Anna Docherty
@annadocherty.bsky.social
Associate Professor, University of Utah
Statistical genetics, psychiatric genetics, bioethics
Chair, PGC Suicide Working Group
Statistical genetics, psychiatric genetics, bioethics
Chair, PGC Suicide Working Group
The PGC Suicide Working Group will provide a symposium at #WCPG2025 🇲🇽 covering our latest multi-ancestry GWAS and CNV meta-analyses, sex-specific meta-analyses, and GxEHR analyses. 🥳
@lcstoshio.bsky.social @andreyshabalin.bsky.social @sarahcolbert.bsky.social @caina89.bsky.social
@lcstoshio.bsky.social @andreyshabalin.bsky.social @sarahcolbert.bsky.social @caina89.bsky.social
October 19, 2025 at 6:18 PM
The PGC Suicide Working Group will provide a symposium at #WCPG2025 🇲🇽 covering our latest multi-ancestry GWAS and CNV meta-analyses, sex-specific meta-analyses, and GxEHR analyses. 🥳
@lcstoshio.bsky.social @andreyshabalin.bsky.social @sarahcolbert.bsky.social @caina89.bsky.social
@lcstoshio.bsky.social @andreyshabalin.bsky.social @sarahcolbert.bsky.social @caina89.bsky.social
Reposted by Anna Docherty
We recently launched The Upright to address the critical gaps in access, effectiveness, and cultural relevance surrounding mental health, suicide prevention, and the lived experience of communities.
Learn more about The Upright and join us for The Summit: www.addevent.com/event/MR2473...
Learn more about The Upright and join us for The Summit: www.addevent.com/event/MR2473...
October 17, 2025 at 4:12 PM
We recently launched The Upright to address the critical gaps in access, effectiveness, and cultural relevance surrounding mental health, suicide prevention, and the lived experience of communities.
Learn more about The Upright and join us for The Summit: www.addevent.com/event/MR2473...
Learn more about The Upright and join us for The Summit: www.addevent.com/event/MR2473...
Reposted by Anna Docherty
Fantastic to see Maria Koromina's great work out in @natneuro.nature.com!
1. A deep look at potential "causal" genetic signals in bipolar disorder
2. A systematic exploration of the analytical choices involved in fine-mapping meta-analysis
1/4
www.nature.com/articles/s41...
1. A deep look at potential "causal" genetic signals in bipolar disorder
2. A systematic exploration of the analytical choices involved in fine-mapping meta-analysis
1/4
www.nature.com/articles/s41...
Fine-mapping genomic loci refines bipolar disorder risk genes - Nature Neuroscience
This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide fu...
www.nature.com
June 26, 2025 at 1:05 PM
Fantastic to see Maria Koromina's great work out in @natneuro.nature.com!
1. A deep look at potential "causal" genetic signals in bipolar disorder
2. A systematic exploration of the analytical choices involved in fine-mapping meta-analysis
1/4
www.nature.com/articles/s41...
1. A deep look at potential "causal" genetic signals in bipolar disorder
2. A systematic exploration of the analytical choices involved in fine-mapping meta-analysis
1/4
www.nature.com/articles/s41...
Reposted by Anna Docherty
Latin America has experienced an increase in suicide rate, contrasting with a global decline. We review possible reasons for this here: www.sciencedirect.com/science/arti...
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.
June 17, 2025 at 12:46 PM
Latin America has experienced an increase in suicide rate, contrasting with a global decline. We review possible reasons for this here: www.sciencedirect.com/science/arti...
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.
Led by Dr. Brenda Cabrera-Mendoza and @renatopolimanti.bsky.social, 1st publication from the LAGC Suicide Working Group.
Reposted by Anna Docherty
We're excited to introduce Tractor-Mix, our new method for GWAS in admixed cohorts with relatedness, led by the fantastic @doubletaotan.bsky.social! Read the full preprint here: www.medrxiv.org/content/10.1...
Thanks to all our amazing collaborators who helped make this work possible!
Thanks to all our amazing collaborators who helped make this work possible!
June 9, 2025 at 6:31 PM
We're excited to introduce Tractor-Mix, our new method for GWAS in admixed cohorts with relatedness, led by the fantastic @doubletaotan.bsky.social! Read the full preprint here: www.medrxiv.org/content/10.1...
Thanks to all our amazing collaborators who helped make this work possible!
Thanks to all our amazing collaborators who helped make this work possible!
Reposted by Anna Docherty
The OpenMx Team is pleased to announce the release of OpenMx version 2.22!: openmx.ssri.psu.edu/node/4942
The big news in this release relates to GREML (Genomic-relatedness-matrix REstricted Maximum-Likelihood): 2 bug-fixes, a patched memory leak, and 2 new features! 1/n
The big news in this release relates to GREML (Genomic-relatedness-matrix REstricted Maximum-Likelihood): 2 bug-fixes, a patched memory leak, and 2 new features! 1/n
OpenMx 2.22 released! | OpenMx
openmx.ssri.psu.edu
June 6, 2025 at 8:10 PM
The OpenMx Team is pleased to announce the release of OpenMx version 2.22!: openmx.ssri.psu.edu/node/4942
The big news in this release relates to GREML (Genomic-relatedness-matrix REstricted Maximum-Likelihood): 2 bug-fixes, a patched memory leak, and 2 new features! 1/n
The big news in this release relates to GREML (Genomic-relatedness-matrix REstricted Maximum-Likelihood): 2 bug-fixes, a patched memory leak, and 2 new features! 1/n
Reposted by Anna Docherty
Postdoc opportunity! At National Genomics Infrastructure in Uppsala we're looking for a postdoc in genomics R&D. Cutting-edge methods dev in an excellent, international environment at the junction between academia and infrastructure. Deadline May 23!
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...
Postdoctoral Researcher, NGI Uppsala, SNP&SEQ Technology Platform - Uppsala University
Postdoctoral Researcher, NGI Uppsala, SNP&SEQ Technology Platform, Department of Medical Sciences, Uppsala University
www.uu.se
May 20, 2025 at 7:43 PM
Postdoc opportunity! At National Genomics Infrastructure in Uppsala we're looking for a postdoc in genomics R&D. Cutting-edge methods dev in an excellent, international environment at the junction between academia and infrastructure. Deadline May 23!
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...
Reposted by Anna Docherty
PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social
An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference https://www.biorxiv.org/content/10.1101/2025.05.14.653986v1
May 20, 2025 at 10:18 AM
PGI Repository v2.0 preprint out! A 🧵 on the main results and updates @robel-alemu.bsky.social @paturley.bsky.social @alextisyoung.bsky.social
Reposted by Anna Docherty
Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
May 20, 2025 at 10:14 AM
Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
Reposted by Anna Docherty
Asked GPT to (impossibly) "write a Bluesky post 100% guaranteed to go viral"
Its suggestion: "just saw a guy confidently order a "croissantini" at the coffee shop and the barista nodded like that was a normal word. i live in a simulation."
Then I said "Make it more viral" and things got weird... 🧵
Its suggestion: "just saw a guy confidently order a "croissantini" at the coffee shop and the barista nodded like that was a normal word. i live in a simulation."
Then I said "Make it more viral" and things got weird... 🧵
May 7, 2025 at 9:31 PM
Asked GPT to (impossibly) "write a Bluesky post 100% guaranteed to go viral"
Its suggestion: "just saw a guy confidently order a "croissantini" at the coffee shop and the barista nodded like that was a normal word. i live in a simulation."
Then I said "Make it more viral" and things got weird... 🧵
Its suggestion: "just saw a guy confidently order a "croissantini" at the coffee shop and the barista nodded like that was a normal word. i live in a simulation."
Then I said "Make it more viral" and things got weird... 🧵
Reposted by Anna Docherty
New preprint! My (now former) postdoc @kvastad.bsky.social led this integration of GWAS and spatial transcriptomics (ST) data to identify tissue structures with enrichment of disease-implicated genes = likely causal drivers of disease biology.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Spatial transcriptomics and genetically implicated genes identify putative causal tissue structures for complex traits
Spatially resolved transcriptomics is transforming our understanding of cellular and molecular diversity of tissues. Here, to identify tissue structures that are enriched for putatively causal disease...
www.biorxiv.org
May 5, 2025 at 3:40 PM
New preprint! My (now former) postdoc @kvastad.bsky.social led this integration of GWAS and spatial transcriptomics (ST) data to identify tissue structures with enrichment of disease-implicated genes = likely causal drivers of disease biology.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Anna Docherty
@sarahcolbert.bsky.social ‘s #SRS25 presentation: Genome-Wide Association Studies of Suicidal Thoughts and Behaviors in the Psychiatric Genomics Consortium
So incredible!
So incredible!
April 24, 2025 at 4:17 PM
@sarahcolbert.bsky.social ‘s #SRS25 presentation: Genome-Wide Association Studies of Suicidal Thoughts and Behaviors in the Psychiatric Genomics Consortium
So incredible!
So incredible!
Reposted by Anna Docherty
Massive multi-ancestry GWAS resource for 1,167 clinical traits & diseases in 6 global biobanks (n=1,789,365)
👉29,139 locus-trait pairs
👉2,624 non-overlapping loci across the genome
👉associated with 6 traits each (median)
👉colocalization across traits for 72% of loci [1/3]
👉29,139 locus-trait pairs
👉2,624 non-overlapping loci across the genome
👉associated with 6 traits each (median)
👉colocalization across traits for 72% of loci [1/3]
April 24, 2025 at 7:57 PM
Massive multi-ancestry GWAS resource for 1,167 clinical traits & diseases in 6 global biobanks (n=1,789,365)
👉29,139 locus-trait pairs
👉2,624 non-overlapping loci across the genome
👉associated with 6 traits each (median)
👉colocalization across traits for 72% of loci [1/3]
👉29,139 locus-trait pairs
👉2,624 non-overlapping loci across the genome
👉associated with 6 traits each (median)
👉colocalization across traits for 72% of loci [1/3]
Reposted by Anna Docherty
Please consider helping @kathleenwreardon.bsky.social with this project—and sharing it widely—to improve how we approach teaching HiTOP for a variety of groups and end users
csufull.qualtrics.com/jfe/form/SV_...
csufull.qualtrics.com/jfe/form/SV_...
April 16, 2025 at 2:03 AM
Please consider helping @kathleenwreardon.bsky.social with this project—and sharing it widely—to improve how we approach teaching HiTOP for a variety of groups and end users
csufull.qualtrics.com/jfe/form/SV_...
csufull.qualtrics.com/jfe/form/SV_...
Reposted by Anna Docherty
Excited to be in Salt Lake City for our 2-week NIH training course in Advanced Statistics in Neuroimaging & Genetics! Today-tomorrow I'm teaching longitudinal & Bayesian modeling in neuroimaging to a stellar group of students. medicine.utah.edu/psychiatry/a...
Advanced Statistical Methods in Neuroimaging and Genetics
medicine.utah.edu
April 7, 2025 at 11:52 PM
Excited to be in Salt Lake City for our 2-week NIH training course in Advanced Statistics in Neuroimaging & Genetics! Today-tomorrow I'm teaching longitudinal & Bayesian modeling in neuroimaging to a stellar group of students. medicine.utah.edu/psychiatry/a...
Reposted by Anna Docherty
Our new study in Molecular Psychiatry, in 1528 children and their parents (@ntrbiopsy.bsky.social) shows that indirect genetic effects—where parental genetics shape offspring traits via environmental influences (genetic nurture)—impact DNA methylation of children. doi.org/10.1038/s413... (1/5)
Intergenerational transmission of complex traits and the offspring methylome - Molecular Psychiatry
Molecular Psychiatry - Intergenerational transmission of complex traits and the offspring methylome
doi.org
April 6, 2025 at 2:07 PM
Our new study in Molecular Psychiatry, in 1528 children and their parents (@ntrbiopsy.bsky.social) shows that indirect genetic effects—where parental genetics shape offspring traits via environmental influences (genetic nurture)—impact DNA methylation of children. doi.org/10.1038/s413... (1/5)
Reposted by Anna Docherty
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
NOT-OD-24-110: Notice of Legislative Mandates in Effect for FY 2024
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Legislative Mandates in Effect for FY 2024 NOT-OD-24-110. NIH
grants.nih.gov
February 8, 2025 at 12:56 AM
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
Reposted by Anna Docherty
Reminder: We hope you will join us TODAY for a timely and important Member’s Meetup regarding the federal changes and updates affecting the NIH.
📅 Wednesday, January 29
🕗 3 PM EST
📍 us06web.zoom.us/meeting/regi...
#psychiatry #psychiatricgenetics
📅 Wednesday, January 29
🕗 3 PM EST
📍 us06web.zoom.us/meeting/regi...
#psychiatry #psychiatricgenetics
January 29, 2025 at 5:16 PM
Reminder: We hope you will join us TODAY for a timely and important Member’s Meetup regarding the federal changes and updates affecting the NIH.
📅 Wednesday, January 29
🕗 3 PM EST
📍 us06web.zoom.us/meeting/regi...
#psychiatry #psychiatricgenetics
📅 Wednesday, January 29
🕗 3 PM EST
📍 us06web.zoom.us/meeting/regi...
#psychiatry #psychiatricgenetics
Reposted by Anna Docherty
Unsure how recent changes in U.S. policy regarding the NIH will impact the psychiatric genetics world? You're not alone. Join ISPG for a Member’s Meetup for community discussion and support:
📅 Wednesday, January 29
🕗 3 PM EST
📍 Pre-Register: us06web.zoom.us/meeting/regi...
📅 Wednesday, January 29
🕗 3 PM EST
📍 Pre-Register: us06web.zoom.us/meeting/regi...
January 24, 2025 at 5:55 PM
Unsure how recent changes in U.S. policy regarding the NIH will impact the psychiatric genetics world? You're not alone. Join ISPG for a Member’s Meetup for community discussion and support:
📅 Wednesday, January 29
🕗 3 PM EST
📍 Pre-Register: us06web.zoom.us/meeting/regi...
📅 Wednesday, January 29
🕗 3 PM EST
📍 Pre-Register: us06web.zoom.us/meeting/regi...
Reposted by Anna Docherty
📢 Quantgen friends:
We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁
Check out our latest program and apply now!
www.grc.org/quantitative...
We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁
Check out our latest program and apply now!
www.grc.org/quantitative...
2025 Quantitative Genetics and Genomics Conference GRC
The 2025 Gordon Research Conference on Quantitative Genetics and Genomics will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 20, 2025 at 3:35 PM
📢 Quantgen friends:
We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁
Check out our latest program and apply now!
www.grc.org/quantitative...
We will continue to accept applications for the GRC on Quantgen in Feb 2025 till 26 Jan or when we are full, so there is still time to put in an application and join us! 😁
Check out our latest program and apply now!
www.grc.org/quantitative...
Reposted by Anna Docherty
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.
www.cell.com/cell/fulltex...
A thread 🧵:
www.cell.com/cell/fulltex...
A thread 🧵:
January 14, 2025 at 5:31 PM
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.
www.cell.com/cell/fulltex...
A thread 🧵:
www.cell.com/cell/fulltex...
A thread 🧵:
Reposted by Anna Docherty
📚 Bias in Faculty Promotions
A @natureportfolio.bsky.social study of 1,571 staff at US universities revealed underrepresented minorities face tougher standards. They received 7% more negative votes & their research was judged more harshly.
🔗 www.nature.com/articles/s41...
#SciComm 🧪 #HigherEd
A @natureportfolio.bsky.social study of 1,571 staff at US universities revealed underrepresented minorities face tougher standards. They received 7% more negative votes & their research was judged more harshly.
🔗 www.nature.com/articles/s41...
#SciComm 🧪 #HigherEd
Underrepresented minority faculty in the USA face a double standard in promotion and tenure decisions - Nature Human Behaviour
Masters-Waage et al. report that underrepresented minority (URM) faculty in the USA face barriers in the promotion and tenure process, receiving more negative votes and fewer unanimous positive decisi...
www.nature.com
December 8, 2024 at 11:23 AM
📚 Bias in Faculty Promotions
A @natureportfolio.bsky.social study of 1,571 staff at US universities revealed underrepresented minorities face tougher standards. They received 7% more negative votes & their research was judged more harshly.
🔗 www.nature.com/articles/s41...
#SciComm 🧪 #HigherEd
A @natureportfolio.bsky.social study of 1,571 staff at US universities revealed underrepresented minorities face tougher standards. They received 7% more negative votes & their research was judged more harshly.
🔗 www.nature.com/articles/s41...
#SciComm 🧪 #HigherEd
Reposted by Anna Docherty
🚨Call for submissions!🚨
We're organizing a special issue on "Behavioral Genetics as a Public Science"🧬🌍
Relevant topics include:
-Public outreach and education
-(Mis)use and (mis)interpretations of BG research
-Ethical, legal, and social issues
tinyurl.com/bgpublicscie...
We're organizing a special issue on "Behavioral Genetics as a Public Science"🧬🌍
Relevant topics include:
-Public outreach and education
-(Mis)use and (mis)interpretations of BG research
-Ethical, legal, and social issues
tinyurl.com/bgpublicscie...
Call for Submissions: Behavior Genetics Special Issue on Public Science
Call for Submissions: Behavioral Genetics as a Public Science: Impacts and Implications Journal: Behavior Genetics Aim and Scope: Genetically informed studies of human behavior captivate a broad a...
tinyurl.com
December 6, 2024 at 3:17 PM
🚨Call for submissions!🚨
We're organizing a special issue on "Behavioral Genetics as a Public Science"🧬🌍
Relevant topics include:
-Public outreach and education
-(Mis)use and (mis)interpretations of BG research
-Ethical, legal, and social issues
tinyurl.com/bgpublicscie...
We're organizing a special issue on "Behavioral Genetics as a Public Science"🧬🌍
Relevant topics include:
-Public outreach and education
-(Mis)use and (mis)interpretations of BG research
-Ethical, legal, and social issues
tinyurl.com/bgpublicscie...
Reposted by Anna Docherty
Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance
Can processes occurring in one individuals nervous system influence the physiology of the descendants? Here we explored the provocative hypothesis that parents sensation or perception of environmental...
www.biorxiv.org
December 5, 2024 at 7:32 PM
Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Anna Docherty
New work by Andy Dahl and Michal Sadowski on using GxE to study genetics of drug response now out in Cell Genomics www.cell.com/cell-genomic...
Characterizing the genetic architecture of drug response using gene-context interaction methods
Sadowski et al. propose a framework to study the genetics of response to commonly prescribed drugs in large biobanks. They quantify the heritability of response to statins, metformin, warfarin, and methotrexate, and identify associated genes. Their analysis also shows the importance of accounting for drug use in genetic risk prediction.
www.cell.com
December 4, 2024 at 8:46 PM
New work by Andy Dahl and Michal Sadowski on using GxE to study genetics of drug response now out in Cell Genomics www.cell.com/cell-genomic...