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Pierre Santucci

@pierresantucci.bsky.social

780 followers 1.2K following 22 posts

PI CNRS - Aix Marseille Université 🇫🇷🇪🇺 All about Mycobacteria, Pathogenesis & Antibiotics 🦠🧫🔬💊 https://pierre-santucci.owlstown.net/

pierre-santucci.owlstown.net

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Pierre Santucci @pierresantucci.bsky.social · Feb 24

Happy to see our work on Mycobacterial CRISPRI featured on the Cover of FEBS Letters 🍾🥳👌

@febspress.bsky.social
@univ-amu.fr
@cnrsbiologie.bsky.social @anrs-mie.bsky.social

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Jan-Willem Veening @veeninglab.com · 13h

News article in English: www.unil.ch/news/en/1760...

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FEMS Journals @femsjournals.bsky.social · 22h

New tools unlock #Bdellovibrio bacteriovorus’s predatory secrets 🦠. By combining inducible gene expression with #CRISPRi-mediated depletion for precise control of essential genes, @lalouxlab.bsky.social uncovered new insights into its unique lifecycle and cell division.
buff.ly/FcDzAY4

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Alfred Millett-Sikking @amsikking.bsky.social · 2d

The future of High-Content Imaging has arrived.

-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!

See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...

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James Briscoe @jamesbriscoe.bsky.social · 4d

The @crick.ac.uk is recruiting Early Career Group Leaders

- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology

Deadline 27 Nov

www.crick.ac.uk/careers-stud...

Early career group leaders

We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.

www.crick.ac.uk

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Cascales Lab @cascaleslab.bsky.social · 5d

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...

Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)

emploi.cnrs.fr

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Shabaana Khader @khadershabaana.bsky.social · 9d

UChicago Microbiology is searching for tenured or tenure-track faculty working in host-pathogens interactions, viral and bacterial pathogenesis, and emerging infectious diseases. Come join our vibrant Department! microbiology.uchicago.edu
Apply here apply.interfolio.com/174404

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

apply.interfolio.com

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Shabaana Khader @khadershabaana.bsky.social · 9d

Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!

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Christophe 🔬 L @christlet.bsky.social · 11d

Want to hear a mid-career PI pontificate about science, career and cooking? Today's your lucky day thanks to The Microscopists podcast! Thanks Peter @yorkbioimaging.bsky.social for having me 🎙️🎧
themicroscopists.bitesizebio.com/episodes/chr...

The Microscopists | Christophe Leterrier (CNRS & Aix-Marseille Université)

This time on The Microscopists, we're joined by Christophe Leterrier, team leader at NeuroCyto in Marseille and director of a Nikon Center of Excellence for super-resolution microscopy.Christophe r...

themicroscopists.bitesizebio.com

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Pierre Santucci @pierresantucci.bsky.social · 12d

Yeaaaah Congratulations @ben-ezraty.bsky.social & team - You guys Rock! 🤘💥

Reposted by Pierre Santucci

PLOS Biology @plosbiology.org · 14d

During chlorite-induced #OxidativeStress MsrPQ repairs periplasmic proteins oxidized at Met residues. @ben-ezraty.bsky.social &co show that in these conditions the #Ecoli chaperone Spy is overproduced & oxidized; its reduction by MsrPQ helps maintain functionality @plosbiology.org 🧪 plos.io/3VHTAI9

Maintaining Spy in its reduced state (left) by MsrP during chlorite stress is critical for its chaperone activity. Image credit: Benjamin Ezraty.

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Andy Edwards @bugsinblood.bsky.social · 15d

Now published! www.nature.com/articles/s41...

Very nice collaboration with Hoogenboom ( @ucl.ac.uk ) and Bonev ( @uniofnottingham.bsky.social ) labs.

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Pierre Santucci @pierresantucci.bsky.social · 16d

Thanks Tiago! ✌️✌️✌️

Pierre Santucci @pierresantucci.bsky.social · 16d

Work led by the talented PhD Candidate Janïs Laudouze, close collaboration with
@alainbaulard.bsky.social
Yuri Antonenko
@alexandregouzy.bsky.social

Big thanks to our funders:
@cnrsbiologie.bsky.social
@univ-amu.fr
@anrs-mie.bsky.social
@agencerecherche.bsky.social

Pierre Santucci @pierresantucci.bsky.social · 16d

🙏🙏🙏 Thanks so much @sfmpathogenesis.bsky.social for the shout out - You guys rock! ✌️✌️✌️

Pierre Santucci @pierresantucci.bsky.social · 16d

Extremely happy to share the fruit of a beautiful collaborative research study.

France 🇫🇷, Russia 🇷🇺 and USA 🇺🇸 teaming up to tackle a long-standing question in the TB field! 🧫🦠💊🥼🩺

Our latest Preprint on Pyrazinamide Mode of Action against M.tuberculosis is online! 👇👇👇

doi.org/10.1101/2025...

Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification

Pyrazinamide (PZA) is a cornerstone drug in tuberculosis (TB) treatment with a strong bactericidal activity in vivo on both actively and non-replicating bacterial subpopulations. Yet the precise mode ...

doi.org

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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 16d

New study shows pyrazinamide kills TB by acidifying bacterial cytosol — not via PanD/CoA depletion. A long-standing debate settled, paving the way for smarter PZA-like drugs. #MicroSky

✍️ J. Laudouze, Y. Antonenko, @alexandregouzy.bsky.social, @pierresantucci.bsky.social & coll.
📖 shorturl.at/tuz6Q

Revisited model of PZA/HPOA efficacy, supporting a pH-dependent mechanism of weak acid permeation and cytosolic acidification as main mechanism of bactericidal activity. In this model, the authors propose that the presence of glycerol potentiates PZA/HPOA efficacy by generating acidic intermediates that lower IBpH. Accordingly, β-alanine and pantothenate might mitigate this effect by acting as buffering molecules that alleviate acidosis. Finally, PanD enzymatic activity consumes protons which in turn increases IBpH. Therefore, in this model PanD minimally contributes to PZA tolerance and cannot be considered as the primary target of the drug.

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J.-F. Cavalier @jefcavalier.bsky.social · 17d

Great collaborative work driven by @pierresantucci.bsky.social which provides clear evidence on the mode of action of a well-known first-line anti-TB drug.

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 17d

Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification https://www.biorxiv.org/content/10.1101/2025.09.26.678883v1

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Cascales Lab @cascaleslab.bsky.social · 16d

We will have soon an Open position for a PhD thesis position to work on bacterial secretion systems !

Stay tuned !!

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Géraldine Laloux @lalouxlab.bsky.social · 20d

📝New preprint! #MicroSky

🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy.

🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation.

www.biorxiv.org/content/10.1...

Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle

The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...

www.biorxiv.org

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febsopenbio.bsky.social @febsopenbio.bsky.social · 20d

📢FEBS Open Bio is an affiliate journal in @ReviewCommons

📩We can receive your refereed preprint with no need to re-submit!

🔎Focus on technical and ethical quality
📖Publish #OpenAccess
👐Not-for-profit: net income supports science

#BioPhysics #Biochemistry #CellBiology

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Pierre Santucci @pierresantucci.bsky.social · 22d

👏👏👏 Congratulations Wendy, Oli & Team - Fantastic to see this beautiful story published! 💥🎉🎊

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Olivier Neyrolles @oneyrolles.bsky.social · 22d

Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC

Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS

Tuberculosis remains the deadliest infectious disease caused by a single pathogen, highlighting the urgent need for novel therapies. A deeper under...

www.pnas.org

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Richard Sever @richardsever.bsky.social · Sep 4

Funder information can now be added to bioRxiv preprints. Incorporation of funding organizations into the Research Organization Registry (ROR) means this is available as standardized metadata for articles.

connect.biorxiv.org/news/2025/09...

Adding funder information to bioRxiv preprints

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

connect.biorxiv.org

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Jessica Blair @jessicamablair.bsky.social · Sep 4

Assistant Prof post in bacterial genomics @unibirmingham.bsky.social Come and join us!!

@imibirmingham.bsky.social
www.jobs.ac.uk/job/DOO184/a...

Assistant Professor (Research and Education) in Bacterial Genomics at University of Birmingham

Looking for a new job opportunity in academia? Check out this job opening for a Assistant Professor (Research and Education) in Bacterial Genomics on jobs.ac.uk!

www.jobs.ac.uk

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Journal of Cell Biology @jcb.org · Sep 3

Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti...

#Reproducibility

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