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Claus Wilke @clauswilke.com · 2d

Also, if your cobs aren't at least 4 feet long what are you even doing.

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Claus Wilke @clauswilke.com · 2d

I think this is a misconception. If correlation was causation, everybody would always want to know which is cause and which is effect, and they'd expect you to figure this out. Instead, today, you can always say "Meh, correlation is not causation."

Chelsea Parlett @chelseaparlett.bsky.social · 2d

My job would be so much easier if correlation was causation😔

Form 8300 and reporting cash payments of over $10,000 | Internal Revenue Service

Claus Wilke @clauswilke.com · 3d

For no good reason, a reminder:
Cash receipts in excess of $10k received during the course of a business transaction (for example, as compensation for services rendered) need to be reported within 15 days via IRS form 8300.
www.irs.gov/businesses/s...

Generally, if you're in a trade or business and receive more than $10,000 in cash in a single transaction or in related transactions, you must file Form 8300.

www.irs.gov

Claus Wilke @clauswilke.com · 3d

Every time I log into Commons I see this message. I have no idea what it means. I have 10 reviews due by October 15 and I have no idea whether I'm supposed to do them or not. The SRO has been completely quiet since the government shutdown.

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Reposted by Claus Wilke

Mark Peifer (He, him) @peiferlabunc.bsky.social · 3d

I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n
unc.peopleadmin.com/postings/307...

Poster with QR code linking to the position

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Claus Wilke @clauswilke.com · 5d

Maybe I should write a series of posts about how to adjust the mineral composition and temperature of water to make the perfect coffee. And how to pick the right grinder for the style of coffee you're brewing.

Claus Wilke @clauswilke.com · 5d

In my experience with blogging, there are often long periods where nobody cares about my posts, and then suddenly a post goes viral and I get a massive inflow of new subscribers.

To everybody who just subscribed or started following: Most of my posts are boring. Sorry. I’m doing the best I can. 😉

Plot showing an inflow of approximately 50 new subscribers between October 7 and October 10.

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Reposted by Claus Wilke

Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 6d

"Biology is just physics and chemistry, and in principle we should be able to write down the equations of motion of any biological system and solve them numerically. In practice, however, any realistic biological system is way too large for this approach and we don’t have the required compute."

Richard Sever @richardsever.bsky.social · 6d

AI in biology: "I read about some new computational method...get excited because it’s exactly what I need...I try the method...Most of the time things don’t work...I have seen this play out so many times my default assumption is nothing is going to work" blog.genesmindsmachines.com/p/we-still-c...

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Reposted by Claus Wilke

Richard Sever @richardsever.bsky.social · 6d

AI in biology: "I read about some new computational method...get excited because it’s exactly what I need...I try the method...Most of the time things don’t work...I have seen this play out so many times my default assumption is nothing is going to work" blog.genesmindsmachines.com/p/we-still-c...

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Reposted by Claus Wilke

Andrew Iwaniuk @evoneuro.bsky.social · 6d

As I tell my students, if you arrived at a simple answer in biology you have done one of two things: arrived at the wrong answer or asked the wrong question

Claus Wilke @clauswilke.com · 8d

Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon.
blog.genesmindsmachines.com/p/we-still-c...

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Reposted by Claus Wilke

Marcin J. Suskiewicz @msuskiewicz.bsky.social · 6d

A good, thoughtful article.

Claus Wilke @clauswilke.com · 8d

Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon.
blog.genesmindsmachines.com/p/we-still-c...

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Reposted by Claus Wilke

Claus Wilke @clauswilke.com · 8d

Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon.
blog.genesmindsmachines.com/p/we-still-c...

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Claus Wilke @clauswilke.com · 7d

In the mean time, a good proxy is how quickly it starts producing designs. If you've got to wait forever and nothing is happening you may have to switch the target. If you're getting results quickly you're probably good.

Claus Wilke @clauswilke.com · 7d

It's too early to make statements about which binding pockets work better or worse. We see there are differences but haven't quantified them in any way. We'll probably write this up as a paper eventually.

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Reposted by Claus Wilke

Titus Brown @titus.idyll.org · 8d

Really good post!

Claus Wilke @clauswilke.com · 8d

Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon.
blog.genesmindsmachines.com/p/we-still-c...

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Claus Wilke @clauswilke.com · 8d

@harmitmalik.bsky.social

Claus Wilke @clauswilke.com · 8d

I'd say even with available training knowledge success is not guaranteed. See the wide spread in performance in supervised prediction of mutational effects.

Reposted by Claus Wilke

Gaurav Sablok, PhD, Taking accepted submitted job offer @omicscode.bsky.social · 8d

Thats very true. I even posted a post on my X account about that. People thought that AI is there so we don’t need interpretation but they didn’t realized that AI is learnt from the available knowledge and not that something which is not present.

Claus Wilke @clauswilke.com · 8d

Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon.
blog.genesmindsmachines.com/p/we-still-c...

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Claus Wilke @clauswilke.com · 8d

It's quite possible that some of the binders are binding and just not giving us a signal in our assays. We're aware of this possibility and thinking about ways to test it.

Disclaimer: This is a large-scale effort with multiple labs involved. My role is computational.

Claus Wilke @clauswilke.com · 8d

Biology is much more complicated than most non-biologists can imagine. And AI is not going to change this anytime soon.
blog.genesmindsmachines.com/p/we-still-c...

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Claus Wilke @clauswilke.com · 9d

I think people have to be careful with target-date funds. Being 70% in cash and bonds by year 65 is a terrible idea if you think you'll live to your late 80s or early 90s. It's probably better to just buy SP500 or Total World Stock Index or similar.