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Reposted by Arutha K

Lorenz Adlung Lab @adlunglab.com · 15h

Very cool talk by @aruthak.bsky.social at #EMBLSpatialBiology!
Spatial signatures predict immunotherapy outcome in non-small cell lung cancer, out in @natgenet.nature.com: www.nature.com/articles/s41... 🧪

Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer - Nature Genetics

This study uses spatial proteomic and spatial compartment-based whole-transcriptome profiling to develop predictive models for immunotherapy outcomes in non-small cell lung cancer.

www.nature.com

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Arutha K @aruthak.bsky.social · 4d

@natgenet.nature.com

Arutha K @aruthak.bsky.social · 4d

Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer www.nature.com/articles/s41... #SpatialMedicine #PrecisionMedicine #LungCancer @lungfoundation.bsky.social @iaslc.bsky.social

Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer - Nature Genetics

This study uses spatial proteomic and spatial compartment-based whole-transcriptome profiling to develop predictive models for immunotherapy outcomes in non-small cell lung cancer.

www.nature.com

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Reposted by Arutha K

Nature Genetics @natgenet.nature.com · Sep 15

📢The September issue of @natgenet.nature.com is out!

Featuring:

✅multiomic analysis in NSCLC
✅ancestral recombination graphs with SINGER
✅mutational landscape of TNBC in African American women
✅scDNAme&3Dgenome atlas of human SAT
✅avena super-pangenome

&more!

⬇️

www.nature.com/ng/volumes/5...

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Arutha K @aruthak.bsky.social · Aug 22

PRISM: a Python package for interactive and integrated analysis of multiplexed tissue microarrays url: academic.oup.com/nargab/artic...

PRISM: a Python package for interactive and integrated analysis of multiplexed tissue microarrays

Abstract. Tissue microarrays (TMAs) enable researchers to analyse hundreds of tissue samples simultaneously by embedding multiple samples into single array

academic.oup.com

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Arutha K @aruthak.bsky.social · Aug 1

Plasma proteomics offers a non-invasive approach to monitor dynamic changes in tumour and immune signatures in non-small cell lung cancer (NSCLC). www.researchsquare.com/article/rs-7...

Dissecting Non-Small Cell Lung Cancer (NSCLC) with Blood Proteomics - From Surgical to Immunotherapeutic Responses

Objectives. Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, with limited biomarkers to guide surgical and immunotherapeutic intervention. This study aimed to id...

www.researchsquare.com

Reposted by Arutha K

Wesley Research Institute @wesleyresearch.bsky.social · Jul 2

Did you catch the Queensland Spatial Biology Centre (QSBC) on Channel 9?

@aruthak.bsky.social shared an exciting world-first discovery! His team has profiled hundreds of proteins & thousands of gene messages from just a single tissue slide, using samples from 84 patients with #headandneckcancer.

Researchers' world-first breakthrough on profiling cancer tissue | 9 News Australia

YouTube video by 9 News Australia

www.youtube.com

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Reposted by Arutha K

Clint Miller @clintomics.bsky.social · May 21

Latest news feature in @natbiotech.nature.com on recent developments in spatial biology to unravel disease mechanisms, with insights from experts in field. @aruthak.bsky.social @nebanovich.bsky.social @ai4pathology.bsky.social @jasmineplummer.bsky.social www.nature.com/articles/s41...

Beyond cell atlases: spatial biology reveals mechanisms behind disease - Nature Biotechnology

As the next generation of spatial transcriptomics tools hits the market, researchers are uncovering previously unknown interactions that could transform clinical research.

www.nature.com

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Reposted by Arutha K

Wesley Research Institute @wesleyresearch.bsky.social · May 12

A/Prof Arutha Kulasinghe @aruthak.bsky.social from the Queensland Spatial Biology Centre (QSBC) presented his lab's latest research at the SelectScience Cancer Research Summit. Watch the webinar💻 www.selectscience.net/video/deciph...

#cancerresearch #research #spatialbiology #spatialresearch

Deciphering the complexities in the tumour microenvironment, one cell at a time

In this presentation, Dr. Arutha Kulasinghe discusses how his team uses AI and spatial biology to develop predictive biomarkers for cancer immunotherapy.

www.selectscience.net

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Reposted by Arutha K

Wesley Research Institute @wesleyresearch.bsky.social · May 2

The QSBC team have presented cutting-edge #cancerresearch findings at the world’s largest #cancer #research conference in Chicago this past week, highlighting how immune cells can block the body’s response to #immunotherapy in aggressive head & neck cancers.
@aruthak.bsky.social

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Arutha K @aruthak.bsky.social · Apr 19

How? SM3DD avoids introducing inaccuracies caused by cell segmentation and the downstream effects of mixed-cell expression profiles that contribute to errors in cell type annotation and differential expression analysis.

Arutha K @aruthak.bsky.social · Apr 19

We are excited to share that our newest spatial method, SM3DD! This is a cell segmentation / annotation-free approach for interpreting 3D Spatial Transcriptomics. Preprint: www.biorxiv.org/cgi/content/...

https://biorxiv.org/content/10.110…

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Reposted by Arutha K

Cure Cancer @curecancer.bsky.social · Apr 11

Their recent tissue-imaging research reveals how the tumour environment, metabolic activity,& immune cells influence patient survival. This groundbreaking work can pave the way for new therapies for one of the deadliest cancers affecting women and people with ovaries today. (2/4)

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Reposted by Arutha K

Cure Cancer @curecancer.bsky.social · Apr 11

🎉New cutting-edge research on ovarian cancer 🎉
Ovarian cancer is one of the deadliest cancers, often detected too late & with few treatment options. But thanks to the work of The University of Queensland's A/Prof @aruthak.bsky.social, Naomi Berrell & their team, there’s new hope on the horizon (1/4)

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Reposted by Arutha K

Wesley Research Institute @wesleyresearch.bsky.social · Mar 27

This stunning image, captured by Queensland Spatial Biology Centre (QSBC) scientists using the Wesley Research Institute Phenocycler, has won the prestigious 2025 National Health and Medical Research Council (NHMRC) Science to Art Award!

@aruthak.bsky.social

#spatialmapping #research #science

Queensland Scientists Win Prestigious NHMRC Science to Art Award - Wesley Research Institute

A breathtaking image capturing the intricate details of skin cancer has earned the Queensland Spatial Biology Centre (QSBC) scientists the prestigious 2025 National Health and Medical Research Council...

wesleyresearch.org.au

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Reposted by Arutha K

Kierzkowski Lab @kierzkowskilab.bsky.social · Mar 26

Do you want to know how mechanical interaction between tissue layers controls the formation of complex organ shapes in plants? 🔬🌼
🚨Our latest collaborative work with @routierlab.bsky.social is now published @natureplants.bsky.social
Find out more👉 rdcu.be/efad3

Mechanical interactions between tissue layers underlie plant morphogenesis

Nature Plants - Anthers, the male reproductive organs in plants, are a model to explore the establishment of complex three-dimensional shapes. Live imaging, genetics and modelling reveal an active...

rdcu.be

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Reposted by Arutha K

Kelton Minor @keltonminor.bsky.social · Mar 18

There are days in life that shake you.

I’m shattered 💔 to share that I just found out that the US Government terminated my 2024 NIH Director’s Early Independence Award (~$2 million), threatening my long-promised assistant professor job at Columbia University
& academic career... 1/🧵

94 840 2K

Reposted by Arutha K

Wesley Research Institute @wesleyresearch.bsky.social · Mar 17

A/Prof Kulasinghe @aruthak.bsky.social from the Queensland Spatial Biology Centre (QSBC) featured in the Australian Weekend Magazine. He unpacks the advanced imaging techniques utilised by his team, that provide unprecedented insight into immune cells’ responses to cancers. bit.ly/3DOFJdH

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Arutha K @aruthak.bsky.social · Mar 15

Checkout today's issue of The Australian Weekend Magazine!

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Reposted by Arutha K

Jim Mansfield @jrmansfield.bsky.social · Feb 17

The inimitable @aruthak.bsky.social !

Wesley Research Institute @wesleyresearch.bsky.social · Feb 17

In a groundbreaking study, researchers from Queensland Spatial Biology Centre have uncovered a crucial factor that determines whether patients with head and neck cancer will respond to immunotherapy. Read the paper translational-medicine.biomedcentral.com/articles/10....
#spatialmapping #research

Spatial interaction mapping of PD-1/PD-L1 in head and neck cancer reveals the role of macrophage-tumour barriers associated with immunotherapy response - Journal of Translational Medicine

Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis is poor due to the high rates of recurrence and metastasis. With approxima...

translational-medicine.biomedcentral.com

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Reposted by Arutha K

Wesley Research Institute @wesleyresearch.bsky.social · Feb 17

In a groundbreaking study, researchers from Queensland Spatial Biology Centre have uncovered a crucial factor that determines whether patients with head and neck cancer will respond to immunotherapy. Read the paper translational-medicine.biomedcentral.com/articles/10....
#spatialmapping #research

Spatial interaction mapping of PD-1/PD-L1 in head and neck cancer reveals the role of macrophage-tumour barriers associated with immunotherapy response - Journal of Translational Medicine

Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis is poor due to the high rates of recurrence and metastasis. With approxima...

translational-medicine.biomedcentral.com

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Reposted by Arutha K

Navinci @navincise.bsky.social · Feb 13

@aruthak.bsky.social and team at the University of Queensland have performed spatial interaction mapping in head & neck cancer patient samples, using a combination of spatial proteomics from Akoya and Navinci’s isPLA

Read the article here: translational-medicine.biomedcentral.com/articles/10....

Spatial interaction mapping of PD-1/PD-L1 in head and neck cancer reveals the role of macrophage-tumour barriers associated with immunotherapy response - Journal of Translational Medicine

Background Mucosal head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage, where the prognosis is poor due to the high rates of recurrence and metastasis. With approxima...

translational-medicine.biomedcentral.com

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Arutha K @aruthak.bsky.social · Dec 24

github.com/clinicalomx/...

GitHub - clinicalomx/napari-prism: Interactive and integrated analysis of multiplexed tissue microarrays

Interactive and integrated analysis of multiplexed tissue microarrays - clinicalomx/napari-prism

github.com

Arutha K @aruthak.bsky.social · Dec 24

🧬 Exciting New #SpatialAnalysis Tool! 🧬
🚀 Introducing PRISM: A powerful Python package for the interactive and integrated analysis of multiplexed tissue microarrays! www.biorxiv.org/content/10.1...

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Reposted by Arutha K

Bernard A. Fox @bernardafox.bsky.social · Dec 19

@Aruthak.bsky.social Yes! The #JEDIs are Innovating & JOE YEONG is pulling us together & time not issue 4 this dedicated group still on a hi from #multiomics2024 /10pm #UK, 6am #Singapore & #Taipei, 8am #AU , 2pm #OR #SpatialMedicine #SpatialCatchUps #SpatialInnovation #FinishCancer #cancer

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