Amir Sariaslan
@amirsariaslan.bsky.social
PhD, Psychiatric Epidemiology. Senior Research Fellow, University of Oxford. Funded by NIHR Oxford Health BRC. Interested in the causes and consequences of psychiatric disorders and violence.
This summarises 95% of all epi papers.
November 17, 2025 at 12:02 PM
This summarises 95% of all epi papers.
Reposted by Amir Sariaslan
I wrote about a rare genetic variant (a CNV) that appears to reduce the risk of schizophrenia diagnosis by ~5x, and why that's not as unambigously amazing as it sounds, but potentially still a pretty big deal.
Its probably nothing, but if it is...
A rare copy number variant appears to significantly reduce the risk of schizophrenia.
open.substack.com
September 2, 2025 at 2:14 PM
I wrote about a rare genetic variant (a CNV) that appears to reduce the risk of schizophrenia diagnosis by ~5x, and why that's not as unambigously amazing as it sounds, but potentially still a pretty big deal.
This is bananas.
September 3, 2025 at 5:48 AM
This is bananas.
I got stuck on the first exercise.
August 31, 2025 at 7:06 PM
I got stuck on the first exercise.
Reposted by Amir Sariaslan
How it started
How it’s going
How it’s going
August 30, 2025 at 8:08 PM
How it started
How it’s going
How it’s going
Reposted by Amir Sariaslan
Amazing work from my colleague and postdoc Dr. Isabelle Foote on the genetic architecture of frailty. Encourage you to check it out!!!!
New work in Nature Genetics from IBG members lead by @isyfoote.bsky.social (along with @andrewgrotzinger.bsky.social) examining different measures of frailty using Genomic SEM. Findings reveal six genomic factors with unique biological pathways and clinical correlates. www.nature.com/articles/s41...
Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling - Nature Genetics
Multivariate genome-wide association analyses of the latent genetic architecture of frailty identify one general factor of genetic overlap across all frailty deficits and six factors indexing a shared...
www.nature.com
August 6, 2025 at 4:16 PM
Amazing work from my colleague and postdoc Dr. Isabelle Foote on the genetic architecture of frailty. Encourage you to check it out!!!!
Reposted by Amir Sariaslan
Structural variants are significant contributor to autism. But many SVs & TRs are hard to detect with short reads. Long read sequencing with @pacbio.bsky.social and @nanoporetech.com captures and maps out alot of what short reads miss. So what can LR-WGS tell us about autism? 🧵
Long Read Genome Sequencing Elucidates Diverse Functional Consequences of Structural and Repeat Variation in Autism https://www.medrxiv.org/content/10.1101/2025.07.20.25331880v1
July 23, 2025 at 10:53 PM
Structural variants are significant contributor to autism. But many SVs & TRs are hard to detect with short reads. Long read sequencing with @pacbio.bsky.social and @nanoporetech.com captures and maps out alot of what short reads miss. So what can LR-WGS tell us about autism? 🧵
Pleased to share our latest paper: academic.oup.com/ije/article/...
Childhood household dysfunction and psychiatric, criminal, and social outcomes in emerging adulthood. A cousin comparison study
AbstractBackground. Childhood household dysfunction is a well-known risk factor for adverse medical and social outcomes. However, less is known about the e
academic.oup.com
June 3, 2025 at 9:56 AM
Pleased to share our latest paper: academic.oup.com/ije/article/...
Reposted by Amir Sariaslan
NEW EDITORIAL 📢
Seena Fazel and Amir Sariaslan respond to a paper looking at the risk of self-harm in people prescribed gabapentinoids (gabapentin and pregabalin) - a class of drugs which are often used to treat epilepsy and pain disorders Read it in the BMJ: www.bmj.com/content/389/...
Seena Fazel and Amir Sariaslan respond to a paper looking at the risk of self-harm in people prescribed gabapentinoids (gabapentin and pregabalin) - a class of drugs which are often used to treat epilepsy and pain disorders Read it in the BMJ: www.bmj.com/content/389/...
Use of real world data to understand self-harm risk in people prescribed gabapentinoids
Consider routine follow-up, especially after medication has been stopped
Gabapentinoids, including gabapentin and pregabalin, are a class of drugs that have anticonvulsant, analgesic, and anxiolytic ...
www.bmj.com
May 6, 2025 at 1:12 PM
NEW EDITORIAL 📢
Seena Fazel and Amir Sariaslan respond to a paper looking at the risk of self-harm in people prescribed gabapentinoids (gabapentin and pregabalin) - a class of drugs which are often used to treat epilepsy and pain disorders Read it in the BMJ: www.bmj.com/content/389/...
Seena Fazel and Amir Sariaslan respond to a paper looking at the risk of self-harm in people prescribed gabapentinoids (gabapentin and pregabalin) - a class of drugs which are often used to treat epilepsy and pain disorders Read it in the BMJ: www.bmj.com/content/389/...
Vad har vi lärt oss om beteendegenetik och psykiatrisk epidemiologi i april?
Jag har sammanfattat ett antal intressanta artiklar. Dela gärna inlägget i era nätverk 🙏🏼
amirsariaslan.substack.com/p/manadens-l...
Jag har sammanfattat ett antal intressanta artiklar. Dela gärna inlägget i era nätverk 🙏🏼
amirsariaslan.substack.com/p/manadens-l...
Månadens lärdomar: April, 2025
Djupdykning i två norska studier om hur utbildning går i arv mellan föräldrar och barn, samt om svårigheten att tolka förändringar i genomsnittligt IQ bland unga män som genomgår mönstring.
amirsariaslan.substack.com
May 5, 2025 at 1:42 PM
Vad har vi lärt oss om beteendegenetik och psykiatrisk epidemiologi i april?
Jag har sammanfattat ett antal intressanta artiklar. Dela gärna inlägget i era nätverk 🙏🏼
amirsariaslan.substack.com/p/manadens-l...
Jag har sammanfattat ett antal intressanta artiklar. Dela gärna inlägget i era nätverk 🙏🏼
amirsariaslan.substack.com/p/manadens-l...
Vad har vi lärt oss om beteendegenetik och psykiatrisk epidemiologi i mars?
Jag har sammanfattat ett antal intressanta artiklar. Dela gärna inlägget i era nätverk 🙏🏼
amirsariaslan.substack.com/p/manadens-l...
Jag har sammanfattat ett antal intressanta artiklar. Dela gärna inlägget i era nätverk 🙏🏼
amirsariaslan.substack.com/p/manadens-l...
Månadens lärdomar: Mars, 2025
Genetiska kopplingar mellan adhd, dyslexi och dyskalkyli; könsskillnader i specifika symtom och tecken för adhd; menstruationscykelns betydelse för psykiatri och mer därtill...
amirsariaslan.substack.com
March 28, 2025 at 9:23 AM
Vad har vi lärt oss om beteendegenetik och psykiatrisk epidemiologi i mars?
Jag har sammanfattat ett antal intressanta artiklar. Dela gärna inlägget i era nätverk 🙏🏼
amirsariaslan.substack.com/p/manadens-l...
Jag har sammanfattat ett antal intressanta artiklar. Dela gärna inlägget i era nätverk 🙏🏼
amirsariaslan.substack.com/p/manadens-l...
Reposted by Amir Sariaslan
Reposted by Amir Sariaslan
Our new study in BJPsych, for anyone with an interest in a) bridging the gap to clinical usefulness for prediction tools, and b) thinking more clearly about assessing/doing helpful things to reduce violence risk in clinical services for psychosis. doi.org/10.1192/bjp.... (open access)
Use of a violence risk prediction tool (Oxford Mental Illness and Violence) in early intervention in psychosis services: mixed methods study of acceptability, feasibility and clinical role | The Briti...
Use of a violence risk prediction tool (Oxford Mental Illness and Violence) in early intervention in psychosis services: mixed methods study of acceptability, feasibility and clinical role
doi.org
March 20, 2025 at 7:19 PM
Our new study in BJPsych, for anyone with an interest in a) bridging the gap to clinical usefulness for prediction tools, and b) thinking more clearly about assessing/doing helpful things to reduce violence risk in clinical services for psychosis. doi.org/10.1192/bjp.... (open access)
Ett nytt mässlingsutbrott i Texas har lett till att 259 barn insjuknat sedan januari. Av dessa var 99,2 % ovaccinerade, inklusive ett barn som avled utan att ha några underliggande sjukdomar.
www.dshs.texas.gov/news-alerts/...
www.dshs.texas.gov/news-alerts/...
Measles Outbreak – March 14, 2025 | Texas DSHS
www.dshs.texas.gov
March 17, 2025 at 7:03 AM
Ett nytt mässlingsutbrott i Texas har lett till att 259 barn insjuknat sedan januari. Av dessa var 99,2 % ovaccinerade, inklusive ett barn som avled utan att ha några underliggande sjukdomar.
www.dshs.texas.gov/news-alerts/...
www.dshs.texas.gov/news-alerts/...
Reposted by Amir Sariaslan
Does nobody have a calculate? Or common sense? Or a olfactory sensor to do a sniff test?
A "new study" finds that 2% of US Adults have been injured at a mass shooting.
No.
"7% reported having been present."
7% of US adults = 18,346,00 people
Are you effing kidding me?
A "new study" finds that 2% of US Adults have been injured at a mass shooting.
No.
"7% reported having been present."
7% of US adults = 18,346,00 people
Are you effing kidding me?
March 9, 2025 at 5:32 AM
Does nobody have a calculate? Or common sense? Or a olfactory sensor to do a sniff test?
A "new study" finds that 2% of US Adults have been injured at a mass shooting.
No.
"7% reported having been present."
7% of US adults = 18,346,00 people
Are you effing kidding me?
A "new study" finds that 2% of US Adults have been injured at a mass shooting.
No.
"7% reported having been present."
7% of US adults = 18,346,00 people
Are you effing kidding me?
Reposted by Amir Sariaslan
I thought this was some stats sorcery behind my comprehension (CUPED? FWL?) but then I looked it up and…it’s literally just about adjustment for pre-treatment variables?! Why do people keep making up terms 😭 Controlled-experiment Using Pre-Experiment Data, seriously???
Regression + liberal use of FWL is CUPED. You could residualize and then run a t test, but why?
March 4, 2025 at 5:04 AM
I thought this was some stats sorcery behind my comprehension (CUPED? FWL?) but then I looked it up and…it’s literally just about adjustment for pre-treatment variables?! Why do people keep making up terms 😭 Controlled-experiment Using Pre-Experiment Data, seriously???
Reposted by Amir Sariaslan
"Some people say, 'Oh, you're a hero,' " Harrison told NPR in 2015. "But I'm in a safe room, donating blood. They give me a cup of coffee and something to nibble on. And then I just go on my way. … No problem, no hardship."
mensch
mensch
James Harrison, whose blood donations saved over 2 million babies, has died. www.npr.org/2025/03/03/n...
James Harrison, whose blood donations saved over 2 million babies, has died
Harrison, whose plasma contained a rare antibody, rolled up his sleeve 1,173 times from 1954 to 2018. The Australian is credited with helping 2.4 million babies and advancing scientific research.
www.npr.org
March 3, 2025 at 5:59 PM
"Some people say, 'Oh, you're a hero,' " Harrison told NPR in 2015. "But I'm in a safe room, donating blood. They give me a cup of coffee and something to nibble on. And then I just go on my way. … No problem, no hardship."
mensch
mensch
Vad har vi lärt oss om beteendegenetik och psykiatrisk epidemiologi i februari? Jag har sammanfattat litteraturen: amirsariaslan.substack.com/p/manadens-l...
Dela gärna inlägget i era nätverk 🙏🏼
Dela gärna inlägget i era nätverk 🙏🏼
Månadens lärdomar: Februari, 2025
Vad visade den nya kanadensiska studien om cannabis och schizofreni egentligen? Även: Oklara effekter av mobilförbud i brittiska skolor samt mer miljö än arv bakom tatueringar i Danmark.
amirsariaslan.substack.com
February 28, 2025 at 5:56 AM
Vad har vi lärt oss om beteendegenetik och psykiatrisk epidemiologi i februari? Jag har sammanfattat litteraturen: amirsariaslan.substack.com/p/manadens-l...
Dela gärna inlägget i era nätverk 🙏🏼
Dela gärna inlägget i era nätverk 🙏🏼
I dagens inlägg förklarar jag bakgrunden till mitt beslut att ta bort betalväggen i mitt nyhetsbrev "Arv, miljö och slump". Du kan läsa inlägget här: amirsariaslan.substack.com/p/so-long-be...
So long, betalvägg!
Nu försvinner betalväggen från nyhetsbrevet. Samtliga inlägg kan numera läsas helt kostnadsfritt.
amirsariaslan.substack.com
February 27, 2025 at 7:38 AM
I dagens inlägg förklarar jag bakgrunden till mitt beslut att ta bort betalväggen i mitt nyhetsbrev "Arv, miljö och slump". Du kan läsa inlägget här: amirsariaslan.substack.com/p/so-long-be...
Reposted by Amir Sariaslan
🚨NEW PAPER! Together with Wuno Akingbuwa (@wonuola.bsky.social) we developed a way to estimate non-linear genetic correlations. It didnt sit well with us that known non-linear relations (e.g. BMI and MDD with a famous U shaped ) are poorly captured in statistical genetics. 🧵
www.biorxiv.org
February 14, 2025 at 1:30 PM
🚨NEW PAPER! Together with Wuno Akingbuwa (@wonuola.bsky.social) we developed a way to estimate non-linear genetic correlations. It didnt sit well with us that known non-linear relations (e.g. BMI and MDD with a famous U shaped ) are poorly captured in statistical genetics. 🧵
Reposted by Amir Sariaslan
1/3
Tutorial on exploring ecological momentary assessment data is online at AMPPS, with:
- Accessible ways to visualize data for better understanding
- Models to get some first insights
- Further reading boxes for more advanced topics
- Reproducible pipeline you can run over your own data
Tutorial on exploring ecological momentary assessment data is online at AMPPS, with:
- Accessible ways to visualize data for better understanding
- Models to get some first insights
- Further reading boxes for more advanced topics
- Reproducible pipeline you can run over your own data
February 13, 2025 at 12:04 PM
1/3
Tutorial on exploring ecological momentary assessment data is online at AMPPS, with:
- Accessible ways to visualize data for better understanding
- Models to get some first insights
- Further reading boxes for more advanced topics
- Reproducible pipeline you can run over your own data
Tutorial on exploring ecological momentary assessment data is online at AMPPS, with:
- Accessible ways to visualize data for better understanding
- Models to get some first insights
- Further reading boxes for more advanced topics
- Reproducible pipeline you can run over your own data
Reposted by Amir Sariaslan
I love all my friends saying things like, “I wish I could make a career off being petty and making diss tracks” after the halftime show, and I’m out here like, “Have you considered academia?”
February 10, 2025 at 2:11 PM
I love all my friends saying things like, “I wish I could make a career off being petty and making diss tracks” after the halftime show, and I’m out here like, “Have you considered academia?”
How was your weekend?
February 9, 2025 at 4:53 PM
How was your weekend?
The small details that seem to matter in the end.
February 5, 2025 at 12:40 PM
The small details that seem to matter in the end.