@badfx75.bsky.social
MD/PhD working at Université Paris Cité, Hôpital Universitaire Robert-Debré, GHU APHP.Nord, NeuroDiderot INSERM UMR1141 & IHU Robert-Debré du Cerveau de l’Enfant.
Interested in neurodevelopment, neuroinflammation and epilepsy
Interested in neurodevelopment, neuroinflammation and epilepsy
Pinned
badfx75.bsky.social
@badfx75.bsky.social
· Mar 31
Online now: Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Metallophilic marginal zone macrophages are positioned strategically within the spleen to process internalized blood-borne materials. Mauvais et al. find that these CD169+ macrophages cross-prime CD8+ T cell responses to internalized antigens using a proteasome-independent pathway, contributing to antitumor immunity independently of type 1 conventional dendritic cells.
dlvr.it
Very proud to see my work published in Immunity. It has been a long journey but very enriching on a personal level. I am grateful to all the collaborators, the three reviewers for their very constructive -and challenging evaluation, and the Editor @cp-immunity.bsky.social
Thank you @fcyimmuno.bsky.social & @sfi-immunologie.bsky.social for highlighting our recent work 🙏🏻
📢 April’s Article Award goes to François-Xavier Mauvais & team!
Their Immunity paper reveals that rare spleen cells—metallophilic marginal zone macrophages—can rival dendritic cells in triggering antitumor T cell responses. 🧠🔥
A breakthrough for cancer immunotherapy!
🔗 tinyurl.com/sfiam25
Their Immunity paper reveals that rare spleen cells—metallophilic marginal zone macrophages—can rival dendritic cells in triggering antitumor T cell responses. 🧠🔥
A breakthrough for cancer immunotherapy!
🔗 tinyurl.com/sfiam25
SFI "Articles of the month" highlights - SFI
Les « Articles du mois » sont de retour en 2025 ! Chaque mois, un(e) doctorant(e) ou post-doctorant(e) et sa publication seront mis en avant ici. Plus d’informations pour soumettre votre article en … ...
tinyurl.com
July 22, 2025 at 3:50 PM
Thank you @fcyimmuno.bsky.social & @sfi-immunologie.bsky.social for highlighting our recent work 🙏🏻
Reposted
Our special issue on #neuroimmunology is online! Check out the collection, with reviews from @jonykipnis.bsky.social @michellemonje.bsky.social @ugolinis.bsky.social @bethstevenslab.bsky.social @movahedilab.bsky.social Matteoli, Butovsky, Kim, Artis, & Prinz! www.cell.com/immunity/col... #AAI2025
May 6, 2025 at 9:40 PM
Our special issue on #neuroimmunology is online! Check out the collection, with reviews from @jonykipnis.bsky.social @michellemonje.bsky.social @ugolinis.bsky.social @bethstevenslab.bsky.social @movahedilab.bsky.social Matteoli, Butovsky, Kim, Artis, & Prinz! www.cell.com/immunity/col... #AAI2025
Proud to be in the short list of #preselected candidates to the #Atip-Avenir program! 🙏🏻
#ATIPAvenir Découvrez la liste des candidats présélectionnés du programme ATIP-Avenir 👩🔬👨🔬
👋 @inserm.fr
👉 Découvrez la liste sur notre site : buff.ly/jZMOlnz
👋 @inserm.fr
👉 Découvrez la liste sur notre site : buff.ly/jZMOlnz
April 10, 2025 at 9:13 PM
Proud to be in the short list of #preselected candidates to the #Atip-Avenir program! 🙏🏻
🙏🏻 for the highlight @frenchdcsociety.bsky.social one important finding was the very efficient #vacuolar pathway in MZ #macrophages challenging the current view that #proteasome dependent pathways (active in DC1) are prominent to generate antigenic peptides for #MHC-I through #cross-presentation
👉 When splenic metallophilic marginal zone macrophages do antigen cross-presentation equally well as conventional DC1. Congrats to the team of Peter van Endert from @inem-necker.bsky.social for this work published in @cp-immunity.bsky.social
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Metallophilic marginal zone macrophages are positioned strategically within the spleen
to process internalized blood-borne materials. Mauvais et al. find that these CD169+
macrophages cross-prime CD8+...
www.cell.com
April 9, 2025 at 4:07 PM
🙏🏻 for the highlight @frenchdcsociety.bsky.social one important finding was the very efficient #vacuolar pathway in MZ #macrophages challenging the current view that #proteasome dependent pathways (active in DC1) are prominent to generate antigenic peptides for #MHC-I through #cross-presentation
🙏🏻 Faculté de Santé @upcite.bsky.social pour la mise en valeur de notre publication @cp-immunity.bsky.social sur le rôle #anti-tumoral des #macrophages de la zone marginale de la #rate
u-paris.fr/sante/des-ma...
@inem-necker.bsky.social @hopitalrobertdebre.bsky.social @hopitalnecker.bsky.social
u-paris.fr/sante/des-ma...
@inem-necker.bsky.social @hopitalrobertdebre.bsky.social @hopitalnecker.bsky.social
Des macrophages gardiens de la rate capables d’activer l’immunité contre les tumeurs | Faculté de Santé
u-paris.fr
April 8, 2025 at 3:59 PM
🙏🏻 Faculté de Santé @upcite.bsky.social pour la mise en valeur de notre publication @cp-immunity.bsky.social sur le rôle #anti-tumoral des #macrophages de la zone marginale de la #rate
u-paris.fr/sante/des-ma...
@inem-necker.bsky.social @hopitalrobertdebre.bsky.social @hopitalnecker.bsky.social
u-paris.fr/sante/des-ma...
@inem-necker.bsky.social @hopitalrobertdebre.bsky.social @hopitalnecker.bsky.social
Very proud to see my work published in Immunity. It has been a long journey but very enriching on a personal level. I am grateful to all the collaborators, the three reviewers for their very constructive -and challenging evaluation, and the Editor @cp-immunity.bsky.social
Online now: Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Metallophilic marginal zone macrophages are positioned strategically within the spleen to process internalized blood-borne materials. Mauvais et al. find that these CD169+ macrophages cross-prime CD8+ T cell responses to internalized antigens using a proteasome-independent pathway, contributing to antitumor immunity independently of type 1 conventional dendritic cells.
dlvr.it
March 31, 2025 at 7:07 AM
Very proud to see my work published in Immunity. It has been a long journey but very enriching on a personal level. I am grateful to all the collaborators, the three reviewers for their very constructive -and challenging evaluation, and the Editor @cp-immunity.bsky.social
Reposted
Splenic metallophilic marginal zone macrophages (MMMs) prime CD8+ T cell responses via MHC class I cross-presentation. Cross-priming by MMMs protects against a splenic tumor in the absence of dendritic cells.
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Metallophilic marginal zone macrophages are positioned strategically within the spleen
to process internalized blood-borne materials. Mauvais et al. find that these CD169+
macrophages cross-prime CD8+...
www.cell.com
March 28, 2025 at 4:48 PM
Splenic metallophilic marginal zone macrophages (MMMs) prime CD8+ T cell responses via MHC class I cross-presentation. Cross-priming by MMMs protects against a splenic tumor in the absence of dendritic cells.
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted
Metallophilic CD169+ marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors using a proteasome- and cDC1-independent pathway @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
March 27, 2025 at 4:25 AM
Metallophilic CD169+ marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors using a proteasome- and cDC1-independent pathway @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted
Online now: Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Metallophilic marginal zone macrophages are positioned strategically within the spleen to process internalized blood-borne materials. Mauvais et al. find that these CD169+ macrophages cross-prime CD8+ T cell responses to internalized antigens using a proteasome-independent pathway, contributing to antitumor immunity independently of type 1 conventional dendritic cells.
dlvr.it
March 25, 2025 at 7:55 PM
Online now: Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Reposted
🚨 New: Spleen-resident macrophages (MMMs) can directly activate CD8+ T cells to fight tumors – independently of dendritic cells. They use a vacuolar MHC-I pathway & need Batf3 for this antitumor response.
🧠 A game-changer for immunotherapy?
🔗 www.cell.com/immunity/abs... @cp-immunity.bsky.social
🧠 A game-changer for immunotherapy?
🔗 www.cell.com/immunity/abs... @cp-immunity.bsky.social
March 26, 2025 at 10:12 AM
🚨 New: Spleen-resident macrophages (MMMs) can directly activate CD8+ T cells to fight tumors – independently of dendritic cells. They use a vacuolar MHC-I pathway & need Batf3 for this antitumor response.
🧠 A game-changer for immunotherapy?
🔗 www.cell.com/immunity/abs... @cp-immunity.bsky.social
🧠 A game-changer for immunotherapy?
🔗 www.cell.com/immunity/abs... @cp-immunity.bsky.social