Alan Parker's emotionally charged portrait of a collapsing marriage showcases the late Diane Keaton and Albert Finney in two of the finest performances of their careers. Too realistic and downbeat to ...

Alan Parker’s emotionally charged portrait of a collapsing marriage showcases the late Diane Keaton and Albert Finney in two of the finest performances of their careers. Too realistic and downbeat to be a wide success in its day, it endures as an uncompromising depiction of human frailty. Gifted child actress Dana Hill passed away prematurely...

Although people living in malaria-endemic areas experience repeated infections with Plasmodium, the role of regulatory T cells (Tregs) in recurrent malaria remains poorly understood. During a primary infection with Plasmodium, Tregs suppress protective immunity by inhibiting germinal center (GC) reactions, thereby impeding the control of parasitemia. In contrast, we demonstrate here that memory Tregs (mTregs) remaining after the clearance of initial Plasmodium infection acquire protective functions upon recall. Relying on longitudinal studies in humans and mice, we show that mTregs undergo antigen-driven expansion and inflammation-induced epigenetic reprogramming during reinfection to transition from Foxp3+ immunosuppressive cells to Bcl6+ follicular T helper (Tfh)-like effectors. These mTreg-derived Tfh-like cells enhance GC responses and the generation of Plasmodium-specific antibodies, ultimately facilitating Plasmodium control. Precluding such mTreg-to-Tfh differentiation abolished protection. Our findings reveal a previously unrecognized adaptive plasticity in canonical mTregs that enables a context-dependent functional switch from immunoregulatory to protective effectors during recurrent infections.

The National Privacy Commission of the Philippines has ordered Tools for Humanity to halt all data processing operations in the country.

In a move sure to raise eyebrows across crypto and privacy advocacy communities, the National Privacy Commission (NPC) clarified on October 13, 2025, what “registration” actually means—and spoiler alert, it’s not a stamp of approval. As the iris-scanning saga involving World/Tools For Humanity continues to unfold in the Philippines, this distinction could be the difference […]

Although people living in malaria-endemic areas experience repeated infections with Plasmodium, the role of regulatory T cells (Tregs) in recurrent malaria remains poorly understood. During a primary infection with Plasmodium, Tregs suppress protective immunity by inhibiting germinal center (GC) reactions, thereby impeding the control of parasitemia. In contrast, we demonstrate here that memory Tregs (mTregs) remaining after the clearance of initial Plasmodium infection acquire protective functions upon recall. Relying on longitudinal studies in humans and mice, we show that mTregs undergo antigen-driven expansion and inflammation-induced epigenetic reprogramming during reinfection to transition from Foxp3+ immunosuppressive cells to Bcl6+ follicular T helper (Tfh)-like effectors. These mTreg-derived Tfh-like cells enhance GC responses and the generation of Plasmodium-specific antibodies, ultimately facilitating Plasmodium control. Precluding such mTreg-to-Tfh differentiation abolished protection. Our findings reveal a previously unrecognized adaptive plasticity in canonical mTregs that enables a context-dependent functional switch from immunoregulatory to protective effectors during recurrent infections.

Woody Allen’s breakthrough film, released 40 years ago this week, is a finely observed romance, a surreal time-traveling autobiography and a stand-up comedy confessional. With the help of cinematograp...

Woody Allen’s breakthrough film, released 40 years ago this week, is a finely observed romance, a surreal time-traveling autobiography and a stand-up comedy confessional. With the help of cinematographer Gordon Willis and editor Ralph Rosenblum, Allen juggles those disparate elements with the skill of a Houdini. Diane Keaton’s exquisitely flakey and funny performance was rewarded by the Academy who named her the Best Actress of 1977.Here's Bob Weide with more thoughts on Woody Allen.