What is the physical basis of death? Can we manipulate cellular rules to avoid it? What does death mean for a machine? Is immortality possible? What does it mean for language, thought, or information to die? My new book @princetonupress.bsky.social is coming soon. press.princeton.edu/books/hardco...

Ryotatsu Yanagimoto and coauthors introduce a programmable nonlinear photonic chip. By projecting light patterns onto a waveguide, they reconfigure how light interacts with light—opening the door to software-defined quantum, sensing, and communication optics. www.nature.com/articles/s41...

Local and long-range biological patterns guided by physical forces. Beautiful.

Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!

Biology and life is beautiful. AI-generated images definitely doesnt do that beauty justice.

Without resistance there can be no transformation of anything into anything else. Like a beaming photon in outer space.

But with too much resistance, energy cannot flow, damage accumulates, and we die. Like electrons trying to flow in a defective mitochondrion.

Thank you Carmen - great insight!

@cellpress.bsky.social @cp-cellmetabolism.bsky.social @biophysicalsoc.bsky.social

Full link to paper here: www.sciencedirect.com/science/arti...

Grateful to have written this with my Dear, @martinpicardenergy.bsky.social .

One of my most exciting & frame-shifting papers to date.

The Energy Resistance Principle shows how resistance to energy shapes the dynamics of life and health.

A new lens to understand & optimize energy across the lifespan, inspiring tools that sense & tune the body’s energetic architecture.

Using RNA-seq to study brain-body interactions is like watching the movement of the stars with a microscope.

Higher resolution isn’t always better. The closer we look, the easier it is to lose sight of patterns that only emerge in the whole.

It's now increasingly clear that mitochondria in all cell types respond to light, transforming photons of different energies (λ, wavelength) into the chemistry that sustains our life.

Could these energy translators also send light back out as information?

🔗https://tinyurl.com/mrfm6psr

Science communication is changing. Too often, ideas vanish in rejected grants, reviewer edits, or word limits.

Love that new spaces for longer, nuanced dialogue are emerging, not just scientist-to-scientist, opening science to the public, sparking curiosity, and supporting more informed decisions!

Same! Once a week feels right, and likely mid-to-end week when my inbox is less chaotic from the Monday rush.

What is energy? A force, a feeling, a pattern of life?

Mark your calendars!

On September 12, we open the global dialogue on understanding what energy truly is and how to reframe our understanding of life itself through the lens of energetic patterning.

Love to see ya'll there.

🔗 www.cell.com/iscience/ful...

Grateful for @MattiaBonzanni @DrNRouleau @caseymhayley and the rest of our brilliant team for pushing toward an optical understanding of brain activity...one where light may carry meaning.

New paper from our lab in #CellPress!

The human brain emits ultraweak light—photons from metabolic & electrical activity.

These emissions pass through the skull and shift with cognition, pointing to a biophysical layer where light may act as a non-invasive marker of brain function.

🔗 to paper ⬇️

Beginning in the 1970s, sleep psychologist Irene Tobler set out behavioral criteria to show that sleep is not unique to higher-order mammals — even cockroaches sleep. (From the archive) www.quantamagazine.org/sleep-evolve...

We've spent over a century building our biomolecular-genetic understanding of cell communication.

To move beyond incremental advances, we must embrace the #energetic dimension—where #biophysical signals shape cells, guide development & control fate.

🔗 tinyurl.com/yc326mar

Bioenergetic resistance can shape the health-disease continuum, yet energy remains the missing dimension in biomedicine.

My new #preprint w/ Martin Picard explores how modifiable energy flow drives adaptation, resilience & transformation.

🔗 tinyurl.com/2pcpuuw4
Would love to hear your thoughts!