Mann Lab
@mannlab.bsky.social
The Mann Lab is a pioneer in mass spectrometry-based proteomics. Posts represent personal views from lab members and Matthias Mann
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Mann Lab
@mannlab.bsky.social
· Jul 1
🎉 Congratulations to Matthias Mann on 20 years leading Proteomics & Signal Transduction at MPI of Biochemistry! Two decades of groundbreaking mass spectrometry research and training excellent future scientists.
#MS #Proteomics #Science @mannlab.bsky.social
#MS #Proteomics #Science @mannlab.bsky.social
Thank you Matthias for your visionary leadership and for creating a scientific family that continues to push boundaries. Congratulations from all members, and looking forward to the future! #MS #Proteomics #20Years
Honored to be included in this reflection on 20 excellent years of MolSystBiol! From our first phosphotyrosine interactome in 2005 to proteome-wide networks - scale has grown exponentially. MS proteomics + AI is transforming systems-level understanding. Exciting times!
embopress.org/doi/pdf/10.1...
embopress.org/doi/pdf/10.1...
embopress.org
November 25, 2025 at 12:44 PM
Honored to be included in this reflection on 20 excellent years of MolSystBiol! From our first phosphotyrosine interactome in 2005 to proteome-wide networks - scale has grown exponentially. MS proteomics + AI is transforming systems-level understanding. Exciting times!
embopress.org/doi/pdf/10.1...
embopress.org/doi/pdf/10.1...
Great to see Brenda Schulman’s team post their new bioRxiv paper. MS-based proteomics helped uncover a beautifully simple mechanism: cysteine levels tune metabolism by flipping the inverse stability of LRRC58 and its substrate CDO1.
www.biorxiv.org/content/bior...
www.biorxiv.org/content/bior...
www.biorxiv.org
November 17, 2025 at 10:27 AM
Great to see Brenda Schulman’s team post their new bioRxiv paper. MS-based proteomics helped uncover a beautifully simple mechanism: cysteine levels tune metabolism by flipping the inverse stability of LRRC58 and its substrate CDO1.
www.biorxiv.org/content/bior...
www.biorxiv.org/content/bior...
Fantastic time at #HUPO2025 in Toronto! Congratulations to our talented Early Career researchers! Proud winners: Oeller Marc Oeller🥇 1st Place Poster, Kathrin Korff 🥈 Runner-up Poster, and @carolineweiss.bsky.social 🎤 3-Minute Thesis award! The future of #proteomics research is bright!
November 13, 2025 at 12:01 PM
Fantastic time at #HUPO2025 in Toronto! Congratulations to our talented Early Career researchers! Proud winners: Oeller Marc Oeller🥇 1st Place Poster, Kathrin Korff 🥈 Runner-up Poster, and @carolineweiss.bsky.social 🎤 3-Minute Thesis award! The future of #proteomics research is bright!
If you are at HUPO 2025, catch up with our team @mannlab.bsky.social to hear about our exciting work in single-cell proteomics, immunopeptidomics, spatial proteomics, and the latest advances in mass spectrometry technology!
November 7, 2025 at 1:20 PM
If you are at HUPO 2025, catch up with our team @mannlab.bsky.social to hear about our exciting work in single-cell proteomics, immunopeptidomics, spatial proteomics, and the latest advances in mass spectrometry technology!
In Nature Communications: MS-based proteomics + machine learning to diagnose Lyme neuroborreliosis with 92% accuracy (CSF) and 80% (blood) - paving the way for earlier, less invasive testing.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The diagnostic potential of proteomics and machine learning in Lyme neuroborreliosis - Nature Communications
Researchers incorporate mass spectrometry-based proteomics and machine learning to assess the potential of a less invasive diagnostic approach for Lyme neuroborreliosis, a common nervous system infect...
www.nature.com
October 31, 2025 at 1:06 PM
In Nature Communications: MS-based proteomics + machine learning to diagnose Lyme neuroborreliosis with 92% accuracy (CSF) and 80% (blood) - paving the way for earlier, less invasive testing.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Awesome talk by @erictopol.bsky.social at the Bavarian Academy of Sciences and Humanities (BAdW). A positive and hopeful take on #AI in medicine. Thanks for highlighting #DVP, too 😊
October 29, 2025 at 8:58 AM
Awesome talk by @erictopol.bsky.social at the Bavarian Academy of Sciences and Humanities (BAdW). A positive and hopeful take on #AI in medicine. Thanks for highlighting #DVP, too 😊
Excited to share AlphaDIA's publication in Nature Biotechnology!
Our open-source DIA framework brings deep learning directly to raw MS data with feature-free processing, transfer learning for any PTM, and performance matching top tools.
www.nature.com/articles/s41...
Our open-source DIA framework brings deep learning directly to raw MS data with feature-free processing, transfer learning for any PTM, and performance matching top tools.
www.nature.com/articles/s41...
AlphaDIA enables DIA transfer learning for feature-free proteomics - Nature Biotechnology
An open-source platform for data-independent acquisition proteomics adapts predicted libraries to experimental settings.
www.nature.com
October 22, 2025 at 1:36 PM
Excited to share AlphaDIA's publication in Nature Biotechnology!
Our open-source DIA framework brings deep learning directly to raw MS data with feature-free processing, transfer learning for any PTM, and performance matching top tools.
www.nature.com/articles/s41...
Our open-source DIA framework brings deep learning directly to raw MS data with feature-free processing, transfer learning for any PTM, and performance matching top tools.
www.nature.com/articles/s41...
How much hands-on lab expertise gets lost? We developed a multimodal AI agent that turns videos into protocols and detects procedural errors. Making science accessible. Great collaboration with #Google.
Preprint: www.biorxiv.org/content/10.1...
@patiskowronek.bsky.social explains👇
Preprint: www.biorxiv.org/content/10.1...
@patiskowronek.bsky.social explains👇
In labs, hands-on expertise is often lost because it's not written down. We leverage multimodal AI agents to capture & share expertise by analyzing video and speech to generate protocols, detect errors, and guide researchers. #AI #TeamMassSpec
📄 Preprint: doi.org/10.1101/2025... 1/🧵
📄 Preprint: doi.org/10.1101/2025... 1/🧵
Multimodal AI agents for capturing and sharing laboratory practice
We present a multimodal AI laboratory agent that captures and shares tacit experimental practice by linking written instructions with hands-on laboratory work through the analysis of video, speech, an...
doi.org
October 9, 2025 at 10:54 AM
How much hands-on lab expertise gets lost? We developed a multimodal AI agent that turns videos into protocols and detects procedural errors. Making science accessible. Great collaboration with #Google.
Preprint: www.biorxiv.org/content/10.1...
@patiskowronek.bsky.social explains👇
Preprint: www.biorxiv.org/content/10.1...
@patiskowronek.bsky.social explains👇
Our preprint on scPortrait is out! We built a framework + format to turn microscopy into standardized single-cell image datasets. #scPortrait scales >100M cells, integrates with @scverse.bsky.social, & enables cross-modality modeling from morphology to transcriptomics
doi.org/10.1101/2025...
doi.org/10.1101/2025...
scPortrait integrates single-cell images into multimodal modeling
Machine learning increasingly uncovers rules of biology directly from data, enabled by large, standardized datasets. Microscopy images provide rich information on cellular architecture and are accessi...
doi.org
September 24, 2025 at 12:22 PM
Our preprint on scPortrait is out! We built a framework + format to turn microscopy into standardized single-cell image datasets. #scPortrait scales >100M cells, integrates with @scverse.bsky.social, & enables cross-modality modeling from morphology to transcriptomics
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Congratulations on the inaugural of #AITHYRA, the new Biomedical AI institute in Vienna. Thank you for the invitation to speak at the symposium and the fascinating discussions on AI × proteomics. #AIforLifeScience
September 15, 2025 at 8:10 AM
Congratulations on the inaugural of #AITHYRA, the new Biomedical AI institute in Vienna. Thank you for the invitation to speak at the symposium and the fascinating discussions on AI × proteomics. #AIforLifeScience
Out in @cp-cellsystems.bsky.social: Deep Visual Proteomics shows xenotransplantation drives colon #organoids toward in-vivo-like proteomes supporting their use in regenerative medicine; culture tweaks can mimic this shift. With @kimbakjensen.bsky.social. Lead author Frederik Post explains below:
September 10, 2025 at 3:16 PM
Out in @cp-cellsystems.bsky.social: Deep Visual Proteomics shows xenotransplantation drives colon #organoids toward in-vivo-like proteomes supporting their use in regenerative medicine; culture tweaks can mimic this shift. With @kimbakjensen.bsky.social. Lead author Frederik Post explains below:
If you are interested in scientific software engineering or experimental work in the fields of spatial and multi-modal -omics, high throughput interaction proteomics, or mass instrumentation, apply until Oct 7th! @mannlab.bsky.social
www.biochem.mpg.de/mann
imprs-ml.mpg.de/How-to-Apply
www.biochem.mpg.de/mann
imprs-ml.mpg.de/How-to-Apply
How to Apply
Learn more about our application process
imprs-ml.mpg.de
September 1, 2025 at 12:09 PM
If you are interested in scientific software engineering or experimental work in the fields of spatial and multi-modal -omics, high throughput interaction proteomics, or mass instrumentation, apply until Oct 7th! @mannlab.bsky.social
www.biochem.mpg.de/mann
imprs-ml.mpg.de/How-to-Apply
www.biochem.mpg.de/mann
imprs-ml.mpg.de/How-to-Apply
Spatial proteomics & transcriptomics chart #ovariancancer evolution from fallopian tube precursors. Deep Visual Proteomics reveals early SUMOylation, TRIP13 epithelial driver, BGN therapeutic target & epithelial-stromal cooperation in progression.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Integration of cell-type resolved spatial proteomics and transcriptomics reveals novel mechanisms in early ovarian cancer
High-grade serous carcinoma (HGSC) is the most common ovarian cancer subtype, typically diagnosed at late stages with poor prognosis. Understanding early molecular events driving HGSC progression is c...
www.medrxiv.org
August 29, 2025 at 8:48 AM
Spatial proteomics & transcriptomics chart #ovariancancer evolution from fallopian tube precursors. Deep Visual Proteomics reveals early SUMOylation, TRIP13 epithelial driver, BGN therapeutic target & epithelial-stromal cooperation in progression.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Reposted by Mann Lab
Congratulations Maria Wahle on your #PhD🎉. We wish you every success in your future career.
@mannlab.bsky.social
@mariawahle.bsky.social
@imprs-ml.bsky.social
@mannlab.bsky.social
@mariawahle.bsky.social
@imprs-ml.bsky.social
August 27, 2025 at 3:38 PM
Congratulations Maria Wahle on your #PhD🎉. We wish you every success in your future career.
@mannlab.bsky.social
@mariawahle.bsky.social
@imprs-ml.bsky.social
@mannlab.bsky.social
@mariawahle.bsky.social
@imprs-ml.bsky.social
New preprint reveals why IDO1 inhibitor trials failed! Led by Peter Murray @mpibiochem.bsky.social our collaboration discovered IDO1 actually kills ovarian cancer cells via GCN2/ISR pathway - not protecting them. Spatial proteomics uncovers unexpected biology.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Spatial proteomics reveals mechanisms of cell-intrinsic tryptophan metabolism controlling ovarian cancer survival
Indole-2,3-dioxygenase (IDO1) depletes tryptophan to dampen anti‑tumor T cells, yet IDO1 inhibitors (IDO1i) have failed clinically. Using deep visual proteomics, we isolated IDO1 high, medium and low ...
www.biorxiv.org
August 20, 2025 at 5:15 AM
New preprint reveals why IDO1 inhibitor trials failed! Led by Peter Murray @mpibiochem.bsky.social our collaboration discovered IDO1 actually kills ovarian cancer cells via GCN2/ISR pathway - not protecting them. Spatial proteomics uncovers unexpected biology.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
If you are at the ASBMB Proteomics conference next week, do attend the session talks and lunch seminars
@abseabio.bsky.social, @evosep.bsky.social to know about the latest research developments in @mannlab.bsky.social
@abseabio.bsky.social, @evosep.bsky.social to know about the latest research developments in @mannlab.bsky.social
August 13, 2025 at 9:21 AM
If you are at the ASBMB Proteomics conference next week, do attend the session talks and lunch seminars
@abseabio.bsky.social, @evosep.bsky.social to know about the latest research developments in @mannlab.bsky.social
@abseabio.bsky.social, @evosep.bsky.social to know about the latest research developments in @mannlab.bsky.social
ICSB2025 in beautiful Dublin with Systems Biology for Health focus.
When: Oct 5-9!
Topics: Cancer, AI/ML, Drug Discovery, Digital Twins, Multi-omics & more
Abstract deadlines:
Oral: Aug 1
Poster: Sep 1
Register: icsb2025.com/registration/
#ICSB2025 #SystemsBiology #Dublin
When: Oct 5-9!
Topics: Cancer, AI/ML, Drug Discovery, Digital Twins, Multi-omics & more
Abstract deadlines:
Oral: Aug 1
Poster: Sep 1
Register: icsb2025.com/registration/
#ICSB2025 #SystemsBiology #Dublin
Register for ICSB 2025 | International Conference on Systems Biology | Dublin
You can now register for ICSB 2025. Join us at the 24th Annual International Conference on Systems Biology taking place in Dublin this October.
icsb2025.com
July 31, 2025 at 2:46 PM
ICSB2025 in beautiful Dublin with Systems Biology for Health focus.
When: Oct 5-9!
Topics: Cancer, AI/ML, Drug Discovery, Digital Twins, Multi-omics & more
Abstract deadlines:
Oral: Aug 1
Poster: Sep 1
Register: icsb2025.com/registration/
#ICSB2025 #SystemsBiology #Dublin
When: Oct 5-9!
Topics: Cancer, AI/ML, Drug Discovery, Digital Twins, Multi-omics & more
Abstract deadlines:
Oral: Aug 1
Poster: Sep 1
Register: icsb2025.com/registration/
#ICSB2025 #SystemsBiology #Dublin
Our collaboration with Ernst Lengyel and team is out in @Nature. The study shows that blocking NNMT reprograms cancer-associated fibroblasts & restores immune response against ovarian cancer. Happy to see that our earlier research contributed to this breakthrough. Congrats all!
🔥 Hot off the press: In a new @nature.com study, Ernst Lengyel, MD, PhD and team show that blocking NNMT in tumor-supporting cells restores immune response & stops ovarian cancer growth, offering a new strategy to treat one of the deadliest cancers. @lengyel-ovca-lab.bsky.social
ow.ly/zzfZ50Wu3UW
ow.ly/zzfZ50Wu3UW
July 24, 2025 at 8:32 AM
Our collaboration with Ernst Lengyel and team is out in @Nature. The study shows that blocking NNMT reprograms cancer-associated fibroblasts & restores immune response against ovarian cancer. Happy to see that our earlier research contributed to this breakthrough. Congrats all!
Apply today and be part of inspiring science! Deadline July 23rd! #Proteomics #Postdocs
Interested in translational, cutting-edge proteomics to redefine how we treat inflammatory skin diseases? The Nordmann-Lab, is looking for a postdoctoral fellow.
Ready to join?
❕apply until July 23
❕https://www.mpg.de/24950076/postdoctoral-position
#Postdoc #jobsinscience @tnordmann.bsky.social
Ready to join?
❕apply until July 23
❕https://www.mpg.de/24950076/postdoctoral-position
#Postdoc #jobsinscience @tnordmann.bsky.social
July 18, 2025 at 1:29 PM
Apply today and be part of inspiring science! Deadline July 23rd! #Proteomics #Postdocs
Thank you Matthias for your visionary leadership and for creating a scientific family that continues to push boundaries. Congratulations from all members, and looking forward to the future! #MS #Proteomics #20Years
🎉 Congratulations to Matthias Mann on 20 years leading Proteomics & Signal Transduction at MPI of Biochemistry! Two decades of groundbreaking mass spectrometry research and training excellent future scientists.
#MS #Proteomics #Science @mannlab.bsky.social
#MS #Proteomics #Science @mannlab.bsky.social
July 1, 2025 at 1:38 PM
Thank you Matthias for your visionary leadership and for creating a scientific family that continues to push boundaries. Congratulations from all members, and looking forward to the future! #MS #Proteomics #20Years
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression
Schweizer et al. profile the tumor progression from non-invasive serous borderline
tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating
cell-type resolved Deep Visual Prot...
www.cell.com
June 26, 2025 at 3:20 PM
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Congratulations!!
After many hours in the lab and tackling tricky research questions, it's now time to celebrate. 🥳 Congratulations on your PhD, Vincent @mannlab.bsky.social. We wish you every success in your future career.
June 25, 2025 at 2:47 PM
Congratulations!!
Don't forget to connect with our team members at #ASMS2025. Talks and poster line-up below 👇
Heading to #ASMS2025? Our team will be there showcasing our latest breakthroughs in mass spectrometry! Don't miss the chance to connect with our team members and discover the cutting-edge work we have been developing.
June 5, 2025 at 1:43 PM
Don't forget to connect with our team members at #ASMS2025. Talks and poster line-up below 👇
Don't forget to check out Marvin Thielert's poster 773 on single cell proteomics at #ASMS2025! #SingleCellProteomics
June 4, 2025 at 2:02 PM
Don't forget to check out Marvin Thielert's poster 773 on single cell proteomics at #ASMS2025! #SingleCellProteomics
Protein digestion in 200 nL on solid-phase tips: SPEC enables low-input proteomics—even with SDS/SDC at high levels. From FFPE and muscle to high throughput plasma. SPEC is a universal and Evosep-compatible protocol.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A Solid-Phase Extraction Capture (SPEC) workflow in nanoliter volumes for fast, robust and ultrasensitive proteomics
Despite great progress, sample preparation remains an area for improvement in proteomics, particularly for low-input samples where conventional protocols lead to losses and incomplete digestion. We pr...
www.biorxiv.org
June 4, 2025 at 6:08 AM
Protein digestion in 200 nL on solid-phase tips: SPEC enables low-input proteomics—even with SDS/SDC at high levels. From FFPE and muscle to high throughput plasma. SPEC is a universal and Evosep-compatible protocol.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...