Aydan Szeto
@aydanszeto.bsky.social
Immunologist @MRC-LMB | Views are my own | he/him π³οΈβπ | I work towards manipulating the Yin and Yang of inflammation
#immunology #immunosky
#immunology #immunosky
Pinned
Aydan Szeto
@aydanszeto.bsky.social
Β· Aug 14
Mef2d potentiates type-2 immune responses and allergic lung inflammation
Innate lymphoid cells (ILCs) and adaptive T lymphocytes promote tissue homeostasis and protective immune responses. Their production depends on the transcription factor GATA3, which is further elevate...
www.science.org
Thrilled to share our newest study in @ScienceMagazine. We created Boolean mice and CRISPR screened the heck outta ILC2s
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
June 1, 2025 at 12:37 PM
Reposted by Aydan Szeto
If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years donβt miss out on applying for the NOSTER & @science.org Microbiome Prize!
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
January 14, 2025 at 5:26 PM
If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years donβt miss out on applying for the NOSTER & @science.org Microbiome Prize!
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
My mind is completely blown by this paradigm-shifting finding. An important piece of work reporting negative results.
Mice lacking microglia (Csf1rβFIRE/βFIRE) have normal
-synapse number and maturation
-seizure susceptibility and hippocampal-prefrontal cortex coherence
-segregation of inputs into the lateral geniculate nucleus
-neuronal and astrocytic gene expression
www.nature.com/articles/s41...
-synapse number and maturation
-seizure susceptibility and hippocampal-prefrontal cortex coherence
-segregation of inputs into the lateral geniculate nucleus
-neuronal and astrocytic gene expression
www.nature.com/articles/s41...
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience
Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. OβKeeffe et al. show that certain neurodevelopmental processes attributed to microglia c...
www.nature.com
January 8, 2025 at 12:09 PM
My mind is completely blown by this paradigm-shifting finding. An important piece of work reporting negative results.
Reposted by Aydan Szeto
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Aydan Szeto
From June '24: The transcription factor Mef2d augments type 2 immune responses during allergic lung inflammation, regulating differentiation of Th2 and ILC2 cells.
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
December 9, 2024 at 5:18 PM
From June '24: The transcription factor Mef2d augments type 2 immune responses during allergic lung inflammation, regulating differentiation of Th2 and ILC2 cells.
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
Welcome to bluesky Sarah! Rod Rahimi assembled several immunology starter packs in case youβd like to connect with them :)
bsky.app/profile/rodr...
bsky.app/profile/rodr...
Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know π§ͺ
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
go.bsky.app/QSEPDoj
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network
Below are the links
If you're an immunologist and I have missed you so far, let me know π§ͺ
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Below are the links
If you're an immunologist and I have missed you so far, let me know π§ͺ
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
December 2, 2024 at 9:24 PM
Welcome to bluesky Sarah! Rod Rahimi assembled several immunology starter packs in case youβd like to connect with them :)
bsky.app/profile/rodr...
bsky.app/profile/rodr...
#immunosky
Soluble Notch agonist have the potential to bypass the need for feeder cell lines in the generation of therapeutic T cells and ILCs. Huge potential and canβt wait to try it out (if itβs available to researchers)!
www.nature.com/articles/d41...
Soluble Notch agonist have the potential to bypass the need for feeder cell lines in the generation of therapeutic T cells and ILCs. Huge potential and canβt wait to try it out (if itβs available to researchers)!
www.nature.com/articles/d41...
Notching up a win: fresh tools for activating Notch
Synthetic protein agonists could boost T-cell biomanufacturing and therapeutic strategies.
www.nature.com
December 1, 2024 at 6:58 PM
#immunosky
Soluble Notch agonist have the potential to bypass the need for feeder cell lines in the generation of therapeutic T cells and ILCs. Huge potential and canβt wait to try it out (if itβs available to researchers)!
www.nature.com/articles/d41...
Soluble Notch agonist have the potential to bypass the need for feeder cell lines in the generation of therapeutic T cells and ILCs. Huge potential and canβt wait to try it out (if itβs available to researchers)!
www.nature.com/articles/d41...
RORgt+ dendritic cells versus Zbtb46+ ILC3s. Same cell or different?
December 1, 2024 at 1:20 PM
RORgt+ dendritic cells versus Zbtb46+ ILC3s. Same cell or different?
Reposted by Aydan Szeto
New PhD opportunity in the lab with @profjudiallen.bsky.social and @douglaspdyer.bsky.social looking at interactions between ILCs and the extracellular matrix. Application deadline Jan 10th 2025 - spread the word Bluesky immunologists!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
(Bicentenary) ILC interactions with the extracellular matrix in inflamed barrier tissues at The University of Manchester on FindAPhD.com
PhD Project - (Bicentenary) ILC interactions with the extracellular matrix in inflamed barrier tissues at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
November 28, 2024 at 3:06 PM
New PhD opportunity in the lab with @profjudiallen.bsky.social and @douglaspdyer.bsky.social looking at interactions between ILCs and the extracellular matrix. Application deadline Jan 10th 2025 - spread the word Bluesky immunologists!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Aydan Szeto
#Immunosky #neuroskyence our team is expanding and weβre recruiting a colleague with a strong background in neuroscience (PhD level) to conduct curiosity-driven research into the role of adaptive immunity in controlling sleep. Details & how to apply here: www.jobs.manchester.ac.uk/Job/JobDetai...
www.jobs.manchester.ac.uk
November 27, 2024 at 5:05 AM
#Immunosky #neuroskyence our team is expanding and weβre recruiting a colleague with a strong background in neuroscience (PhD level) to conduct curiosity-driven research into the role of adaptive immunity in controlling sleep. Details & how to apply here: www.jobs.manchester.ac.uk/Job/JobDetai...
Should we βnormaliseβ the gut myco(& micro)biome across facilities to increase reproducibility? What is normal?
November 27, 2024 at 10:13 PM
Should we βnormaliseβ the gut myco(& micro)biome across facilities to increase reproducibility? What is normal?
The authors further showed that mice from JAX lab (where many of us get lab mice from) lack this commensal. Differences in mycobiome can dramatically influence immunity.
November 27, 2024 at 10:13 PM
The authors further showed that mice from JAX lab (where many of us get lab mice from) lack this commensal. Differences in mycobiome can dramatically influence immunity.
In @nature, Liao et al showed this commensal promotes type-2 immunity in the gut via IL-33/ST2, influencing protective anti-helminth responses and food allergy models.
November 27, 2024 at 10:13 PM
In @nature, Liao et al showed this commensal promotes type-2 immunity in the gut via IL-33/ST2, influencing protective anti-helminth responses and food allergy models.
A naturally occurring fungal symbiont that is missing in some lab mice maybe be contributing to inter-facility variation in type-2 immunity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature
Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.
www.nature.com
November 27, 2024 at 10:13 PM
A naturally occurring fungal symbiont that is missing in some lab mice maybe be contributing to inter-facility variation in type-2 immunity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Aydan Szeto
New blogpost:
deevybee.blogspot.com/2024/11/why-...
deevybee.blogspot.com/2024/11/why-...
Why I have resigned from the Royal Society
The Royal Society is a venerable institution founded in 1660, whose original members included such eminent men as Christopher Wren, Robert H...
deevybee.blogspot.com
November 25, 2024 at 7:49 AM
New blogpost:
deevybee.blogspot.com/2024/11/why-...
deevybee.blogspot.com/2024/11/why-...
Happy to answer any specific questions you may have and/or share my experience either here or privately :)
November 24, 2024 at 4:39 PM
Happy to answer any specific questions you may have and/or share my experience either here or privately :)
We used BD Cytofix/perm, Foxp3 fix/perm or 2% PFA fixation and these were all compatible with 2W1S tetramer staining and downstream cytokine analyses by flow
November 24, 2024 at 3:06 PM
We used BD Cytofix/perm, Foxp3 fix/perm or 2% PFA fixation and these were all compatible with 2W1S tetramer staining and downstream cytokine analyses by flow
I can still see some after stimulation, so itβs not like the stimulation will completely negate tetramer staining (at least for 2W1S-MHCII tetramers). Worth a try!
November 24, 2024 at 2:46 PM
I can still see some after stimulation, so itβs not like the stimulation will completely negate tetramer staining (at least for 2W1S-MHCII tetramers). Worth a try!
Agree with the above and I will add that at least for class 2 tetramers, it will depend on the specific tetramers that you use. Unfortunately a lot of the class 2 tetramers are not great compared to class 1, and in my experience both the MFI and % positives may reduce after stimulation, but
November 24, 2024 at 2:46 PM
Agree with the above and I will add that at least for class 2 tetramers, it will depend on the specific tetramers that you use. Unfortunately a lot of the class 2 tetramers are not great compared to class 1, and in my experience both the MFI and % positives may reduce after stimulation, but
Reposted by Aydan Szeto
π¨π¨one more week to apply for our Research Assistant position in Tissue Immunology in Manchester!
Interested in infection, immunometabolism & sickness behaviour? Then come join me & @juanquintana.bsky.social
#Immunosky #LGBTQSTEM π³οΈβππ³οΈββ§οΈπ§ͺ #Academicsky
www.jobs.manchester.ac.uk/Job/JobDetai...
Interested in infection, immunometabolism & sickness behaviour? Then come join me & @juanquintana.bsky.social
#Immunosky #LGBTQSTEM π³οΈβππ³οΈββ§οΈπ§ͺ #Academicsky
www.jobs.manchester.ac.uk/Job/JobDetai...
Research Assistant in Tissue Immunology:Oxford Road
www.jobs.manchester.ac.uk
November 24, 2024 at 1:32 PM
π¨π¨one more week to apply for our Research Assistant position in Tissue Immunology in Manchester!
Interested in infection, immunometabolism & sickness behaviour? Then come join me & @juanquintana.bsky.social
#Immunosky #LGBTQSTEM π³οΈβππ³οΈββ§οΈπ§ͺ #Academicsky
www.jobs.manchester.ac.uk/Job/JobDetai...
Interested in infection, immunometabolism & sickness behaviour? Then come join me & @juanquintana.bsky.social
#Immunosky #LGBTQSTEM π³οΈβππ³οΈββ§οΈπ§ͺ #Academicsky
www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Aydan Szeto
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network
Below are the links
If you're an immunologist and I have missed you so far, let me know π§ͺ
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Below are the links
If you're an immunologist and I have missed you so far, let me know π§ͺ
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Wonderful to see the #immunology community growing here.
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
November 19, 2024 at 12:33 AM
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network
Below are the links
If you're an immunologist and I have missed you so far, let me know π§ͺ
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Below are the links
If you're an immunologist and I have missed you so far, let me know π§ͺ
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
#immunosky
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
https://www.nature.com/articles/s41586-024-08216-z
t.co
November 23, 2024 at 8:37 PM
#immunosky
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
Can I be added please :)
November 18, 2024 at 9:17 PM
Can I be added please :)
Some of us already hallucinate more than others and we definitely donβt need more of that
November 18, 2024 at 5:15 PM
Some of us already hallucinate more than others and we definitely donβt need more of that