James Lloyd 🧬
@jamespblloyd.bsky.social
2.1K followers 1.8K following 300 posts
Synthetic AstroBotatnist. Engineer of synthetic gene circuits in plants. 🇬🇧🇪🇺 now in 🇦🇺. He/They. Google Scholar: http://shorturl.at/dnHVZ Compbio blog: badgrammargoodsyntax.com
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jamespblloyd.bsky.social
I am super excited to announce the first (brief) pre-print purely from my group:

Start right to end right: authentic open reading frame selection matters

www.biorxiv.org/content/10.1...

This marks a return to NMD research for me. NMD detects early stop codons but we need to find the true stop!
Boromir Meme: One does not simply select the longest ORF
Reposted by James Lloyd 🧬
theplantcell.bsky.social
BREAKTHROUGH REPORT: Structural insights into plant DNA CG methylation maintenance by MET1 (Zhihui Zhang, Wentao Li, Yue Liu, Cheng Chi, Jing Nan, Changshi Wang, Yongkun Zhu, Jun Zhao, Yan Xue, Yong Li, Peiyi Wang, Jixian Zhai, Jiamu Du) doi.org/10.1093/plce... #PlantScience
Structural insights into plant DNA CG methylation maintenance by MET1
Structural studies on the plant CG maintenance DNA methyltransferase MET1 reveal insights into the molecular basis of its autoinhibition regulation and the
doi.org
Reposted by James Lloyd 🧬
djgibbs.bsky.social
We are advertising a PhD project investigating a cellular mechanism that ensures protein quality control during mRNA translation in plants. Please get in touch on here or via email if you are interested and I can provide further details!

Lab website: sites.google.com/site/danielg...
Daniel Gibbs Lab
Welcome to the lab website of Professor Daniel Gibbs @ University of Birmingham
sites.google.com
jamespblloyd.bsky.social
I’m curious which heat shock promoter you used? I used HSP18.2 for the Arabidopsis memory circuit work with FLP recombinase.
Reposted by James Lloyd 🧬
nickdesnoyer.bsky.social
Heat-shock inducible CRE-LOX of RUBY making cool sectors in my primary transformants (though a bit leaky) 🌱🧬
Reposted by James Lloyd 🧬
biorxiv-plants.bsky.social
Primary metabolism underpins the execution of immune responses in different tissues of the same plant https://www.biorxiv.org/content/10.1101/2025.10.11.681807v1
Reposted by James Lloyd 🧬
pdchristine.bsky.social
New pre-print from the team!

The manuscript is @emma-raven.bsky.social's PhD work showing that whether a leaf is a carbon sink or a carbon source influences how they execute immune responses.

Have a read!

#PlantScience
@johninnescentre.bsky.social
biorxiv-plants.bsky.social
Primary metabolism underpins the execution of immune responses in different tissues of the same plant https://www.biorxiv.org/content/10.1101/2025.10.11.681807v1
jamespblloyd.bsky.social
I am over explaining to people that DNA synthesis is not solved. It is still a huge problem.
Reposted by James Lloyd 🧬
atinygreencell.bsky.social
"DNA synthesis is solved"
"We can just print any sequence"
"Biology and biotech are solved fields"
"Sequence-agnostic synthesis is on the horizon"

*plant introns enter the chat*

Humbug.
Reposted by James Lloyd 🧬
engbioirc.bsky.social
A week to go... #EngBio ECRs Meetup returns on 20 Oct. Join us to hear great talks from Konstantina Beritza and
Caroline Faessler 🌱 Don't miss it!
@camplantsci.bsky.social

Sign up here👉 www.tickettailor.com/events/engin...

#plantsciences #marinemicroalga #Nicotianabenthamiana
jamespblloyd.bsky.social
Oh interesting, is this in humans (I’m a plant person).

Does the Kozak sequence encourage cytosolic presence despite a signal peptide?

This might be useful for colleagues trying to get chloroplast only expression, thanks.
Reposted by James Lloyd 🧬
lucygdornan.bsky.social
After many years of hm-ing and haw-ing about why some of the fusion proteins I’ve cloned showed cytoplasmic background I’ve finally found the culprit
Reposted by James Lloyd 🧬
slcuplants.bsky.social
Salicylic acid biosensor, SalicS1, tracks the plant immune hormone salicylic acid in real time - revealing propagation of hormone surge during plant pathogen advance

Latest biosensor from @xanderjones.bsky.social team
In Science doi.org/10.1126/scie...
Summary www.slcu.cam.ac.uk/news/new-bio...
Reposted by James Lloyd 🧬
ekaiserli.bsky.social
Marie Skłodowska-Curie PhD position in our lab @uofglasgow.bsky.social on Enhancing Climate-Resilient Crops by Innovative Priming Strategies. A network led by @goetheuni.bsky.social
cordis.europa.eu/project/id/101227217
International applicants are eligible. Application form:
pollenbiology.cz/page-2
Reposted by James Lloyd 🧬
alexdemendoza.bsky.social
Thrilled to share that the lab has been awarded a @wellcometrust.bsky.social Discovery Award to keep exploring the evolution of 6-methyladenine #6mA in Eukaryotes. We'll open postdoc (3️⃣) and tech (1️⃣) positions to start in 2026, please share with candidates or reach out if you’d like to join us.
Reposted by James Lloyd 🧬
plantevolution.bsky.social
Game changer for cell-based plant genetics: the labs of Caixia Gao & Jin-Long Qiu have developed very efficient self-replicating vectors and they just published a very nice proof-of-concept paper.
#plantscience
www.science.org/doi/10.1126/...
Reposted by James Lloyd 🧬
plantteaching.bsky.social
#NBIAST2025
Designer flowers for art and education
@nickdesnoyer.bsky.social
Combining art, design, and science.
Nick Desnoyer presenting his talk on art and flowers
jamespblloyd.bsky.social
Is it just me, or is it a little odd that OpenAI is encouraging deep fakes of people on social media (see example).

youtube.com/shorts/gTcdv...
🤖 Sora AI slop
YouTube video by 3reate Podcast
youtube.com