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Reposted by Josh Leisring

NEJM.org @nejm.org · 2d

BaxHTN phase 3 trial: Aldosterone dysregulation is considered a key driver of hard-to-control hypertension. Research findings on baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in hard-to-control hypertension are summarized in a new Quick Take video. nej.md/3KCsQGJ

A visual representation of the BaxHTN phase 3 trial, which evaluated baxdrostat, a highly selective, potent aldosterone synthase inhibitor, in patients with hard-to-control hypertension.

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Josh Leisring @joshleisring.bsky.social · 15d

Donate and represent!
#NephJC

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Reposted by Josh Leisring

Tim Doulton @kentkidneydoc.bsky.social · 17d

Our @ukkidney.org guidelines here in BMC Nephrology. 💯% agree that in-unit BP should ONLY be used for determining safety of individual HD sessions and NOT long-term CV risk modification. But changing practice will be a long haul.

link.springer.com/epdf/10.1186...

Management of blood pressure in adults, children and young people on dialysis: UK kidney association clinical practice guideline

link.springer.com

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Reposted by Josh Leisring

John Giacona, PhD, PA-C @giaconajohn.bsky.social · 18d

Subclinical primary aldosteronism is an under-recognized driver of cardiovascular risk. Could it be a new target for CV prevention? Read our Circulation editorial —>

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Reposted by Josh Leisring

Cristina Popa @nephroseeker.medsky.social · 19d

#NephJC is a labor of a passionate volunteer team that believes education should be accessible, no matter where you are from in the world.

Even if editorial team donates unlimited hours of sleep, there are still costs to cover 💸 (👇 blog)

😊 Be kind, help us to #NephItForward

#Medsky #Nephsky

Nephrology Journal Club @nephjc.bsky.social · 26d

It's that time of year again 🍂🍂🍂
The #NephJC Fall pledge drive.
Plese give if you are able to support our decades long mission of #FOAMed for all. #NephSky #MedSky
www.nephjc.com/news/2025/9/22/nephjc-fall-pledge-drive

NephJC 2025 Fall Pledge Drive — NephJC

Help keep NephJC a vital, original, and unbiased source of medical education.

www.nephjc.com

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Reposted by Josh Leisring

Vivek Bhalla, MD, FASN, FAHA @bhallaresearch.bsky.social · 23d

We are thrilled to announce that we have generously received funding for a one-year hypertension fellowship, and we are recruiting now for a candidate to start fellowship July 1, 2026 .
med.stanford.edu/hypertension/e…

-Jehan Zahid Bahrainwala
HTN Fellowship Program Director

https://med.stanford.edu/hypertension/e…

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Reposted by Josh Leisring

Nephrology Journal Club @nephjc.bsky.social · 26d

It's that time of year again 🍂🍂🍂
The #NephJC Fall pledge drive.
Plese give if you are able to support our decades long mission of #FOAMed for all. #NephSky #MedSky
www.nephjc.com/news/2025/9/22/nephjc-fall-pledge-drive

NephJC 2025 Fall Pledge Drive — NephJC

Help keep NephJC a vital, original, and unbiased source of medical education.

www.nephjc.com

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Reposted by Josh Leisring

Rémi Goupil @goupilremi.bsky.social · 25d

🚨 Survey Alert!
Standardized office BP measurements are recommended everywhere, but still underused.
We want to hear from you: what are the barriers to using them as a routine in clinical practice?

Click here to read the consent form and take the survey:
redcap.link/barriers.to....

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Reposted by Josh Leisring

Soumya Rangarajan, MD, MPP @soumya-goblue.medsky.social · 28d

My guess is at least 500 #doctors at my #hospital are on H1B visas including at least a few dozen #hospitalists, and if we lose even a handful to other countries our house of cards #healthcare system will fall apart, let alone all 500+

🦋Dr. Natalia🕊🌻🪬 @solnatamd.medsky.social · 28d

Hmmmm. So, 25% of the US doctors are foreign-trained, and most of them at some point of their career require H1B visa. I don't know how many doctors with active licenses require H1B visa currently, but this is really stupid 👇🏻

Trump to impose new $100,000 fee for H-1B visas in sweeping overhaul: Report - The Economic Times

Donald Trump plans significant H-1B visa changes. A $100,000 fee may be imposed on applications. The administration believes the visa program hurts American workers. Entry under the H-1B system will b...

m.economictimes.com

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Reposted by Josh Leisring

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 28d

Some of my opinions here on @ajkd.bsky.social Blog; ajkdblog.org/2022/01/19/b...

The @ahascience.bsky.social also has a scientific statement here from 2023 www.ahajournals.org/doi/full/10....

#NephJC Catch up

Blood Pressure Measurement in Dialysis: There’s No Place Like Home (Part 1)

This is a 2-part blog post by #NephJC cofounder, hypertension guru, and longtime AJKD contributor Swapnil Hiremath. In Part 1, he outlines the quandaries of blood pressure management in hemodialysi…

ajkdblog.org

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Josh Leisring @joshleisring.bsky.social · Sep 18

At our center we do the initial screen without altering the existing meds. Don’t wanna miss the opportunity. Patients with the most overt PA have suppressed renin even on RAASi+thiazide. If results aren’t conclusive and suspicion still there can then washout or try empiric MRA. #NephJC

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Josh Leisring @joshleisring.bsky.social · Sep 18

Reposting this again - very relevant for #NephJC discussion on the new AHA/ACC guidelines.

Anand Vaidya @anandvaidya17.bsky.social · Sep 7

To accompany the new ACC/AHA BP guidelines, a practical guide on how to test for Primary Aldosteronism: now recommended for most people with hypertension.

www.jacc.org/doi/10.1016/...

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Josh Leisring @joshleisring.bsky.social · Sep 18

Agree, screening seems like the most effective avenue to improve treatment rates on a broad scale.

Also, screening and making the diagnosis of PA in an individual patient allows tailored treatment including follow-up on plasma renin to help guide dose titration to get full benefit of MRA

#NephJC

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Reposted by Josh Leisring

Nephrology Journal Club @nephjc.bsky.social · Sep 16

❤️Check out the VA for the discussion on the AHA/ACC Hypertension Guidelines 9/16/25 at 9pm EST by @sejalplakhani.bsky.social #NephJC #NephSky #MedSky
www.nephjc.com/news/2025/9/ahaacc-htnguide

The AHA/ACC 2025 Hypertension Guidelines visual abstract — NephJC

New updated guidance on hypertension including screening for secondary causes, use of renal denervation, hypertension and pregnancy, risk assessment, monitoring and treatment. Check out this wonderfu...

www.nephjc.com

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Reposted by Josh Leisring

Anand Vaidya @anandvaidya17.bsky.social · Sep 7

To accompany the new ACC/AHA BP guidelines, a practical guide on how to test for Primary Aldosteronism: now recommended for most people with hypertension.

www.jacc.org/doi/10.1016/...

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Reposted by Josh Leisring

Anand Vaidya @anandvaidya17.bsky.social · Sep 7

Confirmatory testing (aldosterone suppression testing) for primary aldosteronism: not reliable, or reproducible, for diagnosis or predicting lateralization. Sensitivity at the expense of specificity, and vice-versa. Time to simplify the process

academic.oup.com/ejendo/artic...

Discordance and shortcomings of aldosterone suppression tests in primary aldosteronism

AbstractBackground. The saline suppression test (SST) and the captopril challenge test (CCT) have traditionally been used to confirm or exclude primary ald

academic.oup.com

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Reposted by Josh Leisring

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Sep 1

Excellent summary of the ACHIEVE trial from @drsaivani.bsky.social & @thekidneywhisperer.bsky.social

#NephJC chat tomorrow

www.nephjc.com/news/achieve

In ESRD is spironolactone an overACHIEVEr? — NephJC

This week, we will discuss the ACHIEVE trial. Will spironolactone achieve CV benefits in ESRD?

www.nephjc.com

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Reposted by Josh Leisring

American Journal of Hypertension @amjhypertension.bsky.social · Aug 31

#WeekendReads from #EditorsChoice

Can you have normal looking adrenal glands with primary aldosteronism?

🔗 academic.oup.com/ajh/article/... 🔓

Morphologically Normal-Appearing Adrenal Glands as a Prevalent Source of Aldosterone Production in Primary Aldosteronism

AbstractBackground. Normal-appearing adrenal glands on cross-sectional imaging may still be the source of aldosterone production in primary aldosteronism (

academic.oup.com

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Reposted by Josh Leisring

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Aug 30

The era of ASIs is slowly dawning

www.nejm.org/doi/full/10....

(Yeah spironolactone is just as good and cheaper)

Disclosure: we recruited patients for this one

Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension | NEJM

Aldosterone dysregulation plays an important pathogenic role in hard-to-control hypertension. In several studies, baxdrostat, an aldosterone synthase inhibitor, reduced the seated systolic blood pr...

www.nejm.org

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Reposted by Josh Leisring

John Giacona, PhD, PA-C @giaconajohn.bsky.social · Aug 28

❓What’s new in BP care?
🎥 Watch the #TargetBP webinar on the 2025 @AHAScience / @ACCinTouch Hypertension Guidelines w/ @drwanpen.bsky.social , @jordybc.bsky.social , Keith Ferdinand, & Dan Jones 👉 targetbp.org

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Josh Leisring @joshleisring.bsky.social · Aug 21

This is excellent! Multiple nice learning points all in one well-written case report.

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Reposted by Josh Leisring

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Aug 20

The CPC from last @ahascience.bsky.social #HypertensionSessions now published in @ahajournals.bsky.social

www.ahajournals.org/doi/10.1161/...

thanks to @drjmluther.bsky.social and all the education editors for the invite

We hope it makes for an educational read!

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Reposted by Josh Leisring

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Aug 18

More on Hydra-ANCA-zine

Four cases, and review of previous (~ 169) cases reported in the literature

academic.oup.com/ckj/article-... in @ckj-era.bsky.social

#NephSky #Hydralazine

Hydralazine-induced antineutrophil cytoplasmic antibody-associated glomerulonephritis

Antineutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) can lead to multi-organ failure and death [1, 2]. As an antihypertensive medica

academic.oup.com

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Josh Leisring @joshleisring.bsky.social · Aug 15

Implementing will be a challenge but that shouldn't discourage broader screening.

From the recent Endo Society guideline - the majority of these newly detected cases can be managed with MRA.

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Josh Leisring @joshleisring.bsky.social · Aug 15

Commentary on expanded screening for primary aldosteronism in the new HTN guideline.

www.ahajournals.org/doi/10.1161/... 🔓

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