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Reposted by Bethan Goulden

NASOM @nasom-obmed.bsky.social · 23h

Join us on October 29 for our upcoming webinar, “The Burning Question of Acetaminophen in Pregnancy.”
Open to both members and non-members — everyone is welcome!
🔗 Register here: sinaihealth.zoom.us/webinar/regi...

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Reposted by Bethan Goulden

Dr Emma S Chambers @emmaschambers.bsky.social · 1d

Happy World Menopause Day. Reminder that as well as the impact of menopause on physical and mental wellbeing. Menopause also seems to be an immune-ageing event www.qmul.ac.uk/media/news/2...

Hormone replacement therapy may help restore immunity in menopausal women

www.qmul.ac.uk

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Reposted by Bethan Goulden

Dr Emma S Chambers @emmaschambers.bsky.social · 10d

I am very grateful to my funders the @vivensa.bsky.social and @bartscharity.bsky.social for funding this research through seed awards. More research is desperately needed to understand the impact of menopause on immunity and I hope more funders consider this as an important research area. #immunosky

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Reposted by Bethan Goulden

Dr Emma S Chambers @emmaschambers.bsky.social · 10d

This study was an amazing Early Career researcher effort with Roel de Maeyer performing the functional monocyte assays, @oliviabracken.bsky.social performing the bioinformatic analysis, and my lovely lab member Justyna performing the Menopause analysis. I am very grateful for all their hard work.

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Reposted by Bethan Goulden

Dr Emma S Chambers @emmaschambers.bsky.social · 10d

Importantly the use of Hormone Replacement Therapy (HRT) in menopausal females kept their monocytes looking ‘young’ and they had improved phagocytosis as compared to age matched controls. Highlighting the potential immune benefits of HRT.

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Reposted by Bethan Goulden

Dr Emma S Chambers @emmaschambers.bsky.social · 10d

In this paper we demonstrate that there is an increase in inflammatory monocytes with altered proteome in post-menopausal females, which is not observed with age in males. Phagocytosis is significantly decreased in post-menopausal as compared to pre-menopausal females.

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Reposted by Bethan Goulden

Dr Emma S Chambers @emmaschambers.bsky.social · 10d

I am so proud to say that our paper is now available at Aging Cell. There is a paucity of data as to how the menopause impacts your immune system, and the aim of this study was to investigate the impact of the menopause on monocyte phenotype and function.
onlinelibrary.wiley.com/doi/10.1111/...

Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy

Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace....

onlinelibrary.wiley.com

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Reposted by Bethan Goulden

MacDonald Obstetric Medicine Society @moms.org.uk · 27d

🌟 New MOMS Webinar Series! 🌟

Breathe and Think: Neuro & Respiratory insights for Midwives
📅 30th Sept 2025
🕡 6:30–8:00 pm (BST)

👉 Free to attend & available for 4 weeks after via obstetricmedic.org.uk

🔗 Register via QR code on poster!
#Midwifery #ObstetricMedicine #Neuro #Respiratory #MOMS

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Reposted by Bethan Goulden

MacDonald Obstetric Medicine Society @moms.org.uk · 26d

💊 Paracetamol remains the drug of choice for pain and fever in pregnancy.

Read the joint statement from UKTIS, BMFMS and MOMS

🤰Clinical guidelines remain unchanged: maternal pain and fever should be treated appropriately.

uktis.org/wp-content/u...

uktis.org

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Reposted by Bethan Goulden

MacDonald Obstetric Medicine Society @moms.org.uk · 22d

📢 Can I have a baby? 📢

Join on 16th Oct 2025, 7.30–9.00pm (UK time) to discuss:
👶 Fertility preservation
🧬 Preimplantation genetic testing
🤰 Surrogacy

Free to attend & available on-demand for 4 weeks!
Register 👉 www.obstetricmedic.org.uk

#Fertility #ObstetricMedicine #ReproductiveHealth

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Reposted by Bethan Goulden

Pregnancy Loss Research Group @pregnancylossie.bsky.social · Sep 11

Fertility clinics must end unproven treatments that don't help couples have babies

www.nice.org.uk/news/article...

Fertility clinics must end unproven treatments that don't help couples have babies

www.nice.org.uk

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Bethan Goulden @bethangoulden.bsky.social · Sep 11

Great not only to have the work we're doing on HLH included in today's conference for the release of the #MBRRACEUK report on UK maternal mortality, but to also see another presentation on this topic. Is HLH as rare as we think, or simply rarely diagnosed?

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Reposted by Bethan Goulden

UCL News @uclnews.bsky.social · Sep 9

The first new UK-wide long-term scientific study of babies and child development in a quarter of a century will be led at UCL's @clscohorts.bsky.social by Profs Alisa Goodman, @drlisac.bsky.social and Pasco Fearon @uclpals.bsky.social @ioe.bsky.social @news.ukri.org www.ucl.ac.uk/news/2025/se...

Text on graphic: Boosts for 'less often heard' groups, including ethnic minority and low income groups. Interviews with fathers and mothers, including those who live apart. Consent to linkage to administrative data.

Map of UK with text: 4,200 babies in Northern Ireland, 4,500 in Wales, 5,000 in Scotland and 16,300 in England

Text on graphic: Generation New Era. 30,000 babies will take part. First new UK-wide study since 2000. 9-11 months: age at first survey. 3-4 years: age at second survey.

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Bethan Goulden @bethangoulden.bsky.social · Sep 1

⏰Final push - UK rheum doctors/nurses/physios/AHPs pleeeease take 5 minutes to complete this. I would particularly welcome thoughts from those practicing in Wales, Scotland or Northern Ireland who are currently under-represented in the respondents!

qualtrics.ucl.ac.uk/jfe/form/SV_...

Bethan Goulden @bethangoulden.bsky.social · Jul 29

**Rheumatology doctors/nurses/physios in the UK**

This is a short survey to map current reproductive health support/advice available across rheum services in the UK. Please fill it in & share within your networks to help guide next steps/guidelines 📑

qualtrics.ucl.ac.uk/jfe/form/SV_...

Qualtrics Survey | Qualtrics Experience Management

The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.

qualtrics.ucl.ac.uk

Reposted by Bethan Goulden

Pharmageddon @pharmageddon.bsky.social · Aug 31

📝 Like Wordle but wish it involved plagues?

It's not quite the same -- there's no spelling just a series of clues in a similar feedback loop as Wordle -- but it's pretty cool! Complements of an anonymous med student on Reddit.

#IDSky #MedSky

www.plagdle.com

Plagdle - Daily Infectious Disease Puzzle Game

Test your medical knowledge! Guess the daily infectious disease based on symptoms, treatment, and characteristics. A new puzzle every day!

www.plagdle.com

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Reposted by Bethan Goulden

British Society for Immunology @britsocimm.bsky.social · Aug 6

✨We’ve just launched our new guide to #vaccinations during #pregnancy!

Understand how immunity changes, which vaccines the NHS recommends, and how they protect both parent and baby during pregnancy and beyond.

Download a copy for trusted information: bit.ly/4fuRqVw

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Reposted by Bethan Goulden

Bethan Goulden @bethangoulden.bsky.social · Jul 29

**Rheumatology doctors/nurses/physios in the UK**

This is a short survey to map current reproductive health support/advice available across rheum services in the UK. Please fill it in & share within your networks to help guide next steps/guidelines 📑

qualtrics.ucl.ac.uk/jfe/form/SV_...

Qualtrics Survey | Qualtrics Experience Management

The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.

qualtrics.ucl.ac.uk

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Reposted by Bethan Goulden

Bethan Goulden @bethangoulden.bsky.social · Jul 29

New systematic review of pregnancy associated HLH
- 104 pregnancies
- commonest cause infections (EBV, CMV, HSV, parvo)
- followed by SLE, stills, lymphoma
- 4/14 tested has positive genetics
- 40% no known cause
onlinelibrary.wiley.com/doi/epdf/10....
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Hemophagocytic Lymphohistiocytosis in Pregnancy: A Systematic Review of Case Reports and Case Series

Aims Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening syndrome caused by excessive immune activation, leading to severe inflammation and multi-organ failure. While adult-onset HL...

onlinelibrary.wiley.com

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Reposted by Bethan Goulden

Cathy Nelson-Piercy @nelson-piercy.bsky.social · Jul 24

obgyn.onlinelibrary.wiley.com/doi/epdf/10....

Very proud to be associated with this much needed guidance that will help reduce inequalities in care for women with cancer in pregnancy @melanienana1.bsky.social @bethangoulden.bsky.social @berniejenner.bsky.social

Cancer in pregnancy: FIGO Best practice advice and narrative review

You have to enable JavaScript in your browser's settings in order to use the eReader.

obgyn.onlinelibrary.wiley.com

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Bethan Goulden @bethangoulden.bsky.social · Jul 29

If you're based in the UK, and look after an individual with HLH in pregnancy or up to 6 weeks postpartum - please flag her to your local UKOSS reporter so we can finally have prospective data on this disease:

npeu.ox.ac.uk/ukoss/curren...

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Haemophagocytic Lymphohistiocytosis (HLH) or Macrophage Activation Syndrome (MAS) | UKOSS | NPEU

The National Perinatal Epidemiology Unit (NPEU) is a multidisciplinary research unit based at the University of Oxford. Our work involves running randomised con

npeu.ox.ac.uk

Bethan Goulden @bethangoulden.bsky.social · Jul 29

And the most recent update of the UK HLH Getting It Right First Time Guideline (which is an excellent introduction to the investigation and management of this disease): gettingitrightfirsttime.co.uk/wp-content/u...

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gettingitrightfirsttime.co.uk

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Bethan Goulden @bethangoulden.bsky.social · Jul 29

And before more data on the safety of anakinra in pregnancy came out from the french teratology service academic.oup.com/rheumatology...

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Exposure during pregnancy to Il-1 targeted therapies and pregnancy, fetal and neonatal outcomes: a study from the French Teratology Information Service

AbstractOBJECTIVE. To describe the outcomes of pregnancies exposed to IL-1 targeted therapies (anti-IL-1): anakinra and/or canakinumab.METHODS. We performe

academic.oup.com

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Bethan Goulden @bethangoulden.bsky.social · Jul 29

Their searches concluded before we published our case series from the national HLH MDT, available open access here: pmc.ncbi.nlm.nih.gov/articles/PMC...

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Haemophagocytic lymphohistiocytosis in pregnancy and the postpartum: A case series from the national HLH network

Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory sepsis-like syndrome that accounts for 1% of maternal deaths in the United Kingdom (UK). In 2019, a UK-wide HLH network was developed t...

pmc.ncbi.nlm.nih.gov

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Bethan Goulden @bethangoulden.bsky.social · Jul 29

- AIHA, HELLP, & CAPS reported with HLH in this population
- of those presenting postpartum, most became unwell within a month of delivery
- 75% had a biopsy (bone marrow or liver), 20 negative for haemophagocytosis,10 had a repeat biopsy - all demonstrated haemophagocytosis
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Bethan Goulden @bethangoulden.bsky.social · Jul 29

New systematic review of pregnancy associated HLH
- 104 pregnancies
- commonest cause infections (EBV, CMV, HSV, parvo)
- followed by SLE, stills, lymphoma
- 4/14 tested has positive genetics
- 40% no known cause
onlinelibrary.wiley.com/doi/epdf/10....
1/6

Hemophagocytic Lymphohistiocytosis in Pregnancy: A Systematic Review of Case Reports and Case Series

Aims Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening syndrome caused by excessive immune activation, leading to severe inflammation and multi-organ failure. While adult-onset HL...

onlinelibrary.wiley.com

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