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Alessandro Gozzi

Alessandro Gozzi

@gozziale.bsky.social

1.1K followers 740 following 120 posts

Senior scientist at Istituto Italiano di Tecnologia (Rovereto, Italy)
🧠 🐁 Functional Neuroimaging, Brain (dys)connectivity and Autism
ERC Grantee
www.gozzilab.it

Neuroscience 77%

Biology 18%

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Alessandro Gozzi @gozziale.bsky.social · Mar 6

Can we use brain scans to identify biologically distinct "autisms"? And If so, how?

In our latest cross-species study 🐭👨 with @iitalk.bsky.social we dive into these questions!

Find out more here 👇👇
www.biorxiv.org/content/10.1...

Thread below 🧵 1/n

Reposted by Alessandro Gozzi

Armin Raznahan @bogglerapture.bsky.social · 11h

How do gonads and sex chromosomes contribute to regional sex differences in the brain? 🤔

Our new preprint summarizes >5 years of work on this question, combining structural neuroimaging and snRNAseq within a sample of >850 mice.

www.biorxiv.org/content/10.6...

Thread below …

Gonadal and sex chromosomal contributions to sex differences in mammalian brain organization

Sex differences in brain development may contribute to well-known sex differences in behavior and neuropsychiatric risk - making it important to comprehensively map and mechanistically annotate normat...

www.biorxiv.org

Alessandro Gozzi @gozziale.bsky.social · 1d

Very cool study! Congrats 👏🏼👏🏼

Reposted by Alessandro Gozzi

Angelo Forli @aforli89.bsky.social · 1d

For decades, imaging has forced the same trade-off:
Set a frame rate → sacrifice resolution or field of view to go fast.

We break that rule

Using an EVENT-BASED CAMERA, we record neural activity without frames. Signals are captured only where and when they occur:

www.biorxiv.org/content/10.6...

Ultrafast Frame-Free Imaging of Neural Activity with Event Cameras

Frame-based fluorescence imaging has long defined how neural activity is optically measured. This approach requires acquiring all pixels within an image, regardless of whether they carry meaningful ne...

www.biorxiv.org

Reposted by Alessandro Gozzi, Yi Zhou

Sergi Roig Puiggros @sroig.bsky.social · 4d

I'm very excited to finally see this one out in @natneuro.nature.com ! It has been an incredible journey alongside extremely talented people! Thanks to everyone involved and enjoy the reading! 1/n
www.nature.com/articles/s41...

Position-independent emergence of neocortical neuron molecular identity, connectivity and function - Nature Neuroscience

Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental programs rather than ...

Reposted by Dorothy Bishop, Alessandro Gozzi

Steve Smith @fmrib-steve.bsky.social · 4d

Preprint on PANDORA by Aslan Abivardi:

A massive archive of UK Biobank brain imaging from 82K subjects. For each of 98 sub-modalities (e.g., FA from dMRI), the images are collated into a convenient subjectsXvoxels HDF5 file.

pages.fmrib.ox.ac.uk/pandora/web/

www.medrxiv.org/content/10.6...

Reposted by Markus Appel, Alessandro Gozzi

Eiko Fried @eikofried.bsky.social · 6d

Would love to hear expert views on this paper. It appears to show that the operationalization of brain activity the field has relied on for 3 decades—the BOLD response—is not actually a sensible measure of brain activity.

www.nature.com/articles/s41...

BOLD signal changes can oppose oxygen metabolism across the human cortex - Nature Neuroscience

Using quantitative brain imaging, the authors show opposite fMRI BOLD signal to metabolic activity due to variable oxygen extraction across the human cortex. This questions the canonical interpretatio...

Reposted by Márk E. Hauber, Alessandro Gozzi

Cheng Huang @huangchengwashu.bsky.social · 9d

Recent review about long-range axons rdcu.be/eXeDG

Long-range axon branching: contributions to brain network plasticity and repair

Nature Reviews Neuroscience - Connectome reconstructions across multiple species reveal that the morphology of axonal projections is highly variable, even between neurons of the same location or...

Reposted by Alessandro Gozzi

Cedric Boeckx @cedricboeckx.bsky.social · 12d

Very happy to see this great study by @skrohn.bsky.social @carstenfinke.bsky.social @engra.me @sofievalk.bsky.social on brain shape & human brain development, out in @natneuro.nature.com
🧪🧠
www.nature.com/articles/s41...

Fractal analysis of brain shape formation predicts age and genetic similarity in human newborns - Nature Neuroscience

Fractal analysis of structural MRI captures the formation of brain shape in human newborns and outperforms other morphological measures in predicting infant age and genetic similarity, including the i...

Reposted by Alessandro Gozzi

PessoaBrain @pessoabrain.bsky.social · 14d

𝗧𝗵𝗲 𝗘𝗻𝘁𝗮𝗻𝗴𝗹𝗲𝗱 𝗕𝗿𝗮𝗶𝗻
Annual reminder that the book is open access.
How do we think of the brain as a deeply interconnected system with highly distributed, non hierarchical processing.
Want to learn about the brain from a fresh perspective?
#neuroskyence
mitpress.mit.edu/978026254460...

The Entangled Brain

Popular neuroscience accounts often focus on specific mind-brain aspects like addiction, cognition, or memory, but The Entangled Brain tackles a much bigger ...

mitpress.mit.edu

Reposted by Alessandro Gozzi

Bryan Roth @zenbrainest.bsky.social · 15d

Postdoctoral fellowship available in structure guided drug discovery in @RothLabUNC
Please RT

Reposted by Jennifer Bussell, Alessandro Gozzi

Ben Hayden @benhayden.bsky.social · 19d

New Perspective from myself, Sarah Heilbronner and @myoo.bsky.social . “Rethinking the centrality of brain areas in understanding functional organization” in Nature Neuroscience. 🧵

rdcu.be/eVZ1A

Rethinking the centrality of brain areas in understanding functional organization

Nature Neuroscience - Parcellation of the cortex into functionally modular brain areas is foundational to neuroscience. Here, Hayden, Heilbronner and Yoo question the central status of brain areas...

Alessandro Gozzi @gozziale.bsky.social · 23d

Wrapping up 2025 with the lab.

Proud moments (including some I once thought impossible) and so many failures, living side by side, as science does. We stuck with it together. Grateful for the shared effort, trust, and fun that shaped this year.

Wishing everyone a peaceful holiday break!

Reposted by Alessandro Gozzi

Rick Betzel @richardfbetzel.bsky.social · Dec 12

Just provisionally accepted -- preprint updated | The dual interpretation of edge time series: Time-varying connectivity versus statistical interaction | www.biorxiv.org/content/10.1...

The dual interpretation of edge time series: Time-varying connectivity versus statistical interaction

Functional connectivity (FC) is frequently operationalized as a correlation. Many studies have examined changes in correlation networks across time, claiming to link time-varying fluctuations to ongoi...

www.biorxiv.org

Reposted by Alessandro Gozzi

Alex Fornito @alexfornito.bsky.social · Dec 11

Come and join our team! We are looking for a Research Officer to help with recruitment and assessment on a large-scale human brain imaging study:

careers.pageuppeople.com/513/cw/en/jo...

careers.pageuppeople.com

Reposted by Alessandro Gozzi

PessoaBrain @pessoabrain.bsky.social · Dec 10

𝗕𝗿𝗮𝗶𝗻 𝗻𝗲𝘁𝘄𝗼𝗿𝗸𝘀, 𝘄𝗵𝗮𝘁 𝗮𝗿𝗲 𝘁𝗵𝗲𝘆?
@lucinauddin.bsky.social explains many of the challenges and controversies! Great discussion too.
Check out the latest Neuroscience & Philosophy Salon.
youtu.be/pP5swFPR0Ns

Prof. Lucina Uddin from UCLA discusses her views on brain networks as studied with functional MRI

YouTube video by Neuroscience & Philosophy Salon

Alessandro Gozzi @gozziale.bsky.social · Dec 9

Very cool result! Congrats! Reminds
of what we found in the rat upon i.v..ghrelin infusion!
👇
pmc.ncbi.nlm.nih.gov/articles/PMC...

Brain Reinforcement System Function is Ghrelin Dependent: Studies in the Rat Using Pharmacological fMRI and Intracranial Self-Stimulation

Ghrelin (GHR) is an orexigenic gut peptide that interacts with brain ghrelin receptors (GHR-Rs) to promote food intake. Recent research suggests that GHR acts as a modulator of motivated behavior, suggesting a direct influence of GHR on brain ...

pmc.ncbi.nlm.nih.gov

Reposted by Alessandro Gozzi

Andrea Luppi @loopyluppi.bsky.social · Dec 8

🧠 Excited to share our latest preprint: Automated Brain Mapping with AI Experts!🤖

www.biorxiv.org/content/10.6...

Ever wanted to summarise the cognitive/systems neuroscience literature beyond MRI and PET? Ever wished we could do the same for macaque 🐒 and mouse 🐭 ? Read on! 🧵👇

Cognitive cartography of mammalian brains using meta-analysis of AI experts

The complexity of the brain is increasingly mirrored by the complexity of the neuroscientific literature, yet no individual mind can fully grasp the diversity of scales, methodologies and model organi...

www.biorxiv.org

Alessandro Gozzi @gozziale.bsky.social · Dec 5

As we chase whole-brain signatures of cognition with fMRI, this fascinating perspective argues that cognitive signals are broadly distributed...but far from everywhere! For those of us using whole-brain neuroimaging lots to think about..
👇
www.nature.com/articles/s41...

How distributed is the brain-wide network that is recruited for cognition? - Nature Reviews Neuroscience

Both localized and distributed views on the functional organization of the brain have been put forward. In this Perspective, Rosen and Freedman examine the degree to which these two views account for ...

Reposted by Alessandro Gozzi

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Dec 3

Cognitive cartography of mammalian brains using meta-analysis of AI experts https://www.biorxiv.org/content/10.64898/2025.12.01.691701v1

Reposted by Alessandro Gozzi

Department of Engineering, University of Cambridge @eng.cam.ac.uk · Dec 3

Dr Andrea Luppi is one of 25 early-career researchers recognised for their outstanding scientific contributions and commitment to mentoring and community-building in neuroscience.
@thetransmitter.bsky.social
@stjohnscollege.bsky.social
www.eng.cam.ac.uk/news/dr-andr...

Dr Andrea Luppi named ‘Rising Star in Neuroscience 2025’

Dr Andrea Luppi is among 25 researchers worldwide to be recognised by The Transmitter – a US-based publication for the neuroscience community. Rising Stars in Neuroscience 2025 honours early-career re...

www.eng.cam.ac.uk

Reposted by Alessandro Gozzi

Rick Betzel @richardfbetzel.bsky.social · Dec 2

Exciting new work from @lindenmp.bsky.social and friends!

Inferring intrinsic neural timescales using optimal control theory
www.nature.com/articles/s41...

Inferring intrinsic neural timescales using optimal control theory - Nature Communications

Here, the authors develop novel dynamical methods to model brain regions’ intrinsic neural timescales (INTs) from data, and find that they couple whole-brain structural connectivity to dynamic switchi...

Reposted by Alessandro Gozzi

OHBM Communications Committee (ComCom) @ohbm-com.com · Dec 2

Each year we have the pleasure of interviewing the OHBM Award Winners 🏆

First up is Prof Mac Shine, winner of the 2025 Early Career Investigator Award! 🌟 @macshine.bsky.social

Watch the interview here: www.ohbm-com.com/blog/intervi...

Interview with Prof. Mac Shine, 2025 Winner of the Early Career Investigator Award — OHBM Communications

Writer: Ashley Tyrer Editor: Audrey Luo, Alfie Wearn Video Editor: Xuqian Michelle Li

www.ohbm-com.com

Reposted by Alessandro Gozzi

Sylvain Baillet @sylvainbaillet.bsky.social · Nov 28

Please repost: another kind of Black-Friday deal!

Reposted by Todd M. Gureckis, Alessandro Gozzi

Bradley Love @profdata.bsky.social · Nov 25

"The inevitability and superfluousness of cell types in spatial cognition". Intuitive cell types are found in random artificial networks using the same selection criteria neuroscientists use with actual data. elifesciences.org/reviewed-pre... 1/2

elifesciences.org

Reposted by Alessandro Gozzi

Ted Satterthwaite @ted-satterthwaite.bsky.social · Nov 24

#PenNLINC is recruiting a clinical coordinator / lab manager!!! Looking for someone who is good with both people + code, wants to learn to acquire + analyze imaging data. Alumni in this role have written 1st author papers + gone to top grad programs.

Website: www.pennlinc.io

Job: bit.ly/4ojvCir

neuroimaging | Satterthwaite Lab | UPenn

www.satterthwaitelab.com Homepage for Satterthwaite lab neuroimaging | neurodevelopment | adolescence | psychiatry | machine learning | network science

www.pennlinc.io

Reposted by Alessandro Gozzi

Ian Shih @shihyyi.bsky.social · Nov 20

1/6 Excited to share our new Nature Protocols article led by Tatiana Shnitko: “Measurement of electrochemical brain activity with fast-scan cyclic voltammetry during fMRI”, a step-by-step guide for simultaneous FSCV + fMRI.
www.nature.com/articles/s41...

Reposted by Stefan Müller, Mark Rubin, Paolo Crosetto , and 3 more Stefan Müller, Mark Rubin, Paolo Crosetto, Madeleine Pownall, Johannes Breuer, Alessandro Gozzi

Dan Quintana @dsquintana.bsky.social · Nov 14

Our paper on improving statistical reporting in psychology is now online 🎉

As a part of this paper, we also created the Transparent Statistical Reporting in Psychology checklist, which researchers can use to improve their statistical reporting practices

www.nature.com/articles/s44...

Transparent and comprehensive statistical reporting is critical for ensuring the credibility, reproducibility, and interpretability of psychological research. This paper offers a structured set of guidelines for reporting statistical analyses in quantitative psychology, emphasizing clarity at both the planning and results stages. Drawing on established recommendations and emerging best practices, we outline key decisions related to hypothesis formulation, sample size justification, preregistration, outlier and missing data handling, statistical model specification, and the interpretation of inferential outcomes. We address considerations across frequentist and Bayesian frameworks and fixed as well as sequential research designs, including guidance on effect size reporting, equivalence testing, and the appropriate treatment of null results. To facilitate implementation of these recommendations, we provide the Transparent Statistical Reporting in Psychology (TSRP) Checklist that researchers can use to systematically evaluate and improve their statistical reporting practices (https://osf.io/t2zpq/). In addition, we provide a curated list of freely available tools, packages, and functions that researchers can use to implement transparent reporting practices in their own analyses to bridge the gap between theory and practice. To illustrate the practical application of these principles, we provide a side-by-side comparison of insufficient versus best-practice reporting using a hypothetical cognitive psychology study. By adopting transparent reporting standards, researchers can improve the robustness of individual studies and facilitate cumulative scientific progress through more reliable meta-analyses and research syntheses.

Reposted by Alessandro Gozzi

Sylvain Baillet @sylvainbaillet.bsky.social · Nov 13

🚨New review paper ! Lovely to reconnect with Sheraz Khan around what we think is a timely review of the state of knowledge about brain electrophysiological markers of early/late Alzheimer’s disease pathophysiology, and what's left to discover.
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Tracking electrophysiological signatures of Alzheimer's disease: a systematic review of multimodal studies

We conducted a review of the electrophysiological manifestations of Alzheimer's disease (AD) as captured by electroencephalography (EEG) and magnetoencephalography (MEG), with a focus on tracking th...

alz-journals.onlinelibrary.wiley.com

Reposted by Dorothy Bishop, Alessandro Gozzi

Kevin Mitchell @wiringthebrain.bsky.social · Nov 13

New paper with @statsepi.bsky.social and @deevybee.bsky.social in which we show there's really no evidence for a link between the gut microbiome and autism www.cell.com/neuron/fullt...

Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism

Claims that the gut microbiome causally contributes to autism regularly appear in the scientific literature and popular press. Mitchell et al. critically examine influential studies underpinning these...

Reposted by Alessandro Gozzi

Ravi Menon @northernthrux.bsky.social · Nov 13

14 months after submission, our article “Stimulus-modulated approach to steady state (SASS): a flexible paradigm for event-related fMRI" is now out in @natmethods.nature.com . You can read it here rdcu.be/ePJo6
It is the first first author paper from my student @renilmathew.bsky.social 👏🏽👏🏽👏🏽 …1/N

Stimulus-modulated approach to steady state (SASS): a flexible paradigm for event-related fMRI

Nature Methods - Stimulus-modulated approach to steady state (SASS) is an acquisition scheme for event-related fMRI that generates data with high temporal signal-to-noise ratios interspaced with...