Mann Lab
@mannlab.bsky.social
The Mann Lab is a pioneer in mass spectrometry-based proteomics. Posts represent personal views from lab members and Matthias Mann
Matthias Mann is a German physicist and biochemist. He is doing research in the area of mass spectrometry and proteomics.
Source: Wikipedia
Biology
49%
Chemistry
44%
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Mann Lab
@mannlab.bsky.social
· Jul 1
🎉 Congratulations to Matthias Mann on 20 years leading Proteomics & Signal Transduction at MPI of Biochemistry! Two decades of groundbreaking mass spectrometry research and training excellent future scientists.
#MS #Proteomics #Science @mannlab.bsky.social
#MS #Proteomics #Science @mannlab.bsky.social
Thank you Matthias for your visionary leadership and for creating a scientific family that continues to push boundaries. Congratulations from all members, and looking forward to the future! #MS #Proteomics #20Years
Reposted by Matthias Mann
embopress.org
Honored to be included in this reflection on 20 excellent years of MolSystBiol! From our first phosphotyrosine interactome in 2005 to proteome-wide networks - scale has grown exponentially. MS proteomics + AI is transforming systems-level understanding. Exciting times!
embopress.org/doi/pdf/10.1...
embopress.org/doi/pdf/10.1...
Mann Lab
@mannlab.bsky.social
· 13d
Elegant chemistry and cryo-EM explain the selective Lys8 ubiquitylation. A clear example of how metabolite sensing and the ubiquitin system intersect.
Mann Lab
@mannlab.bsky.social
· 13d
www.biorxiv.org
Great to see Brenda Schulman’s team post their new bioRxiv paper. MS-based proteomics helped uncover a beautifully simple mechanism: cysteine levels tune metabolism by flipping the inverse stability of LRRC58 and its substrate CDO1.
www.biorxiv.org/content/bior...
www.biorxiv.org/content/bior...
Mann Lab
@mannlab.bsky.social
· 17d
Fantastic time at #HUPO2025 in Toronto! Congratulations to our talented Early Career researchers! Proud winners: Oeller Marc Oeller🥇 1st Place Poster, Kathrin Korff 🥈 Runner-up Poster, and @carolineweiss.bsky.social 🎤 3-Minute Thesis award! The future of #proteomics research is bright!
Mann Lab
@mannlab.bsky.social
· 22d
If you are at HUPO 2025, catch up with our team @mannlab.bsky.social to hear about our exciting work in single-cell proteomics, immunopeptidomics, spatial proteomics, and the latest advances in mass spectrometry technology!
Mann Lab
@mannlab.bsky.social
· 29d
The diagnostic potential of proteomics and machine learning in Lyme neuroborreliosis - Nature Communications
Researchers incorporate mass spectrometry-based proteomics and machine learning to assess the potential of a less invasive diagnostic approach for Lyme neuroborreliosis, a common nervous system infect...
www.nature.com
In Nature Communications: MS-based proteomics + machine learning to diagnose Lyme neuroborreliosis with 92% accuracy (CSF) and 80% (blood) - paving the way for earlier, less invasive testing.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mann Lab
@mannlab.bsky.social
· Oct 29
Awesome talk by @erictopol.bsky.social at the Bavarian Academy of Sciences and Humanities (BAdW). A positive and hopeful take on #AI in medicine. Thanks for highlighting #DVP, too 😊
Mann Lab
@mannlab.bsky.social
· Oct 22
AlphaDIA is open-source and free for academic and commercial users. We are currently preparing version 2.0 - stay tuned!
#AlphaDIA #Bioinformatics #DeepLearning #MassSpectrometry
#AlphaDIA #Bioinformatics #DeepLearning #MassSpectrometry
Mann Lab
@mannlab.bsky.social
· Oct 22
AlphaDIA enables DIA transfer learning for feature-free proteomics - Nature Biotechnology
An open-source platform for data-independent acquisition proteomics adapts predicted libraries to experimental settings.
www.nature.com
Excited to share AlphaDIA's publication in Nature Biotechnology!
Our open-source DIA framework brings deep learning directly to raw MS data with feature-free processing, transfer learning for any PTM, and performance matching top tools.
www.nature.com/articles/s41...
Our open-source DIA framework brings deep learning directly to raw MS data with feature-free processing, transfer learning for any PTM, and performance matching top tools.
www.nature.com/articles/s41...
Mann Lab
@mannlab.bsky.social
· Oct 9
In labs, hands-on expertise is often lost because it's not written down. We leverage multimodal AI agents to capture & share expertise by analyzing video and speech to generate protocols, detect errors, and guide researchers. #AI #TeamMassSpec
📄 Preprint: doi.org/10.1101/2025... 1/🧵
📄 Preprint: doi.org/10.1101/2025... 1/🧵
Multimodal AI agents for capturing and sharing laboratory practice
We present a multimodal AI laboratory agent that captures and shares tacit experimental practice by linking written instructions with hands-on laboratory work through the analysis of video, speech, an...
doi.org
How much hands-on lab expertise gets lost? We developed a multimodal AI agent that turns videos into protocols and detects procedural errors. Making science accessible. Great collaboration with #Google.
Preprint: www.biorxiv.org/content/10.1...
@patiskowronek.bsky.social explains👇
Preprint: www.biorxiv.org/content/10.1...
@patiskowronek.bsky.social explains👇
Reposted by Matthias Mann
Multimodal AI agents for capturing and sharing laboratory practice
We present a multimodal AI laboratory agent that captures and shares tacit experimental practice by linking written instructions with hands-on laboratory work through the analysis of video, speech, an...
doi.org
In labs, hands-on expertise is often lost because it's not written down. We leverage multimodal AI agents to capture & share expertise by analyzing video and speech to generate protocols, detect errors, and guide researchers. #AI #TeamMassSpec
📄 Preprint: doi.org/10.1101/2025... 1/🧵
📄 Preprint: doi.org/10.1101/2025... 1/🧵
Mann Lab
@mannlab.bsky.social
· Sep 24
16/
If this interests you:
🔁 Retweet the first post:
bsky.app/profile/mann...
⭐️ Give our github repo a star github.com/MannLabs/scP...
❓ tell us what you are going to do with #scPortrait
If this interests you:
🔁 Retweet the first post:
bsky.app/profile/mann...
⭐️ Give our github repo a star github.com/MannLabs/scP...
❓ tell us what you are going to do with #scPortrait
Mann Lab
@mannlab.bsky.social
· Sep 24
15/
This work was a fantastic collaboration:
@mannlab.bsky.social
@fabiantheis.bsky.social
@v-hornung.bsky.social
A big shoutout to all of our co-authors: Alessandro Palma,
Altana Namsaraeva, Ali Oğuz Can, Varvara Varlamova, Mahima Arunkumar, @lukasheumos.bsky.social, @georgwa.bsky.social
This work was a fantastic collaboration:
@mannlab.bsky.social
@fabiantheis.bsky.social
@v-hornung.bsky.social
A big shoutout to all of our co-authors: Alessandro Palma,
Altana Namsaraeva, Ali Oğuz Can, Varvara Varlamova, Mahima Arunkumar, @lukasheumos.bsky.social, @georgwa.bsky.social
Mann Lab
@mannlab.bsky.social
· Sep 24
scPortrait integrates single-cell images into multimodal modeling
Machine learning increasingly uncovers rules of biology directly from data, enabled by large, standardized datasets. Microscopy images provide rich information on cellular architecture and are accessi...
doi.org
14/
Bottom line:
scPortrait turns microscopy images into a first-class modality for machine learning and multimodal foundation models, alongside RNA and proteomics 🔬💻
🔗 Preprint: doi.org/10.1101/2025...
🔗 GitHub: github.com/MannLabs/scP...
Bottom line:
scPortrait turns microscopy images into a first-class modality for machine learning and multimodal foundation models, alongside RNA and proteomics 🔬💻
🔗 Preprint: doi.org/10.1101/2025...
🔗 GitHub: github.com/MannLabs/scP...
Mann Lab
@mannlab.bsky.social
· Sep 24
13/
Our extensive documentation and tutorials make scPortrait easy to use and accessible.
And as part of @scverse.bsky.social it’s compatible with existing tools like scanpy, squidpy, bento-tools or Moscot 🚀🐍
mannlabs.github.io/scPortrait/i... #OpenSourceTools #Tutorial #CodeDocumentation
Our extensive documentation and tutorials make scPortrait easy to use and accessible.
And as part of @scverse.bsky.social it’s compatible with existing tools like scanpy, squidpy, bento-tools or Moscot 🚀🐍
mannlabs.github.io/scPortrait/i... #OpenSourceTools #Tutorial #CodeDocumentation