Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...

The third large earthquake to strike between South America and Antarctica this year

Non-steroidal anti-inflammatory drugs (NSAIDs) are known to alleviate pain by reducing inflammation. To the contrary, here, the authors show that selective inhibition of the prostaglandin E2 receptor (EP2) in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation.

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Global network could pinpoint astronomical sources

The blast fungus Magnaporthe oryzae infects plants using a specialised infection structure called an appressorium that generates physical force to break the rice leaf cuticle. Appressorium development...

Understanding host-range determinants in temperate bacteriophages is critical for elucidating phage-host co-evolution and advancing phage therapies.We analysed 3,900 Klebsiella genomes from diverse ec...

The Casselman-Wallach theorem is a foundational result in the theory of representations of real reductive groups connecting algebraic representations to topological representations. We provide a quant...

In this short note, we give a method for computing a non-torsion point of smallest canonical height on a given elliptic curve $E/\mathbb{Q}$ over all number fields of a fixed degree. We then describe ...

We extend work of Voight and the second author to compute the log canonical ring of a wild stacky curve over a field of characteristic $p > 0$, which allows us to compute rings of mod $p$ modular form...

We compute Fourier transforms of functions expressed as a ratio of one of the Jacobi elliptic functions divided by $\sinh(πx)$ or $\cosh(πx)$. In many cases, the resulting Fourier transform remains wi...

An explicit understanding of the (category of all smooth, complex) representations of p-adic groups provides an important tool not just within representation theory. It also has applications to number...

Centrioles are evolutionarily conserved barrel-shaped organelles playing crucial roles in cell division and ciliogenesis. These functions are underpinned by specific structural sub-elements whose functions have been under investigation since many years. The A-C linker structure, connecting adjacent microtubule triplets in the proximal region, has remained unexplored due to its unknown composition. Here, using ultrastructure expansion microscopy, we characterized two recently identified A-C linker proteins, CCDC77 and WDR67, and discovered MIIP as an additional A-C linker protein. Our findings reveal that these proteins localize between microtubule triplets at the A-C linker, forming a complex. Depletion of A-C linker components disrupt microtubule triplet cohesion, leading to breakage at the proximal end. Co-removal of the A-C linker and the inner scaffold demonstrates their joint role in maintaining centriole architecture. Moreover, we uncover an unexpected function of the A-C li