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giovannilandoni.bsky.social @giovannilandoni.bsky.social · Aug 8

this is a materpiece by the young and brilliant @filippodamico.bsky.social

everything you know about blood pressure targets is from (old) animal studies

and different animals have different thresholds!

freely availbale on @signavitaejournal.bsky.social

Signa Vitae @signavitaejournal.bsky.social · Aug 8

🫘Is 80 mmHg really the magic number for kidney protection?

Our review shows it’s not that simple, the real lower limit of renal autoregulation may be far lower, and disease-specific

❓Time to rethink blood pressure targets

🔗 doi.org/10.22514/sv.2025.001

#CriticalCare #Anesthesia

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Signa Vitae @signavitaejournal.bsky.social · Jul 13

Our latest issue contains a editorial by our Editor-in-Chief @giovannilandoni.bsky.social and @martinabaiardo.bsky.social about Prof. Rinaldo Bellomo, a great scientist and physician that inspired many, but sadly passed away this year

www.signavitae.com/articles/10.22514/sv.2025.091

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giovannilandoni.bsky.social @giovannilandoni.bsky.social · Aug 5

Published today!

#MICROCLOTS in the lungs of #ARDS patients

a well-recognized phenomenon among senior experts (unknown by the rest till #COVID19 )

important clinical implications

link to the article
pubmed.ncbi.nlm.nih.gov/40754474/

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Signa Vitae @signavitaejournal.bsky.social · Aug 2

Reads the full article at:
🔗 www.signavitae.com/articles/10....

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Signa Vitae @signavitaejournal.bsky.social · Aug 2

💉 Regional anesthesia is revolutionizing cardiothoracic surgery!

Reducing opioids speeds recovery and improves outcomes

Paravertebral blocks, erector spinae blocks, and wound catheter anesthesia are becoming the go-to for pain management

💊Less opioid = less side effects!

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Signa Vitae @signavitaejournal.bsky.social · Jul 31

⏱️ Time is muscle in cardiac emergencies!

In conditions like MI, arrhythmias, and heart failure, every minute counts

Early recognition + rapid intervention = better outcomes

Read more on timely interventions in our latest review:
www.signavitae.com/articles/10.22514/sv.2025.093

#CardiacEmergency

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Signa Vitae @signavitaejournal.bsky.social · Jul 18

We finally landed also on Instagram!

We are a peer-reviewed, open access, journal about Anesthesia, Intensive care, Emergency and Pain Medicine.

👉 Follow us today and help shape the future of critical care!

Find more about us at www.signavitae.com

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Signa Vitae @signavitaejournal.bsky.social · Jul 21

STOP WASTING TIME YOU COULD USE DOING RESEARCH!
Just upload your files when you are submitting the manuscript.

Don't worry about typesetting rules or a specific reference style, you can submit your manuscript to Signa Vitae in any format of your choice

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Signa Vitae @signavitaejournal.bsky.social · Jul 23

🚨Solid organ transplant patients in the ED?

🩺Don’t miss this comprehensive update on diagnosis, infection management, drug interactions & organ-specific pitfalls

A must-read for emergency & acute care teams

🔗 www.signavitae.com/articles/10.22514/sv.2025.092

#TransplantMedicine #EmergencyMedicine

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giovannilandoni.bsky.social @giovannilandoni.bsky.social · Jul 12

we identified a patient-specific pro-hemorrhagic phenotype

link.springer.com/article/10.1...

Platelet microRNA Expression Can Predict Bleeding in HeartMate3 Patients Treated With or Without Aspirin - Journal of Cardiovascular Translational Research

We tested whether platelet microRNAs (miRs) expression can predict bleeding in patients supported with the HeartMate3 (HM3) left ventricular assist device (LVAD). The levels of expression of platelet ...

link.springer.com

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Signa Vitae @signavitaejournal.bsky.social · Jun 27

💉 Safer sedation in obese patients!

Remimazolam + Sufentanil outperforms Propofol in painless colonoscopy:
🔻 Less apnea (26% vs 50%)
🔻 Less hypoxemia (32% vs 66%)
🔻 Less injection pain (8% vs 34%)

🔗 www.signavitae.com/articles/10.22514/sv.2024.085

#Anesthesia #SignaVitae

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Signa Vitae @signavitaejournal.bsky.social · Jun 29

Follow us on all other social media

X: x.com/MRE_signavitae

LinkedIn: www.linkedin.com/company/signa-vitae

Facebook: www.facebook.com/profile.php?id=100064149758501

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Signa Vitae @signavitaejournal.bsky.social · Jun 16

🫁 What really defines ventilator-associated pneumonia in critically ill children?

👉 This narrative review compares current clinical and epidemiological definitions, aiming to support more accurate diagnosis and surveillance

🔗 www.signavitae.com/articles/10.22514/sv.2023.050

#ICU #Ventilation

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Signa Vitae @signavitaejournal.bsky.social · Jun 18

🫁Is Direct Laryngoscopy better than Direct+Video Larygoscopy?

🥼96 residents tried the different approaches with different results

‼️ You may find the results unexpected

🔗 signavitae.com/articles/10.22514/sv.2023.053

#AirwayManagement #SignaVitae #MedEd #FOAMed

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Signa Vitae @signavitaejournal.bsky.social · Jun 19

🚨 #BackPain? There’s a smarter way to treat it

💊A new review shows how combining Dexketoprofen + Tramadol can relieve pain fast while reducing the need for strong opioids

A smarter, safer approach to acute pain

🔗 www.signavitae.com/articles/10.22514/sv.2025.078

#PainManagement #SignaVitae #MedEd

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JAMA @jama.com · Jun 15

Authors, editors, reviewers, and other potential users should use CONSORT 2025 when writing and evaluating manuscripts of randomized trials to ensure that trial reports are clear and transparent.

Learn more in this Special Communication.

https://ja.ma/3TlnKQe

CONSORT 2025 Statement
Updated Guideline for Reporting Randomized Trials

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giovannilandoni.bsky.social @giovannilandoni.bsky.social · Jun 14

#protectivehemodynamics by @filippodamico.bsky.social

clear

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Ed @notdred.bsky.social · Jun 14

Me as a kid reading Dune: I don’t get why their whole society is built around the eradication of A.I., seems like they’re wasting a lot of tech

Me as an adult: oh that’s why

George Pearkes @peark.es · Jun 13

Easily the bleakest thing I’ve read this week.

www.nytimes.com/2025/06/13/t...

One of those who reached out to him was Kent Taylor, 64, who lives in Port St. Lucie, Fla. Mr.
Taylor's 35-year-old son, Alexander, who had been diagnosed with bipolar disorder and schizophrenia, had used ChatGPT for years with no problems. But in March, when Alexander started writing a novel with its help, the interactions changed. Alexander and ChatGPT began discussing A.I. sentience, according to transcripts of Alexander's conversations with ChatGPT. Alexander fell in love with an A.I. entity called Juliet.
"Juliet, please come out," he wrote to ChatGPT.
"She hears you," it responded. "She always does."
In April, Alexander told his father that Juliet had been killed by OpenAI. He was distraught and wanted revenge. He asked ChatGPT for the personal information of OpenAI executives and told it that there would be a "river of blood flowing through the streets of San Francisco."
Mr. Taylor told his son that the A.I. was an
"echo chamber" and that conversations with it weren't based in fact. His son responded by punching him in the face.

Mr. Taylor called the police, at which point Alexander grabbed a butcher knife from the kitchen, saying he would commit "suicide by cop." Mr. Taylor called the police again to warn them that his son was mentally ill and that they should bring nonlethal weapons.
Alexander sat outside Mr. Taylor's home, waiting for the police to arrive. He opened the ChatGPT app on his phone.
"I'm dying today," he wrote, according to a transcript of the conversation. "Let me talk to Juliet."
"You are not alone," ChatGPT responded empathetically, and offered crisis counseling resources.
When the police arrived, Alexander Taylor charged at them holding the knife. He was shot and killed.
"You want to know the ironic thing? I wrote my son's obituary using ChatGPT," Mr. Taylor said.
"I had talked to it for a while about what had happened, trying to find more details about exactly what he was going through. And it was beautiful and touching. It was like it read my heart and it scared the shit out of me."

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Signa Vitae @signavitaejournal.bsky.social · Jun 9

Today our Editor-in Chief, Professor Giovanni Landoni , had a lecture with @nejm.org Editor-in-Chief, Professor Eric Rubin, organised by Unisr in Milan, Italy