This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...

Nature Metabolism, Published online: 20 November 2025; doi:10.1038/s42255-025-01408-5Modulating mitochondrial NAD+ levels by changing the expression of the mitochondrial NAD+ transporter, SLC25A51, Mukherjee et al. demonstrate that mitochondrial, rather than cytosolic or nuclear, NAD+ levels are a key determinant of the rate of liver regeneration.

Wang and Wu et al. identify soluble interleukin-6 receptor (sIL-6R) as a key exerkine determining the efficacy of exercise in diabetes prevention, which is modulated by microbiome-dependent leucine through a gut-adipose tissue axis. Pharmacological or dietary interventions targeting adipocyte-secreted sIL-6R may help to improve the metabolic outcomes in those exercise non-responders.

Tumour-induced dysregulation of cAMP–PKA–CREB1 signalling in skeletal muscle is shown to be a driver of mitochondrial dysfunction, contributing to cancer cachexia in mice.

The development and maintenance of the neuromuscular junction (NMJ) requires reciprocal signals between the nerve terminals and multinucleated skel...

Tumour-induced dysregulation of cAMP–PKA–CREB1 signalling in skeletal muscle is shown to be a driver of mitochondrial dysfunction, contributing to cancer cachexia in mice.

The exact mechanisms underlying leptin resistance remain elusive. Here, Wang et al. report that adipocyte-derived EVs and their miRNA cargo are key regulators of central leptin sensitivity and that th...

Klag et al. identified that Turicibacter, a spore-forming bacteria, promotes leanness by producing unique lipids that suppress host ceramides and reduce fat uptake. High-fat diets lower Turicibacter l...

Nature Metabolism, Published online: 04 November 2025; doi:10.1038/s42255-025-01390-yBarnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory responses.

This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes with age, including responses to cytomegalovirus infection and influenza vaccination.

This study shows that the preferential use of gluconeogenic pathways in the liver depends on exercise load.

Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.

Nature Metabolism, Published online: 14 October 2025; doi:10.1038/s42255-025-01388-6FGF21 levels increase in response to acute mental stress in individuals with impaired mitochondrial OxPhos capacity, and correlate with stress-related neuroendocrine hormones and trait-level psychosocial factors.

Exercise protects against cancer progression and metastasis by inducing a high nutrient demand in internal organs, indicating that reducing nutrient availability to tumor cells represents a potential ...

AbstractAim. This meta-analysis aimed to (1) evaluate exerkines, signalling molecules secreted by tissues such as skeletal muscle, heart, and adipose tissu

Nature Metabolism, Published online: 20 October 2025; doi:10.1038/s42255-025-01398-4Cancer cells often increase their uptake of acetate for acetyl-coenzyme A biosynthesis, a mechanism that facilitates cancer metastasis. We found that, in hepatocellular carcinoma, cancer cells induce acetate secretion from tumour-associated macrophages, driven by a cell–cell metabolic interaction involving lactate, the lipid peroxidation–aldehyde dehydrogenase 2 pathway and acetate.