As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.

Forgetting is a vital, active process that clears irrelevant memories and supports new learning. Using the model organism Caenorhabditis elegans, we investigated how dopamine, a key neurotransmitter,....

This channel provides clear demonstrations of core C. elegans lab skills, including: recognizing life stages and common phenotypes, picking and manipulating worms, and maintaining healthy cultures. De...

One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

Heterotrimeric G proteins transduce signals from G protein coupled receptors, which mediate key aspects of neuronal development and function. Mutations in the GNAI1 gene, which encodes Gi1, cause a di...

Circadian clock disruption and lack of sleep impair organismal health, but remedies remain elusive. Here, we used multi-omics, molecular and functional assays in C. elegans , human retinal cells and m...

Abstract. Since its inception as a model system, Caenorhabditis elegans has provided insight about the mechanism of action of drugs through genetic analyse

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A Bit About Us: We are Arcadia Science, an evolutionary biology company founded and led by scientists. Our mission is to turn natural innovations into real-world solutions by developing systematic, an...

Caenorhabditis elegans is a genetically tractable organism that has become one of the leading in vivo models for cilia research. Cilia are not require…

Summary: Functional residuomics maps how single amino acid changes shape protein function and cellular homeostasis, offering a new lens on structure–function relationships and disease.