Author | Lightnews

Chris Kotanidis @cpkotanidis.bsky.social · Sep 10

#GLP1s have transformed #obesity care, but can they compete with surgery? #AMichaelLincoff & #ScottShikora argue the pros and cons of #semaglutide vs #bariatricsurgery for a man with obesity in our @nejm.org Clinical Decisions www.nejm.org/doi/full/10....

Managing Obesity | NEJM

This feature about a man with obesity offers a case vignette accompanied by two essays, one supporting initiation of semaglutide therapy and the other recommending bariatric and metabolic surgery.

www.nejm.org

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Reposted by Chris Kotanidis

Radcliffe Department of Medicine @rdm.ox.ac.uk · Sep 8

Congratulations to Dr Christos Kotanidis who has been awarded the 2025 ESC Young Investigator Award in Preventative Cardiology at the European Society of Cardiology Congress in Madrid.

Read more 👇

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Christos Kotanidis wins ESC Young Investigator Award 2025 in Preventive Cardiology

Congratulations to Dr Christos Kotanidis, NIHR-funded Academic Clinical Lecturer in Cardiology, who has been awarded the 2025 ESC Young Investigator Award in Preventive Cardiology at the European Soci...

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Chris Kotanidis @cpkotanidis.bsky.social · Sep 8

www.rdm.ox.ac.uk/news/christo...

Christos Kotanidis wins ESC Young Investigator Award 2025 in Preventive Cardiology

Congratulations to Dr Christos Kotanidis, NIHR-funded Academic Clinical Lecturer in Cardiology, who has been awarded the 2025 ESC Young Investigator Award in Preventive Cardiology at the European Soci...

www.rdm.ox.ac.uk

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Reposted by Chris Kotanidis

Peer Review Congress #PRC10 @peerreviewcongress.bsky.social · Sep 5

#ZakKohane on #AI in #PeerReview: the surge in scientific publication is straining the conventional review system beyond capacity. @ai.nejm.org piloting AI-augmented fast track review: manuscripts w high prior of being good gets assigned to #GPT5 + a human, disposition reviewed by editorial team!

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Reposted by Chris Kotanidis

Peer Review Congress #PRC10 @peerreviewcongress.bsky.social · Sep 4

Comparing submitted vs published RCT abstracts eval'd at @nejm.org in 4 domains (design, outcome, AEs, conclusions). published abstracts improved in a mean 0.9 domains. More improvements observed in leading gen med vs 433 other journals (72 % vs 48%) www.acpjournals.org/...
@cpkotanidis.bsky.social

Our comparisons of submitted and published abstracts suggest that peer review and editorial processes result in substantial revision of research reports. The findings reinforce the importance of editorial oversight in scientific publishing, highlighting its role in refining study design communication, reporting of outcomes, and overall clarity in research dissemination.

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Reposted by Chris Kotanidis

Sarah Gorey @sarahgorey.bsky.social · Sep 4

Well done @cpkotanidis.bsky.social ! Also check out our manuscript in @annalsofim.bsky.social url.us.m.mimecastprotect.com/s/kNYpCDkAO2...

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Chris Kotanidis @cpkotanidis.bsky.social · Aug 29

Excited to present our work tomorrow on a novel #AI #metabolomics score to predict #cardiovascular risk in #psoriasis at the #ESCCongress #WCCardio 2025 Young Investigator Award session in Preventive Cardiology. #PreventiveCardiology #CardioRheumatology #YIA

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Reposted by Chris Kotanidis

NEJM.org @nejm.org · Aug 29

Four Original Articles were simultaneously published in NEJM and presented earlier today at this year’s #ESCCongress in Spain.

@escardio.bsky.social

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Reposted by Chris Kotanidis

Eric Topol @erictopol.bsky.social · Aug 29

The #1 cause of death in women is heart disease. A new report makes the case for treating women with statins who have a high inflammation marker (hs-CRP) but no traditional risk factors academic.oup.com/eurheartj/ad...

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Reposted by Chris Kotanidis

European Society of Cardiology @escardio.bsky.social · Aug 29

🎥 Snackable Science from #ESCCongress 2025 in Madrid!

Roxana Mehran & Michael Gibson break down the new Focus Update of the 2019 #ESCGuidelines on #dyslipidaemias with the latest recommendations you need to know 👇

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Reposted by Chris Kotanidis

NEJM.org @nejm.org · Aug 15

For a man with #obesity, would you recommend the initiation of semaglutide therapy or bariatric and metabolic surgery? Read the case vignette and essays on both treatment options and cast your vote: nej.md/3HiAnJz

#MedSky #EndoSky

Clinical Decisions
Managing Obesity
Christos P. Kotanidis, M.D., D.Phil., A. Michael Lincoff, M.D., and Scott A. Shikora, M.D.

An illustration of the man walking his dog

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Chris Kotanidis @cpkotanidis.bsky.social · Jul 31

evidence.nejm.org/doi/full/10....

How Win Ratios Work

This Stats, STAT! animated video explores the use of win ratios in clinical trials — a method that allows investigators to analyze a composite hierarchy of outcomes.

evidence.nejm.org

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Chris Kotanidis @cpkotanidis.bsky.social · Jul 31

The win ratio method is gaining traction in #RCTs. Is it just a trend or a smarter way to look at composite hierarchical outcomes? We break it down in our latest Stats, STAT!📊 in NEJM Evidence. youtube.com/watch?v=jKtF... #stats @nejm.org @sarahgorey.bsky.social @chardin.bsky.social @ai.nejm.org

How Win Ratios Work | NEJM Evidence

YouTube video by NEJM Group

youtube.com

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CORE IM @coreimpodcast.bsky.social · Jun 25

1/ 🚨 NEW #BeyondJournalClub w/ @nejm.org: REDUCE-AMI

What is the long term benefit of beta blockers in patients with preserved EF following an MI?

🖥️: www.coreimpodcast.com/2025/06/25/b...

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Reposted by Chris Kotanidis

JAMA Internal Medicine @jamainternalmed.com · Jun 24

In older patients with acute coronary syndrome, an early invasive strategy did not reduce all-cause mortality but decreased recurrent myocardial infarction and repeated revascularization. https://ja.ma/40hDK9G

Early Invasive or Conservative Strategies for Older Patients With Acute Coronary Syndromes

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Reposted by Chris Kotanidis

NEJM.org @nejm.org · Jun 13

What is it like to be an NEJM editorial fellow for a year? This year’s fellows discuss what they have learned, how their experience will help their career, and what surprised them. Apply for the 2026–27 NEJM editorial fellowship by August 1. Learn more: nej.md/3cCQajB

#MedSky #MedEd

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Reposted by Chris Kotanidis

NEJM.org @nejm.org · Jun 14

60-Second Journal Club: The SUMMIT trial examined cardiovascular outcomes of treatment with tirzepatide in patients with heart failure with preserved ejection fraction and obesity. Read the full trial results: nej.md/4hRGaTY

#MedSky #CardioSky @cpkotanidis.bsky.social‬

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Reposted by Chris Kotanidis

NEJM.org @nejm.org · Jun 9

A 73-year-old woman presented with severe chest pain. She had undergone multivessel percutaneous coronary intervention 2.5 years earlier. Angiography revealed a large thrombus in an LAD artery stent (shown in videos). Read the full case details: nej.md/4jC2aSa

#MedSky #CardioSky

Aspiration Thrombectomy for Coronary Stent Thrombosis

Panel A: Coronary angiography revealing a large thrombus in the LAD artery stent.
Panel B: The thrombus that was removed with the use of an aspiration catheter.
Panel C: The stent that was dilated with a balloon at high pressure, which resulted in improved flow.

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Reposted by Chris Kotanidis

Sarah Gorey @sarahgorey.bsky.social · May 6

Really enjoying @cpkotanidis.bsky.social’s fascinating presentation on his interesting work at @brighamandwomens.bsky.social on identifying risk markers of CVD in patients with IMIDs 🤩👏👏👏

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Chris Kotanidis @cpkotanidis.bsky.social · Apr 22

New research alert: Our latest report highlights a significant reduction in coronary #inflammation and residual inflammatory risk as captured by #CCTA imaging using CaRi-Heart AI in women with #BreastCancer 2 years post-RT
#AI #CardioOncology #CardioEd #EHJ
@escardio.bsky.social

Coronary inflammation and cardiovascular risk in breast cancer after radiotherapy

Radiotherapy (RT) is known to reduce the rate of disease recurrence following breast-conserving surgery in patients with breast cancer, but also entails ir

academic.oup.com

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Reposted by Chris Kotanidis

NEJM.org @nejm.org · Mar 30

Presented at #ACC25:

In the PROTECT-TAVI trial, the routine use of cerebral embolic protection during TAVI did not reduce the incidence of stroke within 72 hours or before discharge from the hospital (if discharge occurred sooner). Full trial results: nej.md/41RONXi

@accintouch.bsky.social

Routine Cerebral Embolic Protection during Transcatheter Aortic-Valve Implantation | NEJM

Transcatheter aortic-valve implantation (TAVI) is associated with procedure-related stroke. Cerebral embolic protection (CEP) devices may reduce embolization to the cerebral circulation and hence t...

nej.md

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Chris Kotanidis @cpkotanidis.bsky.social · Mar 26

YT link: www.youtube.com/watch?v=to81...

How Interim Analyses Work | NEJM Evidence

YouTube video by NEJM Group

www.youtube.com

Chris Kotanidis @cpkotanidis.bsky.social · Mar 26

Ever wondered how interim analyses work in #RCTs? 📊 Check out our Stats, STAT! video at NEJM Evidence: @nejm.org @ai.nejm.org @sarahgorey.bsky.social evidence.nejm.org/doi/full/10.... #MedStats #ClinicalTrials

How Interim Analyses Work

This Stats, STAT! animated video explores interim analyses in clinical trials. During these evaluations of the data, researchers may assess safety, efficacy, and verify sample size assumptions, but...

evidence.nejm.org

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Reposted by Chris Kotanidis

NEJM.org @nejm.org · Mar 8

Tirzepatide was previously shown to provide sustained weight reductions in adults with #obesity. Longer-term findings in adults with both obesity and prediabetes are summarized in a new Quick Take video. youtu.be/c9uazgSdDJc

#MedSky #EndoSky

- YouTube

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

youtu.be

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Chris Kotanidis @cpkotanidis.bsky.social · Mar 7

🫀New research🫀 Across 6 #RCTs (n=2,257) early invasive management in #female patients with #NSTEACS did not reduce all-cause mortality or MI risk at 6 months vs. delayed management. #AHAJournals @drroxmehran.bsky.social @vijaykunadian.bsky.social
www.ahajournals.org/doi/10.1161/...

Early Versus Delayed Invasive Management of Female Patients With Non–ST-Elevation Acute Coronary Syndrome: An Individual Patient Data Meta-Analysis | Circulation: Cardiovascular Interventions

BACKGROUND: Female patients are at greater risk of adverse events following non–ST-elevation acute coronary syndrome but less frequently receive guideline-recommended coronary angiography and revascul...

www.ahajournals.org

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