A global study reveals sexual selection influences life expectancy differences between sexes in mammals and birds, reshaping aging research and public health.

In this Perspective, Joshua Rubin emphasizes the importance of gender–sex interaction (GSI) differences in cancer biology and clinical parameters to enhance precision medicine. He outlines the challenges and opportunities of integrating GSI effects into personalized oncology and argues that optimal outcomes require extending our current molecular approaches to include family history, life history and individual vulnerabilities in our diverse groups of patients with cancer.

Sex matters in metastasis, but it has received little attention in research. Here, we highlight the emerging and important roles of biological sex in metastasis and advocate for mechanistic and quantitative studies for the future development of sex-tailored therapies.

Abstract. Immune function varies widely across humans. Biological sex is a key factor underlying human immune variability, with men presenting with more se

AbstractAims. The impact of sex-related differences on outcomes following transcatheter aortic valve replacement (TAVR) remains inconclusive. This study in