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Reposted by Pablo Laborda

Patricia Bernal @pbernalt6ss.bsky.social · 26d

We just opened the Bluesky account of the International Microbiology Literacy Initiative (IMiLI) headed by Ken Timmis. Follow us to know more about the initiative or even better become one of our volunteers to bring Microbiology to kids all ages around the world 🦠 🏫

International Microbiology Literacy Initiative - IMiLI @imili-micro.bsky.social · 26d

Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org

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Reposted by Pablo Laborda

International Microbiology Literacy Initiative - IMiLI @imili-micro.bsky.social · 26d

Welcome to the social media account of the International Microbiology Literacy Initiative (IMiLI). Nearly 1,000 researchers freely contribute to the IMiLI project integrating microbiology into education providing downloadable resources for all. Explore at imili.org

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Reposted by Pablo Laborda

Alicia Calvo-Villamañán @aliciapcv.bsky.social · Aug 20

This work is finally published! 🥳🧬
Plasmids are associated with very variable fitness costs in their different bacterial hosts. But, what is the contribution of each of the plasmid-genes in these host-specific effects? Study led by
@jorgesastred.bsky.social, @sanmillan.bsky.social and myself! 1/14

Dissecting pOXA-48 fitness effects in clinical Enterobacterales using plasmid-wide CRISPRi screens

Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...

rdcu.be

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Reposted by Pablo Laborda

Jorge Sastre Domínguez @jorgesastred.bsky.social · Aug 13

New paper out! 🔈🔈📣📣

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation.

Combining experimental and computational approaches, we unveil how two of the most prevalent bacterial MGE accelerate the evolution of AMR. 🧵👇🏻

www.biorxiv.org/content/10.1...

Plasmids promote antimicrobial resistance through Insertion Sequence-mediated gene inactivation

Antimicrobial Resistance (AMR) is a major threat to public health. Plasmids are mobile genetic elements that can rapidly spread across bacterial populations, promoting the dissemination of AMR genes i...

www.biorxiv.org

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Reposted by Pablo Laborda

Jerónimo Rodríguez-Beltrán @jerorb.bsky.social · Jul 22

Do plasmids evolve faster 🐇, slower 🐢, or just like chromosomes 🧬?

In our new paper, we tackled this question using theory, simulations, bioinformatics, and experiments!

👇 Check out all the details in Paula’s thread!

Hint: 🐇 (most of the time)

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Reposted by Pablo Laborda

Carlos Serna @cserna.bsky.social · Jul 17

Our paper “Global dissemination of npmA mediated pan‑aminoglycoside resistance via a mobile element in Gram‑positive bacteria” is now in @natcomms.nature.com. Part of my freshly defended PhD, so doubly happy! 😄🎉

🧵 (1/14)

www.doi.org/10.1038/s414...

Global dissemination of npmA mediated pan-aminoglycoside resistance via a mobile genetic element in Gram-positive bacteria - Nature Communications

The authors investigate the distribution of the aminoglycoside resistance gene npmA in Gram-positive bacteria via a mobile genetic element, highlighting its global presence and cross-species transfer ...

www.doi.org

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Reposted by Pablo Laborda

Jerónimo Rodríguez-Beltrán @jerorb.bsky.social · Jul 2

🚨🚨New paper out in @natcomms.nature.com!!

Come for the first large-scale analysis of plasmid copy number across species,
stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬

👉 www.nature.com/articles/s41...

Universal rules govern plasmid copy number - Nature Communications

Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy number of thousands of diverse b...

www.nature.com

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Pablo Laborda @pablolaborda.bsky.social · Jun 5

Enhorabuena Alberto!! 💪

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Reposted by Pablo Laborda

Centro Nacional de Biotecnología (CNB) @cnb-csic.bsky.social · Jun 4

Una nueva investigación identifica un mecanismo molecular que interviene en la pérdida de la resistencia bacteriana al antibiótico ciprofloxacino.

📰Lee aquí más información: bit.ly/4mMl2AN
DOI: bit.ly/43uUtbT

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Reposted by Pablo Laborda

Sara Hernando-Amado @hernando-amado.bsky.social · Jun 4

Aquí os cuentan mis compañeras Susana de Lucas y Jennifer Palencia, de Comunicación y Cultura Científica del @cnb-csic.bsky.social, nuestro último trabajo. Describimos una estrategia de base evolutiva para eliminar la resistencia a ciprofloxacino en aislados clínicos de P. aeruginosa. Felices! 🤩

Centro Nacional de Biotecnología (CNB) @cnb-csic.bsky.social · Jun 4

Una nueva investigación identifica un mecanismo molecular que interviene en la pérdida de la resistencia bacteriana al antibiótico ciprofloxacino.

📰Lee aquí más información: bit.ly/4mMl2AN
DOI: bit.ly/43uUtbT

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Pablo Laborda @pablolaborda.bsky.social · Jun 4

Check out this cool collaboration with @hernando-amado.bsky.social, just out in @natcomms.nature.com!
We show that ciprofloxacin resistance rapidly declines in clinical P. aeruginosa strains under drug-free conditions, suggesting that ciprofloxacin restriction periods could help in clinics 🦠🧫

Sara Hernando-Amado @hernando-amado.bsky.social · Jun 4

I am very happy to share our latest study on ciprofloxacin resistance instability in P. aeruginosa during periods of drug restriction. A fantastic collaboration @pablolaborda.bsky.social, RuggeroLaRosa, JLMartínez, SørenMolin & HelleJohansen 🥳 @cnb-csic.bsky.social
www.nature.com/articles/s41...

Ciprofloxacin resistance rapidly declines in nfxB defective clinical strains of Pseudomonas aeruginosa - Nature Communications

Antimicrobial resistance can decline due to compensatory mutations or genetic reversions to wild-type alleles. Here, the authors analyse the decline of ciprofloxacin resistance in nfxB-defective Pseud...

www.nature.com

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Pablo Laborda @pablolaborda.bsky.social · May 19

Enhorabuena Sara!! 🚀🚀

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Reposted by Pablo Laborda

Sara Hernando-Amado @hernando-amado.bsky.social · Apr 9

Ceftazidime-avibactam (a last resort drug) use selects multidrug-resistance and prevents designing collateral sensitivity based therapies against P. aeruginosa (no robust patterns emerge). Happy to see it published! 🥳 @cnb-csic.bsky.social @idisba.bsky.social
www.nature.com/articles/s41...

Ceftazidime-avibactam use selects multidrug-resistance and prevents designing collateral sensitivity-based therapies against Pseudomonas aeruginosa - Nature Communications

Ceftazidime-avibactam is a β-lactam/β-lactamase inhibitor combination restricted for the treatment of multidrug-resistant infections of Pseudomonas aeruginosa non-susceptible to ceftazidime and resist...

www.nature.com

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Reposted by Pablo Laborda

Pseudomonas Genome Database @pseudomonas.com · Feb 1

Are you a #Pseudomonas researcher? Please take our survey and help shape the direction and priority of future pseudomonas.com database development: forms.gle/gTPT6ruf3mqb...
#microsky #idsky

The Pseudomonas Genome Database - Genome annotation and comparative genome analysis

pseudomonas.com

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Pablo Laborda @pablolaborda.bsky.social · Jan 27

Last month, I had the chance to share my research in my hometown – more than 7 years since I did my bachelor’s degree over there!
Today, the local newspaper @heraldo.es features some insights from the event participants about their research (and life) abroad
www.heraldo.es/noticias/ara...

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Pablo Laborda @pablolaborda.bsky.social · Jan 23

Our group is looking for a PostDoc with a strong background in molecular microbiology, strain design and genetic engineering. Join us at DTU to work on bacterial infections and antimicrobial resistance!
www.rigshospitalet.dk/job-og-uddan...

www.rigshospitalet.dk

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Pablo Laborda @pablolaborda.bsky.social · Jan 21

Truly well deserved!! Congrats again, Jero!

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Reposted by Pablo Laborda

Juan Díaz-Colunga @jdiazc9.bsky.social · Jan 17

⚠️ Job(s) alert! ⚠️

We are launching a new postdoctoral program in Systems Biology at IBFG. Join us!

👉 Several positions available with competitive work conditions for up to 4 years

📄 More info: jdiazc9.github.io/files/jobs/2...

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Reposted by Pablo Laborda

Bruno Gonzalez Zorn @bgzorn.bsky.social · Jan 16

📣 Postdoc Position open in our lab m in Madrid.

If you are motivated with AMR transmission using Genomics and Metagenomics for the next 3 years send your cv and a motivation letter to [email protected]

#OneHealth

@ucm.es @escmid.bsky.social

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Reposted by Pablo Laborda

Ákos T Kovács @evolvedbiofilm.bsky.social · Jan 14

Hypermutability bypasses genetic constraints in SCV phenotypic switching in Pseudomonas aeruginosa biofilms

-in NPJ Biofilms and Microbiomes from Andrea M. Smania (Argentina)

www.nature.com/articles/s41...

Hypermutability bypasses genetic constraints in SCV phenotypic switching in Pseudomonas aeruginosa biofilms - npj Biofilms and Microbiomes

npj Biofilms and Microbiomes - Hypermutability bypasses genetic constraints in SCV phenotypic switching in Pseudomonas aeruginosa biofilms

www.nature.com

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Reposted by Pablo Laborda

Alvaro San Millan @sanmillan.bsky.social · Dec 30

www.nature.com/articles/s41...
New paper out!!

A plasmid-chromosome crosstalk in multidrug resistant enterobacteria - Nature Communications

The authors describe a new crosstalk between a globally disseminated carbapenem resistance plasmid and clinical enterobacteria clones. This crosstalk provides a fitness advantage to the plasmid-carryi...

www.nature.com

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Reposted by Pablo Laborda

Rachel M. Wheatley @rachelmwheatley.bsky.social · Dec 30

Sharing three fully funded PhD opportunities to join my lab at Queen’s to work on topics spanning bacterial pathogens, antibiotic resistance, microbial interactions, & mobile genetic elements 🦠. Closing dates in January and February, and open to international candidates 🌍 Projects detailed below ⬇️

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Reposted by Pablo Laborda

Sara Hernando-Amado @hernando-amado.bsky.social · Dec 27

How can the use of adjuvants improve the effectiveness of antibiotics and reduce the burden of antimicrobial resistance? Check our latest review! Gil-Gil T, @pablolaborda.bsky.social & JL Martínez.
www.tandfonline.com/eprint/ZC5JQ...

Use of adjuvants to improve antibiotic efficacy and reduce the burden of antimicrobial resistance

The increase in antibiotic resistance, together with the absence of novel antibiotics, makes mandatory the introduction of novel strategies to optimize the use of existing antibiotics. Among these ...

www.tandfonline.com

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Reposted by Pablo Laborda

Ákos T Kovács @evolvedbiofilm.bsky.social · Dec 24

Join our #MicroClock @microclockerc.bsky.social #ERCSyG team as #Postdoc to discover the components of a bacterial circadian clock

Apply by 17 Jan 2025, if you have experience
-with liquid handling robots/screening of bacterial strains
-in molecular biology of model bacteria

tinyurl.com/2d2c8fe5

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Reposted by Pablo Laborda

Sara Hernando-Amado @hernando-amado.bsky.social · Dec 4

Podemos solicitar juntos este contrato predoctoral si quieres hacer la tesis en Ecología y Evolución de la Resistencia a los Antibióticos.
www.cnb.csic.es/index.php/es...
Más info en 🐥👇

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