer #Brainmetastasis #IBC #Ecadherin #ReactiveAstrocytes #CXCR2

👉 biorxiv.org/content/10.110…
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Reposted by Bisrat Debeb
ibcradiation.bsky.social
Wendy Woodward, MD, PhD @ibcradiation.bsky.social · Jun 27
Exciting new ideas about how LMD happens! @debeblab.bsky.social #cansky
johannajoyce.bsky.social Johanna Joyce @johannajoyce.bsky.social · Jun 27
🧠 Neuro-immunology is reshaping how we understand the brain - across many diseases, including #cancer

In this research highlight 🧪🔬 we discuss a new study in #Nature by Remsik, Boire et al showing how IFNγ-activated immune cells in the CNS, incl DCs, help constrain leptomeningeal #metastasis
CNS gatekeepers: IFNγ-activated dendritic cells control leptomeningeal metastasis - Cell Research
Cell Research - CNS gatekeepers: IFNγ-activated dendritic cells control leptomeningeal metastasis
www.nature.com
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debeblab.bsky.social
Bisrat Debeb @debeblab.bsky.social · Jun 27
Huge thanks to our collaborators and funders - @DoD, @METAvivor, @ACS, @NIH/NCI … And big congrats to Xiaoding Hu for leading this impactful work!👏👏👏 @mdanderson.bsky.social
debeblab.bsky.social Bisrat Debeb @debeblab.bsky.social · Jun 27
Excited to share our latest pre-print “Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer” led by the outstanding Xiaoding Hu, an instructor in my lab. #Breastcancer #Brainmetastasis #IBC #Ecadherin #ReactiveAstrocytes #CXCR2

👉 biorxiv.org/content/10.110…
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debeblab.bsky.social
Bisrat Debeb @debeblab.bsky.social · Jun 27
Importantly, we show that sEcad remodels the brain microenvironment by promoting reactive astrocytes through the CXCL1–CXCR2 axis; blocking this pathway reduced brain metastasis burden and prolonged mouse survival.
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debeblab.bsky.social
Bisrat Debeb @debeblab.bsky.social · Jun 27
Using novel IBC brain metastasis models, we show that sEcad drives brain metastasis by impacting multiple steps of the metastatic cascade, including invasion, anoikis resistance, endothelial adhesion, and BBB transmigration.
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debeblab.bsky.social
Bisrat Debeb @debeblab.bsky.social · Jun 27
We describe novel tumor cell-intrinsic and - extrinsic mechanisms by which soluble E-cadherin (sEcad) promotes brain metastatic growth in aggressive breast cancers. Serum sEcad levels are correlated with increased development of brain metastasis and death in breast cancer patients.
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debeblab.bsky.social
Bisrat Debeb @debeblab.bsky.social · Jun 27
Excited to share our latest pre-print “Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer” led by the outstanding Xiaoding Hu, an instructor in my lab. #Breastcancer #Brainmetastasis #IBC #Ecadherin #ReactiveAstrocytes #CXCR2

👉 biorxiv.org/content/10.110…
1 4 8
Reposted by Bisrat Debeb
tennesseelookout.com
Tennessee Lookout @tennesseelookout.com · Jun 20
Vanderbilt University Medical Center, one of the largest academic research and hospital care systems in the southeast, expects to lay off 650 employees as a result of grant and other funding cuts made by the Trump Administration, it said in a statement. From @anitawadhwani.bsky.social.
Vanderbilt University Medical Center to lay off up to 650 after Trump administration grant cuts • Tennessee Lookout
Vanderbilt University Medical Center, expects to lay off 650 employees as a result of grant and funding cuts by the Trump Administration,
tennesseelookout.com
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Reposted by Bisrat Debeb
repbillfoster.bsky.social
Congressman Bill Foster @repbillfoster.bsky.social · May 1
The massive funding cuts Trump and DOGE have made to scientific research should concern everyone; they will stifle American innovation and reduce economic growth.

Researchers found that "a 50 percent reduction in funding would lower [GDP] nearly 7.6 percent" and cause permanent economic damage:
Trump’s Cuts to Science Funding Could Hurt U.S. Economy, Study Shows
Reducing federal support for research and development could cause long-run economic damage and reduce government revenue.
www.nytimes.com
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Reposted by Bisrat Debeb
drsl.bsky.social
Dr. Suzanne Le Menestrel @drsl.bsky.social · May 2
The Spencer Foundation is offering rapid response bridge funding for those who lost NSF research grants.

www.spencer.org/grant_types/...
Rapid Response Bridge Funding Program
In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...
www.spencer.org
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Reposted by Bisrat Debeb
drkevinrmcclure.com
Kevin R. McClure @drkevinrmcclure.com · May 2
FYI “Spencer Foundation, Alfred P. Sloan Foundation, William T. Grant Foundation and Kapor Foundation are providing quick turnaround grants of up to $25k for education scholars impacted by the abrupt NSF grant cancellations.” www.spencer.org/news/meeting...
Meeting the Moment Together
We are returning from the AERA Annual Meeting in Denver reinvigorated and with a deep appreciation for all that scholars and higher education leaders are holding in this moment. Rapid shifts in fed...
www.spencer.org
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