The Lancet Diabetes Endocrinology
The Lancet is a weekly peer-reviewed general medical journal, founded in England in 1823. It is one of the world's… more
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New in the November issue:
Managing adults with screen-detected islet autoantibody positivity: a pragmatic framework www.thelancet.com/journals/lan...
#type 1 #diabetes #T1D
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Managing adults with screen-detected islet autoantibody positivity: a pragmatic framework www.thelancet.com/journals/lan...
#type 1 #diabetes #T1D
#MedSky #EndoSky
Managing adults with screen-detected islet autoantibody positivity: a pragmatic framework
New disease-modifying therapies, such as teplizumab, offer opportunities to delay
the clinical onset of type 1 diabetes but require islet autoantibody screening to
identify individuals at increased ri...
www.thelancet.com
New in the November issue:
Addressing educational needs in older adults with type 1 #diabetes www.thelancet.com/journals/lan...
#T1D #olderadults
#FREE to read
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Addressing educational needs in older adults with type 1 #diabetes www.thelancet.com/journals/lan...
#T1D #olderadults
#FREE to read
#MedSky #EndoSky
Addressing educational needs in older adults with type 1 diabetes
Type 1 diabetes is a lifelong condition requiring a multitude of tasks and constant
adaptation to evolving physiological and lifestyle needs. Following a type 1 diabetes
diagnosis, and throughout thei...
www.thelancet.com
Read our November Issue, featuring glucocorticoid-induced osteoporosis, obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease, type 1 diabetes, medical education, older adults, & much more tinyurl.com/mwfu4c6m
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#MedSky #EndoSky #RheumSky
Reposted by The Lancet Diabetes Endocrinology
New review - Age-related changes of the gastrointestinal tract
www.thelancet.com/journals/lan...
#GastroSky #MedSky
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Carmine Zoccali & Francesca Mallamaci comment on:
#Empagliflozin in chronic #kidney disease: evidence for early, inclusive, and confident use thelancet.com/journals/lan...
#SGLT2 inhibitor #CKD
#FREE to read with registration (also FREE)
#MedSky #EndoSky #RenalSky
#Empagliflozin in chronic #kidney disease: evidence for early, inclusive, and confident use thelancet.com/journals/lan...
#SGLT2 inhibitor #CKD
#FREE to read with registration (also FREE)
#MedSky #EndoSky #RenalSky
Empagliflozin in chronic kidney disease: evidence for early, inclusive, and confident use
The scenario of chronic kidney disease (CKD) management has been transformed by the
advent of sodium glucose co-transporter-2 (SGLT2) inhibitors, a class of drugs with
benefits extending well beyond g...
thelancet.com
New—Effects of #empagliflozin on conventional and exploratory acute and chronic #kidney outcomes: an individual participant-level meta-analysis thelancet.com/journals/lan...
#SGLT2 inhibitor #CKD
#OpenAccess
#MedSky #EndoSky #RenalSky
#SGLT2 inhibitor #CKD
#OpenAccess
#MedSky #EndoSky #RenalSky
Effects of empagliflozin on conventional and exploratory acute and chronic kidney outcomes: an individual participant-level meta-analysis
SGLT2 inhibition reduces risk of acute and chronic kidney outcomes irrespective of
the size of the acute dip in eGFR. Kidney benefits are evident irrespective of diabetes
status, heart failure status,...
thelancet.com
#Hyperprolactinaemia can result from dopamine antagonist drug effects and reduced prolactin clearance with liver or kidney disease with loss of feedback regulation thelancet.com/journals/lan...
#prolactinoma #pituitary #adenoma
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#prolactinoma #pituitary #adenoma
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There is substantial heterogeneity in the contributors to the pathophysiology of #MASLD, which might influence its rate of progression, its relationship with #cardiometabolic diseases, and the response to therapy www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky #LiverSky #HepSky
#OpenAccess
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Although obesity & a sedentary lifestyle are considerable contributors, research over the last 25 years has shown that type 2 #diabetes develops on a predisposing #genetic background, with family & twin studies indicating considerable heritability (ie, 31–72%) www.thelancet.com/journals/lan...
#T2D
#T2D
Dissection of type 2 diabetes: a genetic perspective
Diabetes is a leading cause of global mortality and disability, and its economic burden
is substantial. This Review focuses on type 2 diabetes, which makes up 90–95% of all
diabetes cases. Type 2 diab...
www.thelancet.com
Controlling weight and cardiovascular risk factors is paramount in type 2 #diabetes management; however, the definition and feasibility of #remission warrant closer examination www.thelancet.com/journals/lan...
#T2D
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#T2D
#MedSky #EndoSky #CardioSky
Re-evaluating the concept of remission in type 2 diabetes: a call for patient-centric approaches
Controlling weight and cardiovascular risk factors is paramount in type 2 diabetes
management; however, the definition and feasibility of remission warrant closer examination.
Type 2 diabetes remissio...
www.thelancet.com
Reposted by The Lancet Diabetes Endocrinology
Our latest issue is out now at www.thelancet.com/gastrohep!
Content includes #obesity, #MASLD, #FMT for #Cdiff #viralhepatitis, #cirrhosis, #DGBI & more!
#GastroSky #LiverSky #MedSky
Content includes #obesity, #MASLD, #FMT for #Cdiff #viralhepatitis, #cirrhosis, #DGBI & more!
#GastroSky #LiverSky #MedSky
by The Lancet — Reposted by The Lancet Diabetes Endocrinology
The treatment of type 1 diabetes is entering a transformative era.
A recent Review explores three paradigm-shifting developments poised to transform type 1 diabetes treatment: tinyurl.com/2834ymk7
A recent Review explores three paradigm-shifting developments poised to transform type 1 diabetes treatment: tinyurl.com/2834ymk7
#Glucocorticoid treatment has become the most common drug-induced form of #osteoporosis because of its broad therapeutic use for various inflammatory & haematological diseases & its pivotal role in transplantation medicine www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky #RheumSky
#OpenAccess
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Glucocorticoid-induced osteoporosis: novel concepts and clinical implications
Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay
in the management of various immune-mediated diseases. High cumulative doses of exogenous
glucocorticoids lead...
www.thelancet.com
Has the WHO Model Essential Medicines List lost its way? www.thelancet.com/journals/lan...
#FREE to read
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#FREE to read
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Recovery of β-cell function is the dominant determinant of the remission of prediabetes, akin to its role in remission of diabetes but at an earlier point in the natural history of dysglycaemia www.thelancet.com/journals/lan...
#prediabetes #remission
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#prediabetes #remission
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The central role of recovery of β-cell function in the remission of prediabetes: a prospective cohort study in Canada
Recovery of β-cell function is the dominant determinant of the remission of prediabetes,
akin to its role in remission of diabetes but at an earlier point in the natural history
of dysglycaemia.
www.thelancet.com
As screening and early treatment for type 1 #diabetes become more widespread, the European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) consortium highlights the need for clearer, more consistent terminology www.thelancet.com/journals/lan... #T1D
A syndromic framework grounded in molecular pathophysiology could ultimately reorient #diabetes care towards precise, stratified risk prediction, personalised prevention, and targeted therapy www.thelancet.com/journals/lan... #T2D
#FREE to read with registration (also FREE)
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#FREE to read with registration (also FREE)
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Type 2 diabetes subtypes classification: a global reckoning with heterogeneity
For decades, type 2 diabetes has been managed as a monolithic condition, defined by
hyperglycaemia and treated via uniform, stepwise algorithms. Although operationally
convenient, this practice increa...
www.thelancet.com
by The Lancet — Reposted by The Lancet Diabetes Endocrinology
Incretin-based therapies are becoming a core component of diabetes care.
By linking digestion, metabolism, & cardiovascular function, incretin-based therapies can help reduce morbidity & mortality.
Find out more in @thelancetendo.bsky.social: tinyurl.com/dvtv7j28
By linking digestion, metabolism, & cardiovascular function, incretin-based therapies can help reduce morbidity & mortality.
Find out more in @thelancetendo.bsky.social: tinyurl.com/dvtv7j28
Joint Linked Comment by Adrian F Daly:
Experience evolves into evidence in the new MEN1 guidelines thelancet.com/journals/lan...
#MEN1
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Experience evolves into evidence in the new MEN1 guidelines thelancet.com/journals/lan...
#MEN1
#FREE to read with registration (also FREE)
#MedSky #EndoSky #OncSky
Experience evolves into evidence in the new MEN1 guidelines
Nearly a quarter of a century has passed since the publication of the first clinical
practice guideline on multiple endocrine neoplasia type 1 (MEN1) in 2001, which followed
the identification of the ...
thelancet.com
Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis thelancet.com/journals/lan...
#MEN1
#OpenAccess
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#MEN1
#OpenAccess
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Treatments for MEN1-associated endocrine tumours: three systematic reviews and a meta-analysis
In patients with MEN1, subtotal parathyroidectomy achieved greater reductions in persistence
and recurrence of primary hyperparathyroidism than less than subtotal parathyroidectomy;
for non-functionin...
thelancet.com
Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice thelancet.com/journals/lan...
#MEN1
#FREE to read with registration (also FREE)
#MedSky #EndoSky #OncSky
#MEN1
#FREE to read with registration (also FREE)
#MedSky #EndoSky #OncSky
Multiple endocrine neoplasia type 1 (MEN1): recommendations and guidelines for best practice
Multiple endocrine neoplasia type 1 (MEN1) is characterised by combined occurrence
of parathyroid tumours, duodenopancreatic neuroendocrine tumours, and anterior pituitary
adenomas. Some patients migh...
thelancet.com
Fragility fractures remain a common & serious
complication of long-term oral glucocorticoid therapy
that can affect all skeletal sites although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky
complication of long-term oral glucocorticoid therapy
that can affect all skeletal sites although the spine is
particularly prone to fractures owing to its high proportion
of trabecular bone www.thelancet.com/journals/lan...
#OpenAccess
#MedSky #EndoSky
Glucocorticoid-induced osteoporosis: novel concepts and clinical implications
Despite advances in targeted therapies, treatment with glucocorticoids remains a mainstay
in the management of various immune-mediated diseases. High cumulative doses of exogenous
glucocorticoids lead...
www.thelancet.com
Kishore M Gadde & colleagues comment on:
Peripheral CB1 receptor blockade for treatment of obesity www.thelancet.com/journals/lan...
#monlunabant #obesity #metabolic #syndrome
#MedSky #EndoSky
Peripheral CB1 receptor blockade for treatment of obesity www.thelancet.com/journals/lan...
#monlunabant #obesity #metabolic #syndrome
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Peripheral CB1 receptor blockade for treatment of obesity
The endocannabinoid system—comprising cannabinoid receptors (CB1 and CB2), lipid-derived
ligands, and metabolic enzymes—plays a major role in regulating energy homoeostasis.1
CB1 receptors are abundan...
www.thelancet.com
The implications of this trial, combined with existing evidence, suggest that #monlunabant has potential as a novel treatment option for people with #obesity and #metabolic #syndrome, if a safe and effective therapeutic window can be established www.thelancet.com/journals/lan...
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The evolutionary basis for type 2 #diabetes prevalence in the Arabian Peninsula www.thelancet.com/journals/lan... #T2D
#MedSky #EndoSky
#MedSky #EndoSky
#Hyperprolactinaemia can result from physiological causes, pharmacological agents, or pathological conditions such as #prolactin-secreting #pituitary #adenomas and other pituitary stalk-compressing masses
www.thelancet.com/journals/lan...
#prolactinomas
#MedSky #EndoSky #OncSky
www.thelancet.com/journals/lan...
#prolactinomas
#MedSky #EndoSky #OncSky
Prolactin-secreting adenomas: pathogenesis, diagnosis, and management
Hyperprolactinaemia can result from physiological causes, pharmacological agents,
or pathological conditions such as prolactin-secreting pituitary adenomas and other
pituitary stalk-compressing masses...
www.thelancet.com
As the targets of tyrosine kinase inhibitors (#TKIs) also have roles in many physiological processes, TKIs can cause multiple treatment-related adverse events, among which an increase in serum #thyroid stimulating hormone (TSH) concentrations frequently occurs www.thelancet.com/journals/lan... .
The unique signature of tyrosine kinase inhibitor-induced hypothyroidism
Tyrosine kinase inhibitors (TKIs) are anti-cancer agents that inhibit the activity
of oncogenic protein kinases. Thyroid hormone abnormalities are common during treatment
with TKIs, typically manifest...
www.thelancet.com
by The Lancet — Reposted by The Lancet Diabetes Endocrinology
Tune in on October 3rd for the official launch of the 2025 EAT-Lancet Commission. A major update to the science and what it means for our global food system.
🔗 Register for the livestream here: bit.ly/3Kg9SW8
🔗 Register for the livestream here: bit.ly/3Kg9SW8
by The Lancet — Reposted by The Lancet Diabetes Endocrinology
Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlled, adaptive dose-ranging trial tinyurl.com/bdenbtyb
Minimum effective low dose of antithymocyte globulin in people aged 5–25 years with recent-onset stage 3 type 1 diabetes (MELD-ATG): a phase 2, multicentre, double-blind, randomised, placebo-controlle...
In young people with recent-onset, clinical type 1 diabetes, 2·5 mg/kg and 0·5 mg/kg
ATG reduced loss of β-cell function, showing the potential of an affordable, repurposed
agent, ATG, in a low and sa...
tinyurl.com
The gut–bone axis: implications of gut hormone-based therapies for bone health thelancet.com/journals/lan...
#GLP-1 #GIP #incretins #weightloss #obesity #overweight #Bonehealth #osteoporosis
#MedSky #EndoSky #RheumSky
#GLP-1 #GIP #incretins #weightloss #obesity #overweight #Bonehealth #osteoporosis
#MedSky #EndoSky #RheumSky
The gut–bone axis: implications of gut hormone-based therapies for bone health
Historical trends and future projections of the number of people with overweight and
obesity suggest alarming parallel increases in serious and potentially fatal comorbidities,
particularly type 2 dia...
thelancet.com