Anil Makam
@anilmakam.bsky.social
230 followers 250 following 25 posts
UCSF Hospital Medicine Physician Scientist at SFGH. Think about evidence, clinical medicine, outcomes, health services, policy. https://hopelab.ucsf.edu/people/anil-makam-md
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🚨New Study in Annals🚨

GLP1ra & SGLT2i are the only diabetes meds that reduce heart attacks & death

But can't work if can't prescribe

TLDR

40% Medicaid enrollees have restricted access to GLP1 & 25% to SGLT2i

much state/plan variability

GLP access plateaued in '22

bit.ly/3Y72K2z
Availability of Cardioprotective Medications for Type 2 Diabetes in the Medicaid Program | Annals of Internal Medicine
Background: Sodium–glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are the only type 2 diabetes medications that reduce cardiovascular disease an...
www.acpjournals.org
You misspelled clueless
Reposted by Anil Makam
This study seems riddled with selection and detection biases and I can't see how any knowledgeable expert could just take the results at face value and conclude a doubling of risk of long-covid with reinfection.
Children and teens who had a Covid reinfection had a doubling of #LongCovid risk (PASC) and a significant increase in many other adverse outcomes (Figure) www.thelancet.com/journals/lan...
We had our first OFF site Division retreat last week!

Incredible energy, connection & culture building

Plus iconic SF views & food :)

UCSF DHM based at ZSFG is becoming the best academic Division of Hospital Medicine in the country

And not just for a safety-net

We're hiring btw
Reposted by Anil Makam
Recent FDA actions on Covid vaccines:
1. Novavax approved (👏)
2. Narrowed indications for all (pros and cons)
3. Called for clinical trials (👍)
No doubt we're relying too much on old data to inform clinical practice. Some thoughts on what we gain… and what we risk. blogs.jwatch.org/hiv-id-obser...
The Pros and Cons of the Latest FDA Actions on COVID Vaccines
In case you missed it, last week the FDA granted full approval for the Novavax COVID-19 vaccine. This vaccine, which uses a more traditional protein-plus-adjuvant strategy instead of the mRNA approach...
blogs.jwatch.org
Agree for commercial insurance or Medicare

Too expensive within Medicaid
If there is one clinical driver of practice and it's not accounted for in any analysis I can't in any confidence trust the observational comparative effectiveness

Other than the rate of ODS is very very low which is most important part of evidence base
No, it does

It's just pseudo random but may correlate with other practice patterns and serve as a marker
FWIW I do fast correction for most

And if they live in low 120s from chronic badness I don't bother fixing it unless underlying issues fixable
Remains the sole clinical driver of speed

Rest is practice variation

Can't omit it and trust evidence at all
None of these adjust for chronicity

It's the major confounded here between an acute episodic thing vs chronic badness
Reposted by Anil Makam
🚨New Study in Annals🚨

GLP1ra & SGLT2i are the only diabetes meds that reduce heart attacks & death

But can't work if can't prescribe

TLDR

40% Medicaid enrollees have restricted access to GLP1 & 25% to SGLT2i

much state/plan variability

GLP access plateaued in '22

bit.ly/3Y72K2z
Availability of Cardioprotective Medications for Type 2 Diabetes in the Medicaid Program | Annals of Internal Medicine
Background: Sodium–glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are the only type 2 diabetes medications that reduce cardiovascular disease an...
www.acpjournals.org
Copied from my Twitter thread:

NOW WHAT?

removing restrictions would improve access w/o step therapy (which makes no sense here) or prior auth

But $$$ is a real concern

Here is our pitch why may be less of an issue in Medicaid

AND

Restricting DPP4i instead of GLP/SGLT can offset some costs
🚨New Study in Annals🚨

GLP1ra & SGLT2i are the only diabetes meds that reduce heart attacks & death

But can't work if can't prescribe

TLDR

40% Medicaid enrollees have restricted access to GLP1 & 25% to SGLT2i

much state/plan variability

GLP access plateaued in '22

bit.ly/3Y72K2z
Availability of Cardioprotective Medications for Type 2 Diabetes in the Medicaid Program | Annals of Internal Medicine
Background: Sodium–glucose cotransporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are the only type 2 diabetes medications that reduce cardiovascular disease an...
www.acpjournals.org
Reposted by Anil Makam
This was inspired by an amazing study that I did a very popular Twitter thread on

x.com/AnilMakam/st...
x.com
x.com
This matters because different skills translates to different probabilities for the same patient
A key take home is that Doctors are unique diagnosticians

There is NO single 'doctor' with fixed abilities

What this means is that doctors can be the "master of their ROC" and strive for diagnostic excellence in both ruling in AND ruling out badness
I've been thinking more and more about evidence-based diagnosis

Penned this piece with Gurpreet & Oanh on the SSRN preprint server titled:

Striving for Diagnostic Excellence: "The Median Is Not the Message"

Tell me what you think
Agree. Not enjoyable so far. Place is great if you like echo chambers, especially ones that celebrate an assassination because of the industry. Thought the selling point was more sanity and compassion? Will lurk time to time to see if gets better, but find me at the other place
The Discover feed is pretty terrible, and I am not sure how to guide the algorithm to make it better.

I know I can use various lists, but I really want a feed that includes serendipity, trends, and a broader set of topics than the one that I follow but isn't full of noise. How do you get that?
0. HTN is mostly a risk factor, not a disease. Decide whether benefits>risks and life expectancy >2 years.

For many I see #1-10 won't matter
LRs & references?

Likely poor LR- with these sensitivities

They are part of risk stratification scores for mortality

May not exclude any PE but may exclude PEs of clinical significance

With ubiquity of modern imaging, a lot more "PEs" so may differentiate better then VQ scan days
Just ask them if would they recommend a rate of correction without knowing chronicity